Projects

Control of Fusarium Mycotoxins in Corn, Wheat, and Barley Appropriated (D)   Accession Number: 409643

Publications

Structural and functional characterization of TRI3 acetyltransferase from fusarium sporotrichioides - (Peer Reviewed Journal)

Garvey, G.S., Mccormick, S.P., Alexander, N.J., Rayment, I. 2009. Structural and functional characterization of TRI3 acetyltransferase from fusarium sporotrichioides. Journal of Protein Chemistry. 18(4):747-761.

Phytotoxicity of trichothecenes - (Book/Chapter) - (18-Dec-08)

The role of trichothecene-chemotypes in Fusarium head blight disease spread and trichothecene accumulation in wheat - (Abstract)

Foroud, N.A., Macmillan, T., Mccormick, S.P., Ellis, B.E., Kendra, D.F., Eudes, F. 2008. The role of trichothecene-chemotypes in Fusarium head blight disease spread and trichothecene accumulation in wheat [abstract].

Effects of xanthotoxin treatment on trichothecene production in Fusarium sporotrichioides - (Peer Reviewed Journal)

Alexander, N.J., Mccormick, S.P., Blackburn, J.A. 2008. Effects of xanthotoxin treatment on trichothecene production in Fusarium sporotrichioides . Canadian Journal of Microbiology. 54:1023-1031.

Variation in nucleotide sequence of TRI1 in 13 trichothecene-producing species of Fusarium: evidence for a complex evolutionary history of a mycotoxin biosynthetic locus - (Abstract)

Proctor, R., Mc Cormick, S.P., Alexander, N.J., Desjardins, A.E. 2008. Variation in nucleotide sequence of TRI1 in 13 trichothecene-producing species of Fusarium: evidence for a complex evolutionary history of a mycotoxin biosynthetic locus [abstract]. European Conference on Fungal Genetics. p. 29.

Quantification of trichothecene biosynthetic genes during the growth cycle of Fusarium sporotrichioides in culture - (Abstract)

Alexander, N.J., Mc Cormick, S.P. 2008. Quantification of trichothecene biosynthetic genes during the growth cycle of Fusarium sporotrichioides in culture [abstract]. 9th European Conference on Fungal Genetics. p. 134.

Phytotoxicity of trichothecenes using Arabidopsis detached leaf and Chlamydomonas assays - (Abstract)

Mc Cormick, S.P., Appell, M.D., Alexander, N.J., Desjardins, A.E. 2008. Phytotoxicity of trichothecenes using Arabidopsis detached leaf and Chlamydomonas assays [abstract]. American Chemical Society. Available: http://www.acs.org Paper #AGFD #145.

Structural and Functional Studies of Trichothecene Biosynthetic Enzymes: a Novel Approach to Combating Fusarium Head Blight - (Abstract)

Garvey, G., Mc Cormick, S.P., Rayment, I. 2007. Structural and functional studies of trichothecene biosynthetic enzymes: a novel approach to combating fusarium head blight [abstract]. National Fusarium Head Blight Forum Proceedings. p. 29.

Quantitative expression of Fusarium sporotrichioides genes in the presence of xanthotoxin - (Abstract)

Alexander, N.J., Mc Cormick, S.P. 2007. Quantitative expression of Fusarium sporotrichioides genes in the presence of xanthotoxin [abstract]. National Fusarium Head Blight Forum. p. 23.

Structural and functional characterization of the TRI101 trichothecene 3-O-acetyltransferase from Fusarium sporotrichioides and Fusarium graminearum: kinetic insights to combating fusarium head blight - (Peer Reviewed Journal)

Garvey, G.S., Mc Cormick, S.P., Rayment, I. 2007. Structural and functional characterization of the TRI101 trichothecene 3-O-acetyltransferase from Fusarium sporotrichioides and Fusarium graminearum: kinetic insights to combating Fusarium head blight. Journal of Biological Chemistry. 283:1660-1669.

Structure-activity relationships of trichothecene toxins in an Arabidopsis thaliana leaf assay - (Peer Reviewed Journal)

Desjardins, A.E., Mc Cormick, S.P., Appell, M.D. 2007. Structure-activity relationships of trichothecene toxins in an Arabidopsis thaliana leaf assay. Journal of Agricultural and Food Chemistry. 55(16):6487-6492.

Phytotoxicity of trichothecenes using an Arabidopsis detached leaf assay - (Abstract)

Mc Cormick, S.P., Desjardins, A.E., Appell, M.D. 2007. Phytotoxicity of trichothecenes using an Arabidopsis detached leaf assay [abstract]. American Chemical Society. Available: http://www.acs.org Paper AGFD #85.

Ab Initio study of acetylated derivatives of deoxynivalenol and nivalenol - (Abstract)

Appell, M.D., Mc Cormick, S.P., Desjardins, A.E. 2007. Ab Initio study of acetylated derivatives of deoxynivalenol and nivalenol [abstract]. American Chemical Society. Available: http://www.acs.org Paper #AGFD #95.

Myrothecium roridum Tri4 Encodes a Multifunctional Oxygenase Required for Three Oxygenation Steps - (Peer Reviewed Journal)

Mc Cormick, S.P., Alexander, N.J. 2007. Myrothecium roridum Tri4 encodes a multifunctional oxygenase required for three oxygenation steps. Canadian Journal of Microbiology. 53:572-579.

A novel gene cluster in Fusarium graminearum expressed under mycotoxin induction conditions - (Abstract)

Harris, L., Saparno, A., Alexander, N.J., Blackwell, B., Mc Cormick, S.P., Schneiderman, D., Desjardins, A.E., Tinker, N., Hattori, J., Seifert, K., Ouellet, T. 2007. A novel gene cluster in Fusarium graminearum expressed under mycotoxin induction conditions [abstract]. Fungal Genetics Conference. p. 104.

The identification of a gene in Fusarium graminearum that contributes to butenolide synthesis - (Abstract)

Alexander, N.J., Harris, L.J., Mc Cormick, S.P., Saparno, A., Blackwell, B., Desjardins, A.E., Tinker, N., Hattori, J., Ouellet, T. 2006. The identification of a gene in Fusarium graminearum that contributes to butenolide synthesis [abstract]. National Fusarium Head Blight Forum. Available: http://www.scabusa.org p. 135.

The TRI101 Story: Engineering Wheat and Barley to Resist Fusarium Head Blight - (Abstract)

Alexander, N.J., Blechl, A.E., Okubara, P.A., Mc Cormick, S.P., Manoharan, M., Dahleen, L.S., Kendra, D.F. 2006. The TRI101 Story: Engineering Wheat and Barley to Resist Fusarium Head Blight [abstract]. World Mycotoxin Forum, the Fourth Conference. p. 123.

A Novel Biosynthetic Gene Cluster in Fusarium Graminearum Contributes to Butenolide Synthesis - (Peer Reviewed Journal)

Harris, L., Alexander, N.J., Saparno, A., Blackwell, B., Mc Cormick, S.P., Desjardins, A.E., Robert, L., Tinker, N., Hattori, J., Piche, C., Schernthaner, J., Watson, R., Ouellet, T. 2007. A novel gene cluster in Fusarium graminearum contains a gene that contributes to butenolide synthesis. Fungal Genetics and Biology. 44(4):293-306.

Heterologous Expression of Myrothecium Trichothecene P450 Oxygenase in Fusarium Verticillioides - (Abstract)

Mc Cormick, S.P., Alexander, N.J. 2006. Heterologous expression of myrothecium trichothecene p450 oxygenase in fusarium verticillioides [abstract]. American Society of Pharmacognosy. P-022.

Myrothecium Roridum Tri4 Encodes a Lethal Factor for Host Bacterium - (Abstract)

Alexander, N.J., Mc Cormick, S.P. 2006. Myrothecium roridum tri4 encodes a lethal factor for host bacterium [abstract]. Phytopathology. 96:S4.

Expression of 3-Oh Trichothecene Acetyltransferase in Barley and Effects on Fusarium Head Blight - (Peer Reviewed Journal)

Manoharan, M., Dahleen, L.S., Hohn, T.M., Neate, S.M., Yu, X., Alexander, N.J., Mc Cormick, S.P., Bregitzer, P., Schwarz, P.B., Horsley, R.D. 2006. Expression of 3-OH trichothecene acetyltransferase in barley (Hordeum vulgare L.) and effects on deoxynivalenol. Plant Science. 171:699-706.

Myrothecium Roridum Tri4 Controls Three Oxygenation Steps in Macrocylic Trichothecene Biosynthesis. - (Abstract)

Mc Cormick, S.P., Alexander, N.J. 2006. Myrothecium roridum tri4 controls three oxygenation steps in macrocylic trichothecene biosynthesis [abstract]. Phytochemical Society of North America Meeting and Newsletter. Abstract 11. p. 25.

Emerging Mycotoxin Issues - (Abstract)

Mc Cormick, S.P., Desjardins, A.E. 2006. Emerging mycotoxin issues [abstract]. 47th Annual Corn Dry Milling Conference. p. 10.

Biosynthesis of Fusarium Mycotoxins and Genomics of Fusarium Verticillioides. - (Peer Reviewed Journal)

Proctor, R.H., Desjardins, A.E., Brown, D.W., McCormick, S.P., Butchko, R.A.E., Alexander, N., Busman, M. 2006. Biosynthesis of Fusarium mycotoxins and genomics of Fusarium verticillioides. Mycotoxin Research. 22(2):75-78.

Fusarium Tri4 Encodes a Multifunctional Oxygenase Required for Trichothecene Biosynthesis - (Peer Reviewed Journal)

McCormick, S.P., Alexander, N.J., Proctor, R.H. 2006. Fusarium Tri4 encodes a multifunctional oxygenase required for trichothecene biosynthesis. Canadian Journal of Micribiology. 52:636-642.

The Trichothecene Triangle: Toxins, Genes and Populations - (Abstract)

Mc Cormick, S.P. 2005. The trichothecene triangle: toxins, genes, and populations [abstract]. National Fusarium Head Blight Forum Proceedings. p. 178.

Functional Genomics and Proteomics Studies of F. Graminearum - (Abstract)

Saparno, A., Alexander, N.J., Blackwell, B., McCormick, S.P., Desjardins, A.E., Anoop, V., Kelso, S., Sprott, D., Robert, L., Tinker, N., Gleddie, S., Ouellet, T. 2005. Functional genomics and proteomics studies of F. graminearum [abstract]. The Canadian Workshop on Fusarium Head Blight. p. 70.

Heterologous Expression of Two Trichothecene P450 Genes in Fusarium Verticillioides - (Peer Reviewed Journal)

McCormick, S.P., Alexander, N.J., Proctor, R. H. 2006. Heterologous expression of two trichothecene P450 genes in Fusarium verticillioides. Canadian Journal of Microbiology. 52:220-226.

Heterologous Expression of Fusarium Trichothecene P450 Genes - (Abstract)

Mc Cormick, S.P., Alexander, N.J., Proctor, R. 2005. Heterologous expression of fusarium trichothecene p450 genes [abstract]. Phytochemical Society of North America Proceedings. p. 68.

Biosynthesis of Fusarium Mycotoxins and Genomics of Fusarium Verticillioides - (Abstract)

Proctor, R.H., Desjardins, A.E., Brown, D.W., McCormick, S.P., Butchko, R.A.E., Alexander, N., Busman, M. 2006. Biosynthesis of Fusarium mycotoxins and genomics of Fusarium verticillioides [abstract]. EU-USA Bilateral Workshop on Toxigenic Fungi and Mycotoxins.

Identification and Heritability of Fumonisin Insensitivity in Zea Mays - (Peer Reviewed Journal)

Desjardins, A.E., Plattner, R.D., Stessman, R.J., Mc Cormick, S.P., Millard, M.J. 2005. Identification and heritability of fumonisin insensitivity in Zea mays. Phytochemistry. 66(20):2474-2480.

Genetic Control of Trichothecene Biosynthesis in Fusarium - (Abstract)

Alexander, N.J., Mc Cormick, S.P., Larson, T.M., Proctor, R.H., Desjardins, A.E. 2005. Genetic control of trichothecene biosynthesis in fusarium. American Phytopathological Society. 95(6):S124.

Functional Analysis of Trichothecene Biosynthetic Genes Via Heterologous Expression in a Trichothecene-Nonproducing Fusarium Species - (Abstract)

Alexander, N.J., Mc Cormick, S.P., Proctor, R., Harris, L.J. 2004. Functional analysis of trichothecene biosynthetic genes via heterologous expression in a trichothecene-nonproducing fusarium species [abstract]. Proceedings of the 2nd International Symposium of Fusarium Head Blight. p. 552.

Functional Genomics of Fusarium Graminearum - (Abstract)

Harris, L., Alexander, N.J., Saparno, A., Blackwell, B., Mcalpin, C.E., Desjardins, A.E., Robert, L., Tinker, N., Ouellet, T. 2004. Functional genomics of fusarium graminearum [abstract]. Proceedings of the 2nd International Symposium on Fusarium Head Blight. p. 567.

Heterologous Expression of Two Fusarium Trichothecene P450 Genes - (Abstract)

Mc Cormick, S.P., Alexander, N.J., Proctor, R. 2004. Heterologous expression of two fusarium trichothecene p450 genes. Phytochemical Society of North America Proceedings.

Heterologous Expression Provides Method for Proving the Multifunctionality of the Tri4 Oxygenase in Trichothecene Biosynthesis in Fusarium - (Abstract)

Alexander, N.J., Mc Cormick, S.P., Proctor, R. 2004. Heterologous expression provides method for proving the multifunctionality of the tri4 oxygenase in trichothecene biosynthesis in fusarium. Meeting Abstract.

Heterologous Expression of the Fusarium Graminearum Tri4 Gene in F. Verticillioides Provides Evidence for a Multifunctional Oxygenase in Trichothecene Biosynthesis - (Abstract)

Alexander, N.J., Mc Cormick, S.P., Proctor, R. 2004. Heterologous expression of the fusarium graminearum tri4 gene in f. verticillioides provides evidence for a multifunctional oxygenase in trichothecene biosynthesis. Meeting Abstract.

Tri1 in Fusarium Graminearum Encodes a P450 Oxygenase - (Peer Reviewed Journal)

Mc Cormick, S.P., Harris, L.J., Alexander, N.J., Ouellet, T., Saparno, A., Allard, S., Desjardins, A.E. 2004. Tri1 in fusarium graminearum encodes a p450 oxygenase. Applied And Environmental Microbiology. 70(4):2044-2051.

Functional Demarcation of the Fusarium Core Trichothecene Gene Cluster - (Peer Reviewed Journal)

Brown, D.W., Dyer, R.B., Mc Cormick, S.P., Kendra, D.F., Plattner, R.D. 2004. Functional demarcation of the fusarium core trichothecene gene cluster. Fungal Genetics and Biology. 41:454-462.

Expression of Tri15 in Fusarium Sporotrichioides - (Peer Reviewed Journal)

Alexander, N.J., Mc Cormick, S.P., Larson, T.M., Jurgenson, J.E. 2004. Expression of Tri15 in Fusarium sporotrichioides. Current Genetics. 45:157-162.

Characterization of Tri16 from Fusarium Sporotrichioides and F. Graminearum - (Abstract) - (23-Mar-03)

Isolation and Characterization of Tri16 from Fusarium Sporotrichioides - (Abstract) - (09-Dec-02)

Transformation of a Commercial Cultivar with Genes for Resistance to Fusarium Head Blight - (Abstract)

MANOHARAN, M., DAHLEEN, L.S., HOHN, T., MC CORMICK, S.P., ALEXANDER, N.J., SCHWARZ, P., HORSLEY, R.D. TRANSFORMATION OF A COMMERCIAL CULTIVAR WITH GENES FOR RESISTANCE TO FUSARIUM HEAD BLIGHT. IN VITRO CELLULAR AND DEVELOPMENTAL BIOLOGY. 2002. VOL. 38:27A

Engineering Deoxynivalenol Metabolism in Wheat Through the Expression of a Fugal Trichothecene Acetyltransferase Gene - (Peer Reviewed Journal) - (05-Apr-02)