IMPACT OF CEB TOOLS IN BIOMEDICAL RESEARCH
No.User GroupInvestigatorsNLM ToolImage TypeStudy/Project NameObjectiveDescriptionStatusMedical Journal Publications
1 National Cancer Institute, DCEG/HREB NCI: Jose Jeronimo, M.D.; Mark Schiffman, M.D. Boundary Marking Tool, Multimedia Database Tool, Virtual Microscope, Teaching Tool Uterine cervix – digitized 35 mm color slides; Uterine cervix – digitized biopsy (histology) slides Tool development for uterine cervix cancer research Develop suite of software tools for archiving image and clinical text data for uterine cervix; to allow Web access to the data for research and further data collection; to provide tools for medical expert training. 100,000 digitized slides of uterine cervix; 2,000 digitized histology images. Longitudinal, multi-year data collected in Costa Rica and in the U.S. In progress
2 National Cancer Institute, DCEG/HREB Jose Jeronimo, M.D. Boundary Marking Tool Uterine cervix – digitized 35 mm color slides Lesion marking on digital images Examine Reproducibility of Lesion Marking; Correlation of Visual Diagnosis with HPV Infection 939 images, 20 expert observers Complete
3 National Cancer Institute, DCEG/Viral Epidemiology James Goedert, M.D. Boundary Marking Tool Skin lesions – digital photos Kaposi Sarcoma Nicotine Treatment Evaluation regression of Kaposi sarcoma skin lesions under treatment with nicotine patch 24 patients; 950 images obtained over 15 weeks; 2 expert observers Complete
4 National Cancer Institute, DCEG/HREB Jose Jeronimo, M.D.; Phil Castle, Ph.D. Boundary Marking Tool Uterine cervix – digitized 35 mm color slides Age-related changes of the cervix Study correlation between amount of columnar epithelium/age to presence of carcinogenic and non-carcinogenic HPV 945 patients; 945 images; 1 expert observer Complete
5 National Cancer Institute, DCEG/HREB Julia Gage, Ph.D.; Jose Jeronimo M.D. Boundary Marking Tool Uterine cervix – digitized 35 mm color slides Multinational evaluation of a new approach for cervical cancer screening and treatment A new approach of cervical cancer prevention based on HPV-DNA testing followed by visual inspection will be tested with physicians and nurses from USA, Peru, Costa Rica, Nicaragua, and South Africa. 721 images, approx. 20 trained observers (midwives) in Peru Complete
  • Gage JC, et al. An evaluation by midwives and gynecologists of treatability of cervical lesions by cryotherapy among HPV-positive women. Accepted for publication in International Journal of Gynecological Cancer.
  • Gage JC et al. Treatability by Cryotherapy in a Screen-and-Treat Strategy. Accepted for publication in Journal of Lower Genital Tract Diseases.
6 American Soc. for Colposcopy and Cervical Pathology; National Cancer Institute, DCEG/HREB ASCCP: Dennis O’Connor, M.D.; Alan Waxman, M.D. NCI: Jose Jeronimo, M.D. Boundary Marking Tool Uterine cervix – digitized 35 mm color slides Multi-expert evaluation and consensus in the evaluation of digitized cervigrams to be used for training purposes Selection of pictures with consensus among the expert colposcopists to be used for training in colposcopy. 150 images, 6 expert observers Complete
  • Massad JS. American Society for Colposcopy and Cervical Pathology and the National Institutes of Health explore research collaboration. [Editorial] Journal of Lower Genital Tract Disease, 2006, 10(1), 1-2.
7 American Soc. for Colposcopy and Cervical Pathology; National Cancer Institute ASCCP: L. Stewart Massad, M.D. NCI: Jose Jeronimo, M.D.; Mark Schiffman, M.D. Boundary Marking Tool Uterine cervix – digitized 35 mm color slides Interobserver agreement Estimate reproducibility of expert visual evaluation of acetowhite lesions. 862 patients; 862 images, 20 observers Complete
8 National Cancer Institute, DCEG/HREB Mark Schiffman, M.D.; Melinda Butch-Kovacic, Ph.D. Virtual Microscope Uterine cervix – digitized biopsy (histology) slides Evaluate virtual microscope for cell counting   500 images; 1 observer In progress  
9 American Soc. for Colposcopy and Cervical Pathology; National Cancer Institute, DCEG/HREB ASCCP: Alan Waxman, M.D.; Kathy Poole, Exec. Admin.NCI: Nico Wentzensen, M.D.; Mark Schiffman, M.D. Teaching Tool Uterine cervix – digitized 35 mm color slides Medical Training Create image-based system for information collection and expert assessment over the Web   In progress  
10 National Cancer Institute, DCEG/HREB NCI: Nico Wentzensen, M.D.; Mark Schiffman, M.D. Boundary Marking Tool; Multimedia Database Tool Uterine cervix – digitized 35 mm color slides Cervix Biopsy Create data collection with biopsy points marked on cervix images; store actual biopsy outcomes to create set of medical outcomes correlated with spatial location data for the tissue regions. 1,000 patients; 1,000 images, from University of Oklahoma Health Sciences Center In progress  
11 National Cancer Institute, DCEG/Genetic Epidemiology; Center for Cancer Research / Cell and Cancer Biology Maria Teresa Landi, M.D., Ph.D.; Ilona Linnoila, M.D. Virtual Microscope Lung – digitized biopsy (histology) slides Lung Diagnosis from Digital Image Investigate efficacy of lung cancer diagnosis from digital biopsy versus glass slides. Approx. 200 lung histology images In progress  
12 National Cancer Institute, DCEG/Biostatistics Catharine Schairer, Ph.D. Inflammatory Breast Cancer Tool Breast Anatomy – digitized color photos Case-control study of inflammatory breast cancer in North Africa and France. Investigate causes of inflammatory breast cancer, using digitized images to confirm diagnosis by local physicians. Images for 400 IBC cases
Data is collected from two centers in Egypt, one center in Morocco, one center in Tunisia, and four private clinics in Tunisia.		 In progress  
13 National Cancer Institute, DCEG/HREB Sophia Wang, Ph.D.; Nicolas Wentzensen, M.D. HPV Linear Array Tool Digitized HPV Linear Array Strips Computer Interpretation of HPV Linear Array Strips Investigate automated reading of HPV linear array strips as aid in labor required and in reproducibility of interpretations. 84 images, 1,018 patient visits In progress

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