Volume 105(Suppl 5) September 1997
Table of Contents
Toxicology of Natural and Man-Made Fibrous and Non-Fibrous Particles
PrefaceGünter Oberdörster and Kevin E. Driscoll
Physical and Chemical Properties of Particles/Mechanisms of Toxicity
p. 1001Mineral Properties and Their Contributions to Particle Toxicity
Carcinogenesis and Genotoxicity
George D. Guthrie Jr.
p. 1003Surface Reactivity in the Pathogenic Response to Particulates
Bice Fubini
p. 1013Chemical Characterization and Reactivity of Iron Chelator-treated Amphibole Asbestos
Julie Gold, Helena Amandusson, Anatol Krozer, Bengt Kasemo, Tore Ericsson, Giovanna Zanetti, and Bice Fubini
p. 1021Study of the Stability of a Paramagnetic Label Linked to Mesoporous Silica Surface in Contact with Rat Mesothelial Cells in Culture
Laura Mollo, Valerie Levresse, Maria F. Ottaviani, Sophie Ellouk-Achard, Marie-Claude Jaurand, and Bice Fubini
p. 1031Demonstration of Nitric Oxide on Asbestos and Silicon Carbide Fibers with a New Ultraviolet Spectrophotometric Assay
Per Leanderson, Verner Lagesson, and Christer Tagesson
p. 1037Can Microwave Radiation at High Temperatures Reduce the Toxicity of Fibrous Crocidolite Asbestos?
Mairam Gulumian, Zolani L. Nkosibomvu, Kalavati Channa, and Herman Pollak
p. 1041Significance of the Biodurability of Man-made Vitreous Fibers to Risk Assessment
Hartwig Muhle and Bernd Bellmann
p. 1045Investigations on Health-related Properties of Two Sepiolite Samples
Bernd Bellmann, Hartwig Muhle, and Heinrich Ernst
p. 1049Bioavailable Transition Metals in Particulate Matter Mediate Cardiopulmonary Injury in Healthy and Compromised Animal Models
Daniel L. Costa and Kevin L. Dreher
p. 1053Oncogenes and Tumor-Suppressor Genes in Mesothelioma--A Synopsis
Intracellular Signaling Pathways
John F. Lechner, Johannes Tesfaigzi, and Brenda I. Gerwin
p. 1061Susceptibility of p53-deficient Mice to Induction of Mesothelioma by Crocidolite Asbestos Fibers
Jean M. Marsella, Brenda L. Liu, Charles A. Vaslet, and Agnes B. Kane
p. 1069Mechanisms of Fiber-induced Genotoxicity
Marie-Claude Jaurand
p. 1073Malignant Transformation of Immortalized Human Bronchial Epithelial Cells by Asbestos Fibers
Tom K. Hei, Li J. Wu, and Chang Q. Piao
p. 1085Neutrophils Amplify the Formation of DNA Adducts by Benzo[a]pyrene in Lung Target Cells
Paul J.A. Borm, Ad M. Knaapen, Roel P.F. Schins, Roger W.L. Godschalk, and Frederik-Jan Van Schooten
p. 1089A New Mechanism for DNA Alterations Induced by Alpha Particles Such as Those Emitted by Radon and Radon Progeny
Bruce E. Lehnert and Edwin H. Goodwin
p. 1095Fiber-specific Molecular Features of Tumors Induced in Rat Peritoneum
Klaus Unfried, Markus Roller, Friedrich Pott, Johannes Friemann, and Walter Dehnen
p. 1103Mechanism of Asbestos-mediated DNA Damage: Role of Heme and Heme Proteins
Qamar Rahman, Nayyara Mahmood, Sikander G. Khan, Jamal M. Arif, and Mohammad Athar
p. 1109Asbestos, Asbestosis, and Lung Cancer: Observations in Quebec Chrysotile Workers
Bruce W. Case and André Dufresne
p. 1113Cell Signaling Pathways Elicited by Asbestos
Cytokines/Immune Mechanisms
Brooke T. Mossman, Steven Faux, Yvonne Janssen, Luis A. Jimenez, Cynthia Timblin, Christine Zanella, Jonathan Goldberg, Eric Walsh, Aaron Barchowsky, and Kevin Driscoll
p. 1121Possible Role of Lipid Peroxidation in the Induction of NF-
B and AP-1 in RFL-6 Cells by Crocidolite Asbestos: Evidence following Protection by Vitamin E
Stephen P. Faux and Peter J. Howden
p. 1127Increased Focal Adhesion Kinase- and Urokinase-type Plasminogen Activator Receptor-associated Cell Signaling in Endothelial Cells Exposed to Asbestos
A. Barchowsky, B.M. Lannon, L.C. Elmore, and M.D. Treadwell
p. 1131Asbestos and Silica-induced Changes in Human Alveolar Macrophage Phenotype
Andrij Holian, Margaret O. Uthman, Tatiana Goltsova, Steven D. Brown, and Raymond F. Hamilton Jr.
p. 1139p53, Cip1, and Gadd153 Expression following Treatment of A549 Cells with Natural and Man-made Vitreous Fibers
Neil F. Johnson and Richard J. Jaramillo
p. 1143Crocidolite Asbestos Induces Apoptosis of Pleural Mesothelial Cells: Role of Reactive Oxygen Species and Poly(ADP-ribosyl) Polymerase
V. Courtney Broaddus, Lin Yang, Louis M. Scavo, Joel D. Ernst, and Alice M. Boylan
p. 1147Alterations in Protein Glycosylation in PMA-differentiated U-937 Cells Exposed to Mineral Particles
Nourredine Trabelsi, Anne Greffard, Jean-Claude Pairon, Jean Bignon, Giovanna Zanetti, Bice Fubini, and Yannick Pilatte
p. 1153Cytokines and Particle-induced Inflammatory Cell Recruitment
Models/Mechanisms
Kevin E. Driscoll, Janet M. Carter, Diana G. Hassenbein, and Brian Howard
p. 1159Analyzing the Genes and Peptide Growth Factors Expressed in Lung Cells in Vivo Consequent to Asbestos Exposure and in Vitro
Arnold R. Brody, Jing-Yao Liu, David Brass, and Miriam Corti
p. 1165Effects of Mineral Fibers on the Expression of Genes Whose Product May Play a Role in Fiber Pathogenesis
Tohru Tsuda, Yasuo Morimoto, Hiroshi Yamato, Hiromi Nakamura, Hajime Hori, Nobuhiko Nagata, Masamitsu Kido, Toshiaki Higashi, and Isamu Tanaka
p. 1173Particulate-Cell Interactions and Pulmonary Cytokine Expression
Jacob N. Finkelstein, Carl Johnston, Ted Barrett, and Günter Oberdörster
p. 1179Localization of Intercellular Adhesion Molecule-1 (ICAM-1) in the Lungs of Silica-exposed Mice
Ricardo C. Nario and Andrea K. Hubbard
p. 1183Alveolar Macrophage Interaction with Air Pollution Particulates
Carroll-Ann Goldsmith, Charles Frevert, Amy Imrich, Constantinos Sioutas, and Lester Kobzik
p. 1191Immunohistochemical Localization of Transforming Growth Factor Beta Isoforms in Asbestos-related Diseases
Jaishree Jagirdar, Theodore C. Lee, Joan Reibman, Leslie I. Gold, Christopher Aston, Raymond Bégin, and William N. Rom
p. 1197Early Mesothelial Cell Proliferation after Asbestos Exposure: In Vivo and in Vitro Studies
Oxidative Stress
Ian Y.R. Adamson
p. 1205Comparison of Pleural Responses of Rats and Hamsters to Subchronic Inhalation of Refractory Ceramic Fibers
Jeffrey I. Everitt, Thomas R. Gelzleichter, Edilberto Bermudez, James B. Mangum, Brian A. Wong, Derek B. Janszen, and Owen R. Moss
p. 1209Mechanisms of Mineral Dust-induced Emphysema
Andrew Churg, Katalin Zay, and Kevin Li
p. 1215Lung Proliferative and Clearance Responses to Inhaled para-Aramid RFP in Exposed Hamsters and Rats: Comparisons with Chrysotile Asbestos Fibers
David B. Warheit, Suzanne I. Snajdr, Mark A. Hartsky, and Steven R. Frame
p. 1219Chronic Inhalation Study of Fiber Glass and Amosite Asbestos in Hamsters: Twelve-month Preliminary Results
T.W. Hesterberg, C. Axten, E.E. McConnell, G. Oberdörster, J. Everitt, W.C. Miiller, J. Chevalier, G.R. Chase, and P. Thevenaz
p. 1223Sites of Particle Retention and Lung Tissue Responses to Chronically Inhaled Diesel Exhaust and Coal Dust in Rats and Cynomolgus Monkeys
Kristen J. Nikula, Kelly J. Avila, William C. Griffith, and Joe L. Mauderly
p. 1231Short-term Inhalation and in Vitro Tests as Predictors of Fiber Pathogenicity
Richard Thomas Cullen, Brian George Miller, John Michael Gordon Davis, David McAllister Brown, and Kenneth Donaldson
p. 1235Silica-induced Apoptosis in Alveolar and Granulomatous Cells in Vivo
James Leigh, He Wang, Antonio Bonin, Matthew Peters, and Xiuyao Ruan
p. 1241Expression of Matrix Metalloproteinases, Tissue Inhibitors of Metalloproteinases, and Extracellular Matrix mRNA following Exposure to Mineral Fibers and Cigarette Smoke in Vivo
Yasuo Morimoto, Tohru Tsuda, Hiromi Nakamura, Hajime Hori, Hiroshi Yamato, Nobuhiko Nagata, Toshiaki Higashi, Masamitsu Kido, and Isamu Tanaka
p. 1247Dose-Response Relationship of Fibrous Dusts in Intraperitoneal Studies
Markus Roller, Friedrich Pott, Kenji Kamino, Gerhard-Heinrich Althoff, and Bernd Bellmann
p. 1253Pleural Macrophage Recruitment and Activation in Asbestos-induced Pleural Injury
Nonghoon Choe, Shogo Tanaka, Weijia Xia, David R. Hemenway, Victor L. Roggli, and Elliott Kagan
p. 1257Cell Size of Alveolar Macrophages: An Interspecies Comparison
Fritz Krombach, Silvia Münzing, Anne-Marie Allmeling, J. Tilman Gerlach, Jürgen Behr, and Martina Dörger
p. 1261Intratracheal Instillation versus Intratracheal Inhalation: Influence of Cytokines on Inflammatory Response
M. Osier, R.B. Baggs, and G. Oberdörster
p. 1265Efflux of Reduced Glutathione after Exposure of Human Lung Epithelial Cells to Crocidolite Asbestos
Approaches to Safety Evaluation and Risk Assessment
Scott A. Golladay, Sun-Hee Park, and Ann E. Aust
p. 1273In Vivo and in Vitro Proinflammatory Effects of Particulate Air Pollution (PM10)
X.Y. Li, P.S. Gilmour, K. Donaldson, and W. MacNee
p. 1279Free Radical Activity of PM10: Iron-mediated Generation of Hydroxyl Radicals
Kenneth Donaldson, David M. Brown, Colin Mitchell, Miglena Dineva, Paul H. Beswick, Peter Gilmour, and William MacNee
p. 1285Formation and Persistence of 8-Oxoguanine in Rat Lung Cells as an Important Determinant for Tumor Formation following Particle Exposure
Peter Nehls, Frank Seiler, Bernd Rehn, Ruth Greferath, and Joachim Bruch
p. 1291Expression of Inducible Nitric Oxide Synthase and Formation of Nitric Oxide by Alveolar Macrophages: An Interspecies Comparison
Natalie K. Jesch, Martina Dörger, Georg Enders, Gabriele Rieder, Claus Vogelmeier, Konrad Messmer, and Fritz Krombach
p. 1297The Role of Reactive Oxygen and Nitrogen Species in the Response of Airway Epithelium to Particulates
Linda D. Martin, Thomas M. Krunkosky, Janice A. Dye, Bernard M. Fischer, Nan Fei Jiang, Lori G. Rochelle, Nancy J. Akley, Kevin L. Dreher, and Kenneth B. Adler
p. 1301Interspecies Comparison of Rat and Hamster Alveolar Macrophage Antioxidative and Oxidative Capacity
Martina Dörger, Anne-Marie Allmeling, Ariane Neuber, Jürgen Behr, Walter Rambeck, and Fritz Krombach
p. 1309Free Radical Activity of Industrial Fibers: Role of Iron in Oxidative Stress and Activation of Transcription Factors
Peter S. Gilmour, David M. Brown, Paul H. Beswick, William MacNee, Irfan Rahman, and Kenneth Donaldson
p. 1313Augmentation of Pulmonary Reactions to Quartz Inhalation by Trace Amounts of Iron-containing Particles
Vincent Castranova, Val Vallyathan, Dawn M. Ramsey, Jeffrey L. McLaurin, Donna Pack, Steven Leonard, Mark W. Barger, Jane Y.C. Ma, Nar S. Dalal, and Alex Teass
p. 1319Involvement of Protein Kinase C, Phospholipase C, and Protein Tyrosine Kinase Pathways in Oxygen Radical Generation by Asbestos-stimulated Alveolar Macrophage
Young Lim, Sun-Hyung Kim, Kyoung-Ah Kim, Min-Wha Oh, and Kweon-Haeng Lee
p. 1325Approaches to Characterizing Human Health Risks of Exposure to Fibers
Vanessa T. Vu and David Y. Lai
p. 1329Relevance of Particle-induced Rat Lung Tumors for Assessing Lung Carcinogenic Hazard and Human Lung Cancer Risk
Joe L. Mauderly
p. 1337Pulmonary Carcinogenicity of Inhaled Particles and the Maximum Tolerated Dose
G. Oberdörster
p. 1347Strategies for Setting Occupational Exposure Limits for Particles
Helmut A. Greim and Kyriakoula Ziegler-Skylakakis
p. 1357Use of Mechanistic Data in Assessing Human Risks from Exposure to Particles
Roger O. McClellan
p. 1363
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