| Principal Investigators
Ellen Leibenluft,
M.D. |
|
|
Ellen Leibenluft, M.D. is Senior
Investigator and Chief of the
Section on Bipolar Spectrum
Disorders in the Emotion and
Development Branch, Mood and
Anxiety Program, National
Institute of Mental Health, and
Clinical Associate Professor of
Psychiatry at Georgetown
University School of Medicine.
Dr. Leibenluft received her B.A.
from Yale University summa cum
laude and her M.D. from
Stanford University. After
completing residency training at
Georgetown University Hospital,
she served on the faculty there
as director of the psychiatric
inpatient unit and day hospital.
She came to the NIMH in 1989,
and since that time has been
conducting research on bipolar
disorder. Her research focuses
on the brain mechanisms
involved in bipolar disorder in
children and adolescents. Her
work involves the use of
cognitive neuroscience
techniques and neuroimaging
modalities, including functional
MRI. In addition, since questions
have been raised as to whether
children with impairing irritability should be diagnosed with bipolar
disorder, Dr. Leibenluft conducts
research on this question,
including studies on the brain
mechanisms mediating severe
irritability in children. |
Research Interests |
Dr.
Leibenluft is Chief of the Section on Bipolar Spectrum Disorders
in the Emotion and Development Branch,
Mood
and Anxiety Disorders Program, National Institute
of Mental Health. While behavioral testing and fMRI are the core research techniques in the lab, we also
use structural MRI, magnetoencephalography, and diffusion tensor imaging. An
emerging focus is the integration of genotyping into our behavioral and imaging studies.
In addition, we conduct pilot clinical trials of novel, mechanism-based treatments.
Importantly, all of our research subjects receive careful clinical phenotyping and we
strive to deliver state-of-the-art care.
The Section conducts clinical research on youth with bipolar disorder (BD), those at
familial risk for BD, and those with severe, impairing irritability (severe mood
dysregulation, SMD; Leibenluft et al, 2003). Our interest in SMD stems from the
questions that have arisen as to whether such irritability should be considered to be a
pediatric form of mania.
For each of our target populations, our goal is to elucidate the brain mechanisms
mediating psychopathology in order to inform novel treatment approaches. To
accomplish this, we employ an applied neuroscience approach i.e., we first use
standardized behavioral paradigms to assess responses to emotion stimuli and related
psychological functions (e.g., cognitive control, attentional processes) and then, when
between-group differences are found, we use functional MRI (fMRI) to study the
mediating neural circuitry. The Section takes a developmental approach, in that our work
in youth at risk for BD includes children preschool age through adolescence, and we
perform studies comparing adults and children with BD. |
Representative Selected Recent Publications: |
- Baroni A, Lunsford JR, Luckenbaugh DA, Towbin KE, Leibenluft E:
The assessment of bipolar disorder in children and adolescents. (View PDF)
Child Psychology and Psychiatry, 50, 203-215, 2009.
- Brotman MA, Guyer AE, Lawson ES, Horsey SE, Rich BA, Dickstein DP, Pine DS, Leibenluft E.:
Facial emotion labeling deficits in children and adolescents at risk for bipolar disorder.
Am J Psychiatry, 165, 385-389, 2008. (View PDF)
- Leibenluft E, Rich BA, Vinton DT, Nelson EE, Fromm SJ, Berghorst LH, Joshi, P, Robb A, Schachar RJ, Dickstein DP, McClure EB, Pine DS:
Neural circuitry engaged during unsuccessful motor inhibition in pediatric bipolar disorder vs. controls.
Am J Psychiatry, 164, 309-317, 2007. (View PDF)
- Dickstein DP, Nelson EE, McClure EB, Grimley ME, Knopf LV, Brotman MA, Rich BA, Pine DS, Leibenluft, E:
Cognitive flexibility in phenotypes of pediatric bipolar disorder.
J Am Acad Child Adolesc Psychiatry, 46, 341-355, 2007. (View PDF)
- Rich BA, Schmajuk M, Perez-Edgar KE, Fox NA, Pine DS, Leibenluft E:
Frustration elicits different psychophysiological and behavioral responses in pediatric bipolar disorder and severe mood dysregulation.
Am J Psychiatry, 164, 309-317, 2007. (View PDF)
- Rich BA, Vinton DT, Roberson-Nay R, Hommer RE, McClure EB, Fromm SJ, Pine DS, Leibenluft E:
Limbic hyperactivation during processing of neutral facial expressions in children with bipolar disorder.
Proc Natl Acad Sci USA, 103, 8900-8905, 2006. (View PDF)
|
Address:
|
Dr. Ellen Leibenluft Section on Bipolar Spectrum Disorders Mood and Anxiety Disorders Program, NIMH Building 15K -MSC 2670 Bethesda, MD 20892-2670 |
Phone: |
Office: 301-496-9435 Laboratory: 301-496-9435 |
Email Dr. Leibenluft |
FAX |
301-402-6100 |
Lab Web Site: |
http://intramural.nimh.nih.gov/mood/ |
|
|
|
|
|