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Table 1. Estimated Relative and Absolute Risk of Developing Colorectal Cancer (CRC)
|
Family History
|
Relative Risk for CRC [41]
|
Absolute Risk of CRC by Age 79a
|
| No family history |
1 |
4%a |
| One first-degree relative with colorectal cancer |
2.3 (95% CI, 2.0–2.5) |
9%b |
| More than one first-degree relative with colorectal cancer |
4.3 (95% CI, 3.0–6.1) |
16%b |
| One affected first-degree relative diagnosed with colorectal cancer before age 45 y |
3.9 (95% CI, 2.4–6.2) |
15%b |
| One first-degree relative with colorectal adenoma |
2.0 (95% CI, 1.6–2.6) |
8%b |
|
CI = confidence interval.
|
|
aData from the Surveillance, Epidemiology, and End Results (SEER) database.
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bThe absolute risks of CRC for individuals with affected relatives was calculated using the relative risks for CRC [41] and the absolute risk of CRC by age 79a.
|
|
|
References
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Johns LE, Houlston RS: A systematic review and meta-analysis of familial colorectal cancer risk. Am J Gastroenterol 96 (10): 2992-3003, 2001.
[PUBMED Abstract]
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