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Michael J. DeVito,¹ Linda S. Birnbaum,¹ William H. Farland,² and Thomas A. Gasiewicz³

¹Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711 USA
²Office of Health and Environmental Assessment, U.S. Environmental Protection Agency, Washington, DC 20460 USA
³Department of Environmental Medicine, University Rochester School of Medicine, Rochester, NY 14642 USA

Abstract
Humans are exposed to mixtures of polyhalogenated aromatic hydrocarbons, and the potential health effects of these exposures are uncertain. A subset of this class of compounds produce similar spectra of toxicity in experimental animals as does 2,3,7,8-tetrachlorodibenzo-p  -dioxin (TCDD) , and these chemicals have been classified as "dioxins." In this study, we compared the body burdens of dioxins that produce effects in experimental animals to body burdens associated with these effects in humans. Human body burdens were estimated from lipid-adjusted serum concentrations of dioxins, assuming dioxins are equally distributed in body fat and an adult has 22% body fat. The toxic equivalency factor (TEF) method was used to calculate body burdens of dioxins in humans. These calculations included dibenzo-p -dioxins, dibenzofurans, and polychlorinated biphenyls. In the general population, average background concentrations were estimated at 58 ng TCDD equivalents (TEQ) /kg serum lipid, corresponding to a body burden of 13 ng TEQ/kg body weight. Populations with known exposure to dioxins have body burdens of 96-7,000 ng TEQ/kg body weight. For effects that have been clearly associated with dioxins, such as chloracne and induction of CYP1A1, humans and animals respond at similar body burdens. Induction of cancer in animals occurs at body burdens of 944-137,000 ng TCDD/kg body weight, while noncancer effects in animals occur at body burdens of 10-12,500 ng/kg. Available human data suggest that some individuals may respond to dioxin exposures with cancer and noncancer effects at body burdens within one to two orders of magnitude of those in the general population. Key words: dioxins, polychlorinated biphenyls, risk assessment, toxic equivalency factors. Environ Health Perspect 103:820-831 (1995)

Address correspondence to M.J. DeVito, Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711 USA.

We thank Mel Andersen, Bob Leubke, and Ralph Smialowicz for critically reviewing the manuscript. This study was supported in part by the National Institute of Health through a National Research Service Award (1F32 ESO5600-01) to M.D.V. This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.

Received 13 March 1995 ; accepted 23 May 1995.