LTG 1 Use Of Mechanistic Data in Risk Assessment
Lead: Julian Preston (NHEERL) |
Topic: Ah Receptor Mechanism
Lead: Mike DeVito (NHEERL) |
LTG 1-01 |
Dose-Response Modeling for Dioxins
(MS PowerPoint, 2.4 MB)
Mike DeVito (NHEERL) |
LTG 1-02 |
Use of Mode of Action in Developing Cross-Species Dose Metrics
(MS PowerPoint, 2.8 MB)
Janet Diliberto (NHEERL) |
LTG 1-03 |
Use of Mode of Action in the Risk Characterization of Dioxins
(MS PowerPoint, 2.5 MB)
Linda Birnbaum (NHEERL) |
Topic: Oxidative Stress
Lead: Jane Gallagher (NHEERL) |
LTG 1-04 |
Oxidative Stress and Human Health
(MS PowerPoint, 7.6 MB)
Reeder Sams (NCEA) |
LTG 1-05 |
Oxidative Stress as a Common Toxicity Pathway Linking Exposure to Toxicity
(MS PowerPoint, 4.4 MB)
Gary Hatch (NHEERL) |
LTG 1-06 |
Research to Improve the Predictive Value of Biomarkers of Oxidative Stress
(MS PowerPoint, 4.8 MB)
Jane Gallagher (NHEERL) |
Topic: Luteinizing Hormone Disruption
Lead: Ralph Cooper (NHEERL) |
LTG 1-07 |
Harmonization of Tumor and Reproductive Effects of Atrazine
(MS PowerPoint, 2.6 MB)
Tammy Stoker (NHEERL) |
LTG 1-08 |
Characterizing the Adverse Reproductive Outcomes Following Luteinizing Hormone Disruption
(MS PowerPoint, 11.4 MB)
Susan Laws (NHEERL) |
LTG 1-09 |
Identifying How Environmental Chemicals Affect LH Secretion: A Systems Biology Approach
(MS PowerPoint, 2.3 MB)
Jerome Goldman (NHEERL) |
Topic: Mixed Mode of Action
Lead: David Thomas (NHEERL) |
LTG 1-10 |
Research Directed to Improve the Arsenic Cancer Risk Assessment: Defining the Role of Biomethylation and Reactive Oxygen Species in Arsenic Carcinogenesis
(MS PowerPoint, 11.8 MB)
Stephen Nesnow (NHEERL) |
LTG 1-11 |
Internal Dosimetry and Physiological Modeling: The Bridge between Arsenic Exposure and Health Effects
(MS PowerPoint, 3.3 MB)
Elaina Kenyon (NHEERL) |
LTG 1-12 |
Metabolism as a Critical Aspect of the Actions of Arsenic as a Toxin and Carcinogen
(MS PowerPoint, 2.8 MB)
David Thomas (NHEERL) |
Topic: p450 Mode of Action
Lead: Stephen Nesnow (NHEERL) |
LTG 1-13 |
Discovering the Mode(s) of Action of Conazole Toxicity Using the Tools of Toxicogenomics and Toxicology for Harmonization, Interspecies Extrapolation and Computational Toxicology
(MS PowerPoint, 10.4 MB)
Stephen Nesnow (NHEERL) |
LTG 1-14 |
Mode of Action Studies of Conazoles in Rats: Determination of Pathways in Carcinogenesis
(MS PowerPoint, 6 MB)
Doug Wolf (NHEERL) |
LTG 1-15 |
Toxicogenomic and Traditional Approaches Applied to Identifying the Mode(s) of Action of Conazole-Induced Mouse Liver Cancer
(MS PowerPoint, 1.6 MB)
James Allen (NHEERL) |
LTG 1-16 |
A Toxicogenomic Approach to Determining the Mode(s) of Action for Reproductive Toxicities of Conazoles
(MS PowerPoint, 4.8 MB)
David Dix (NHEERL) |
Topic: Risk Assessment and Mode of Action
Lead: Hugh Barton (NHEERL) |
LTG 1-17 |
Overview of Use of Mechanistic Data in Risk Assessment
(MS PowerPoint, 2.6 MB)
Hugh Barton (NHEERL) |
LTG 1-18 |
Dose-Response Modeling
(MS PowerPoint, 2.3 MB)
Jeff Gift (NCEA) |
LTG 1-19 |
Mode of Action as the Biological Basis for Cancer Risk Assessment
(MS PowerPoint, 2.1 MB)
Resha Putzrath (NCEA) |
LTG1-20 |
ORD's Computational Toxicology Research Program
(MS PowerPoint, 6.4 MB)
Robert Kavlock (NCCT) |