Biography

Dr. Caporaso received his undergraduate degree from Rutgers University and his M.D. from the University of Medicine and Dentistry of New Jersey. In 1983 he came to the NCI as an Oncology fellow in the Medicine Branch. He served as a research fellow and biotechnology fellow in the Environmental Epidemiology Branch of NCI. Since 1996, he has been the Chief of the Pharmacogenetics Section, Genetic Epidemiology Branch. He is a current member of the Prostate, Lung, Colorectal and Ovarian (PLCO) steering committee, the DCEG Lung Cancer Interest Group, the NCI Program Review Group for Lung Cancer, and the National Lung Screening Trial (NLST) Biomarkers and Research Evaluation Subcommittees. He helps guide NCI Tobacco priorities and implementation of tobacco-related research as Co-Chair of the Tobacco Research Opportunity Team. He is the Chair of the Phenotype Harmonization Committee for GENEVA (GeneEnvironment Association Studies) and Co-Chair of the PhenX group, creating standard questionnaire modules for studies of cancer in populations. He is PI of a Grant funded by GENEVA under the Gene-Environment initiative to conduct a GWAS on lung cancer and smoking and co-PI on a UO1 supporting the Genetic Epidemiology of CLL Consortium.

Research Interests

• Molecular epidemiology of lung cancer and tobacco
• Etiology of chronic lymphocytic leukemia and related hematologic and lymphoproliferative conditions

Keywords

lung cancer, chronic lymphocytic leukemia, molecular epidemiology, tobacco, nicotine dependency

Selected Publications

• Caporaso N, Gu F, Chatterjee N, Sheng-Chih J, Yu K, Yeager M, Chen C, Jacobs K, Wheeler W, Landi MT, Ziegler RG, Hunter DJ, Chanock S, Hankinson S, Kraft P, Bergen AW. Genome-wide and candidate gene association study of cigarette smoking behaviors. PLoS ONE 2009 Feb 27; 4(2):e4653.
• Landgren O, Albitar M, Ma W, Abbasi F, Hayes RB, Ghia P, Marti GE, Caporaso NE B-cell clones as early markers for chronic lymphocytic leukemia. N Engl J Med 2009;Feb 12;360(7):659-67.
• Azzato EM, Morton LM, Bergen AW, Wang SS, Chatterjee N, Kvale P, Yeager M, Hayes RB, Chanock SJ, Caporaso NE SLC6A3 and body mass index in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. BMC Med Genet. 2009 Jan 30;10:9.
• Wacholder S, Chatterjee N, Caporaso N. Intermediacy and gene-environment interaction: the example of CHRNA5-A3 region, smoking, nicotine dependence, and lung cancer. J Natl Cancer Inst. 2008 Nov 5;100(21): 1488-91. Epub 2008 Oct 28.
• Goldin LR, Caporaso NE. Family studies in chronic lymphocytic leukaemia and other lymphoproliferative tumours. Br J Haematol 2007 Dec;139(5):774-9. Review.
• McMaster ML, Caporaso N. Waldenström macroglobulinaemia and IgM monoclonal gammopathy of undetermined significance: emerging understanding of a potential precursor condition . Br J Haematol 2007 Dec;139(5):663-71. Review.
• Landi MT, Consonni D, Rotunno M, Bergen AW, Goldstein AM, Lubin JH, Goldin L, Alavanja M, Morgan G, Subar AF, Linnoila I, Previdi F, Corno M, Rubagotti M, Marinelli B, Albetti B, Colombi A, Tucker M, Wacholder S, Pesatori AC, Caporaso NE, Bertazzi PA. Environment And Genetics in Lung cancer Etiology (EAGLE) study: an integrative population-based case-control study of lung cancer . BMC Public Health 2008; doi: 10.1186/1471-2458-8-203.
• Landi MT, Dracheva T, Rotunno M, Figueroa JD, Liu H, Dasgupta A, Mann FE, Fukuoka J, Hames M, Bergen AW, Murphy SE, Yang P, Pesatori AC, Consonni D, Bertazzi PA, Wacholder S, Shih JH, Caporaso NE, Jen J. Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival . PLoS ONE 2008 Feb 20;3(2):e1651.
• Landgren O, Katzmann JA, Hsing AW, Pfeiffer RM, Kyle RA, Yeboah ED, Biritwum RB, Tettey Y, Adjei AA, Larson DR, Dispenzieri A, Melton LJ 3rd, Goldin LR, McMaster ML, Caporaso NE, Rajkumar SV. Prevalence of monoclonal gammopathy of undetermined significance among men in Ghana. Mayo Clin Proc . 2007 Dec;82(12):1468-73.
• Caporaso N, Goldin L, Plass C, Calin G, Marti G, Bauer S, Raveche E, McMaster ML, Ng D, Landgren O, Slager S. Chronic lymphocytic leukaemia genetics overview. Br J Haematol 2007;139(5):630-4. Review.
• Marti GE, Rawstron AC, Ghia P, Hillmen P, Houlston RS, Kay N, Schleinitz TA, Caporaso N on behalf of the International Familial CLL Consortium. Diagnostic criteria for monoclonal B-cell lymphocytosis. Br J Haematol 2005;130:325-332.