| Sunday, May 3, 1998 - Arrival of Participants
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| 5:00 p.m. - 7:00 p.m. | Reception and Posters
Visitors Center Level and Nobel Laureate Level
Building 10 |
| Monday, May 4, 1998 |
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| 8:00 a.m. - 9:00 a.m. | Registration |
| 9:00 a.m. - 9:25 a.m. | Introduction for NINDS | Audrey Penn, M.D.
Acting Director, NINDS, NIH |
| Introduction for NIAAA | Enoch Gordis, M.D.
Director, NIAAA, NIH |
| 9:25 a.m. - 9:35 a.m. | "Pooling Medications Development Initiatives on Glutamate and CNS Disorders Across Intramural and Extramural NIH Worlds" | Barbara H. Herman, Ph.D.
Chair, Glutamate Cascade Meeting
NIDA, NIH |
| May 4th Morning Session Presentations
Receptors/Stroke/Epilepsy
Philip H. Sheridan, M.D., Chair
NINDS, NIH |
| 9:35 a.m. - 10:15 a.m. | Glutamate Receptors
"Overview of Glutamate Receptors" and "Kainate Receptor Deficient Mice" | Stephen F. Heinemann, Ph.D.
The Salk Institute |
| 10:15 a.m. - 10:55 a.m. | "Manipulating Glutamatergic Neurotransmission as a Strategy for Drug Development" and "Glutamate and the Ischemic Brain" | Dennis W. Choi, M.D., Ph.D.
Washington University
School of Medicine |
| 10:55 a.m. - 11:15 a.m. | Break |
| 11:15 a.m. - 11:45 a.m. | "Glutamate Neurotransmission in Epilepsy: New Treatment Strategies" | Michael A. Rogawski, M.D., Ph.D.
NINDS, NIH |
| 11:45 a.m. - 11:55 a.m. | Questions and Answers for Morning Presentation | Speaker Panel |
| 11:55 a.m. - 12:00 p.m. | Medications Summary from the Morning | Philip H. Sheridan, M.D.
Chair |
| 12:00 p.m. - 1:30 p.m. | Lunch |
| 12:00 p.m. - 1:30 p.m. | Author-Attended Poster Presentations (GI-A and GI-B) |
| May 4th Afternoon Session Presentations
Opiate/Cocaine/Amphetamine/Alcohol
Barbara H. Herman, Ph.D., Chair
NIDA, NIH |
| 1:30 p.m. - 2:00 p.m. | "NMDA Receptors/Nitric Oxide Synthase Cascade in Pain and Opiate Tolerance" | Gavril Pasternak, M.D., Ph.D.
Memorial Sloan-Kettering Cancer Center |
| 2:00 p.m. - 2:30 p.m. | "NMDA Antagonists Modify Opiate Drug-Seeking: Preclinical and Preliminary Clinical Findings" | Piotr Popik, M.D., Ph.D.
Polish Academy of Sciences |
| 2:30 p.m. - 3:00 p.m. | "Glutamate During the Natural History of Psychostimulant Dependence: Synaptic Plasticity and Medications Development" | Luigi Pulvirenti, M.D.
University of Rome - Tor Vergata |
| 3:00 p.m. - 3:30 p.m. | Break |
| 3:30 p.m. - 4:00 p.m. | "Glutamate-Mediated Neuroplasticity: Role in Amphetamine Addiction" | Marina E. Wolf, Ph.D.
The Chicago Medical School |
| 4:00 p.m. - 4:30 p.m. | "Alcohol and NMDA Receptor Function" | Paula L. Hoffman, Ph.D.
University of Colorado
Health Sciences Center |
| 4:30 p.m. - 5:00 p.m. | "Acamprosate, A Novel Anti-Craving Compound Acts via Glutamatergic Pathways" | Walter Zieglgänsberger, M.D., Ph.D.
Max Planck - Institute of Psychiatry |
| 5:00 p.m. - 5:10 p.m. | Questions and Answers for Afternoon Presentation | Speaker Panel |
| 5:10 p.m. - 5:15 p.m. | Medications Summary from the Afternoon | Barbara H. Herman, Ph.D.
Chair |
| Tuesday, May 5, 1998 |
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| May 5th Morning Session Presentations
Neurodegenerative Disorders and Brain Injury
Bradley Wise, Ph.D., Chair
NIA, NIH |
| 9:00 a.m. - 9:30 a.m. | "Glutamate Receptor Plasticity in the Hippocampus: Implications for Aging" | John H. Morrison, Ph.D.
Mount Sinai School of Medicine |
| 9:30 a.m. - 10:00 a.m. | "Excitotoxic Apoptoses and Necrosis in AIDS Dementia and Stroke: Potential Treatment with NMDA Open-Channel Blockers and Nitric Oxide-Related Species" | Stuart A. Lipton, M.D., Ph.D.
Brigham and Women's Hospital
Harvard Medical School |
| 10:00 a.m. - 10:30 a.m. | "Glutamatergic Mechanisms in the Cause and Treatment of Parkinson's Disease" | J. Timothy Greenamyre, M.D., Ph.D.
Emory University |
| 10:30 a.m. - 11:00 a.m. | Break |
| 11:00 a.m. - 11:30 a.m. | "Glutamatergic Mechanisms in the Pathophysiology and Treatment of Traumatic Brain Injury" | Tracy K. McIntosh, Ph.D.
University of Pennsylvania |
| 11:30 a.m. - 12:00 p.m. | "Role of Glutamate Receptor Maturation in Perinatal Brain Injury" | Frances E. Jensen, M.D.
Children's Hospital (Boston)
and Harvard Medical School |
| 12:00 p.m. - 12:10 p.m. | Questions and Answers for Morning Presentation | Speaker Panel |
| 12:10 p.m. - 12:15 p.m. | Medications Summary from the Morning | Bradley Wise, Ph.D.
Chair |
| 12:15 p.m. - 1:45 p.m. | Lunch |
| 12:15 p.m. - 1:45 p.m. | Author-Attended Poster Presentations (GII-A and GII-B) |
| May 5th Afternoon Session Presentations
Psychiatric Disorders/Affective States/Pain
Linda Brady, Ph.D., Chair
NIMH, NIH |
| 1:45 p.m. - 2:15 p.m. | "Schizophrenia: A Glutamatergic Perspective" | Stephen R. Zukin, M.D.
NIDA, NIH |
| 2:15 p.m. - 2:45 p.m. | "Development of Novel Anxiolytics and Antidepressants via Modulation of Glutamatergic Pathways" | Phil Skolnick, Ph.D.
Lilly Research Laboratories |
| 2:45 p.m. - 3:15 p.m. | Break |
| 3:15 p.m. - 3:45 p.m. | "The Role of Glutamate in Chronic Inflammatory Pain and Painful Peripheral Neuropathies" | Gary J. Bennett, Ph.D.
Allegheny University of the Health Sciences |
| 3:45 p.m. - 4:15 p.m. | "Clinical Studies of NMDA and AMPA/Kainate Receptor Blockers in Acute and Chronic Pain" | Mitchell B. Max, M.D.
NIDR, NIH |
| 4:15 p.m. - 4:25 p.m. | Questions and Answers for Afternoon Presentation | Speaker Panel |
| 4:25 p.m. - 4:30 p.m. | Medications Summary from the Afternoon | Linda Brady, Ph.D.
Chair |
| 4:30 p.m. - 4:45 p.m. | Conclusions and New Directions | Barry J. Hoffer, M.D., Ph.D.
NIDA, NIH |
| 4:45 p.m. | Adjournment |
