Organization	APC Gene Test Recommended	Age Screening Initiated	Frequency	Method	Comment
NCCN [109]	Yes	10–15 y	Annual	FS or C	Consider MYH mutation testing if APC testing is negative and family history is compatible with recessive inheritance; in families in which no mutation is found, offspring of those affected are screened as if they were carriers.
American Cancer Society [110]	NA	Puberty	NA	"Endoscopy"	Referral to a center specializing in FAP screening suggested.
GI Societiesa [106]	Yes	10–12 y	Annual	FS
American Society of Colon and Rectal Surgeons [111-113]	Yes	NA	NA	NA

C = colonoscopy; FS = flexible sigmoidoscopy; NA = not addressed; NCCN = National Comprehensive Cancer Network.

aGI Societies – American Academy of Family Practice, American College of Gastroenterology, American College of Physicians-American Society of Internal Medicine, American College of Radiology, American Gastroenterological Association, American Society of Colorectal Surgeons, and American Society for Gastrointestinal Endoscopy.

References

106. Winawer S, Fletcher R, Rex D, et al.: Colorectal cancer screening and surveillance: clinical guidelines and rationale-Update based on new evidence. Gastroenterology 124 (2): 544-60, 2003.  [PUBMED Abstract]
     
     
109. Levin B, Barthel JS, Burt RW, et al.: Colorectal Cancer Screening Clinical Practice Guidelines. J Natl Compr Canc Netw 4 (4): 384-420, 2006.  [PUBMED Abstract]
     
     
110. Smith RA, Cokkinides V, von Eschenbach AC, et al.: American Cancer Society guidelines for the early detection of cancer. CA Cancer J Clin 52 (1): 8-22, 2002 Jan-Feb.  [PUBMED Abstract]
     
     
111. Church J, Simmang C; Standards Task Force., American Society of Colon and Rectal Surgeons.Collaborative Group of the Americas on Inherited Colorectal Cancer and the Standards Committee of The American Society of Colon and Rectal Surgeons., et al.: Practice parameters for the treatment of patients with dominantly inherited colorectal cancer (familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer). Dis Colon Rectum 46 (8): 1001-12, 2003.  [PUBMED Abstract]
     
     
113. Standard Task Force., American Society of Colon and Rectal Surgeons., Collaborative Group of the Americas on Inherited Colorectal Cancer.: Practice parameters for the identification and testing of patients at risk for dominantly inherited colorectal cancer. Dis Colon Rectum 44 (10): 1403, 2001.  [PUBMED Abstract]