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Sponsored by: |
National Institute of Neurological Disorders and Stroke (NINDS) |
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Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00884351 |
Background:
Scientists do not yet know where absence seizures begin in the brain. Some evidence suggests that these seizures begin in the thalamus, a structure deep in the brain, but other studies suggest that they begin in the frontal cortex, at the front part of the brain.
Objectives:
Eligibility:
Design:
Condition |
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Seizures |
Study Type: | Observational |
Study Design: | Prospective |
Official Title: | Magnetoencephalography in Absence Seizures |
Estimated Enrollment: | 33 |
Study Start Date: | April 2009 |
Estimated Study Completion Date: | March 2011 |
Estimated Primary Completion Date: | March 2011 (Final data collection date for primary outcome measure) |
Objective:
This protocol will test the hypothesis that the 3-Hz spike-wave discharges seen in absence epilepsy originate in the thalamus. We will use an emerging modality, magnetoencephalograpy (MEG), to test this hypothesis.
Study Population:
33 patients with absence seizures.
Design:
This is a non-invasive imaging study that involves a 275-channel whole head MEG recording and a structural MRI for co-registration of MEG data.
Outcome Measure:
The primary outcome measure is the source localization of spike-wave discharges on magnetoencephalography.
Ages Eligible for Study: | 7 Years to 35 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
INCLUSION CRITERIA:
EXCLUSION CRITERIA:
Contact: Patient Recruitment and Public Liaison Office | (800) 411-1222 | prpl@mail.cc.nih.gov |
Contact: TTY | 1-866-411-1010 |
United States, Maryland | |
National Institutes of Health Clinical Center, 9000 Rockville Pike | Recruiting |
Bethesda, Maryland, United States, 20892 |
Study ID Numbers: | 090125, 09-N-0125 |
Study First Received: | April 17, 2009 |
Last Updated: | July 11, 2009 |
ClinicalTrials.gov Identifier: | NCT00884351 History of Changes |
Health Authority: | United States: Federal Government |
Epilepsy MEG Epilepsy Seizures |
Signs and Symptoms Epilepsy Epilepsy, Absence Seizures |
Neurologic Manifestations Central Nervous System Diseases Brain Diseases Epilepsy, Generalized |
Signs and Symptoms Epilepsy Nervous System Diseases Seizures Epilepsy, Absence |
Neurologic Manifestations Central Nervous System Diseases Brain Diseases Epilepsy, Generalized |