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Copyright © 2008 Zhang et al; licensee BioMed Central Ltd. Genetic characterization of Measles Viruses in China, 2004 Yan Zhang,1 Yixin Ji,1 Xiaohong Jiang,1 Songtao Xu,1 Zhen Zhu,1 Lei Zheng,2 Jilan He,3 Hua Ling,4 Yan Wang,5 Yang Liu,6 Wen Du,7 Xuelei Yang,8 Naiying Mao,1 and Wenbo Xu  1,91WHO WPRO Regional Reference Measles Lab, National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Beijing 100050, PR China 2Shanxi Provincial Center for Disease Control and Prevention, PR China 3Sichuan Provincial Center for Disease Control and Prevention, PR China 4Chongqing Provincial Center for Disease Control and Prevention, PR China 5Liaoning Provincial Center for Disease Control and Prevention, PR China 6Tianjin Provincial Center for Disease Control and Prevention, PR China 7Guizhou Provincial Center for Disease Control and Prevention, PR China 8Pediatric Institute of People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi city, Xinjiang province, PR China 9State Key Laboratory for Molecular Virology & Genetic Engineering, National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Beijing 100050, PR China Corresponding author.Yan Zhang: zhangyanft/at/hotmail.com; Yixin Ji: heartsound/at/vip.sina.com; Xiaohong Jiang: measleslab/at/sina.com; Songtao Xu: xsttz886/at/hotmail.com; Zhen Zhu: Zhuzhen76/at/163.com; Lei Zheng: xhanximlab608/at/sohu.com; Jilan He: jilanhe/at/sina.com; Hua Ling: hua_ling/at/yahoo.com; Yan Wang: wy-0124/at/163.com; Yang Liu: angel68/at/yahoo.com; Wen Du: duwen1987/at/163.com; Xuelei Yang: xueleiy/at/yahoo.com; Naiying Mao: maonaiying/at/hotmail.com; Wenbo Xu: wenbo_xu1/at/yahoo.com.cn Received August 26, 2008; Accepted October 20, 2008. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | ||||
Abstract Genetic characterization of wild-type measles virus was studied using nucleotide sequencing of the C-terminal region of the N protein gene and phylogenetic analysis on 59 isolates from 16 provinces of China in 2004. The results showed that all of the isolates belonged to genotype H1. 51 isolates were belonged to cluster 1 and 8 isolates were cluster 2 and Viruses from both clusters were distributed throughout China without distinct geographic pattern. The nucleotide sequence and predicted amino acid homologies of the 59 H1 strains were 96.5%–100% and 95.7%–100%, respectively. The report showed that the transmission pattern of genotype H1 viruses in China in 2004 was consistent with ongoing endemic transmission of multiple lineages of a single, endemic genotype. Multiple transmission pathways leaded to multiple lineages within endemic genotype. | ||||
