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Sponsored by: |
Helsinki University |
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Information provided by: | Helsinki University |
ClinicalTrials.gov Identifier: | NCT00867022 |
Through complex hormonal pathways, insulin resistance can lead to the activation of the sympathetic nervous system, and vice versa. Schobel et al. showed that in PE patients, mus-cle sympathetic nerve activity (MSNA) is increased compared with normotensive pregnant and non-pregnant women. Studies assessing heart-rate variability and plasma noradrenalin concentrations also suggest increased sympathetic activity in PE. It has been hypothesized that sympathetic over-activity is a precursor of PE, normally compensated for by vasodilating mechanisms, but resulting in PE when the mechanisms fail. In addition to sympathetic activity, various markers of inflamma-tion are also associated with reduced insulin sensitivity, suggesting that chronic sub-clinical inflamma-tion could be part of the insulin resistance syndrome. The role of sympathetic over-activity and inflammatory markers in gestational diabetes has not been investigated
Condition |
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Gestational Diabetes |
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | Autonomic Nervous Activity in Women With Gestational Diabetes |
Enrollment: | 80 |
Study Start Date: | August 2004 |
Study Completion Date: | March 2009 |
Primary Completion Date: | November 2007 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
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1
Women with gestational diabetes
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2
Pregnant women without gestational daibetes
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3
Women with gestational diabetes and hypertension
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4
Non pregnant women
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Ages Eligible for Study: | 18 Years to 45 Years |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Gestational diabetic women having or not hypertension with two control groups, one pregnant on non-pregnant.
All the women are studied during night time to study the arousal of the sympathetic activity in the early morning hours
Inclusion Criteria:
Exclusion Criteria:
Responsible Party: | Helsinki University Hospital ( Risto Kaaja ) |
Study ID Numbers: | GESTSYMPIS |
Study First Received: | March 20, 2009 |
Last Updated: | March 20, 2009 |
ClinicalTrials.gov Identifier: | NCT00867022 History of Changes |
Health Authority: | Finland: Ethics Committee |
Inflammatory factors Coagulation factors Sympathetic activity |
Pregnancy Complications Metabolic Diseases Diabetes Mellitus Endocrine System Diseases |
Diabetes, Gestational Endocrinopathy Glucose Metabolism Disorders Metabolic Disorder |
Pregnancy Complications Metabolic Diseases Diabetes Mellitus |
Endocrine System Diseases Diabetes, Gestational Glucose Metabolism Disorders |