Introduction: Trichloroethylene Health Risks--State of the Science
Cheryl Siegel Scott and V. James Cogliano
p. 159
Hazard Identification
Trichloroethylene and Cancer: Epidemiologic Evidence
Daniel Wartenberg, Daniel Reyner, and Cheryl Siegel Scott
p. 161
Metabolism
of Trichloroethylene
Lawrence H. Lash, Jeffrey W. Fisher, John C. Lipscomb, and Jean C. Parker
p. 177
Human Variability and Susceptibility to Trichloroethylene
Gina M. Pastino, Wendy Y. Yap, and Maria Carroquino
p. 201
Mutagenicity of Trichloroethylene and Its Metabolites: Implications
for the Risk Assessment of Trichloroethylene
Martha M. Moore and Karen Harrington-Brock
p. 215
Modes of Action of Trichloroethylene for Kidney Tumorigenesis
Lawrence H. Lash, Jean C. Parker, and Cheryl Siegel Scott
p. 225
Mode of Action of Liver Tumor Induction by Trichloroethylene and Its
Metabolites, Trichloroacetate and Dichloroacetate
Richard J. Bull
p. 241
Pulmonary Toxicity and Carcinogenicity of Trichloroethylene: Species
Differences and Modes of Action
Trevor Green
p. 261
Dose-Response Assessment
Physiologically Based Pharmacokinetic Models for Trichloroethylene and
Its Oxidative Metabolites
Jeffrey W. Fisher
p. 265
Statistical
Analysis of Fisher et al. PBPK Model of Trichloroethylene Kinetics
Frédéric Yves Bois
p. 275
Development
of a Physiologically Based Pharmacokinetic Model of Trichloroethylene
and Its Metabolites for Use in Risk Assessment
Harvey J. Clewell III, P. Robinan Gentry, Tammie R. Covington, and Jeffery
M. Gearhart
p. 283
Statistical
Analysis of Clewell et al. PBPK Model of Trichloroethylene Kinetics
Frédéric Yves Bois
p. 307
Neurotoxic
and Pharmacokinetic Responses to Trichloroethylene as a Function of
Exposure Scenario
William K. Boyes, Philip J. Bushnell, Kevin M. Crofton, Marina Evans,
and Jane Ellen Simmons
p. 317
Evaluating
Noncancer Effects of Trichloroethylene: Dosimetry, Mode of Action, and
Risk Assessment
Hugh A. Barton and Harvey J. Clewell III
p. 323
Biologically
Based Dose-Response Model for Liver Tumors Induced by Trichloroethylene
Chao W. Chen
p. 335
Dose-Response
Analyses of the Carcinogenic Effects of Trichloroethylene in Experimental
Animals
Lorenz R. Rhomberg
p. 343
Exposure Assessment
Exposure Assessment of Trichloroethylene
Chieh Wu and John Schaum
p. 359
