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| On the Cover | Climate change is most definitely a hot topic this spring, as the Intergovernmental Panel on Climate Change releases the first in a trio of summaries and subsequent reports on the current state of the science—and takes the strongest stance to date that human activity is accelerating climate change. Several articles in this month’s news address a few of the consequences that can be expected from this global phenomenon. image credit: ShutterStockPurchase This Issue | |
Perspectives
Director's Perspective
p. A 182
Correspondence
p. A 184
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Environews
Forum
p. A 188
NIEHS News
p. A 192
Focus
p. A 196
Spheres of Influence
p. A 204
Innovations
p. A 208
Science Selections
p. A 212
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Commentaries & Reviews
Commentaries
POPULATION HEALTH | Using Nutrition for Intervention and Prevention against Environmental Chemical Toxicity and Associated Diseases
Bernhard Hennig, Adrienne S. Ettinger, Ronald J. Jandacek, Sung Koo, Craig McClain, Harold Seifried, Allen Silverstone, Bruce Watkins, and William A. Suk
493 [ Abstract ] [ Full ] [ PDF ]
RISK ASSESSMENT | Biodiesel Exhaust: The Need for Health Effects Research
Kimberly J. Swanson, Michael C. Madden, and Andrew J. Ghio
496 [ Abstract ] [ Full ] [ PDF ]
Reviews
RISK ASSESSMENT | Hormesis and Its Place in Nonmonotonic Dose–Response Relationships: Some Scientific Reality Checks
Paul Mushak
500 [ Abstract ] [ Full ] [ PDF ]
Research
RESPIRATORY DISEASE | Ambient and Microenvironmental Particles and Exhaled Nitric Oxide Before and After a Group Bus Trip
Sara Dubowsky Adar, Gary Adamkiewicz, Diane R. Gold, Joel Schwartz, Brent A. Coull, and Helen Suh
507 [ Abstract ] [ Full ] [ PDF ]
CARCINOGENESIS | Cyclooxygenase-2 Induction by Arsenite through the IKKβ/NFκB Pathway Exerts an Antiapoptotic Effect in Mouse Epidermal Cl41 cells
Weiming Ouyang, Dongyun Zhang, Qian Ma, Jingxia Li, and Chuanshu Huang
513 [ Abstract ] [ Full ] [ PDF ]
HUMAN TOXICOLOGY | Proton Magnetic Resonance Spectroscopic Evidence of Glial Effects of Cumulative Lead Exposure in the Adult Human Hippocampus
Marc G. Weisskopf, Howard Hu, David Sparrow, Robert E. Lenkinski, and Robert O. Wright
519 [ Abstract ] [ Full ] [ PDF ]
AGING | Air Pollution and Mortality in Chile: Susceptibility among the Elderly
Sabit Cakmak, Robert E. Dales, and Claudia Blanco Vidal
524 [ Abstract ] [ Full ] [ PDF ]
EPIDEMIOLOGY | Mortality among Pesticide Applicators Exposed to Chlorpyrifos in the Agricultural Health Study
Won Jin Lee, Michael C.R. Alavanja, Jane A. Hoppin, Jennifer A. Rusiecki, Freya Kamel, Aaron Blair, and Dale P. Sandler
528 [ Abstract ] [ Full ] [ PDF ]
CARDIOVASCULAR DISEASE | Up-regulation of Tissue Factor in Human Pulmonary Artery Endothelial Cells after Ultrafine Particle Exposure
Edward D. Karoly, Zhuowei Li, Lisa A. Dailey, Xhevahire Hyseni, and Yuh-Chin T. Huang
535 [ Abstract ] [ Full ] [ PDF ]
TOXICOLOGY | Mammary Gland Development as a Sensitive End Point after Acute Prenatal Exposure to an Atrazine Metabolite Mixture in Female Long-Evans Rats
Rolondo R. Enoch, Jason P. Stanko, Sara N. Greiner, Geri L. Youngblood, Jennifer L. Rayner, and Suzanne E. Fenton
541 [ Abstract ] [ Full ] [ PDF ]
ASTHMA | In Utero Exposure to Environmental Tobacco Smoke Potentiates Adult Responses to Allergen in BALB/c Mice
Arthur L. Penn, Rodney L. Rouse, David W. Horohov, Michael T. Kearney, Daniel B. Paulsen, and Larry Lomax
548 [ Abstract ] [ Full ] [ PDF ]
NEURODEVELOPMENT | Ontogenetic Alterations in Molecular and Structural Correlates of Dendritic Growth after Developmental Exposure to Polychlorinated Biphenyls
Pamela J. Lein, Dongren Yang, Adam D. Bachstetter, Hugh A. Tilson, G. Jean Harry, Ronald F. Mervis, and Prasada Rao S. Kodavanti
556 [ Abstract ] [ Full ] [ PDF ]
POPULATION HEALTH | The NIEHS Environmental Health Sciences Data Resource Portal: Placing Advanced Technologies in Service to Vulnerable Communities Keith Pezzoli,
Robert Tukey, Hiram Sarabia, Ilya Zaslavsky, Marie Lynn Miranda, William A. Suk, Abel Lin, and Mark Ellisman
Also see Science Selections, p. A213
564 [ Abstract ] [ Full ] [ PDF ]
TOXICOGENOMICS | Identification of Genes Implicated in Methapyrilene-Induced Hepatotoxicity by Comparing Differential Gene Expression in Target and Nontarget Tissue
J. Todd Auman, Jeff Chou, Kevin Gerrish, Qihong Huang, Supriya Jayadev, Kerry Blanchard, and Richard S. Paules
572 [ Abstract ] [ Full ] [ PDF ]
RESPIRATORY DISEASE | Vermiculite, Respiratory Disease, and Asbestos Exposure in Libby, Montana: Update of a Cohort Mortality Study
Patricia A. Sullivan
579 [ Abstract ] [ Full ] [ PDF ]
BIOMONITORS | Pulmonary Biomarkers Based on Alterations in Protein Expression after Exposure to Arsenic
R. Clark Lantz, Brandon J. Lynch, Scott Boitano, Gerald S. Poplin, Sally Littau, George Tsaprailis, and Jefferey L. Burgess
586 [ Abstract ] [ Full ] [ PDF ]
ENDOCRINE SYSTEM | Perinatal Bisphenol A Exposure Increases Estrogen Sensitivity of the Mammary Gland in Diverse Mouse Strains
Perinaaz R. Wadia, Laura N. Vandenberg,
Cheryl M. Schaeberle, Beverly S. Rubin, Carlos Sonnenschein, and Ana M. Soto
592 [ Abstract ] [ Full ] [ PDF ]
GENE POLYMORPHISM | Genetic Polymorphisms Influencing Arsenic Metabolism: Evidence from Argentina
Karin Schläwicke Engström, Karin Broberg, Gabriela Concha, Barbro Nermell, Margareta Warholm, and Marie Vahter
599 [ Abstract ] [ Full ] [ PDF ]
ENVIRONMENTAL MEDICINE
RISK ASSESSMENT | Case Report: Potential Arsenic Toxicosis Secondary to Herbal Kelp Supplement
Eric Amster, Asheesh Tiwary, and Marc B. Schenker
Also see Science Selections, p. A212
606 [ Abstract ] [ Full ] [ PDF ]
CHILDREN'S HEALTH
NEURODEVELOPMENT | Dose–Response Relationship of Prenatal Mercury Exposure and IQ: An Integrative Analysis of Epidemiologic Data
Daniel A. Axelrad, David C. Bellinger, Louise M. Ryan, and Tracey J. Woodruff
Also see Science Selections, p. A212
609 [ Abstract ] [ Full ] [ PDF ]
ASTHMA | Parental Smoking Modifies the Relation between Genetic Variation in Tumor Necrosis Factor-α (TNF) and Childhood Asthma
Hao Wu, Isabelle Romieu, Juan-Jose Sienra-Monge, Blanca Estela del Rio-Navarro, Daniel M. Anderson, Erin W. Dunn, Lori L. Steiner, Irma del Carmen Lara-Sanchez, and Stephanie J. London
Also see Science Selections, p. A213
616 [ Abstract ] [ Full ] [ PDF ]
NEURODEVELOPMENT | Smoking during Pregnancy Affects Speech-Processing Ability in Newborn
Alexandra P.F. Key, Melissa Ferguson, Dennis L. Molfese, Kelley Peach, Casey Lehman, and Victoria J. Molfese
623 [ Abstract ] [ Full ] [ PDF ]
RISK ASSESSMENT | Elevated Blood Lead Concentrations and Vitamin D Deficiency in Winter and Summer in Young Urban Children
Francis W. Kemp, Prasad V.S.V. Neti, Roger W. Howell, Peter Wenger, Donald B. Louria, and John D. Bogden
630 [ Abstract ] [ Full ] [ PDF ]
MINI-MONOGRAPH
RISK ASSESSMENT | Health Effects of Exposure to Natural Arsenic in Groundwater and Coal in China: An Overview of Occurrence
Guangqian Yu, Dianjun Sun, and Yan Zheng
636 [ Abstract ] [ Full ] [ PDF ]
RISK ASSESSMENT | Arsenic and Fluoride Exposure in Drinking Water: Children’s IQ and Growth in Shanyin County, Shanxi Province, China
San-xiang Wang, Zheng-hui Wang, Xiao-tian Cheng, Jun Li,
Zhi-ping Sang, Xiang-dong Zhang, Ling-ling Han, Xiao-yan Qiao, Zhao-ming Wu, and Zhi-quan Wang
643 [ Abstract ] [ Full ] [ PDF ]
RISK ASSESSMENT | Urinary Arsenic Metabolites in Children and Adults Exposed to Arsenic in Drinking Water in Inner Mongolia, China
Guifan Sun, Yuanyuan Xu, Xin Li, Yaping Jin, Bing Li, and Xiance Sun
648 [ Abstract ] [ Full ] [ PDF ]
RISK ASSESSMENT | Unventilated Indoor Coal-Fired Stoves in Guizhou Province, China: Cellular and Genetic Damage in Villagers Exposed to Arsenic in Food and Air
Aihua Zhang, Hong Feng, Guanghong Yang, Xueli Pan, Xianyao Jiang, Xiaoxin Huang, Xuexin Dong, Daping Yang, Yaxiong Xie, Luo Peng, Li Jun, Changjun Hu, Li Jian, and Xilan Wang
653 [ Abstract ] [ Full ] [ PDF ]
RISK ASSESSMENT | Unventilated Indoor Coal-Fired Stoves in Guizhou Province, China: Reduction of Arsenic Exposure through Behavior Changes Resulting from Mitigation and Health Education in Populations with Arsenicosis
Dong An, Dasheng Li, Yin Liang, and Zhengjin Jing
659 [ Abstract ] [ Full ] [ PDF ]
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