Home
Search
Study Topics
Glossary
|
|
|
|
|
Sponsors and Collaborators: |
University of California, San Francisco National Institutes of Health (NIH) |
---|---|
Information provided by: | University of California, San Francisco |
ClinicalTrials.gov Identifier: | NCT00305279 |
The purpose of this study is to determine the effects of different amounts of phosphorus in the diet on hormones that control phosphorus and bone health both in people who are healthy and in ones who have moderate kidney disease.
Condition | Intervention |
---|---|
Healthy Kidney Failure, Chronic |
Other: Dietary |
Study Type: | Interventional |
Study Design: | Randomized, Single Blind (Subject), Active Control, Crossover Assignment |
Official Title: | The Effects of Dietary Phosphate Intake on Calciotropic Hormones and FGF23 |
Estimated Enrollment: | 32 |
Study Start Date: | February 2006 |
Estimated Study Completion Date: | December 2009 |
Estimated Primary Completion Date: | December 2009 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
---|---|
1: Active Comparator |
Other: Dietary
Dietary
|
2: Active Comparator |
Other: Dietary
Dietary
|
3: Active Comparator |
Other: Dietary
Dietary
|
Chronic kidney disease affects 11% of the US population; over half of those affected have skeletal manifestations of their renal disease. Renal osteodystrophy is a complex disease, in which multiple mineral systems and related hormones play a role, including phosphate homeostasis. Phosphate regulation primarily depends on renal handling of phosphate, which is partly controlled by parathyroid hormone and vitamin D. However, other mediators in this system clearly exist. Recently, evidence has been accruing that one such factor may be FGF23, a protein produced by osteogenic cells. States of excess FGF23 are associated with marked phosphate wasting, hypophosphatemia, osteomalacia, and inappropriately low calcitriol. FGF23 levels are measurable in healthy humans and markedly elevated in patients who require hemodialysis, although its physiologic role in either state is unknown. Some retrospective evidence suggests that FGF23 is affected by phosphate intake. We are performing a study to gather data describing the response of FGF23 to changes in dietary phosphorus intake in healthy men and women and in men and women with moderate renal insufficiency. The specific aims of this pilot study are: 1) To examine the physiologic effects of alterations in dietary phosphorus on FGF23 in healthy subjects; 2) To examine the physiologic response of FGF23 to dietary phosphorus alterations in patients with moderate renal failure; and 3) To assess whether serum levels of 1,25-dihydroxyvitamin D vary inversely with those of FGF23 when dietary phosphate is changed. The proposed research plan is a dietary intervention trial in which we will study the response of serum FGF23 levels to diets with varying phosphorus contents in healthy adults and adults with moderate renal insufficiency.
Ages Eligible for Study: | 21 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
HEALTHY SUBJECTS:
CHRONIC KIDNEY DISEASE SUBJECTS:
Exclusion Criteria:
United States, California | |
University of California | |
San Francisco, California, United States, 94143 |
Principal Investigator: | Diana M Antoniucci, MD | University of California, San Francisco |
Responsible Party: | University of California, San Francisco ( Diana Antoniucci, MD ) |
Study ID Numbers: | H40550-27771, 1K23RR020343 |
Study First Received: | March 17, 2006 |
Last Updated: | September 4, 2008 |
ClinicalTrials.gov Identifier: | NCT00305279 History of Changes |
Health Authority: | United States: Institutional Review Board; United States: National Institutes of Health |
Renal Insufficiency Urologic Diseases Renal Insufficiency, Chronic Kidney Failure, Chronic |
Healthy Kidney Diseases Hormones Kidney Failure |
Renal Insufficiency Urologic Diseases Renal Insufficiency, Chronic |
Kidney Failure, Chronic Kidney Diseases Kidney Failure |