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Research
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| Influence of Short-Term Dietary Measures on Dioxin Concentrations in Human Milk Hendrik J Pluim, E. Rudy Boersma, Ilse Kramer, Kees Olie, Johannes W. van der Slikke, and Janna G. Koppe Abstract
Breast-feeding may expose infants to high levels of toxic chlorinated dioxins. To diminish intake of these lipophilic compounds by the baby, two diets were tested for their ability to reduce concentrations of dioxins in human milk. The diets were a low-fat/high-carbohydrate/low-dioxin diet (about 20% of energy intake derived from fat) and a high-fat/low-carbohydrate/low-dioxin diet. These diets were tested in 16 and 18 breast-feeding women, respectively. The test diets were followed for 5 consecutive days in the fourth week after delivery. Milk was sampled before and at the end of the dietary regimen, and dioxin concentrations and fatty acid concentrations were determined. Despite significant influences of these diets on the fatty acid profiles, no significant influence on the dioxin concentrations in breast milk could be found. We conclude that short-term dietary measures will not reduce dioxin concentrations in human milk. Key words : dioxins, dibenzofurans, dietary measures, human milk, xenobiotics. Environ Health Perspect 102:968-971 (1994) http://ehpnet1.niehs.nih.gov/docs/1994/102-11/pluim.html
Address correspondence to J.G. Koppe, Department of Neonatology, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands. We thank L. van Lint, A.A. Nijenhuis, and R.B.H. Schutgens for quantification of the fatty acids in the breast milk samples. We gratefully acknowledge L. Mathus-Vliegen for carefully reading the manuscript and J. Oosting for statistical assistance. This research was supported by grant no. 28-1690 of the Praeventiefonds in the Netherlands. Received 28 April 1994 ; accepted 4 August 1994.
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