Phase III Randomized Study of Whole Brain Radiotherapy and Stereotactic Radiosurgery With Versus Without Temozolomide or Erlotinib in Patients With Non-Small Cell Lung Cancer and Brain Metastases
Final eligibility for a clinical trial is determined by the health professionals conducting the trial.
Patients will be randomly assigned to one of three groups.
Patients in group one will undergo radiation therapy to the whole brain once a day, 5 days a week, for 3 weeks. They will undergo stereotactic radiosurgery within 2 weeks after completing whole brain radiation therapy.
Patients in group two will undergo radiation therapy to the whole brain and stereotactic radiosurgery as in group one. Beginning on the first day of whole-brain radiation therapy, they will receive temozolomide by mouth once a day for 3 weeks. Four weeks after completing whole-brain radiation therapy, patients will receive temozolomide by mouth once a day for 5 days. Treatment with temozolomide may be repeated every 4 weeks for up to six courses.
Patients in group three will undergo radiation therapy to the whole brain and stereotactic radiosurgery as in group one. Beginning on the first day of whole-brain radiation therapy, they will receive erlotinib by mouth once a day for up to 6 months.
If you are interested in participating in a clinical trial, contact your doctor for a referral or call a trial contact person listed below. You may see the same contact person listed at more than one site, however, if you call the number listed you can ask to speak to the study coordinator or person involved with the specific trial you are interested in. If you have questions about cancer or clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). General information about clinical trials, including risks, benefits, and costs, can be found on
NCI's Web site.
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| U.S.A. |
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| California |
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Burbank |
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| | Providence Saint Joseph Medical Center - Burbank |
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| | Clinical Trials Office - Providence Saint Joseph Medical Center - Burbank | |
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Los Angeles |
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| | Kaiser Permanente Medical Center - Los Angeles |
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| | Michael Girvigian | | Ph: | 323-667-4011 | | 800-954-8000 |
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Pomona |
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| | Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center |
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| | Clinical Trials Office - Robert and Beverly Lewis Family Cancer Care Center | |
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| Colorado |
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Grand Junction |
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| | St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center |
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| | Douglas Rock, MD | |
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| Florida |
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Jacksonville |
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| | Baptist Cancer Institute - Jacksonville |
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| | Clinical Trials Office - Baptist Cancer Institute - Jacksonville | |
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| | Integrated Community Oncology Network at Southside Cancer Center |
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| | Douglas Johnson, MD | |
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Jacksonville Beach |
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| | Integrated Community Oncology Network |
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| | Douglas Johnson, MD | |
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Jascksonville |
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| | Baptist Medical Center South |
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| | Douglas Johnson, MD | |
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Orange Park |
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| | Integrated Community Oncology Network - Orange Park |
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| | Douglas Johnson, MD | |
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Orlando |
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| | M.D. Anderson Cancer Center at Orlando |
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| | Alan Forbes, MD, PhD | | Ph: | 407-648-3800 | | 800-648-3818 |
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Palatka |
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| | Florida Cancer Center - Palatka |
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| | Douglas Johnson, MD | |
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Panama City |
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| | Bay Medical |
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| | R. Charles Nichols, MD | |
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Saint Augustine |
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| | Flagler Cancer Center |
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| | Douglas Johnson, MD | |
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Tallahassee |
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| | Tallahassee Memorial Hospital |
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| | Timothy Bolek, MD | |
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| Georgia |
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Columbus |
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| | John B. Amos Cancer Center |
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| | Clinical Trials Office - John B. Amos Cancer Center | |
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| Idaho |
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Boise |
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| | Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center |
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| | Clinical Trials Office - Saint Alphonsus Cancer Care Center | |
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| Illinois |
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Arlington Heights |
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| | Northwest Community Hospital |
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| | Stephen Nigh, MD | |
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Chicago |
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| | Robert H. Lurie Comprehensive Cancer Center at Northwestern University |
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| | Clinical Trials Office - Robert H. Lurie Comprehensive Cancer Center at Northwestern University | |
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cancer@northwestern.edu |
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Springfield |
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| | Cancer Institute at St. John's Hospital |
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| | Bruce Shevlin, MD | | Ph: | 217-525-5666 | | 800-524-0575 |
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| Indiana |
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Fort Wayne |
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| | Parkview Regional Cancer Center at Parkview Health |
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| | David Hornback, MD | |
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Hammond |
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| | Oncology Center at Saint Margaret Mercy Healthcare Center |
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| | Urmi Kalokhe, MD | |
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Indianapolis |
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| | Methodist Cancer Center at Methodist Hospital |
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| | Alexander Yeh, MD | | Ph: | 317-962-8288 | | 800-265-3220 |
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| Maryland |
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Baltimore |
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| | Greenebaum Cancer Center at University of Maryland Medical Center |
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| | Clinical Trials Office - Greenebaum Cancer Center at University of Maryladn Medical Center | |
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| | St. Agnes Hospital Cancer Center |
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| | Richard Hudes, MD | |
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| Michigan |
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Ann Arbor |
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| | University of Michigan Comprehensive Cancer Center |
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| | Clinical Trials Office - University of Michigan Comprehensive Cancer Center | |
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Detroit |
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| | Barbara Ann Karmanos Cancer Institute |
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| | Clinical Trials Office - Barbara Ann Karmanos Cancer Institute | |
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Kalamazoo |
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| | West Michigan Cancer Center |
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| | Clinical Trials Office - West Michigan Cancer Center | |
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| Minnesota |
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Burnsville |
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| | Fairview Ridges Hospital |
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| | Paul Sperduto, MD | |
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Coon Rapids |
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| | Mercy and Unity Cancer Center at Mercy Hospital |
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| | Paul Sperduto, MD | |
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Edina |
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| | Fairview Southdale Hospital |
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| | Clinical Trials Office - Fairview Southdale Hospital | |
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Fridley |
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| | Mercy and Unity Cancer Center at Unity Hospital |
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| | Paul Sperduto, MD | |
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Minneapolis |
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| | Virginia Piper Cancer Institute at Abbott - Northwestern Hospital |
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| | Clinical Trials Office - Virginia Piper Cancer Institute | |
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Robbinsdale |
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| | Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center |
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| | Clinical Trials Office - Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center | |
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Saint Cloud |
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| | CentraCare Clinic - River Campus |
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| | Barbi Kaplan-Frenkel, DO | |
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| | Coborn Cancer Center |
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| | Barbi Kaplan-Frenkel, DO | | Ph: | 320-229-4907 | | 877-229-4907 |
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Saint Louis Park |
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| | CCOP - Metro-Minnesota |
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| | Paul Sperduto, MD | |
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| | Park Nicollet Cancer Center |
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| | Paul Sperduto, MD | |
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Saint Paul |
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| | United Hospital |
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| | Paul Sperduto, MD | |
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Waconia |
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| | Ridgeview Medical Center |
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| | Paul Sperduto, MD | | Ph: | 952-442-2191 | | 800-967-4620 |
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| Missouri |
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Saint Louis |
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| | Saint Louis University Cancer Center |
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| | Clinical Trials Office - Saint Louis University Cancer Center | |
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| Nevada |
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Las Vegas |
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| | CCOP - Nevada Cancer Research Foundation |
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| | John Ellerton, MD, CM | |
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Reno |
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| | Renown Institute for Cancer at Renown Regional Medical Center |
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| | Lawrence Dardick, MD | |
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| New Jersey |
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Red Bank |
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| | Booker Cancer Center at Riverview Medical Center |
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| | Adnan Danish | |
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Sparta |
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| | Frederick R. and Betty M. Smith Cancer Treatment Center |
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| | Maria Werner-Wasik, MD | |
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| New York |
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Rochester |
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| | James P. Wilmot Cancer Center at University of Rochester Medical Center |
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| | Paul Okunieff, MD | |
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| North Carolina |
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Asheville |
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| | Mission Hospitals - Memorial Campus |
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| | Clinical Trials Office - Mission Hospitals - Memorial Campus | |
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| Ohio |
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Akron |
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| | Summa Center for Cancer Care at Akron City Hospital |
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| | Clinical Trials Office - Akron City Hospital | |
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Cleveland |
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| | Cleveland Clinic Taussig Cancer Center |
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| | Clinical Trials Office - Cleveland Clinic Taussig Cancer Center | |
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| Oklahoma |
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Tulsa |
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| | Natalie Warren Bryant Cancer Center at St. Francis Hospital |
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| | Charles Stewart | |
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| Pennsylvania |
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Drexel Hill |
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| | Delaware County Regional Cancer Center at Delaware County Memorial Hospital |
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| | Deborah Markiewicz, MD | |
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Philadelphia |
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| | Fox Chase Cancer Center - Philadelphia |
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| | Clinical Trials Office - Fox Chase Cancer Center - Philadelphia | |
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| | Kimmel Cancer Center at Thomas Jefferson University - Philadelphia |
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| | Clinical Trials Office - Kimmel Cancer Center at Thomas Jefferson University - Philadelphia | |
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Reading |
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| | McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center |
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| | Clinical Trials Office - McGlinn Family Regional Cancer Center | |
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| South Carolina |
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Charleston |
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| | Hollings Cancer Center at Medical University of South Carolina |
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| | Clinical Trials Office - Hollings Cancer Center at Medical University of South Carolina | |
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| Tennessee |
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Knoxville |
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| | Thompson Cancer Survival Center |
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| | Clinical Trials Office - Thompson Cancer Survival Center | |
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| Texas |
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Dallas |
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| | Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas |
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| | Clinical Trials Office - Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas | | Ph: | 866-460-4673; 214-648-7097 | | |
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Galveston |
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| | University of Texas Medical Branch |
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| | Clinical Trials Office - University of Texas Medical Branch | |
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Houston |
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| | M. D. Anderson Cancer Center at University of Texas |
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| | Clinical Trials Office - M. D. Anderson Cancer Center at the University of Texas | |
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| Virginia |
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Norfolk |
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| | Sentara Cancer Institute at Sentara Norfolk General Hospital |
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| | Clinical Trials Office - Sentara Cancer Institute at Sentara Norfolk General Hospital | |
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| Washington |
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Seattle |
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| | CCOP - Virginia Mason Research Center |
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| | Huong Pham, MD | |
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| Wisconsin |
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Madison |
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| | University of Wisconsin Paul P. Carbone Comprehensive Cancer Center |
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| | Clinical Trials Office - University of Wisconsin Paul P. Carbone Comprehensive Cancer Center | |
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Milwaukee |
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| | Medical College of Wisconsin Cancer Center |
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| | Clinical Trials Office - Medical College of Wisconsin Cancer Center | |
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| Canada |
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| Ontario |
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Ottawa |
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| | Ottawa Hospital Regional Cancer Centre - General Campus |
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| | Gad Perry | | Ph: | 613-737-7700 ext. 70209 | | 888-627-5346 |
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| Quebec |
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Montreal |
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| | McGill Cancer Centre at McGill University |
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| | David Roberge | |
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