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Research Project:
CONTROL AND PROTECTION TOOLS FOR INTEGRATED PEST MANAGEMENT OF MOSQUITOES AND FILTH FLIES
Location: Mosquito and Fly Research Unit
Title: Synthesis and structure-activity relationships of 1-undec-10-enoyl-piperidines as adulticides against the yellow fever mosquito Aedes aegypti (Diptera: Culicidae)
Authors
Submitted to: Entomological Society of America Annual Meeting
Publication Type:
Abstract
Publication Acceptance Date: December 10, 2006
Publication Date: N/A
Technical Abstract: The yellow fever mosquito, Aedes aegypti (L.), is considered the primary vector for both dengue and yellow fever. Using insecticide is one of the major ways to control this medically important insect pest. However, few new insecticides have been developed for mosquito control. As part of our collaborative effort to search for new insecticides to control mosquito, piperidine was used as lead compound for further optimization. Herein, we report the toxicities of ten 1-undec-10-enoyl-piperidines against female adults of Aedes aegypti (L.). On the basis of 24-h LD50 values after topical application, the most toxic compound was 2-ethyl-1-undec-10-enoyl-piperidine (LD50=0.80 micrograms per mosquito). Piperine [(E, E)-1-piperoyl-piperidine], a commercially available insecticide ingredient, was less toxic (LD50=8.13 micrograms per mosquito) than all the tested ethyl- or methyl- derivatives of 1-undec-10-enoyl-piperidines. The toxicities of 1-undec-10-enoyl-piperidines were significantly decreased when a benzyl moiety was added to the carbon of the piperidine ring, regardless the carbon position to which it was conjugated. Taking together, these preliminary results could be a useful guide for further modification of the piperidine ring in the development of a potential insecticide.
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| Related Projects |
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DEVELOPMENT OF TECHNOLOGIES FOR PROTECTION OF DEPLOYED WAR FIGHTERS FROM ARTHROPODS THAT VECTOR DISEASE |
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STRUCTURE-ACTIVITY STUDIES OF KNOWN ARTHROPOD REPELLENTS USING CODESSA |
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BARRIER TREATMENT FOR PROTECTION FROM MOSQUITOES |
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BITING PROTECTION ASSESSMENT OF U.S. MILITARY UNIFORMS AND DEVELOPMENT OF NEW CRITERIA TO PROTECT TROOPS ON FUTURE FIELD DEPLOYMENTS |
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EVALUATION OF REPELLENTS AND CONTROL COMPOUNDS IN MOSQUITOES, SAND FLIES, AND TICKS INFECTED WITH MILITARILY IMPORTANT HUMAN PATHOGENS |
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DEVELOPMENT OF PORTABLE DEVICES FOR DETECTION AND QUANTIFICATION OF INSECTICIDES, REPELLENTS, AND INHIBITORS |
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DEFINITION OF THE EXCITO-REPELLENCY OF THE INSECTICIDE DUET AND ITS SUBCOMPONENTS AGAINST MOSQUITOES |
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DEPLOYED WARFIGHTER PROTECTION RESEARCH PROGRAM (FY2007) |
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DEPLOYED WARFIGHTER PROTECTION RESEARCH PROGRAM (FY2007) |
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EVALUATION OF REPELLENTS, INHIBITORS, BARRIER TREATMENTS, AND ULV INSECTICIDES, & OTHER NEW PRODUCTS IN A SOUTHERN CALIFORNIA DESERT HABITAT |
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DEVELOPMENT OF SUSTAINED RELEASE DEVICES FOR BITING INSECT CONTROL |
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EVALUATION OF REPELLENTS, INHIBITORS, BARRIER TREATMENTS, AND ULV INSECTICIDES, AND OTHER NEW PRODUCTS IN SUB-SAHARAN AFRICA |
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DEPLOYED WARFIGHTER PROTECTION RESEARCH PROGRAM (FY2008) |
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BITING PROTECTION ASSESSMENT OF U.S. MILITARY UNIFORMS AND DEVELOPMENT OF NEW CRITERIA TO PROTECT TROOPS ON FUTURE FIELD DEPLOYMENTS |
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AIRCRAFT DISINSECTION RESEARCH |
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