Diagnostic Usefulness of Fluorine–18-α–Methyltyrosine PET in Combination With 18F-FDG in Sarcoidosis Patient

This study has been completed.

First Received: August 29, 2006 Last Updated: November 6, 2006 History of Changes

Sponsored by:	Gunma University
Information provided by:	Gunma University
ClinicalTrials.gov Identifier:	NCT00369980

Purpose

L-[3-18F]-α–methyltyrosine (FMT) is amino-acid tracer for positron emission tomography (PET), and is used for tumor detection because malignant tumor cells accumulate 18F-FMT based on the increased expression of amino-acid transporter. This study was conducted to investigate a usefulness of 18F-FMT PET in combination with 18F-FDG PET for the diagnosis of sarcoidosis in patients with suspected malignancy.

Condition
Sarcoidosis

Study Type:	Observational
Study Design:	Screening, Longitudinal, Defined Population, Prospective Study

Resource links provided by NLM:

MedlinePlus related topics: Sarcoidosis

U.S. FDA Resources

Further study details as provided by Gunma University:

Study Start Date:	September 1998
Estimated Study Completion Date:	August 2005

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Eligible patients were required to have histologically proven noncaseating epithelioid cell granuloma and at least one disease that the possibility of coexistent malignancy could not be excluded as follows; 1) extrapulmonary lesions mimicking malignant diseases including systemic lymphadenopathy, hepatosplenic involvement, or other lesions, 2) multiple nodular lesions mimicking pulmonary metastasis, 3) the occurrence of BHL in cancer patient.

Exclusion Criteria:

The patients that PET imaging using 18F-FDG and 18F-FMT was performed before establishment of the final diagnosis of sarcoidosis, patients undergoing treatment for sarcoidosis before the PET study, and patient having diabetes mellitus.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00369980

Locations

Japan
Gunma University Graduate School of Medicine
Gunma, Japan, 371-8511

Sponsors and Collaborators

Gunma University

Investigators

Principal Investigator:

kyoichi kaira, MD

Gunma University Graduate School of Medicine

More Information

No publications provided by Gunma University

Additional publications automatically indexed to this study by National Clinical Trials Identifier (NCT ID):

Kaira K, Oriuchi N, Otani Y, Yanagitani N, Sunaga N, Hisada T, Ishizuka T, Endo K, Mori M. Diagnostic usefulness of fluorine-18-alpha-methyltyrosine positron emission tomography in combination with 18F-fluorodeoxyglucose in sarcoidosis patients. Chest. 2007 Apr;131(4):1019-27.

Study ID Numbers:	GunmaU
Study First Received:	August 29, 2006
Last Updated:	November 6, 2006
ClinicalTrials.gov Identifier:	NCT00369980 History of Changes
Health Authority:	Japan: Institutional Review Board

Study placed in the following topic categories:

Lymphatic Diseases
Sarcoidosis
Fluorides
Lymphoproliferative Disorders

Additional relevant MeSH terms:

Lymphatic Diseases
Sarcoidosis
Lymphoproliferative Disorders

ClinicalTrials.gov processed this record on August 12, 2009