Volume 105 Supplement 3, April 1997
Table of Contents
Introduction
Introduction: Hormones, Hormone Metabolism, Environment, and Breast Cancer: A Workshop of the National Action Plan on Breast Cancer's Etiology Working Group
Devra Lee Davis and Susan M. Sieber
p. 557Hormonal Metabolites as Biologic Markers of Breast Cancer Risk
Estradiol Metabolism: An Endocrine Biomarker for Modulation of Human Mammary Carcinogenesis
Nitin T. Telang, Meena Katdare, H. Leon Bradlow, and Michael P. Osborne
p. 559Commentary: Hormone-associated Cancer: Mechanistic Similarities between Human Breast Cancer and Estrogen-induced Kidney Carcinogenesis in Hamsters
Joachim G. Liehr
p. 565Medical Hypothesis: Bifunctional Genetic-Hormonal Pathways to Breast Cancer
Devra Lee Davis, Nitin T. Telang, Michael P. Osborne, and H. Leon Bradlow
p. 571During Development, 17 alpha-Estradiol Is a Potent Estrogen and Carcinogen
Richard A. Hajek, Audra D. Robertson, Dennis A. Johnston, Nguyen T. Van, Robert K. Tcholakian, Laura A. Wagner,
Claudio J. Conti, Marvin L. Meistrich, Nancy Contreras, Creighton L. Edwards, and Lovell A. Jones
p. 577Human Studies on Hormonal Metabolism and Breast Cancer
Serum Sex Hormone Levels Are Related to Breast Cancer Risk in Postmenopausal Women
Joanne F. Dorgan, Christopher Longcope, Hugh E. Stephenson Jr., Roni T. Falk, Rosetta Miller, Charlene Franz, Lisa Kahle, William S. Campbell, Joseph A. Tangrea, and Arthur Schatzkin
p. 583Endogenous Estrogens and Breast Cancer Risk: The Case for Prospective Cohort Studies
Paolo G. Toniolo
p. 587Sex Steroid Hormones, Bone Mineral Density, and Risk of Breast Cancer
Lewis H. Kuller, Jane A. Cauley, Lee Lucas, Steve Cummings, and Warren S. Browner
p. 593A Pilot Study of Urinary Estrogen Metabolites (16 alpha-OHE1 and 2-OHE1) in Postmenopausal Women with and without Breast Cancer
Giske Ursin, Stephanie London, Frank Z. Stanczyk, Elisabet Gentzschein, Annlia Paganini-Hill, Ronald K. Ross, and Malcolm C. Pike
p. 601Quantifying Estrogen Metabolism: An Evaluation of the Reproducibility and Validity of Enzyme Immunoassays for 2-Hydroxyestrone and 16 alpha-Hydroxyestrone in Urine
Regina G. Ziegler, Susan C. Rossi, Thomas R. Fears, H. Leon Bradlow, Herman Adlercreutz, Daniel Sepkovic, Paula Kiuru,
Kristiina Wahala, Jimmie B. Vaught, Jennifer L. Donaldson, Roni T. Falk, Capri-Mara Fillmore, Pentti K. Siiteri,
Robert N. Hoover, and Mitchell H. Gail
p. 607Effects of Environmental Exposures on Estrogenic Activity
In Vitro Synergistic Interaction of Alligator and Human Estrogen Receptors with Combinations of Environmental Chemicals
Steven F. Arnold, Peter M. Vonier, Bridgette M. Collins, Diane M. Klotz, Louis J. Guillette Jr., and John A. McLachlan
p. 615Neoplastic Transformation of Cultured Mammalian Cells by Estrogens and Estrogenlike Chemicals
Takeki Tsutsui and J. Carl Barrett
p. 619Estrogenic and DNA-damaging Activity of Red No. 3 in Human Breast Cancer Cells
Craig Dees, Minoo Askari, Scott Garrett, Kellie Gehrs, Don Henley, C. Murray Ardies
p. 625Dietary Estrogens Stimulate Human Breast Cells to Enter the Cell Cycle
Craig Dees, James S. Foster, Shamila Ahamed, and Jay Wimalasena
p. 633Estrogenic Activity of Natural and Synthetic Estrogens in Human Breast Cancer Cells in Culture
David T. Zava, Marilyn Blen, and Gail Duwe
p. 637Establishing the Risks from Xenohormones
Developing a Marker of Exposure to Xenoestrogen Mixtures in Human Serum
Ana M. Soto, Mariana F. Fernandez, Maria F. Luizzi, Anita S. Oles Karasko, and Carlos Sonnenschein
p. 647Predicting Health Effects of Exposures to Compounds with Estrogenic Activity: Methodological Issues
Ruthann Rudel
p. 655A Dichotomy in the Lipophilicity of Natural Estrogens, Xenoestrogens, and Phytoestrogens
Albert R. Cunningham, Gilles Klopman, and Herbert S. Rosenkranz
p. 665Environmental Effects and Aquatic Organisms: Investigations of Molecular Mechanisms of Carcinogenesis
Rebecca J. Van Beneden
p. 669Is There an Association between Exposure to Environmental Estrogens and Breast Cancer?
Stephen H. Safe
p. 675Breast Cancer and Pesticides in Hawaii: The Need for Further Study
Ruth H. Allen, Michelle Gottlieb, Eve Clute, Montira J. Pongsiri, Janette Sherman, and G. Iris Obrams
p. 679Commentary: Mechanisms, Proof, and Unmet Needs: The Perspective of a Cancer Activist
Sandra Steingraber
p. 685
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