Projects

THE EFFECT OF DIETARY PROBIOTICS ON IMMUNE AND GASTROINTESTINAL FUNCTION Appropriated (D)   Accession Number: 408040

IMPACT OF NUTRITIONAL STATUS ON IMMUNE-INDUCED CHANGES IN GUT FUNCTION Appropriated (D)   Accession Number: 408279

MEASURING MUCOSAL DERIVED IMMUNITY IN SWINE WITH DIFFERENT VITAMIN A STATUS TO YIELD BIOMARKERS OF HUMAN NUTRIENT/DISEASE INTERACTIONS Appropriated (D)   Accession Number: 409575

DEVELOPMENT OF AN INTEGRATED RISK MODEL FOR FOODBORNE ZOONOTIC PARASITES IN SWINE Appropriated (D)   Accession Number: 409642

EFFECT OF DIETARY INDUCED OXIDATIVE STRESS ON INTESTINAL PHYSIOLOGY AND THE DEVELOPMENT OF MUCOSAL IMMUNITY TO ENTERIC PATHOGENS Appropriated (D)   Accession Number: 408041

GENETIC AND IMMUNE STRATEGIES TO CONTROL MUCOSAL PATHOGENS OF SWINE Appropriated (D)   Accession Number: 414571

Publications

Anti-inflammatory Mechanisms of Enteric Heligmosomoides polygyrus Infection on TNBS-Induced Colitis in a Murine Model - (Peer Reviewed Journal)

Sutton, T.L., Zhao, A., Madden, K.B., Elfrey, J.E., Tuft, B.A., Sullivan, C.A., Urban Jr, J.F., Shea-Donohue, T. 2008. Anti-inflammatory mechanisms of enteric Heligmosomoides polygyrus infection on TNBS-induced colitis in a murine model. Infection and Immunity 76(10):4772-82.

Helminth Infection Induces Persistent Changes to the Immunological Environment of the Lung that Result in Dampened Responses to Secondary Allergen Challenge - (Peer Reviewed Journal)

Reece, J.J., Urban Jr, J.F., Siracusa, M.C., Southard, T.L., Brayton, C.F., Scott, A.L. 2008. Helminth Infection Induces Persistent Changes to the Immunological Environment of the Lung that Result in Dampened Responses to Secondary Allergen Challenge. Journal of Immunology.

Counter-regulatory anti-parasite cytokine responses during concurrent Plasmodium yoelii and intestinal helminth infections in mice - (Peer Reviewed Journal)

Noland, G.S., Urban Jr, J.F., Fried, B., Kumar, N. 2008. Counter-regulatory anti-parasite cytokine responses during concurrent Plasmodium yoelii and intestinal helminth infections in mice. Parasite Immunology. 119(2):272-278.

Th2 cytokine-induced alterations in intestinal smooth muscle function depend on alternatively activated macrophages - (Peer Reviewed Journal)

Zhao, A., Urban Jr, J.F., Anthony, R.M., Sun, R., Stiltz, J., van Rooijen, N., Wynn, T.A., Gause, W.C., Shea-Donohue, T. 2008. Th2 cytokine-induced alterations in intestinal smooth muscle function depend on alternatively activated macrophages. Gastroenterology. 135(1):217-225.

The Suitability of Swine as Models for Humans to Assess the Effect of Nutrition on Immunity - (Proceedings/Symposium)

Dawson, H.D., Reece, J.J., Chen, C.T., Urban Jr, J.F. 2008. The suitability of swine as models for humans to assess the effect of nutrition on immunity. International Symposium: Swine And Biomedical Research. p.48.

Molecular Evidence For the Health Benefits of Cinnamon Through Its Insulin-like and Anti-inflammatory Effects - (Abstract)

Cao, H., Urban Jr, J.F., Anderson, R.A. 2008. Molecular Evidence For the Health Benefits of Cinnamon Through Its Insulin-like and Anti-inflammatory Effects. BARC Poster Day.

Production and characterization of ZFP36L1 antiserum against recombinant protein from Escherichia coli - (Peer Reviewed Journal)

Cao, H., Lin, R., Ghosh, S., Anderson, R.A., Urban Jr, J.F. 2008. Production and characterization of ZFP36L1 antiserum against recombinant protein from Escherichia coli. Biotechnology Progress. 24(2)326-333.

Neutrophils clear bacteria associated with parasitic nematodes augmenting the development of an effective Th2-type response - (Peer Reviewed Journal)

Pesce, J., Liu, Z., Hamed, H., Alem, F., Whitmire, J., Liu, H., Liu, Q., Urban Jr, J.F., Gause, W. 2008. Neutrophils clear bacteria associated with parasitic nematodes augmenting the development of an effective Th2-type response. Journal of Immunology. 180(1):464-474.

Production and Characterization of ZFP36L1 Antiserum Against Recombinant Protein From Escherichia coli - (Abstract)

Cao, H., Lin, R., Ghosh, S., Anderson, R.A., Urban Jr, J.F. 2008. Production and Characterization of ZFP36L1 Antiserum Against Recombinant Protein From Escherichia coli. [abstract]. Journal of Federation of American Societies for Experimental Biology. 22:1003.7.

Cinnamon polyphonol extract affects immune responses by regulating anti- and proinlammatory and glucose transporter gene expression in mouse macrophages - (Peer Reviewed Journal)

Cao, H., Urban Jr, J.F., Anderson, R.A. 2008. Cinnamon polyphonol extract affects immune responses by regulating anti- and proinflammatory and glucose transporter gene expression in mouse macrophages. Journal of Nutrition. May;138:833-840.

Cinnamon Affects Immune Responses By Regulating Anti- and Pro-inflammatory Gene Expression and Energy Metabolism In Macrophages - (Peer Reviewed Journal)

Cao, H., Urban Jr, J.F., Anderson, R.A. 2008. Cinnamon Affects Immune Responses By Regulating Anti- and Pro-inflammatory Gene Expression and Energy Metabolism In Macrophages. Federation of American Societies for Experimental Biology Conference. J22:158.6.

The Unique Functions of the Type-II IL-4 Receptor are revealed in IL-13R¿1-deficient mice - (Peer Reviewed Journal)

Ramalingam, T.R., Pesce, J.T., Sheikh, F., Cheever, A.W., Mentink-Kane, M.M, Wilson, M.S., Stevens, S., Valenzuela, D.M., Murphy, A.J., Yancopoulos,G.D., Urban Jr, J.F., Donnelly, R.P.,Wynn, T.A. 2008. Unique functions of the type-II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha 1 chain. Nature Immunology. (1):25-33.

The Beltsville Human Nutrition Research Center's Porcine Immunology and Nutrition Resource Database - (Abstract)

Dawson, H.D., Guidry, C.A., Vangimalla, V.R., Urban Jr, J.F. 2007. The Beltsville Human Nutrition Research Center's Porcine Immunology and Nutrition Resource Database. Experimental Biology.

Protective Immune Mechanisms in Helminth Infection - (Review Article)

Anthony, R., Rutitzky, L., Urban Jr, J.F., Stadecker, M., Gause, W. 2007. Protective Immune Mechanisms in Helminth Infection. Nature Reviews Microbiology. 7(12)975-987.

THE ROLE OF B CELLS IN THE DEVELOPMENT OF CD4 EFFECTOR T CELLS DURING A POLARIZED TH2 IMMUNE RESPONSE. - (Peer Reviewed Journal)

Liu, Q., Liu, Z., Whitmire, J., Hossein, A., Vannoy, J., Urban Jr, J.F., Gause, W.C. 2007. The role of B cells in the development of CD4 effector T cells during a polarized TH2 immune response. Journal of Immunology. 179(6):3821-30.

Prevention of obesity by plant polyphenols via tristetraprolin-medicated cytokine mRNA instability - (Abstract)

Cao, H., Urban Jr, J.F., Anderson, R.A. 2007. Prevention of obesity by plant polyphenols via tristetraprolin-medicated cytokine mRNA instability. Obesity. 15(10)A90.

Alternatively activated macrophages in helminth infections - (Review Article)

Kreider, T., Anthony, R.M., Urban Jr, J.F., Gause, W.C. 2008. Alternatively activated macrophages in helminth infections. Current Opinions in Immunology. 19(4)448-453.

Infection with parasitic nematodes confounds vaccination efficacy - (Review Article)

Urban Jr, J.F., Steenhard, N.R., Solano-Aguilar, G.I., Dawson, H.D., Iweala, O.I., Nagler, C.R., Noland, G.S., Kumar, N., Anthony, R.M., Shea-Donohue, T., Weinstock, J., Gause, W.C. 2007. Infection with parasitic nematodes confounds vaccination efficacy. Veterinary Parasitology. 148(1):14-20.

A Comparative Analysis of the Porcine, Murine, and Human Immune Systems - (Abstract)

Dawson, H.D., Reece, J.J., Urban Jr, J.F. 2007. A comparative analysis of the porcine, murine, and human immune systems. Veterinary Immunology International Symposium. p.120.

The Porcine Immunology and Nutrition Resource Database - (Abstract)

Dawson, H.D., Guidry, C.A., Vangimalla, V.R., Urban Jr, J.F. 2007. The porcine immunology and nutrition resource database. Veterinary Immunology International Symposium. p15.

Generating a Natural Porcine Model of Gastrointestinal Food Allergy to Peanut - (Abstract)

Reece, J.J., Kohn, K., Ets, H., Urban Jr, J.F., Dawson, H.D. 2007. Generating a Natural Porcine Model of Gastrointestinal Food Allergy to Peanut. BARC Poster Day.

T cell IL-3 production is critical for parasite infection-induced basophil production, Aa well as basaphil survival in vitro, yet in vivo basophil survival is IL-3 independent. - (Peer Reviewed Journal)

Shen, T., Wang, L., Kim, S., Lantz, C., Urban Jr, J.F., Le Gros, G., Min, B. 2007. T cell IL-3 production is critical for parasite infection-induced basophil production, as well as basaphil survival in vitro, yet in vivo basophil survival is IL-3 independent. Journal of Immunology. July 15. epub ahead of print.

Feeding Probiotic Bacteria To Swine Enhances Immunity To Ascaris Suum - (Proceedings/Symposium)

Solano Aguilar, G., Shea-Donohue, T., Madden, K., Dawson, H.D., Jones, Y., Restrepo, M.P., Beshah, E., Urban Jr, J.F. 2007. Feeding probiotic bacteria to swine enhances immunity to Ascaris Suum. Veterinary Immunology International Symposium. p.110.

Prevention of obesity by plant polyphenols via tristetraprolin-mediated cytokine mrna instability - (Abstract)

Cao, H., Urban Jr, J.F., Anderson, R.A. 2007. Prevention of obesity by plant polyphenols via tristetraprolin-mediated cytokine mrna instability. BARC Poster Day.

Insulin increases tristetraprolin and decreases vascular endothelial growth factor gene expression in mouse 3T3-L1 adipocytes - (Peer Reviewed Journal)

Cao, H., Urban Jr, J.F., Anderson, R.A. 2008. Insulin increases tristetraprolin and decreases vascular endothelial growth factor gene expression in mouse 3T3-L1 adipocytes. Obesity. 16:1208-1218.

Selenium (Se) deficiency alters intestinal diaphorase activity in mice infected with the intestinal parasitic worm Heligmosomoides polygyrus - (Abstract)

Urban Jr, J.F., Smith, A.D., Botero, S., Dawson, H.D., Anthony, R., Gause, W., Shea-Donohue, T. 2007. Selenium (Se) deficiency alters intestinal diaphorase activity in mice infected with the intestinal parasitic worm Heligmosomoides polygyrus. Experimental Biology.

GREEN TEA INCREASES THE ANTIINFLAMMATORY TRISTETRAPROLIN AND DECREASES THE PROINFLAMMATORY TUMOR NECROSIS FACTOR mRNA LEVELS IN RATS. - (Peer Reviewed Journal)

Cao, H., Kelly, M.A., Kari, F., Dawson, H.D., Urban, Jr, J.F., Coves, S., Roussel, A.M., Anderson, R.A. 2007. Green tea increases the antiinflammatory tristetraprolin and decreases the proinflammatory tumor necrosis factor mrna levels in rats. Inflammation. 4:1-12.

Heligmosomoides polygyrus promotes T regulatory cytokine production in the normal distal murine intestine. - (Peer Reviewed Journal)

Setiawan, T., Metwali, A., Blum, A., Urban Jr, J.F., Elliott, D., Weinstock, J. 2007. Heligmosomoides polygyrus promotes T regulatory cytokine production in the normal distal murine intestine. Infection and Immunity.

Unique maturation program of the IgE response in vivo - (Peer Reviewed Journal)

Erazo, A., Kutchukhidze, N., Leung, M., Guarnieri-Christ, A.P.,Urban Jr,J.F., Curotto De Lafailli, M.A., Laifaille, J.J. 2007. Unique maturation program of the IgE response in vivo. Immunity. 26(2):191-203.

L3L4ES antigen and secretagogues induce histamine release from porcine peripheral blood basophils after Ascaris suum infection - (Peer Reviewed Journal)

Uston, P.I., Urban Jr, J.F., Ashraf, M., Ampy, F.R. 2007. L3l4es antigen and secretagogues induce histamine release from porcine peripheral blood basophils after ascaris suum infection. Parasitology Research. 100(3):603-611.

Mechanisms of Neonatal Mucosal Antibody Protection - (Peer Reviewed Journal)

Harris, N.L., Spoerri, I., Schopfer, J.F., Nembrini, C., Merky, P., Massacand, J., Urban Jr, J.F., Lamarre, A., Burki, K., Odermatt, B., Zinkernagel, R.M., Macpherson, A.J. 2006. Mechanisms of neonatal mucosal antibody protection. Journal of Immunology. 177(9):6256-6262.

Amphiregulin-a Th2 cytokine enhancing resistance to nematodes - (Peer Reviewed Journal)

Zaiss, D.M., Yang, L., Shah, P.R., Kobie, J.J., Urban, J.F., Mosmann, T.R. 2006. Amphiregulin-a TH2 cytokine enhancing resistance to nematodes. Science. 314(5806):1746.

ASCARIS SUUM-DERIVED PRODUCTS SUPPRESS MUCOSAL ALLERGIC INFLAMMATION IN AN INTERLEUKIN-10-INDEPENDENT MANNER VIA INTERFERENCE WITH DENDRITIC CELL FUNCTION. - (Peer Reviewed Journal)

McConchie, B.W., Norris, H.H., Bundoc, V.G., Trivedi, S., Boesen, A., Urban Jr, J.F., Keane-Myers, A.M. 2006. Ascaris suum-derived products suppress mucosal allergic inflammation in an interleukin-10-independent manner via interference with dendritic cell function. Infection and Immunity. 74(12):6632-6641.

Il-4producing memory T-cells induce alternatively activated macrophages to mediate protection against nematode parasites. - (Peer Reviewed Journal)

Anthony, R.M., Urban Jr, J.F., Alem, F., Hamed, H.A., Boucher, J., Van Rooijen, N., Gauge, W.C. 2006. IL-4-producing memory T cells induce alternatively activated macrophages to mediate protection against nematode parasites. Nature (Medicine). 12(8):955-960.

A MAMMARY GLAND BIOLOGIST'S PERSEPECTIVE ON FUNCTIONAL GENOMICS - (Proceedings/Symposium)

Capuco, A.V., Meyer, M.J., Li, R.W., Connor, E.E., Van Tassell, C.P., Boisclair, Y.R., Van Amburgh, M.E., Sonstegard, T.S., Urban Jr, J.F. 2006. A mammary gland biologist's persepective on functional genomics. World Congress on Genetics Applied to Livestock Production. Belo Horizonte, Brazil, August 13-18, pp 01-6.

BIOFIOBACTERIUM LACTIS ENHANCES TOLL-LIKE RECEPTOR (TLR) PATHWAY GENE EXPRESSION LOCALLY IN THE COLON AND ENHANCES GLUCOSE UPTAKE IN THE SMALL INTESTINE OF PIGS INFECTED WITH PARASITIC NEMATODE ASCARIS SUM. - (Proceedings/Symposium)

Solano Aguilar, G., Dawson, H.D., Shea-Donohue, T., Madden, K., Jones, Y.L., Beshah, E., Restrepo, M., Schoene, N.W., Hare Jr, W.R., Urban Jr, J.F. 2006. Biofiobacterium lactis enhances toll-like receptor (tlr) pathway gene expression locally in the colon and enhances glucose uptake in the small intestine of pigs infected with parasitic nematode ascaris sum. American Society for Microbiology Proceedings. 106:45A.

IL-18 STIMULATES IL-13 MEDIATED IFN-GAMMA SENSITIVE HOST RESISTANCE IN VIVO - (Peer Reviewed Journal)

Liu, Q., Liu, Z., Whitmire, J., Alem, F., Hamed, H., Pesce, J., Urban Jr, J.F., Gause, W. 2006. IL-18 stimulates IL-13 mediated INF-gamma sensitive host resistance in vivo. European Journal of Immunology. 36(5):1187-1198.

BIFIDOBACTERIUM LACTIS AFFECTS IMMUNE DEVELOPMENT OF NEONATAL PIGS: A MODEL FOR NUTRIENT CONDITIONING IN INFANTS. - (Abstract)

Solano Aguilar, G., Dawson, H.D., Jones, Y.L., Schoene, N.W., Beshah, E., Restrepo, M., Hare, W., Urban Jr, J.F. 2006. Bifidobacterium lactis affects immune development of neonatal pigs: a model for nutrient conditioning in infants. Meeting Abstract.

CONTRIBUTION OF 5-HT2A RECEPTOR IN NEMATODE INFECTION-INDUCED MURINE INTESTINAL SMOOTH MUSCLE HYPER CONTRACTILITY - (Peer Reviewed Journal)

Zhao, A., Urban, Jr, J.F., Morimoto, M., Elfrey, J., Madden, K., Finkelman, F., Shea-Donohue, T. 2006. Contribution of 5-HT2A receptor in nematode infection-induced murine intestinal smooth muscle hyper contractility. Gastroenterology. 131(2):568-578

HELIGMOSOMOIDES POLYGYRUS INDUCES TLR4 ON MURINE MUCOSAL T CELLS THAT PRODUCE TGF-BETA AFTER LIPOPOLYSACCHARIDE STIMULATION - (Peer Reviewed Journal)

Ince, N., Elliott, D., Setiawan, T., Blum, A., Metwali, A., Wang, Y., Urban, J., Weinstock, J. 2006. Heligmosomoides polygyrus induces TLR4 on murine mucosal T cells that produce TGFbeta after lipopolysaccharide stimulation. Journal of Immunology. 176(2):726-729

FUNCTIONAL IMPORTANCE OF REGIONAL DIFFERENCES IN LOCALIZED GENE EXPRESSION OF RECEPTORS FOR IL-13 IN MURINE GUT - (Peer Reviewed Journal)

Morimoto, M., Morimoto, M., Zhao, A., Madden, K., Dawson, H., Finkleman, F., Mentink-Kane, M., Urban Jr., J.F., Wynn, T., and Shea-Donohue, T. 2006. Functional importance of regional differences in localized gene expression of receptors for IL-13 in murine gut. Journal of Immunology. 176(1):491-495.

ALTERNATIVELY ACTIVATED MACROPHAGES ACCUMULATE AT THE HOST PARASITE INTERFACE AND CONTRIBUTE TO PROTECTION AGAINST A NEMATODE PARASITE. - (Abstract)

Anthony, R., Urban Jr, J.F., Alem, F., Hamed, H., Van Rooijen, N., Gause, W. 2005. Alternatively activated macrophages accumulate at the host parasite interface and contribute to protection against a nematode parasite.. Meeting Abstract.

UP-REGULATION OF INFLAMMATORY, REGULATORY AND TH1-IMMUNE MARKERS IN SWINE RESPONDING TO ACUTE TOXOPLASMA GONDII INFECTION. - (Abstract)

Nishi, S.M., Dawson, H.D., Kuhar, D.J., Dubey, J.P., Urban Jr, J.F., Lunney, J.K. 2005. Up-regulation of inflammatory, regulatory and th1-immune markers in swine responding to acute toxoplasma gondii infection. Proceedings of American Association of Veterinary Parasitologists. p. 33-34.

Helminth infections in animals and man: Population dynamics, host susceptibility and immuno-modeulatory effects - (Proceedings/Symposium)

Kringel, H., Dawson, H.D., Urban Jr, J.F., Roepstorff, A. 2005. Helminth infections in animals and man: Population dynamics, host susceptibility and immuno-modeulatory effects. Proceedings of the Abildgaard Symposium. University of Life Sciences. Danish Centre for Experimental Parasitology. pp. 65-72.

THE IL-21 RECEPTOR AUGUMENTS TH2 EFFECTOR FUNCTION AND ALTERNATIVE MACROPHAGE ACTIVATION. - (Peer Reviewed Journal)

Pesce, J., Kaviratne, M., Ramalingam, T., Thompson, R.W., Urban Jr, J.F., Cheever, A., Young, D., Collins, M., Grusby, M., Wynn, T. 2006. The IL-21 receptor auguments Th2 effector function and alternative macrophage activation. Journal of Clinical Investigation. 116(7):2044-2055.

IMMUNE REGULATION OF PROTEASE-ACTIVATED RECEPTOR-1 EXPRESSION IN MURINE SMALL INTESTINE DURING NIPPOSTRONGYLUS BRASILIENSIS INFECTION - (Peer Reviewed Journal)

Zao, A., Morimoto, M., Dawson, H., Elfrey, J.E., Madden, K.B., Gause, W.C., Min, B., Finkelman, F.D., Urban, J.F. Jr., Shea-Donohue, T. 2005. Immune regulation of protease-activated receptor-1 expression in murine small intestine during nippostrongylus brasiliensis infection. Journal of Immunology. 175(4):2563-2569.

EFFECT OF SELENIUM AND/OR VITAMIN E DEFICIENCIES ON HELIGMOSOMOIDES POLYGYRUS INFECTIONS IN MICE - (Peer Reviewed Journal)

Smith, A.D., Madden, K. B., Au Yeung, K., Zhao, A., Elfrey, J., Finkelman, F., Levander, O.A., Shea Donohue, P.T., and Urban Jr, J.F. 2005. Effect of selenium and/or vitamin E deficiencies on Heligmosomoides polygyrus infections in mice. Journal of Nutrition. 135:830-836.

LOCALIZED MULTI-GENE EXPRESSION PATTERNS SUPPORT AN EVOLVING TH1/TH2-LIKE PARADIGM IN RESPONSE TO INFECTION WITH TOXOPLASMA GONDII AND ASCARIS SUUM - (Peer Reviewed Journal)

Dawson, H., Beshah, E., Nishii, S., Solano-Aguilar, G., Morimoto, M., Zhao, A. Madden, K., Ledbetter, T., Dubey, J.P., Shea-Donohue, T., Lunney, J.K., and Urban, J. F. Jr. 2005. Localized multi-gene expression patterns support an evolving Th1/Th2-like paradigm in response to infections with Toxoplasma gondii and Ascaris suum. Infection and Immunity. 73(2):1116-1128.

IMPACT OF VITAMIN E OR SELENIUM DEFICIENCY ON NEMATODE-INDUCED ALERATIONS IN MURINE INTESTINAL FUNCTION - (Peer Reviewed Journal)

Auyeung, K., Smith, A.D., Zhao, A., Madden, K., Elfrey, J., Sullivan, C., Levander, O.A., Urban Jr, J.F., Shea Donohue, P.T. 2005. Impact of vitamin E or selenium deficiency on nematode-induced alerations in murine intestinal function. Experimental Parasitology. 109:201-208.

INCREASED TH2-ASSOCIATED IMMUNITY IN ASCURIS-INFECTED SWINE TREATED WITH RETINOIC ACID - (Abstract)

Dawson, H.D., Jones, E.A., Beshah, E., Solano Aguilar, G., Urban Jr, J.F. 2005. Increased Th2-associated immunity in ascuris-infected swine treated with retinoic acid. [abstract]. Federation of American Societies for Experimental Biology Journal. 19:A1466.

TRICHURIS SUIS GUT THERAPY IN CROHN'S DISEASE - (Peer Reviewed Journal)

Summers, R., Elliott, D., Urban Jr, J.F., Thompson, R., Weinstock, J. 2005. Trichuris suis gut therapy in crohn's disease. Gut. 54:87-90.

IL-4 AND IL-13 MEDIATED HOST PROTECTION AGAINST INTESTINAL NEMATODE PARASITES. - (Review Article)

Finkelman, F., Shea-Donohue, T., Morris, S., Gildea, L., Strait, R., Madden, K., Urban Jr, J.F. 2004. IL-4 and IL-13 mediated host protection against intestinal nematode parasites. Immunological Reviews 201:139-155.

HELIGMOSOMOIDES POLYGYRUS INHIBITS ESTABLISHED COLITIS IN IL-10 DEFICIENT MICE - (Peer Reviewed Journal)

Elliott, D.E., Setiawan T., Metwali, A., Blum, A., Urban, Jr., J.F., Weinstock, J.V. 2004. Heligmosomoides polygyrus inhibites established colitis in IL-10 deficient mice. European Journal of Immunology. 34:2690-2696.

CONDITIONAL DELETION OF GATA-3 REVEALS ITS CRITICAL ROLE IN TH1/TH2 RESPONSES - (Peer Reviewed Journal)

Zhu, J., Min, B., Hu-Li, J., Watson, C., Grinberg, A., Wang, Q., Killeen, N., Urban Jr, J.F., Guo, L., Paul, W. 2004. Conditional deletion of gata-3 reveals its critical role in th1/th2 responses. Nature Immunology. 5(11):1157-1165.

REQUIREMENTS FOR THE DEVELOPMENT OF IL-4PRODUCING T CELLS DURING INTESTINAL NEMATODE INFECTIONS: WHAT IT TAKES TO MAKE A TH2 CELL IN VIVO. - (Review Article)

Liu, Z., Liu, Q., Pesce, J., Anthony, R., Lamb, E., Whitmire, J., Hamed, H., Morimoto, M., Urban Jr, J.F., Gause, W.C. 2004. Requirements for the development of IL-4producing T cells during intestinal nematode infections: what it takes to make a Th2 cell in vivo. Immunological Reviews 201:57-74.

TH2-INDUCING PARASITE INFECTION LEADS TO THE PRODUCTION OF IL-4 AND TISSUE ACCUMULATION OF BASOPHILS - (Peer Reviewed Journal)

Min, B., Prout, M., Hu-Li, J., Zhu, J., Jankovic, D., Morgan, E., Urban Jr, J.F., Dvorak, A., Finkelman, F., Legros, G. 2004. Th2-inducing parasite infection leads to the production of IL-4 and tissue accumulation of basophils. Journal of Experimental Medicine. 200:507-517 (2004)

MOLECULAR CLONING OF THE SWINE IL-4 RECEPTOR AND IL-13 RECEPTOR ALPHA 1 CHAINS: EFFECTS OF EXPERIMENTAL TOXOPLASMA GONDII, ASCARIS SUUM AND TRICHURIS SUIS INFECTIONS ON TISSUE MRNA LEVELS - (Peer Reviewed Journal)

Zarlenga, D.S., Dawson, H.D., Kringel, H., Solano Aguilar, G., Urban Jr, J.F. 2004. Molecular cloning of the swine IL-4 receptor and IL-13 receptor alpha 1 chains: effects of experimental toxoplasma gondii, ascaris suum and trichuris suis infections on tissue mrna levels. Veterinary Immunology and Immunopathology 101(3-4):223-234.

THE EFFECT OF PROBIOTIC BACTERIA ON THE IMMUNE SYSTEM OF WEANED PIGS MONITORED BY REAL TIME PCR - (Peer Reviewed Journal)

Solano Aguilar, G., Ledbetter, T., Dawson, H.D., Andrews, K., Harvey, R.B., Schoene, N., Urban Jr, J.F. 2004. The effect of probiotic bacteria on the immune system of weaned pigs monitored by Real time PCR. Proceedings 18th International Pig Veterinary Society Meeting, Hamburg, Germany, October 2004. p. 380.

MOLECULAR CLONING OF THE SWINE IL-4 RECEPTOR AND IL-13 RECEPTOR ALPHA 1 CHAINS: EFFECTS OF EXPERIMENTAL TOXOPLASMA GONDII, ASCARIS SUUM AND TRICHURIS SUIS INFECTIONS ON TISSUE MRNA LEVELS - (Peer Reviewed Journal)

Zarlenga, D.S., Dawson, H.D., Kringle, H., Solano Aguilar, G., Urban Jr, J.F. 2004. Molecular cloning of the swine il-4 receptor and il-13 receptor alpha 1 chains: effects of experimental toxoplasma gondii, ascaris suum and trichuris suis infections on tissue mrna levels. Veterinary Immunology and Immunopathology. 101(3-4):223-34 (2004)

TRICHURIS SUIS THERAPY FOR ACTIVE ULCERATIVE COLITIS: A RANDOMIZED CONTROLLED TRIAL - (Peer Reviewed Journal)

Summers, R.W., Elliott, D.E., Urban, J.F. Jr., Thompson, R.A., Weinstock, J.V. 2005. Trichuris suis therapy for active ulcerative colitis: A randomized controlled trial. Gastroenterology. 128:825-832.

ENTERIC NEMATODES INDUCE STEREOTYPIC STAT6-DEPENDENT ALTERATIONS IN INTESTINAL EPITHELIAL CELL FUNCTION - (Peer Reviewed Journal)

Madden, K., Auyeung, K., Zhao, A., Gause, W., Finkelman, F., Katona, I., Urban Jr, J.F., Shea Donohue, P.T. 2004. Enteric nematodes induce stereotypic stat6-dependent alterations in intestinal epithelial cell function. Journal of Immunology. 172:5616-5621 (2004)

SIMULTANEOUS DEFICIENCY IN CD28 AND STAT6 RESULTS IN CHRONIC ECTOPARASITES-INDUCED INFLAMMATORY SKIN DISEASE. - (Peer Reviewed Journal)

Liu, Q., Callendar, C., Liu, Q., Whitmire, J., Grusby, M., Finkleman, F., Darling, T., Cheever, A., Swearengen, J., Urban Jr, J.F. 2004. Simultaneous deficiency in cd28 and stat6 results in chronic ectoparasites-induced inflammatory skin disease. Infection and Immunity. 72:3706-3715 (2004)

SELENIUM (SE) AND VITAMIN E (VE) DEFICIENCIES IMPAIR INTESTINAL FUNCTION AND RESULT IN PERSISTENT INFECTION WITH HELIGMOSOMOIDES POLYGYRUS - (Abstract)

Smith, A.D., Madden, K., Zhao, A., Auyeung, K., Levander, O.A., Finkelman, F., Urban Jr, J.F., Shea Donohue, P.T. 2004. Selenium (se) and vitamin E (ve) deficiencies impair intestinal function and result in persistent infection with heligmosomoides polygyrus [abstract]. Federation of American Society of Experimental Biology Journal. 18(4):A9.

PERIPHERAL CD4 CELLS RAPIDLY ACCUMULATE AT THE HOST: PARASITE INTERFACE AN INFLAMMATORY TH2 MEMORY RESPONSE - (Peer Reviewed Journal)

Morimoto, M., Morimoto, M., Whitmire, J., Star, R., Urban Jr, J.F., Gause, W. 2004. Peripheral cd4 cells rapidly accumulate at the host: Parasite interface and express a polarized th2 memory response in situ. Journal of Immunology. 172:2424-2430 (2004).

GASTOINTESTINAL PARASITES AND HOST INTERACTIONS - (Literature)

Shea Donohue, P.T., Urban Jr, J.F. 2004. Gastointestinal parasites and host interactions. Current Opinions in Gastroenterology. 20:3-9 (2004).

IMPACT OF ASCARIS SUUM - (Trade Journal)

Urban Jr, J.F. 2003. Impact of ascaris suum. Pig Progress. 3-27. Available: http://www.agriworld.nl. 23-27

THE EFFECT OF HUMAN DERIVED PROBIOTIC BACTERIA ON THE IMMUNE AND INTESTINAL FUNCTION OF PIGS - (Abstract)

Solano Aguilar, G., Dawson, H.D., Ledbetter, T., Shea Donohue, P.T., Schoene, N.W., Call, J.E., Beshah, E., Hare Jr, W.R., Urban Jr, J.F. 2003. The effect of human derived probiotic bacteria on the immune and intestinal function of pigs [abstract]. Allen D. Leman Swine Conference. 30:26.

IN SITU LOCALIZATION OF GENE EXPRESSION USING LASER CAPTURE MICRO DISSECTION - (Peer Reviewed Journal)

Morimoto, M., Morimoto, M., Whitemire, J., Star, R., Urban Jr, J.F., Gause, W. 2003. In situ localization of gene expression using laser capture micro dissection. In: PCR Primer: A Laboratory Manual. 11:135-148.

HUMAN DERIVED PROBIOTIC BACTERIA SPECIES CAN REGULATE INTESTINAL RESPONSES TO PARASITIC NEMATODES IN PIGS - (Peer Reviewed Journal)

Solano Aguilar, G., Dawson, H.D., Ledbetter, T., Shea Donohue, P.T., Schoene, N.W., Call, J., Beshah, E., Hare Jr, W.R., and Urban Jr, J.F. 2004. Human derived probiotic bacteria species can regulate intestinal responses to parasitic nematodes in pigs. Veterinary Parasitology. 125:47-161.

THE EFFECTS OF DIETARY PROBIOTICS ON IMMUNITY TO ASCARIS SUUM IN PIGS - (Abstract)

Solano Aguilar, G., Dawson, H.D., Ledbetter, T., Shea Donohue, P.T., Schoene, N.W., Call, J., Beshah, E., Hare Jr, W.R., Urban Jr, J.F. 2003. The effects of dietary probiotics on immunity to ascaris suum in pigs [abstract]. Proceedings of American Association of Veterinary Parasitologists. Paper No. 56-54.

ENHANCEMENT OF DISEASE AND PATHOLOGY BY SYNERGY OF TRICHURIS SUIS AND CAMPYLOBACTER JEJUNI IN THE COLON OF IMMUNOLOGICALLY NAIVE SWINE - (Peer Reviewed Journal)

Mansfield, L., Gauthier, D., Abner, S., Jones, K., Wilder, S., Urban Jr, J.F. 2003. Enhancement of disease and pathology by synergy of trichuris suis and campylobacter jejuni in the colon of immunologically naive swine. American Journal of Tropical Medicine and Hygiene 68(1):70-80 (2003)

CLONING AND CHARACTERIZATION OF A TGF-BETA HOMOLOGUE WITHIN POPULATIONS OF ASCARIS SUUM 4TH STAGE LARVAE (L4): REGULATED TRANSCRIPTION AND MULTIPLE SPLICING DIFFERENTIATIVE L4 IN THE JEJUNUM AND ILEUM DURING SPONTANEOUS CURE. - (Abstract)

Zarlenga, D.S., Morimoto, M., Urban Jr, J.F., Mccarter, J.P. 2003. Cloning and characterization of a tgf-beta homologue within populations of ascaris suum 4th stage larvae (l4): regulated transcription and multiple splicing differentiative l4 in the jejunum and ileum during spontaneous cure [abstract]. World Association for the Advancement of Veterinary Parasitology.

DEPENDENCE OF I1-4, IL-13, AND NEMATODE-INDUCED ALTERATIONS IN MURINE SMALL INTESTINAL SMOOTH MUSCLE CONTRACTILITY ON STAT6 AND ENTERIC NERVES - (Peer Reviewed Journal)

Zhao, A., Mcdermott, J., Urban Jr, J.F., Gause, W., Madden, K., Auyeung, K., Morris, S., Finkelman, F., Shea-Donohue, T. 2004. Dependence of i1-4, il-13, and nematode-induced alterations in murine small intestinal smooth muscle contractility on stat6 and enteric nerves. Journal of Immunology. 171:948-954 (2003).

ANIMAL MODEL OF NIPPOSTRONGYLUS BRASILIENSIS AND HELIGMOSOMOIDES POLYGYRUS - (Book/Chapter)

Camberis, M., Le Gros, G., Urban Jr, J.F. 2003. Animal model of nippostrongylus brasiliensis and heligmosomoides polygyrus. In: Coico, R., editor. Current Protocols in Immunology. John Wiley and Sons, Incorporated. 19.12:1-27 (2003).

THE EFFECT OF DIETARY PROBIOTIC IN THE IMMUNE RESPONSE OF PIGS - (Abstract)

Solano Aguilar, G., Ledbetter, T., Dawson, H.D., Schoene, N.W., Urban Jr, J.F. 2003. The effect of dietary probiotic in the immune response of pigs [abstract]. 9th International Symposium on Digestive Physiology in Pigs. 2:69.

THE IMMUNE RESPONSE TO PARASITIC HELMINTHS: INSIGHT FROM MURINE MODELS. - (Review Article)

Gause, W., Urban Jr, J.F., Stadecker, M. 2003. The immune response to parasitic helminths: insight from murine models. Trends in Immunology. 24:269-277.

IL-4 EXACERBATES ANAPHYLAXIS - (Peer Reviewed Journal)

Strait, R., Morris, S., Smiley, K., Urban Jr, J.F., Finkelman, F. 2003. Il-4 exacerbates anaphylaxis. Journal of Immunology. 170:3835-3842 (2003)

ASCARIS SUUM: CDNA MICROARRAY ANALYSIS OF 4TH STAGE LARVAE (L4) DURING SELF-CURE FROM THE INTESTINE - (Peer Reviewed Journal)

Morimoto, M., Zarlenga, D.S., Beard, H.S., Alkharouf, N., Matthews, B.F., Urban Jr, J.F. 2003. Ascaris suum: cdna microarray analysis of 4th stage larvae (l4) during self-cure from the intestine. Experimental Parasitology. 104:113-121 (2003)

THE ROLE OF OX40L INTERACTION IN THE DEVELOPMENT OF THE PRIMARY AND MEMORY TH2 RESPONSE TO THE GASTROINTESTINAL NEMATODE PARASITE HELIGMOSOMOIDES POLYGYRUS - (Peer Reviewed Journal)

Ekkens, M., Liu, Z., Liu, Q., Foster, A., Ehitmire, J., Pesce, J., Vannoy, J., Sharpe, A., Urban Jr, J.F., Gause, W. 2003. The role of ox40l interaction in the development of the primary and memory th2 response to the gastrointestinal nematode parasite heligmosomoides polygyrus. Journal of Immunology. 170:384-393 (2003)

ROLE OF STAT6 AND MAST CELLS IN IL4-AND IL-13-INDUCED ALTERATIONS IN MURINE INTESTINAL EPITHELIAL CELL FUNCTION - (Peer Reviewed Journal)

Madden, K., Whitman, L., Sullivan, C., Gause, W., Donaldson, D., Urban Jr, J.F., Katona, I., Finkelman, F., Shea Donohue, P.T. 2002. Role of stat6 and mast cells in il4-and il-13-induced alterations in murine intestinal epithelial cell function. Journal of Immunology. 169:4417-4432 (2002)

LIMITED EFFECT OF RECOMBINANT PORCINE INTERLEUKIN 12 ON PORCINE LYMPHOCYTES DUE TO A LOW LEVEL OF IL-12 BETA 2 RECEPTOR - (Peer Reviewed Journal)

Solano Aguilar, G., Zarlenga, D.S., Beshah, E., Gasbarre, L.C., Junker, D., Cochran, M., Dawson, H.D., Urban Jr, J.F., Lunney, J.K. 2002. Limited effect of recombinant porcine interleukin 12 on porcine lymphocytes due to a low level of il-12 beta 2 receptor. Veterinary Immunology and Immunopathology. 89:133-148 (2002)

FUNCTIONAL GENOMIC ASSESSMENT OF PORCINE DISEASE RESISTANCE: REAL TIME ASSAYS OF PORCINE IMMUNE GENE EXPRESSION - (Proceedings/Symposium)

Dawson, H.D., Nishi, S., Beshah, E., Solano Aguilar, G., Zarlenga, D.S., Urban Jr, J.F., Lunney, J.K. 2002. Functional genomic assessment of porcine disease resistance: real time assays of porcine immune gene expression. World Congress of Genetics Applied in Livestock Production #13-41.

A TGF-BETA HOMOLOGUE WITHIN POPULATIONS OF ASCARIS SUUM 4TH STAGE LARVAE (L4): EVIDENCE FOR MULTIPLE SPLITING AND REGULATED TRANSCRIPTION BETWEEN L4 IN THE JEJUNUM AND ILEUM FOLLOWING SPONTANEOUSLY CURE. - (Abstract)

Zarlenga, D.S., Morimoto, M., Urban Jr, J.F., Mccarter, J.P. 2002. A tgf-beta homologue within populations of ascaris suum 4th stage larvae (l4): evidence for multiple spliting and regulated transcription between l4 in the jejunum and ileum following spontaneously cure [abstract]. American Association of Veterinary Parasitologists Proceedings.