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| On the Cover | The scientific community generates an unprecedented volume of data about potential hazards to the environment and human health, but the process of interpretation remains in the hands of political, economic, and even cultural interests, which can vary dramatically from one hazard to the next, as well as from one jurisdiction to the next. This article (p. A104) describes how a given agent might be labeled a toxic threat in one place while being tolerated without prejudice somewhere else, even as the architects of each policy looked at the very same data.
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Perspectives
Correspondence
p. A 98
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Environews
Forum
p. A 100
Focus
p. A 104
Spheres of Influence
p. A 112
Science Selections
p. A 116
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Commentary
HEALTH POLICY | Why Public Health Agencies Cannot Depend on Good Laboratory Practices as a Criterion for Selecting Data: The Case of Bisphenol A
John Peterson Myers,
Frederick S. vom Saal, Benson T. Akingbemi, Koji Arizono, Scott Belcher, Theo Colborn, Ibrahim Chahoud, D. Andrew Crain, Francesca Farabollini, Louis J. Guillette Jr., Terry Hassold, Shuk-mei Ho, Patricia A. Hunt, Taisen Iguchi, Susan Jobling, Jun Kanno, Hans Laufer, Michele Marcus, John A. McLachlan, Angel Nadal, Jörg Oehlmann, Nicolás Olea, Paola Palanza, Stefano Parmigiani, Beverly S. Rubin, Gilbert Schoenfelder, Carlos Sonnenschein, Ana M. Soto, Chris E. Talsness, Julia A. Taylor, Laura N. Vandenberg,
John G. Vandenbergh, Sarah Vogel, Cheryl S. Watson, Wade V. Welshons, and R. Thomas Zoeller
309 [ Abstract ] [ Full ] [ PDF ]
Reviews
EPIDEMIOLOGY | The Controversy about a Possible Relationship between Mobile Phone Use and Cancer
Michael Kundi
 Also see Science Selections, p. A116
316 [ Abstract ] [ Full ] [ PDF ]
NEUROTOXICOLOGY | Manganese Neurotoxicity: Lessons Learned from Longitudinal Studies in Nonhuman Primates
Neal C. Burton and Tomás R. Guilarte
325 [ Abstract ] [ Full ] [ PDF ]
Research
TOXICOLOGY | Concentrated Ambient Particles Alter Myocardial Blood Flow during Acute Ischemia in Conscious Canines
Carlo R. Bartoli, Gregory A. Wellenius, Brent A. Coull,
Ichiro Akiyama, Edgar A. Diaz, Joy Lawrence, Kazunori Okabe, Richard L. Verrier, and John J. Godleski
333 [ Abstract ] [ Full ] [ PDF ]
NEUROTOXICOLOGY | Ultraviolet Photolysis of Chlorpyrifos: Developmental Neurotoxicity Modeled in PC12 Cells
Theodore A. Slotkin, Frederic J. Seidler, Changlong Wu, Emiko A. MacKillop, and Karl G. Linden
338 [ Abstract ] [ Full ] [ PDF ]
POPULATION HEALTH | Impact of the Spanish Smoking Law on Exposure to Secondhand Smoke in Offices and Hospitality Venues: Before-and-After Study
Manel Nebot,
Maria J. López, Carles Ariza, Mónica Pérez-Ríos, Marcela Fu, Anna Schiaffino, Gloria Muñoz, Esteve Saltó, and Esteve Fernández, on behalf of the Spanish Smoking Law Evaluation Group
344 [ Abstract ] [ Full ] [ PDF ]
MIXTURES | The Synergistic Toxicity of Pesticide Mixtures: Implications for Risk Assessment and the Conservation of Endangered Pacific Salmon
Cathy A. Laetz, David H. Baldwin,
Tracy K. Collier, Vincent Hebert, John D. Stark, and Nathaniel L. Scholz
Also see Science Selections, p. A117
348 [ Abstract ] [ Full ] [ PDF ]
ENVIRONMENTAL TOXICOLOGY | Elevated Human Telomerase Reverse Transcriptase Gene Expression in Blood Cells Associated with Chronic Arsenic Exposure in Inner Mongolia, China
Jinyao Mo, Yajuan Xia, Zhixiong Ning, Timothy J. Wade, and Judy L. Mumford
354 [ Abstract ] [ Full ] [ PDF ]
TOXICOLOGY | Mechanisms of Inhaled Fine Particulate Air-Pollution–Induced Arterial Blood Pressure Changes
Carlo R. Bartoli, Gregory A. Wellenius, Edgar A. Diaz, Joy Lawrence, Brent A. Coull, Ichiro Akiyama, Lani M. Lee, Kazunori Okabe, Richard L. Verrier, and John J. Godleski
361 [ Abstract ] [ Full ] [ PDF ]
CARDIOVASCULAR DISEASE | Methylmercury Exposure and Adverse Cardiovascular Effects in Faroese Whaling Men
Anna L. Choi, Pal Weihe, Esben Budtz-Jørgensen, Poul J. Jørgensen,
Jukka T. Salonen,Tomi-Pekka Tuomainen, Katsuyuki Murata, Hans Petur Nielsen, Maria Skaalum Petersen, Jórun Askham, and Philippe Grandjean
367 [ Abstract ] [ Full ] [ PDF ]
IMMUNE SYSTEM | Proximity to Traffic: Inflammation, and Immune Function among Women in the Seattle, Washington, Area
Lori A. Williams, Cornelia M. Ulrich, Timothy Larson,
Mark H. Wener, Brent Wood, Peter T. Campbell, John D. Potter, Anne McTiernan, and Anneclaire J. De Roos
373 [ Abstract ] [ Full ] [ PDF ]
TOXICOLOGY | The Proteasome Is a Molecular Target of Environmental Toxic Organotins
Guoqing Shi, Di Chen, Guangshu Zhai, Marina S. Chen, Qiuzhi Cindy Cui, Qunfang Zhou, Bin He, Q. Ping Dou, and Guibin Jiang
Also see Science Selections, p. A116
379 [ Abstract ] [ Full ] [ PDF ]
ASTHMA | Exposure to Mouse Allergen in U.S. Homes Associated with Asthma Symptoms
Päivi M. Salo, Renee Jaramillo, Richard D. Cohn, Stephanie J. London, and Darryl C. Zeldin
387 [ Abstract ] [ Full ] [ PDF ]
ALTERNATIVE MODEL DEVELOPMENT | Profiling Chemicals Based on Chronic Toxicity Results
from the U.S. EPA ToxRef Database
Matthew T. Martin, Richard S. Judson, David M. Reif,
Robert J. Kavlock, and David J. Dix
392 [ Abstract ] [ Full ] [ PDF ]
GENE REGULATION/GENE EXPRESSION | Diesel Exhaust Particles Activate the Matrix-Metalloproteinase-1 Gene in Human Bronchial Epithelia in a β-Arrestin–Dependent Manner via Activation of RAS
Jinju Li, Andrew J. Ghio, Seung-Hyun Cho, Constance E. Brinckerhoff, Sidney A. Simon, and Wolfgang Liedtke
400 [ Abstract ] [ Full ] [ PDF ]
POPULATION HEALTH | Public Health Strategies for Western Bangladesh That Address Arsenic, Manganese, Uranium, and Other Toxic Elements in Drinking Water
Seth H. Frisbie,
Erika J. Mitchell, Lawrence J. Mastera, Donald M. Maynard, Ahmad Zaki Yusuf, Mohammad Yusuf Siddiq, Richard Ortega, Richard K. Dunn, David S. Westerman, Thomas Bacquart, and Bibudhendra Sarkar
410 [ Abstract ] [ Full ] [ PDF ]
EXPOSURE SCIENCE | Apparent Half-Lives of Dioxins, Furans, and Polychlorinated Biphenyls as a Function of Age, Body Fat, Smoking Status, and Breast-Feeding
Meghan O'Grady Milbrath, Yvan Wenger, Chiung-Wen Chang, Claude Emond, David Garabrant, Brenda W. Gillespie, and Olivier Jolliet
417 [ Abstract ] [ Full ] [ PDF ]
NEURODEVELOPMENT | Developmental Exposure to Polychlorinated Biphenyls Interferes with Experience-Dependent Dendritic Plasticity and Ryanodine Receptor Expression in Weanling Rats
Dongren Yang, Kyung Ho Kim, Andrew Phimister, Adam D. Bachstetter, Thomas R. Ward, Robert W. Stackman, Ronald F. Mervis, Amy B. Wisniewski,Sabra L. Klein, Prasada Rao S. Kodavanti, Kim A. Anderson, Gary Wayman, Isaac N. Pessah, and Pamela J. Lein
426 [ Abstract ] [ Full ] [ PDF ]
MUTAGENESIS | Activated Toxicity of Diesel Particulate Extract by Ultraviolet A Radiation in Mammalian Cells: Role of Singlet Oxygen
Lingzhi Bao, An Xu, Liping Tong, Shaopeng Chen,
Lingyan Zhu, Ye Zhao, Guoping Zhao, Erkang Jiang, Jun Wang, and Lijun Wu
436 [ Abstract ] [ Full ] [ PDF ]
OBESITY | Neighborhood Food Environment and Walkability Predict Obesity in New York City
Andrew Rundle, Kathryn M. Neckerman, Lance Freeman, Gina S. Lovasi, Marnie Purciel, James Quinn, Catherine Richards, Neelanjan Sircar, and Christopher Weiss
442 [ Abstract ] [ Full ] [ PDF ]
EPIDEMIOLOGY | Short-Term Mortality Rates during a Decade of Improved Air Quality in Erfurt, Germany
Susanne Breitner, Matthias Stölzel, Josef Cyrys, Mike Pitz, Gabriele Wölke, Wolfgang Kreyling, Helmut Küchenhoff, Joachim Heinrich, H.-Erich Wichmann, and Annette Peters
448 [ Abstract ] [ Full ] [ PDF ]
BIOMONITORS | Variability in Biomarkers of Arsenic Exposure and Metabolism in Adults
over Time
Molly L. Kile, Elaine Hoffman, Yu-Mei Hsueh, Sakila Afroz, Quazi Quamruzzaman, Mahmuder Rahman, Golam Mahiuddin, Louise Ryan, and David C. Christiani
455 [ Abstract ] [ Full ] [ PDF ]
CHILDREN'S HEALTH
RISK CHARACTERIZATION | Exposure of U.S. Children to Residential Dust Lead, 1999–2004: I. Housing and Demographic Factors
Joanna M. Gaitens, Sherry L. Dixon, David E. Jacobs, Jyothi Nagaraja, Warren Strauss, Jonathan W. Wilson, and Peter J. Ashley
Also see Science Selections, p. A117
461 [ Abstract ] [ Full ] [ PDF ]
RISK ASSESSMENT | Exposure of U.S. Children to Residential Dust Lead, 1999–2004: II. The Contribution of Lead-Contaminated Dust to Children's Blood Lead Levels
Sherry L. Dixon, Joanna M. Gaitens, David E. Jacobs, Warren Strauss, Jyothi Nagaraja, Tim Pivetz,
Jonathan W. Wilson, and Peter J. Ashley
Also see Science Selections, p. A117
468 [ Abstract ] [ Full ] [ PDF ]
RESPIRATORY DISEASE | The Effects of Fine Particle Components on Respiratory Hospital Admissions in Children
Bart Ostro, Lindsey Roth, Brian Malig, and Melanie Marty
475 [ Abstract ] [ Full ] [ PDF ]
ALTERNATIVE MODEL DEVELOPMENT | A Physiologically Based Pharmacokinetic Model for the Assessment of Infant Exposure to Persistent Organic Pollutants in Epidemiologic Studies
Marc-André Verner, Pierre Ayotte, Gina Muckle, Michel Charbonneau, and Sami Haddad
481 [ Abstract ] [ Full ] [ PDF ]
NEURODEVELOPMENT | Lactational Exposure to Polychlorinated Biphenyls, Dichlorodiphenyltrichloroethane, and Dichlorodiphenyldichloroethylene and Infant Neurodevelopment: An Analysis of the Pregnancy, Infection, and Nutrition Babies Study
I-Jen Pan, Julie L. Daniels, Barbara D. Goldman, Amy H. Herring, Anna Maria Siega-Riz, and Walter J. Rogan
488 [ Abstract ] [ Full ] [ PDF ]
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