DISEASE CHARACTERISTICS:

• Histologically confirmed relapsed or refractory grade I, II, or III non-Hodgkin's lymphoma (NHL), including follicular, small lymphocytic, or marginal zone/MALT lymphoma

• Previously treated with radiotherapy, immunotherapy, and/or chemotherapy for NHL

  • Progression of disease or no response since last treatment for NHL
• 1D10+ lymphoma by immunohistochemistry or flow cytometry
• Bidimensionally measurable disease at least 2 cm in a single dimension
• No CNS metastases
• Circulating tumor cells no greater than 5,000/mm^3

PATIENT CHARACTERISTICS:

Age:

• 18 and over

Performance status:

• ECOG 0-2

Life expectancy:

• At least 3 months

Hematopoietic:

• Platelet count at least 75,000/mm^3 (unless disease related)
• Neutrophil count at least 1,000/mm^3 (unless disease related)
• Hemoglobin greater than 8.0 g/dL

Hepatic:

• Bilirubin less than 2.5 mg/dL
• SGOT less than 4 times upper limit of normal

Renal:

• Creatinine less than 2.5 mg/dL

Cardiovascular:

• No clinically significant cardiac disease (New York Heart Association class III or IV)
• No evidence of myocardial infarction or cardiac arrhythmia (unless surgically repaired) within the past 6 months

Pulmonary:

• No clinically significant pulmonary disease

Other:

• No other malignancy within the past 2 years except non-melanoma skin cancer or carcinoma in situ
• No significant psychiatric or CNS impairment
• No active serious infection
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception during and for 1 month after study
• Negative anti-Hu1D10 antibody response (HAHA/HAMA)
• HIV negative

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• See Disease Characteristics
• At least 4 weeks since prior interferon therapy
• At least 3 months since prior immunotherapy
• No prior monoclonal antibody Hu1D10

Chemotherapy:

• See Disease Characteristics
• At least 4 weeks since prior cytotoxic chemotherapy

Endocrine therapy:

• At least 4 weeks since prior corticosteroids (more than 10 mg prednisone/day)
• No concurrent corticosteroids at more than 10 mg prednisone/day for pre-existing diseases or adverse reactions

Radiotherapy:

• See Disease Characteristics
• At least 4 weeks since prior external beam radiotherapy
• At least 3 months since prior radioimmunotherapy

Surgery:

• Not specified

Other:

• No other concurrent lymphoma therapy