Introduction: INSERM-IARC-CNRS Workshop on Biopersistence of Respirable Synthetic Fibers and Minerals 3

J. Bignon, R. Saracci, and J.-C. Touray
p. 3

Open Issues From Multidisciplinary Points of View

Biopersistence of Respirable Synthetic Fibers and Minerals: Point of View of the Chest Physician

Paul De Vuyst
p. 7

Biopersistence of Respirable Synthetic Fibers and Minerals: The Point of View of the Epidemiologist

Paolo Boffetta
p. 11

An Experimental Approach to the Evaluation of the Biopersistence of Respirable Synthetic Fibers and Minerals

David M. Bernstein, Richard Mast, Robert Anderson, Thomas W. Hesterberg, Rod Musselman, Ole Kamstrup, and John Hadley
p. 15

Cellular and Molecular Mechanisms of Asbestos Carcinogenicity: Implications for Biopersistence

J. Carl Barrett
p. 19

In Vitro Assessment of the Biopersistence of Vitreous Fibers: State of the Art from the Physical-Chemical Point of View

Jean-Claude Touray and Patrick Baillif
p. 25

The Occupational Physician's Point of View: The Model of Man-made Vitreous Fibers

P. Brochard, J. C. Pairon, and J. Bignon
p. 31

Glass Fiber Manufacturing and Fiber Safety: the Producer's Perspective

Joel R. Bender and John G. Hadley
p. 37

Material-tissue Interfaces: The Role of Surface Properties and Processes

Bengt Kasemo and Jukka Lausmaa
p. 41

In Vitro Assessment of Biopersistence

In Vitro Assessment of Biodurability: Acellular Systems

A. de Meringo, C. Morscheidt, S. Thélohan, and H. Tiesler
p. 47

In Vitro Assessment of Biopersistence Using Mammalian Cell Systems

Marie-Claude Jaurand
p. 55

Dual pH Durability Studies of Man-made Vitreous Fiber (MMVF)

Jon F. Bauer, Bruce D. Law, and Thomas W. Hesterberg
p. 61

Durability of Ceramic and Novel Man-Made Mineral Fibers

I. C. Alexander, R. C. Brown, G. A. Jubb, P. Pickering, and J. A. Hoskins
p. 67

SEM-EDS Analysis of Glass Fibers Corroded in Physiological Solutions by Dynamic Tests with Variable Flow Rates

Patrice Lehuédé and Alain de Meringo
p. 73

Chemical Behavior of Aluminum and Phosphorus during Dissolution of Glass Fibers in Physiological Saline Solutions

Patrick Baillif and Jean-Claude Touray
p. 77

Effect of Chemical Composition of Man-made Vitreous Fibers on the Rate of Dissolution in Vitro at Different pHs

V. R. Christensen, S. Lund Jensen, M. Guldberg, and O. Kamstrup
p. 83

Glass Fiber Dissolution in Simulated Lung Fluid and Measures Needed to Improve Consistency and Correspondence to In Vivo Dissolution

Stephanie M. Mattson
p. 87

In Vitro Dynamic Solubility Test: Influence of Various Parameters

Sylvie Thélohan and Alain de Meringo
p. 91

Phagosomal pH and Glass Fiber Dissolution in Cultured Nasal Epithelial Cells and Alveolar Macrophages: Preliminary Study

Neil F. Johnson
p. 97

Assessment of Biopersistence in Experimental Animals

Dissolution of Man-made Vitreous Fibers in Rat Alveolar Macrophage Culture and Gamble's Saline Solution: Influence of Different Media and Chemical Composition of the Fibers

Kirsi Luoto, Mikko Holopainen, Kirsti Karppinen, Michael Perander, and Kai Savolainen
p. 103

Characterization of Exposure and Dose of Man-made Vitreous Fiber in Experimental Studies

R. D. Hamilton, W. C. Miiller, D. R. Christensen, R. Anderson, and T. W. Hesterberg
p. 109

The Role of Clearance and Dissolution in Determining the Durability or Biopersistence of Mineral Fibers

John M. G. Davis
p. 113

In Vivo Evaluation of Chemical Biopersistence of Nonfibrous Inorganic Particles

Joseph D. Brain, John Godleski, and Wolfgang Kreyling
p. 119

In Vivo Evaluation of Chemical Biopersistence of Man-made Mineral Fibers

Arthur Morgan
p. 127

Relationship between Lung Biopersistence and Biological Effects of Man-made Vitreous Fibers after Chronic Inhalation in Rats

Thomas W. Hesterberg, William C. Miiller, Richard Mast, Ernest E. McConnell, David M. Bernstein, and Robert Anderson
p. 133

Biopersistences of Man-made Vitreous Fibers and Crocidolite Fibers in Rat Lungs Following Short-term Exposures

Rod P. Musselman, William C. Miiller, Walter Eastes, John G. Hadley, Ole Kamstrup, Philippe Thevenaz, and Thomas W. Hesterberg
p. 139

Significance of Durability of Mineral Fibers for their Toxicity and Carcinogenic Potency in the Abdominal Cavity of Rats in Comparison with the Low Sensitivity of Inhalation Studies

Friedrich Pott, Markus Roller, Kenji Kamino, and Bernd Bellmann
p. 145

Biopersistence of Inhaled Organic and Inorganic Fibers in the Lungs of Rats

David B. Warheit, Mark A. Hartsky, Tim A. McHugh, and Kristen A. Kellar
p. 151

Use of the Short-term Inflammatory Response in the Mouse Peritoneal Cavity to Assess the Biological Activity of Leached Vitreous Fibers

K. Donaldson, J. Addison, B. G. Miller, R. T. Cullen, J. M. G. Davis
p. 159

Comparative Investigations of the Biodurability of Mineral Fibers in the Rat Lung

Hartwig Muhle, Bernd Bellmann, and Friedrich Pott
p. 163

Clearance of Inhaled Ceramic Fibers From Rat Lungs

H. Yamato, I. Tanaka, T. Higashi, and M. Kido
p. 169

Correlation between Particle Size, in Vivo Particle Persistence, and Lung Injury

Günter Oberdörster, Juraj Ferin, and Bruce E. Lehnert
p. 173

Effect of Coexposure to Asbestos and Kerosene Soot on Pulmonary Drug-Metabolizing Enzyme System

J.M. Arif, S.G. Khan, N. Mahmood, M. Aslam, and Q. Rahman
p. 181

Investigation on the Durability of Man-made Vitreous Fibers in Rat Lungs

Bernd Bellmann, Hartwig Muhle, Ole Kamstrup, and Utz F. Draeger
p. 185

Investigation of the Biodurability of Wollastonite and Xonotlite

Bernd Bellmann and Hartwig Muhle
p. 191

Persistence of Long, Thin Chrysotile Asbestos Fibers in the Lungs of Rats

Patrick G. Coin, Victor L. Roggli, and Arnold R. Brody
p. 197

One-Year Follow-up of the Phagocytic Activity of Leukocytes after Exposure of Rats to Asbestos and Basalt Fibers

Marta Hurbánková
p. 201

Solubility of Chrysotile Asbestos and Basalt Fibers in Relation to their Fibrogenic and Carcinogenic Action

F. M. Kogan and O. V. Nikitina
p. 205

Chronic Inhalation and Biopersistence of Refractory Ceramic Fiber in Rats and Hamsters

R. W. Mast, T. W. Hesterberg, L. R. Glass, E. E. McConnell, R. Anderson, and D. M. Bernstein
p. 207

Enhanced Translocation of Particles from Lungs by Jaggery

Anand P. Sahu and Ashok K. Saxena
p. 211

Pulmonary Deposition and Clearance of Glass Fiber in Rat Lungs after Long-term Inhalation

Isamu Tanaka, Takako Oyabu, Sumiyo Ishimatsu, Hajime Hori, Toshiaki Higashi, and Hiroshi Yamato
p. 215

Possible Application of Urinary Analysis to Estimate Dissolution of Some Man-made Vitreous Fibers

Agnès Wastiaux, Olivier Blanchard, and Sylvie Honnons
p. 217

Significance of Biopersistence in Relation to Pathogenic Effects in Humans

Epidemiological Significance of Mineral Fiber Persistence in Human Lung Tissue

J. C. McDonald
p. 221

Biopersistence of Man-made Vitreous Silicate Fibers in the Human Lung

P. Sébastien
p. 225

Persistence of Natural Mineral Fibers in Human Lungs: An Overview

Andrew Churg and Joanne L. Wright
p. 229

Chrysotile Biopersistence in the Lungs of Persons in the General Population and Exposed Workers

Arthur M. Langer and Robert P. Nolan
p. 235

Influence of Particle Size and Chemical Composition on Efficiency of Clearance Mechanisms: Electron Microscopy Studies on Humans

M. Falchi, G. Donelli, and L. Paoletti
p. 241

Lung Content Analysis of Cases Occupationally Exposed to Chrysotile Asbestos

R. P. Nolan, A. M. Langer, and J. Addison
p. 245

Environmental Asbestotic Pleural Plaques in Northeast Corsica: Correlations with Airborne and Pleural Mineralogic Analysis

F. Rey, C. Boutin, J. R. Viallat, J. Steinbauer, P. Alessandroni, P. Jutisz, D. Di Giambattista, M. A. Billon-Galland, P. Hereng, P. Dumortier, and P. De Vuyst
p. 251

Retention of Asbestos Fibers in the Human Body

A. Tossavainen, A. Karjalainen, and P. J. Karhunen
p. 253

Comparative Analysis of Inhaled Particles Contained in Human Bronchoalveolar Lavage Fluids, Lung Parenchyma and Lymph Nodes

P. Dumortier, P. De Vuyst, and J. C. Yernault
p. 257

Fiber Levels and Disease in Workers from a Factory Predominantly Using Amosite

A. R. Gibbs, M. J. Gardner, F. D. Pooley, D. M. Griffiths, B. Blight, and J. C. Wagner
p. 261

Biopersistence of the Mineral Matter of Coal Mine Dusts in Silicotic Human Lungs: Is There a Preferential Release of Iron?

Jean-Luc Tourmann and Raimund Kaufmann
p. 265

Biopersistence of Nonfibrous Mineral Particles in the Respiratory Tracts of Subjects following Occupational Exposure 269

Jean-Claude Pairon, Marie-Annick Billon-Galland, Yuriko Iwatsubo, Martine Bernstein, Annie Gaudichet, Jean Bignon, and Patrick Brochard
p. 269

Role of Biopersistence in the Pathogenicity of Man-made Fibers and Methods for Evaluating Biopersistence: A Summary of Two Round-table Discussions

Roger O. McClellan and Thomas W. Hesterberg
p. 277

Last update: October 20, 1998