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Sponsored by: |
National Heart, Lung, and Blood Institute (NHLBI) |
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Information provided by: | National Heart, Lung, and Blood Institute (NHLBI) |
ClinicalTrials.gov Identifier: | NCT00014859 |
The purpose of this study is to test the hypothesis that excess, rare, functionally disruptive single nucleotide polymorphisms (SNPs) characterize genes (e.g., the surfactant protein-B gene)(SFTPB) and gene networks (e.g., the pulmonary surfactant metabolic network) associated with increased risk of neonatal respiratory distress syndrome (RDS).
Condition |
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Lung Diseases Respiratory Distress Syndrome, Newborn |
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | Epidemiology of Surfactant Protein-B Deficiency |
DNA and tracheal aspirate samples
Estimated Enrollment: | 1747 |
Study Start Date: | June 2001 |
Estimated Study Completion Date: | June 2012 |
Estimated Primary Completion Date: | June 2012 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
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I
Descriptive cohort of population-based DNA samples from the newborn screening program in Missouri with vital statistics based, linked phenotype data
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II
Case-control cohort of infants with and without neonatal respiratory distress syndrome
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Ages Eligible for Study: | up to 1 Year |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Cohort I is a population-based cohort from Missouri. Cohort II is a case-control cohort from the Neonatal Intensive Care Unit at St. Louis Children's Hospital and from patients referred from other centers.
Inclusion Criteria:
Exclusion Criteria:
United States, Missouri | |
Washington University School of Medicine | Recruiting |
St. Louis, Missouri, United States, 63110 | |
Contact: F. Sessions Cole, MD 314-454-6148 cole@kids.wustl.edu |
Principal Investigator: | F. Sessions Cole, MD | Washington University, St. Louis |
Responsible Party: | Washington University School of Medicine ( F. Sessions Cole, MD ) |
Study ID Numbers: | 967, R01 HL65174 |
Study First Received: | April 11, 2001 |
Last Updated: | July 14, 2009 |
ClinicalTrials.gov Identifier: | NCT00014859 History of Changes |
Health Authority: | United States: Federal Government |
Pulmonary surfactant Surfactant protein B Surfactant protein C |
Protein C Respiratory Tract Diseases Lung Diseases Respiration Disorders Respiratory Distress Syndrome, Adult |
Acute Respiratory Distress Syndrome Respiratory Distress Syndrome, Newborn Infant, Newborn, Diseases Infant, Premature, Diseases Pulmonary Surfactants |
Pathologic Processes Disease Respiratory Tract Diseases Syndrome Lung Diseases |
Respiration Disorders Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome, Newborn Infant, Newborn, Diseases Infant, Premature, Diseases |