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Alternative Testing Methodologies
Preface
Bernard D. Goldstein and David Peakall
p. 403
Introduction
Joint Reports
- Alternative Testing Methodologies
and Conceptual Issues
Bas J. Blaauboer, Michael Balls, Martin Barratt, Silvia Casati, Sandra
Coecke, Mostafa K. Mohamed,Jack Moore, David Rall, Kirk R. Smith, Raymond
Tennant, B.A. Schwetz, William S. Stokes, and Maged Younes
p. 413
- Validation and Acute Toxicity
Testing
Rodger Curren, Leon Bruner, Alan Goldberg, and Erik Walum
p. 419
- Alternative Testing Methodologies
for Organ Toxicity
Horst Spielmann, Nikolay P. Bochkov, Lucio Costa, Laura Gribaldo,
Andre Guillouzo, Jerrold J. Heindel, Meryl Karol, Ralph Parchment,
Walter Pfaller, Pilar Prieto Peraita, and Tim Zacharewski
p. 427
Alternative Testing Methodologies
for Ecotoxicity
Colin Walker, Klaus Kaiser, Werner Klein, Laurent Lagadic, David Peakall,
Steven Sheffield, Thomas Soldan, and Masayuki Yasuno
p. 441
Conceptual Issues
Validation and Acute Toxicity Testing
Organ Toxicity
Ecotoxicity
Human Health Effects of Dioxins and Furans
- Introduction:
Dioxins and Furans: Epidemiologic Assessment of Cancer Risks and Other
Human Health Effects
Heiko Becher and Dieter Flesch-Janys
p. 623
- The Seveso Studies on Early
and Long-Term Effects of Dioxin Exposure: A Review
Pier A. Bertazzi, Ilaria Bernucci, Gabriella Brambilla, Dario Consonni,
and Angela C. Pesatori
p. 625
- Evaluation of Cardiovascular
Outcomes among U.S. Workers Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin
Geoffrey M. Calvert, David K. Wall, Marie Haring Sweeney, and Marilyn
A. Fingerhut
p. 635
- Exposure to Dioxin and Nonneoplastic
Mortality in the Expanded IARC International Cohort Study of Phenoxy
Herbicide and Chlorophenol Production Workers and Sprayers
John Vena, Paolo Boffetta, Heiko Becher, Trevor Benn, H. Bas Bueno-de-Mesquita,
David Coggon, Didier Colin, Dieter Flesch-Janys, Lois Green, Timo
Kauppinen, Margareta Littorin, Elsebeth Lynge, John D. Mathews, Manfred
Neuberger, Neil Pearce, Angela C. Pesatori, Rodolfo Saracci, Kyle
Steenland, and Manolis Kogevinas
p. 645
- Estimation of the Cumulated
Exposure to Polychlorinated Dibenzo-p-dioxins/furans and Standardized
Mortality Ratio Analysis of Cancer Mortality by Dose in an Occupationally
Exposed Cohort
Dieter Flesch-Janys, Karen Steindorf, Petra Gurn, and Heiko Becher
p. 655
- Quantitative Cancer Risk Assessment
for Dioxins Using an Occupational Cohort
Heiko Becher, Karen Steindorf, and Dieter Flesch-Janys
p. 663
- Exposure to Agent Orange
and Occurrence of Soft-Tissue Sarcomas or Non-Hodgkin Lymphomas: An
Ongoing Study in Vietnam
Eva Kramárová, Manolis Kogevinas, Cung Thuyet Anh, Hoang
Dinh Cau, Le Cao Dai, Steven D. Stellman, and D. Maxwell Parkin
p. 671
- Some Aspects of the Etiology
of Non-Hodgkin's Lymphoma
Lennart Hardell, Gunilla Lindström, Bert van Bavel, Mats Fredrikson,
and Göran Liljegren
p. 679
- Cancer Incidence in Danish
Phenoxy Herbicide Workers, 1947-1993
Elsebeth Lynge
p. 683
- Immunologic Findings in Workers
Formerly Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin and
its Congeners
Detlev Jung, Peter A. Berg, Lutz Edler, Wolfram Ehrenthal, Dietrich
Fenner, Dieter Flesch-Janys, Christoph Huber, Reinhild Klein, Christina
Koitka, George Lucier, Alfred Manz, Axel Muttray, Larry Needham, Olaf
Päpke, Michael Pietsch, Christopher Portier, Donald Patterson,
Winfried Prellwitz, Dirk M. Rose, Anne Thews, and Johannes Konietzko
p. 689
- Effects of Dioxins and Furans
on Liver Enzymes, Lipid Parameters, and Thyroid Hormones in Former
Thermal MetalRecycling Workers
Gerhard Triebig, Egon Werle, Olaf Päpke, Günther Heim, Christoph
Broding, and Heidi Ludwig
p. 697
- Immune Cell Functions in Industrial
Workers after Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin:
Dissociation of Antigen-Specific T-Cell Responses in Cultures of Diluted
Whole Blood and of Isolated Peripheral Blood Mononuclear Cells
Martin Ernst, D. Flesch-Janys, I. Morgenstern, and A. Manz
p. 701
- PCDD/PCDF Indoor Exposure
in Day-Care Centers and PCDD/PCDF Blood Concentrations of Female Employees
Sabine von Manikowsky, Helmut Sagunski, Olaf Päpke, Karl-Rainer
Fabig, Hermann Neus, Michael Schümann, Karen Spannhake, Wilfried
Karmaus, Nadia Osius, and Bernd Zier
p. 707
- Occupational Exposure to Dioxins
by Thermal Oxygen Cutting, Welding, and Soldering of Metals
Heinrich Michl Menzel, Ulrich Bolm-Audorff, Erich Turcer, Hans Günter
Bienfait, Gerd Albracht, Dirk Walter, Chris Emmel, Udo Knecht, and
Olaf Päpke
p. 715
- PCDD/PCDF: Human Background
Data for Germany, a 10-Year Experience
Olaf Päpke
p. 723
- Blood Lipid Concentrations
of Dioxins and Furans in a Sample of BASF Employees Included in the
IARC Registry of Workers Exposed to Phenoxy Acid Herbicides and/or
Chlorophenols
Peter Messerer, Andreas Zober, and Heiko Becher
p. 733
- Commentary: A Selective
Historical Review of Congener-Specific Human Tissue Measurements as
Sensitive and Specific Biomarkers of Exposure to Dioxins and Related
Compounds
Arnold Schecter
p. 737
- Estimation of Occupational
Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Using a Minimal
Physiologic Toxicokinetic Model
Karl Thomaseth and Alberto Salvan
p. 743
- An IARC Evaluation of Polychlorinated
Dibenzo-p-dioxins and Polychlorinated Dibenzofurans as Risk
Factors in Human Carcinogenesis
Douglas B. McGregor, Christiane Partensky, Julian Wilbourn, and Jerry
M. Rice
p. 755
Animal Models of Human Response
to Dioxins
Jean A. Grassman, Scott A. Masten, Nigel J. Walker, and George W.
Lucier
p. 761
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