ARS : Jose Ordovas

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Jose Ordovas (Tufts University)
Human Nutrition Research Center on Aging
(This person is no longer with ARS)

Projects

Nutrition, Obesity, Cardiovascular Health and Genomics

	Appropriated (D)
	Accession Number: 416581

Nutrition, Cardiovascular Health, and Genomics

	Specific Cooperative Agreement (S)
	Accession Number: 411666

Publications

The effects of ABCG5/G8 polymorphisms on plasma HDL cholesterol concentrations depend on smoking habit in the Boston Puerto Rican Health Study - (Peer Reviewed Journal)

Junyent, M., Tucker, K., Smith, C., Garcia-Rios, A., Mattei, J., Lai, C., Parnell, L.D., Ordovas, J.M. 2008. The effects of ABCG5/G8 polymorphisms on plasma HDL cholesterol concentrations depend on smoking habit in the Boston Puerto Rican Health Study. Journal of Lipid Research. 50:565-573.

Matrix Gla Protein polymorphisms are associated with coronary artery calcification - (Peer Reviewed Journal)

Crosier, M.D., Booth, S.L., Peter, I., Dawson-Hughes, B., Price, P.A., O'Donnell, C.J., Hoffman, U., Williamson, M.K., Ordovas, J.M. 2009. Matrix Gla Protein polymorphisms are associated with coronary artery calcification. Journal of Nutritional Science and Vitaminology. 55:59-65.

Wdtc1, An Ortholog of Drosphilia Adipose Gene, Associates with Human Obesity - (Peer Reviewed Journal)

Lai, C., Parnell, L.D., Garcia-Bailo, B., Tucker, K., Ordovas, J.M. 2008. WDTC1, an ortholog of Drosphilia adipose gene, associates with human obesity. Obesity. 17(3):593-600.

Effects of Perilipin (PLIN) Gene Variation on Metabolic Syndrome Risk and Weight-Loss in Obese Children and Adolescents - (Peer Reviewed Journal)

Deram, S., Nicolau, C.Y., Perez-Martinez, P., Guazzelli, I., Halpern, A., Wajchenberg, B.L., Ordovas, J.M., Villares, S.M. 2008. Effects of Perilipin (PLIN) Gene Variation on Metabolic Syndrome Risk and Weight-Loss in Obese Children and Adolescents. Journal of Clinical Endocrinology and Metabolism. 93: 4933 - 4940.

Adipoq Polymorphisms, Monounsaturated Fatty Acids, and Obesity Risk: the Goldn Study - (Peer Reviewed Journal)

Warodomwichit, D., Shen, J., Arnett, D., Tsai, M., Kabagambe, E., Peacock, J., Hixson, J., Straka, R., Province, M., An, P., Lai, C., Parnell, L.D., Borecki, I., Ordovas, J.M. 2009. ADIPOQ Polymorphisms, Monounsaturated Fatty Acids, and Obesity Risk: The GOLDN Study. Obesity. 17:510-517.

Smoking, inflammatory patterns, and postprandial hypertriglyceridemia - (Peer Reviewed Journal)

Kabagambe, E.K., Ordovas, J.M., Tsai, M.Y., Borecki, I.B., Hopkins, P.N., Arnett, D.K. 2009. Smoking, inflammatory patterns, and postprandial hypertriglyceridemia. Atherosclerosis. 203(2):633-639.

Perilipin Polymorphism Interacts with Dietary Carbohydrates to Modulate Anthropometric Traits in Hispanics of Caribbean Origin - (Peer Reviewed Journal)

Smith, C., Tucker, K., Yiannakouris, N., Garcia-Bailo, B., Mattei, J., Lai, C., Parnell, L.D., Ordovas, J.M. 2008. Perilipin Polymorphism Interacts with Dietary Carbohydrates to Modulate Anthropometric Traits in Hispanics of Caribbean Origin. Journal of Nutrition. 138(10):1852-1858.

Gene¿Environment Interactions and Susceptibility to Metabolic Syndrome and Other Chronic Diseases - (Review Article)

Ordovas, J.M., Shen, J. 2008. Gene¿Environment Interactions and Susceptibility to Metabolic Syndrome and Other Chronic Diseases. Journal of Periodontology. 79(8S):1508-1513.

A Common Missense Variant in the Glucokinase Regulatory Protein Gene (GCKR) Is Associated with Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations - (Peer Reviewed Journal)

Orho-Melander, M., Melander, O., Guiducci, C., Perez-Martinez, P., Corella, D., Roos, C., Tewhey, R., Rieder, M.J., Hall, J., Abecasis, G., Tai, E., Welch, C., Arnett, D.K., Lyssenko, V., Lindholm, E., Saxena, R., De Bakker, P., Burtt, N., Voight, B.F., Hirschhorn, J.N., Tucker, K., Hedner, T., Tuomi, T., Isomaa, B., Eriksson, K., Taskinen, M., Wahlstrand, B., Hughes, T.E., Parnell, L.D., Lai, C., Berglund, G., Peltonen, L., Vartiainen, E., Jousilahti, P., Havulinna, A.S., Salomaa, V., Nilsson, P., Groop, L., Altshuler, D., Ordovas, J.M., Kathiresan, S. 2008. A Common Missense Variant in the Glucokinase Regulatory Protein Gene (GCKR) Is Associated with Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations. Diabetes. 57:3112-3121.

The challenges of molecular nutrition research 1- Linking genotype to healthy nutrition - (Review Article)

Williams, C.M., Ordovas, J.M., Lairon, D., Hesketh, J., Lietz, G., Gibney, M., Van Ommen, B. 2008. The challenges of molecular nutrition research 1- Linking genotype to healthy nutrition. Genes and Nutrition. 3(2):41¿49.

Adiponectin Gene Variants are Associated with Insulin Sensitivity in Response to Dietary Fat Consumption in Caucasian Men - (Peer Reviewed Journal)

Perez-Martinez, P., Lopez-Miranda, J., Cruz-Teno, C., Delgado-Lista, J., Jimenez-Gomez, Y., Fernandez, J.M., Gomez, M.J., Marin, C., Perez-Jimenez, F., Ordovas, J.M. 2008. Adiponectin Gene Variants are Associated with Insulin Sensitivity in Response to Dietary Fat Consumption in Caucasian Men. Journal of Nutrition. 138(9): 1609-1614.

Influence of genetic factors in the modulation of postprandial lipemia - (Review Article)

Perez-Martinez, P., Lopez-Miranda, J., Perez-Jimenez, F., Ordovas, J.M. 2008. Influence of genetic factors in the modulation of postprandial lipemia. Atherosclerosis Supplements. 9:49-55.

Vitamin K circulating cytokines and bone mineral density in older men and women - (Peer Reviewed Journal)

Shea, K., Dallal, G., Dawson-Hughes, B., Ordovas, J.M., O'Donnell, C., Gundberg, C., Peterson, J., Booth, S.L. 2008. Vitamin K circulating cytokines and bone mineral density in older men and women. American Journal of Clinical Nutrition. 88:356-63.

The effect of IL6-174C/G polymorphisms on postprandial triglycerides metabolism in the GOLDN study - (Peer Reviewed Journal)

Shen, J., Arnett, D.K., Perez-Martinez, P., Parnell, L.D., Peacock, J.M., Hixson, J.E., Tsai, M.Y., Lai, C., Straka, R.J., Hopkins, P.N., Ordovas, J.M. 2008. The effect of IL6-174C/G polymorphisms on postprandial triglycerides metabolism in the GOLDN study. Journal of Lipid Research. 49:1839-1845.

Clinical significance of apolipoprotein A5 - (Review Article)

Tai, E., Ordovas, J.M. 2008. Clinical significance of apolipoprotein A5. Current Opinion in Lipidology. 19(4):349-354.

Associations between vitamin K and circulating cytokines in older men and women - (Abstract)

Shea, K.M., Dallal, G., Dawson-Hughes, B., Ordovas, J.M., O'Donnell, C.J., Gundberg, C., Peterson, J.W., Booth, S.L. 2008. Associations between vitamin K and circulating cytokines in older men and women. FASEB Journal. 22:1106.1

Association of common C-protein (CRP) gene polymorphism with baseline plasma CRP levels and fenofibrate response: The GOLDN Study - (Peer Reviewed Journal)

Shen, J., Arnett, D.K., Parnell, L.D., Peacock, J.M., Lai, C., Hixson, J.E., Tsai, M.Y., Province, M., Straka, R.J., Ordovas, J.M. 2008. Association of common C-protein (CRP) gene polymorphism with baseline plasma CRP levels and fenofibrate response: The GOLDN Study. Diabetes Care. 31(5):910-915.

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans - (Peer Reviewed Journal)

Kathiresan, S., Melander, O., Guiducci, C., Surti, A., Burtt, N.P., Rieder, M.J., Cooper, G.M., Roos, C., Voight, B.F., Havulinna, A.S., Wahlstrand, B., Hedner, T., Corella, D., Tai, E.S., Ordovas, J.M., Berglund, G., Vartiainen, E., Jousilahti, P., Hedblad, B., Taskinen, M., Newton-Cheh, C., Salomaa, V., Peltonen, L., Groop, L., Altshuler, D.M., Orho-Melander, M. 2008. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nature Genetics. 40(2):189-197.

Ppargc1a Variations Associated with DNA Damage, Diabetes, and Cardiovascular Diseases: the Boston Puerto Rican Study - (Review Article)

Lai, C., Tucker, K., Parnell, L.D., Adiconis, X., Garcia-Bailo, B., Griffith, J., Meydani, M., Ordovas, J.M. 2008. PPARGC1A Variations Associated with DNA Damage, Diabetes, and Cardiovascular Diseases: The Boston Puerto Rican Study. Diabetes. 57:809-816.

Genetic Influences on Blood Lipids and Cardiovascular Risk - (Book/Chapter)

Ordovas, J.M. 2008. Genetic Influences on Blood Lipids and Cardiovascular Risk. In: Coulston, A., Boushey, C. Nutrition in the Prevention and Treatment of Disease, 2nd Edition. Elsevier: 485-513.

The genetic architecture of fasting plasma triglyceride response to fenofibrate treatment - (Peer Reviewed Journal)

Ordovas, J.M., Smith, J., Arnett, D., Kelly, R., Sun, Y., Hopkins, P., Hixson, J., Straka, R., Peacock, J., Kardia, S. 2008. The genetic architecture of fasting plasma triglyceride response to fenofibrate treatment. European Journal of Human Genetics. 16(5):603-613.

Genetic predisposition, non-genetic risk factors and coronary infarct - (Peer Reviewed Journal)

Ordovas, J.M., Trichopoulou, A., Yiannakouris, N., Bamia, C., Benetou, V., Trichopoulos, D. 2008. Genetic predisposition, non-genetic risk factors and coronary infarct. Archives of Internal Medicine. 168(8)891-896.

The APOB -516C/T polymorphism has no effect on lipid and apolipoprotein response following changes in dietary fat intake in a healthy population - (Peer Reviewed Journal)

Perez-Martinez, P., Perez-Jimenez, F., Ordovas, J.M., Bellido, C., Moreno, J.A., Gomez, P., Marin, C., Frenandez De La Puebla, R.A., Paniagua, J.A., Lopez-Miranda, J. 2007. The APOB -516C/T polymorphism has no effect on lipid and apolipoprotein response following changes in dietary fat intake in a healthy population. Nutrition Metabolism and Cardiovascular Disease. 17(3):224-229.

Red blood cell fatty acid composition and the metabolic syndrome: NHLBI GOLDN study - (Peer Reviewed Journal)

Ordovas, J.M., Kabagambe, E., Tsai, M., Arnett, D., Peacock, J., Hopkins, P., Borecki, I., Hixson, J. 2008. Red blood cell fatty acid composition and the metabolic syndrome: NHLBI GOLDN study. Clinical Chemistry. 54(1):154-162.

Genotype-phenotype associations: Modulation by diet and obesity - (Review Article)

Ordovas, J.M. 2008. Genotype-phenotype associations: Modulation by diet and obesity. Obesity. 16:S40-S46.

Folic acid, homocysteine and cardiovascular disease: Are the dots connecting? - (Review Article)

Ordovas, J.M. 2008. Folic acid, homocysteine and cardiovascular disease: Are the dots connecting?. Current Cardiovascular Risk Reports. 2(1):7-8.

Gender, a Significant Factor in the Cross Talk Between Genes, Environment, and Health - (Review Article)

Ordovas, J.M. 2007. Gender, a Significant Factor in the Cross Talk Between Genes, Environment, and Health. Principles of Gender-specific Medicine. 4(B): S111-22.

Postprandial Triglyceride Metabolism is Modified by the Presence of Genetic Variation at the Perilipin (PLIN) Locus in Two Caucasian Populations - (Peer Reviewed Journal)

Perez-Martinez, P., Yiannakouris, N., Lopez Miranda, J., Arnett, D., Tsai, M., Galan, E., Straka, R., Delgado-Lista, J., Province, M., Ruano, J., Borecki, I., Hixson, J., Garcia-Bailo, B., Perez-Jimenez, F., Ordovas, J.M. 2008. Postprandial Triglyceride Metabolism is Modified by the Presence of Genetic Variation at the Perilipin (PLIN) Locus in Two Caucasian Populations. American Journal of Clinical Nutrition. 87(3):744-752.

Single Nucleotide Polymorphisms in ABCG5 and ABCG8 are associated with changes in cholestrol metabolism during weight loss - (Peer Reviewed Journal)

Santosa, S., Demonty, I., Lichtenstein, A.H., Ordovas, J.M., Jones, P.J. 2007. Single Nucleotide Polymorphisms in ABCG5 and ABCG8 are associated with changes in cholestrol metabolism during weight loss. Journal of Lipid Research. 48(12):2607-2613.

Are dietary preferences linked to genes? - (Review Article)

Ordovas, J.M., Tanaka, T. 2007. Are dietary preferences linked to genes? Future of Lipidology. 2(5):485-488. doi:10.2217/17460875.2.5.485

A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study - (Peer Reviewed Journal)

Kathiresan, S., Manning, A.K., Demissie, S., D'Agostino, R.B., Surti, A., Guiducci, C., Gianniny, L., Burtt, N., Melander, O., Arnett, D.K., Peloso, G.M., Ordovas, J.M., Cupples, L.A., Orho-Melander, M. 2007. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. BMC Medical Genetics. 8:1.

Speed-Mapping Quantitative Trait Loci Using Microarrays - (Peer Reviewed Journal)

Lai, C., Leips, J., Zou, W., Roberts, J.F., Wollenberg, K.R., Parnell, L.D., Zeng, Z., Ordovas, J.M., Mckay, T.F. 2007. Speed-Mapping Quantitative Trait Loci Using Microarrays. Nature Methods. 4(10):839-841.

Estimating interaction between genetic and environmental risk factors efficiency of sampling designs within a cohort - (Peer Reviewed Journal)

Bureau, A., Diallo, M.S., Ordovas, J.M., Cupples, L.A. 2008. Estimating interaction between genetic and environmental risk factors efficiency of sampling designs within a cohort. Epidemiology. 19(1):83-93.

An apolipoprotein A-II polymorphism (-265T/C, rs5082), regulates postprandial response to a saturated fat overload in healthy men - (Peer Reviewed Journal)

Delgado-Lista, J., Perez-Jimenez, F., Tanaka, T., Perez-Martinez, P., Jiminez-Gomez, Y., Marin, C., Ruano, J., Parnell, L.D., Ordovas, J.M., Lopez-Miranda, J. 2007. An apolipoprotein A-II polymorphism (-265T/C, rs5082), regulates postprandial response to a saturated fat overload in healthy men. Journal of Nutrition. 137:2024-2028.

Interleukin 1B genetic polymorphisms interact with polyunsaturated fatty acids to affect risk of the metabolic syndrome in the GOLDN Study - (Peer Reviewed Journal)

Shen, J., Arnett, D.K., Peacock, J.M., Parnell, L.D., Aldi, K., Hixson, J.E., Tsai, M.Y., Kabagambe, E.K., Lai, C., Stratka, R.J., Ordovas, J.M. 2007. Interleukin 1B genetic polymorphisms interact with polyunsaturated fatty acids to affect risk of the metabolic syndrome in the GOLDN Study. Journal of Nutrition. 137(8):1846-1851.

Ten commandments for the future of ageing research in the UK: a vision for action - (Other)

Franco, O., Krikwood, T.B., Powell, J.R., Catt, M., Goodwinn, J., Ordovas, J.M., Van Der Ouderaa, F. 2007. Ten commandments for the future of ageing research in the UK: a vision for action. BMC Geriatrics. 7:10.

The -256T>C Polymorphism in the Apolipoprotein A-II Gene Promoter Is Associated with Body Mass Index and Food Intake in the Genetics of Lipid Lowering Drugs and Diet Network Study - (Peer Reviewed Journal)

Corella, D., Arnett, D.K., Tsai, M.Y., Kabagambe, E.K., Peacock, J.M., Hixson, J.E., Straka, R.J., Province, M., Lai, C., Parnell, L.D., Borecki, I., Ordovas, J.M. 2007. The -256T>C Polymorphism in the Apolipoprotein A-II Gene Promoter Is Associated with Body Mass Index and Food Intake in the Genetics of Lipid Lowering Drugs and Diet Network Study. Clinical Chemistry.53:1144-1152.

Fenofibrate Effect on Triglyceride and Postprandial Response of Apolipoprotein A5 Variants: The GOLDN Study - (Peer Reviewed Journal)

Lai, C., Arnett, D.K., Straka, R.J., Tsai, M.Y., Peacock, J.M., Adiconis, X., Parnell, L.D., Hixson, J.E., Province, M.A., Ordovas, J.M. 2007. Fenofibrate Effect on Triglyceride and Postprandial Response of Apolipoprotein A5 Variants: The GOLDN Study. Arteriosclerosis Thrombo Vasc Biol. 27:1417-1425.

Peroxisome proliferator-activated receptor alpha polymorphisms and postprandial lipemia in healthy men - (Peer Reviewed Journal)

Tanaka, T., Ordovas, J.M., Delgado-Lista, J., Perez-Jimenez, F., Marin, C., Perez-Martinez, P., Gomez, P., Lopez-Miranda, J. 2007. Peroxisome proliferator-activated receptor alpha polymorphisms and postprandial lipemia in healthy men. Journal of Lipid Research. 48:1402-08.

Nutrition in the genomics era: Cardiovascular disease risk and the Mediterranean diet - (Review Article)

Ordovas, J.M., Kaput, J., Corella, D. 2007. Nutrition in the genomics era: Cardiovascular disease risk and the Mediterranean diet. Molecular Nutrition and Food Research. 51(10):1293-9.

Two independent apolipoprotein A5 haplotypes modulate postprandial lipoprotein metabolism in a healthy Caucasian population - (Peer Reviewed Journal)

Moreno, R., Perez-Jimenez, F., Marin, C., Perez-Martinez, P., Gomez, P., Jimenez-Gomez, Y., Delgado-Lista, J., Moreno, J.A., Tanaka, T., Ordovas, J.M., Lopez-Miranda, J. 2007. Two independent apolipoprotein A5 haplotypes modulate postprandial lipoprotein metabolism in a healthy Caucasian population. Journal of Clinical Endocrinology and Metabolism. 92(6):2280-85.

Nutritional Genomic Testing: What Role Will Clinical Labs Play? - (Review Article)

Ordovas, J.M. 2007. Nutritional Genomic Testing: What Role Will Clinical Labs Play?. Clinical Laboratory News. 33:4.

Genetic Links between Diabetes Mellitus and Coronary Atherosclerosis - (Review Article)

Ordovas, J.M. 2007. Genetic Links between Diabetes Mellitus and Coronary Atherosclerosis. Current Atherosclerosis Reports. 9(3):204-210.

Medicine, Genetics and Race: the Case of Cardiovascular Diseases - (Other)

Ordovas, J.M. 2007. Medicine, Genetics and Race: the Case of Cardiovascular Diseases. Personalized Medicine.4(1):1-6.

The role of perilipin in human obesity and insulin resistance - (Review Article)

Tai, E.S., Ordovas, J.M. 2007. The role of perilipin in human obesity and insulin resistance. Current Opinion in Lipidology. 18(2):152-156.

Gene-environment interaction: Introduction - (Review Article)

Ordovas, J.M. 2007. Gene-environment interaction: Introduction. Nutrition Metabolism and Cardiovascular Disease. 17(2):71.

Identification of a functional polymorphism at the Adipose Fatty Acid Binding protein gene (FABP4) and demonstration of its association with cardiovascular disease: A path to follow - (Review Article)

Ordovas, J.M. 2007. Identification of a functional polymorphism at the Adipose Fatty Acid Binding protein gene (FABP4) and demonstration of its association with cardiovascular disease: A path to follow. Nutrition Reviews. 65(3):130-4.

Heritability of Lipid Phenotypes among African-Americans: Jackson Heart Study - (Abstract)

Goosby Landry, L., Wilson, J.G., Lichtenstein, A.H., Ordovas, J.M., Tucker, K., Taylor, H.A., Destefano, A.L. 2007. Heritability of Lipid Phenotypes among African-Americans: Jackson Heart Study. Annual Conference on Cardiovascular Disease Epidemiology and Prevention. 115:e300.

Scavenger Receptor Class B Type I (SCARB1) c.1119C>T Polymorphism Affects Postprandial Triglyceride Metabolism in Men - (Peer Reviewed Journal)

Tanaka, T., Delgado-Lista, J., Lopez-Miranda, J., Perez-Jimenez, F., Marin, C., Perez-Martinez, P., Gomez, P., Ordovas, J.M. 2007. Scavenger Receptor Class B Type I (SCARB1) c.1119C>T Polymorphism Affects Postprandial Triglyceride Metabolism in Men. Journal of Nutrition. 137:578-582.

Postprandial Lipemia is Modified by the Presence of the APOB-516C/T Polymorphism in a Healthy Caucasian Population - (Peer Reviewed Journal)

Perez-Martinez, P., Perez-Jimenez, F., Ordovas, J.M., Moreno, J.A., Marin, C., Moreno, R., Jimenez-Gomez, Y., Paniagua, J.A., Lopez-Miranda, J. 2007. Postprandial Lipemia is Modified by the Presence of the APOB-516C/T Polymorphism in a Healthy Caucasian Population. Lipids. 42(2):143-150.

Candidate genes affecting Drosophila life span identified by integrating microarray gene expression analysis and QTL mapping - (Abstract)

Lai, C., Parnell, L.D., Lyman, R.F., Ordovas, J.M., Mackay, T.F. 2006. Candidate genes affecting Drosophila life span identified by integrating microarray gene expression analysis and QTL mapping. Mechanisms of Aging and Development 128:237-249.

Apoa5 Gene Variation Modulates the Effects of Dietary Fat Intake on Body Mass Index and Obesity Risk in the Framingham Heart Study - (Peer Reviewed Journal)

Corella, D., Lai, C., Demissie, S., Cupples, A., Manning, A.K., Tucker, K., Ordovas, J.M. 2007. APOA5 gene variation modulates the effects of dietary fat intake on body mass index and obesity risk in the Framingham Heart Study. Journal of Molecular Medicine.85:119-128.

The APOB -516C/T polymorphism is associated with differences in insulin sensitivity in healthy males during the consumption of diets with different fat content - (Peer Reviewed Journal)

Perez-Martinez, P., Perez-Jimenez, F., Ordovas, J.M., Moreno, J.A., Moreno, R., Fuentes, F., Ruano, J., Gomez, P., Marin, C., Lopez-Miranda, J. 2007. The APOB -516C/T polymorphism is associated with differences in insulin sensitivity in healthy males during the consumption of diets with different fat content. British Journal of Nutrition. 97(4):622-627.

Metabolic syndrome pathophysiology: the role of adipose tissue - (Review Article)

Laclaustra, M., Corella, D., Ordovas, J.M. 2007. Metabolic syndrome pathophysiology: the role of adipose tissue. Nutrition Metabolism and Cardiovascular Disease. 17(2):125-39.

Nutrition and Diet in the Era of Genomics - (Book/Chapter)

Ordovas, J.M., Corella, D. 2008. Nutrition and Diet in the Era of Genomics. In: Willard, H.F. and Ginsburg, G.S, editors. Genomic and Personalized Medicine. vol. 1-2. New York, NY: Elsevier.

Informative-Transmission Disequilibrium Test (i-TDT):Combined Linkage and Association Mapping That Includes Unaffected Offspring as Well as Affected Offspring - (Peer Reviewed Journal)

Guo, C.Y., Lunetta, K.L., Destefano, A.L., Ordovas, J.M., Cupples, L.A. 2006. Informative-Transmission Disequilibrium Test (i-TDT):Combined Linkage and Association Mapping That Includes Unaffected Offspring as Well as Affected Offspring. Genetic Epidemiology. 31(2):115-33.

A direct assessment of genetic contribution to the incidence of coronary infarct in the general population Greek EPIC cohort - (Peer Reviewed Journal)

Yiannakouris, N., Trichopoulou, A., Benetou, V., Psaltopoulou, T., Ordovas, J.M., Trichooulos, D. 2006. A direct assessment of genetic contribution to the incidence of coronary infarct in the general population Greek EPIC cohort. European Journal of Epidemiology. 21(12):859-867.

Lifespan modification by glucose and methionine in Drosophila melanogaster fed a chemically defined diet - (Peer Reviewed Journal)

Troen, A.M., French, E.E., Roberts, J.F., Selhub, J., Ordovas, J.M., Parnell, L.D., Lai, C. 2006. Lifespan modification by glucose and methionine in Drosophila melanogaster fed a chemically defined diet. Age.29:29-39.

Age and vitamin E-induced changes in Gene Expression Profiles of T cells - (Peer Reviewed Journal)

Han, S., Adolfsson, O., Lee, C., Prolla, T.A., Ordovas, J.M., Meydani, S. 2006. Age and vitamin E-induced changes in Gene Expression Profiles of T cells. Journal of Immunology. 177(12): 6052-6061.

The effect of vitamin E supplementation at different ages on prevention of atherosclerosis and mortality in LDLR-/-mice - (Abstract)

Band, M., Goutis, J., Ordovas, J., Meydani, M. 2006. The effect of vitamin E supplementation at different ages on prevention of atherosclerosis and mortality in LDLR-/-mice. AGE. 28(1):23-24.

Genetic Variation at the Perilipin Locus Is Associated with Changes in Serum Free Fatty Acids and Abdominal Fat Following Mild Weight Loss - (Peer Reviewed Journal)

Jang, Y., Kim, O., Lee, J., Koh, S., Chae, J., Kim, J., Park, S., Cho, H., Lee, J., Ordovas, J.M. 2006. Genetic variation at the perilipin locus is associated with changes in serum free fatty acids and abdominal fat following mild weight loss. International Journal of Obesity. 30:1601-1608.

Nutrigenetics, plasma lipids, and cardiovascular risk - (Review Article)

Ordovas, J.M. 2006. Nutrigenetics, plasma lipids, and cardiovascular risk. Journal Of The American Dietetic Association. 106(7):1074-81.

Perilipin Gene Variation Determines Higher Susceptibility to Insulin Resistance in Asian Women When Consuming a High-Saturated Fat, Low-Carbohydrate Diet - (Peer Reviewed Journal)

Corella, D., Qi, L., Tai, E., Deurenberg-Yap, M., Tan, C.E., Chew, S.K., Ordovas, J.M. 2006. Perilipin gene variation determines higher susceptibility to insulin resistance in asian women when consuming a high-saturated fat, low-carbohydrate diet. Diabetes Care. 29(6):1313-9.

The Association of Snp276g>t at Adiponectin Gene with Circulating Adiponectin and Insulin Resistance in Response to Mild Weight Loss - (Peer Reviewed Journal)

Shin, M., Jang, Y., Koh, S., Chae, J., Kim, O., Lee, J., Ordovas, J.M., Lee, J. 2006. The association of SNP276G>T at adiponectin gene with circulating adiponectin and insulin resistance in response to mild weight loss. International Journal of Obesity. 30: 1702¿1708.

The ABCG5 Polymorphism Contributes to Individual Responses to Dietary Cholesterol and Carotenoids in Eggs - (Peer Reviewed Journal)

Herron, K.L., Mcgrane, M.M., Waters, D., Lofgren, I.E., Clark, R.M., Ordovas, J.M., Fernandez, M.L. 2006. The ABCG5 Polymorphism Contributes to Individual Responses to Dietary Cholesterol and Carotenoids in Eggs. Journal of Nutrition. 5:1161-1165.

Dietary Intake of N-6 Fatty Acids Modulates Effect of Apolipoprotein A5 Gene on Plasma Fasting Triglycerides, Remnant Lipoprotein Concentrations, and Lipoprotein Particle Size: the Framingham Heart Study - (Peer Reviewed Journal)

Lai, C., Corella, D., Demissie, S., Cupples, A., Adiconis, X., Zhu, Y., Ordovas, J.M. 2006. Dietary intake of n-6 fatty acids modulates effect of apolipoprotein a5 gene on plasma fasting triglycerides, remnant lipoprotein concentrations, and lipoprotein particle size: the framingham heart study. Circulation. 113(17):2062-70.

Nutrigenetics, Plasma Lipids and Cardiovascular Risk - (Review Article)

Ordovas, J.M. 2006. Nutrigenetics, plasma lipids and cardiovascular risk. Journal Of The American Dietetic Association. 106(7):1074-81; quiz 1083.

Variants at the Apoa5 Locus, Association with Carotid Atherosclerosis, and Modification by Obesity: the Framingham Study - (Peer Reviewed Journal)

Elosua, R., Ordovas, J.M., Cupples, L., Lai, C., Demissie, S., Fox, C., Polak, J.F., Wolf, P.A., D'Agostino, R.A., O'Donnell, C. 2006. Variants at the apoa5 locus, association with carotid atherosclerosis, and modification by obesity: the framingham study. Journal of Lipid Research. 47(5):990-6.

Uncoupling protein 2 promoter polymorphism -866G/A, central adiposity, and metabolic syndrome in Asians - (Peer Reviewed Journal)

Shen, H., Qi, L., Tai, E., Chew, S.K., Tan, C.E., Ordovas, J.M. 2006. Uncoupling protein 2 promoter polymorphism -866G/A, central adiposity, and metabolic syndrome in Asians. Obesity (Silver Spring, Md.). 14(4):656-61.

Association between well-characterized lipoprotein-related genetic variants and carotid intimal medial thickness and stenosis: The Framingham Heart Study - (Peer Reviewed Journal)

Elosua, R., Cupples, L.A., Fox, C.S., Polak, J.F., D'Agostino, R.A., Wolf, P.A., O'Donnell, C.J., Ordovas, J.M. 2006. Association between well-characterized lipoprotein-related genetic variants and carotid intimal medial thickness and stenosis: The Framingham Heart Study. Atherosclerosis. 189(1):222-8.

Nutrigenetics, Plasma Lipids and Cardiovascular Risk - (Review Article)

Ordovas, J.M. 2006. Nutrigenetics, plasma lipids and cardiovascular risk. Journal Of The American Dietetic Association. 106(7):1074-1081.

Metagenomics: the Role of the Microbiome in Cardiovascular Diseases - (Other)

Ordovas, J.M., Mooser, V. 2006. Metagenomics: the role of the microbiome in cardiovascular diseases. Current Opinion in Lipidology. 17(2):157-61.

Polymorphisms of ATP binding cassette G5 and G8 transporters: their effect on cholesterol metabolism after moderate weight loss in overweight and obese hyperlipidemic women - (Abstract)

Santosa, S., Demonty, I., Lichtenstein, A.H., Ordovas, J.M., Jones, P.J. 2006. Polymorphisms of ATP binding cassette G5 and G8 transporters: their effect on cholesterol metabolism after moderate weight loss in overweight and obese hyperlipidemic women. Federation of American Societies for Experimental Biology Conference. San Francisco, CA: April 1-5, 2006. Abstract no. 503.3.

Long-Term Vitamin E Supplementation Reduces Atherosclerosis and Mortality in Ldlr-/-Mice - (Abstract)

Band, M., Goutis, J., Ordovas, J., Meydani, M. 2006. Long-term vitamin e supplementation reduces atherosclerosis and mortality in ldlr-/-mice. FASEB Letters. 20:A1316.

Interleukin 6-174c>g Polymorphism Is Associated with Low Bone Mineral Density in Older Subjects Consuming Low Calcium - (Abstract)

Shen, J., Crosier, M.D., Parnell, L.D., Shea, K., Dawson-Hughes, B., Ordovas, J.M., Booth, S.L. 2006. Interleukin 6-174c>g polymorphism is associated with low bone mineral density in older subjects consuming low calcium. Experimental Biology 2006 Annual Meeting. April 1- 5, 2006. San Francisco, CA. Abstract no. 398.1.

The Nutrition, Aging, and Memory in Elders (Name) Study: Design and Methods for a Study of Micronutrients and Cognitive Function in a Homebound Elderly Population - (Peer Reviewed Journal)

Scott, T.M., Peter, I., Tucker, K.L., Arsenault, L., Bergethon, P., Bhadelia, R., Buell, J., Collinsa, L., Dashe, J.F., Griffith, J., Hibberd, P., Leins, D., Liu, T., Ordovas, J.M., Patz, S., Price, L., Qui, W., Sarnak, M., Selhub, J., Smaldone, L., Wagner, C., Wang, L., Weiner, D., Yee, J., Rosenberg, I., Folstein, M. 2006. The nutrition, aging, and memory in elders (name) study: design and methods for a study of micronutrients and cognitive function in a homebound elderly population. International Journal or Geriatric Psychiatry. 21(6):519-28.

Genetics, Diet and Cardiovascular Diseases - (Review Article)

Corella, D., Ordovas, J.M. 2005. Genetics, diet and cardiovascular diseases. CABI International United Kingdom. Nutrition Abstracts and Reviews: Series A75(4):1N-13N. Available at http://www.nutritionandfoodsciences.org/Reviews.

Single Nucleotide Polymorphisms That Influence Lipid Metabolism: Interaction with Dietary Factors - (Review Article)

Corella, D., Ordovas, J.M. 2005. Single nucleotide polymorphisms that influence lipid metabolism: interaction with dietary factors. Annual Review of Nutrition. Available online 5/2/2005 at http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.nutr.25.050304

The Apoa1/c3/a4/a5 Gene Cluster, Lipid Metabolism and Cardiovascular Disease Risk - (Review Article)

Lai, C., Parnell, L.D., Ordovas, J.M. 2005. The apoa1/c3/a4/a5 gene cluster, lipid metabolism and cardiovascular disease risk. Current Opinion in Lipidology 2005, 16:153-166.

The Metabolic Syndrome: Obesity and Diet Modulates the Expression of Its Genetic Predisposition - (Book/Chapter)

Ordovas, J.M., Corella, D. 2005. The metabolic syndrome: obesity and diet modulates the expression of its genetic predisposition. In Rios, M.S., Caro, J.F., Gutierrez Fuentes, J.A. The Metabolic Syndrome At the Beginning Of The XXIst Century: A Genetic And Molecular Approach. Madrid: Elsevier Health Sciences.

Genetic Interactions with Diet Influence the Risk of Cardiovascular Disease - (Review Article)

Ordovas, J.M. 2006. Genetic interactions with diet influence the risk of cardiovascular disease. American Journal of Clinical Nutrition. 83(2):443s-446s.

Supplement: Living Well to 100: Nutrition, Genetics, Inflammation (Preface) - (Other)

Ordovas, J.M. 2006. Supplement: living well to 100: nutrition, genetics, inflammation (preface). American Journal of Clinical Nutrition. 83(2):403S.

Global Gene Expression Analysis of the Living Human Fetus Using Cell-Free Messenger Rna in Amniotic Fluid - (Peer Reviewed Journal)

Larrabee, P.B., Johnson, K.L., Lai, C., Ordovas, J.M., Cowan, J.W., Tantravahi, U., Bianchi, D.W. 2005. Global gene expression analysis of the living human fetus using cell-free messenger RNA in amniotic fluid. Journal of the American Medical Association. 16;293(7):836-42.

Polyunsaturated Fatty Acids Interact with the Ppara-L162v Polymorphism to Affect Plasma Triglyceride and Apolipoprotein C-Iii Concentrations in the Framingham Heart Study - (Peer Reviewed Journal)

Tai, E.S., Corella, D., Demissie, S., Cupples, L.A., Coltell, O., Schaefer, E., Tucker, K., Ordovas, J.M. 2005. Polyunsaturated fatty acids interact with the PPARA-L162V polymorphism to affect plasma triglyceride and apolipoprotein C-III concentrations in the Framingham Heart Study. Journal of Nutrition. 135:397-403.

Intragenic Linkage Disequilibrium Structure of the Human Perilipin Gene (Plin) and Haplotype Associated with Increased Obesity Risk in a Multi-Ethnic Asian Population - (Peer Reviewed Journal)

Qi, L., Tai, E.S., Tan, C.E., Shen, H., Chew, S.K., Greenberg, A.S., Corella, D., Ordovas, J.M. 2005. Intragenic linkage disequilibrium structure of the human perilipin gene (PLIN) and haplotype associated with increased obesity risk in a multi-ethnic Asian population. Journal of Molecular Medicine. Available at http://springerlink.com (E-Pub) DOI: 10.1007/s00109-004-0630-4

Effects of Chronic Ethanol Feeding on Hepatic Cell Proliferation, Erk Activation and Altered Hepatic Foci Formation in Diethylnitrosamine-Initiated Rats - (Abstract)

Chavez, P.R., Russell, R., Mason, J.B., Ordovas, J.M., Wang, X. 2005. Effects of chronic ethanol feeding on hepatic cell proliferation, ERK activation and altered hepatic foci formation in diethylnitrosamine-initiated rats [abstract]. Journal of Federation of American Societies for Experimental Biology. 19:A78.

Vitamin E and Gene Expression in Immune Cells - (Proceedings/Symposium)

Han, S., Adolfsson, O., Lee, C., Prolla, T.A., Ordovas, J.M., Meydani, S. 2004. Vitamin E and gene expression in immune cells. In: Annals Of The New York Academy Of Sciences. Vitamin E and Health Symposium, May 22-24, 2004, Boston, Massachusetts, USA. p.96-101.

Influence of the Apolipoprotein A5 Locus on Plasma Triglyceride, Remnant-Like Particles, and Lipoprotein Subfraction Concentrations -Implication for Cardiovascular Risk in the Framingham Heart Study - (Peer Reviewed Journal)

Lai, C., Demissie, S., Cupples, A., Zhu, Y., Adiconis, X., Parnell, L.D., Corella, D., Ordovas, J.M. 2004. Influence of the apolipoprotein a5 locus on plasma triglyceride, remnant-like particles, and lipoprotein subfraction concentrations -implication for cardiovascular risk in the framingham heart study. Arteriosclerosis Thrombosis and Vascular Biology. 2004; 45: 2096-2105

Genetic Variation at the Perilipin (Plin) Locus Is Associated with Obesity-Related Phenotypes in White Women - (Peer Reviewed Journal)

Qi, L., Corella, D., Sorli, J.V., Portoles, O., Shen, H., Coltell, O., Godoy, D., Greenberg, A.S., Ordovas, J.M. 2004. Genetic variation at the perilipin (PLIN) locus is associated with obesity-related phenotypes in White women. Clinical Genetics. 66(4):299-310.

Fish Consumption Shifts Lipoprotein Subfractions to a Less Atherogenic Pattern in Humans - (Peer Reviewed Journal)

Li, Z., Lamon-Fava, S., Otvos, J., Lichtenstein, A.H., Velez-Carrasco, W., Mcnamara, J.R., Ordovas, J.M., Schaefer, E. 2004. Fish consumption shifts lipoprotein subfractions to a less atherogenic pattern in humans. Journal of Nutrition. 134:1724-1728.

A Common Polymorphism in the Methylenetetrahydrofolate Reductase (Mthfr) Gene Is Associated with Quantitative Ultrasound in Those with Low Plasma Folate - (Peer Reviewed Journal)

Mclean, R.R., Karasik, D., Selhub, J., Tucker, K., Ordovas, J.M., Russo, G.T., Cupples, A., Jacques, P., Kiel, D.P. 2004. A common polymorphism in the methylenetetrahydrofolate reductase (mthfr) gene is associated with quantitative ultrasound in those with low plasma folate. Journal of Bone and Mineral Research. 19:410-418.

Last Modified: 05/06/2009

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