Alternate Title
Basic Trial Information
Objectives
Entry Criteria
Expected Enrollment
Outcomes
Outline
Trial Contact Information
Related Information
Registry Information

Alternate Title

Radiation Therapy in Treating Patients With Stage II Prostate Cancer

Basic Trial Information

Phase Type Status Age Sponsor Protocol IDs Phase III Treatment Active 18 and over NCI RTOG-0415 RTOG-0415, NCT00331773

Special Category: NCI Web site featured trial, CTSU trial

Objectives

Primary

1. Compare the disease-free survival (DFS) of patients with favorable-risk stage II prostate cancer treated with hypofractionated vs conventionally fractionated three-dimensional conformal radiotherapy (3D-CRT) or intensity-modulated radiotherapy (IMRT).

Secondary

1. Compare time to local progression, freedom from biochemical recurrence, and disease-specific and overall survival of patients treated with these regimens.
2. Compare the incidence of gastrointestinal and genitourinary toxic effects in patients treated with these regimens.
3. Compare the degree, duration, and significant differences in disease-specific health-related quality of life (HRQOL) decrements, using the Expanded Prostate Cancer Index Composite (EPIC), in patients treated with these regimens.
4. Determine whether anxiety and/or depression, as measured by the Hopkins Symptom Checklist-25 (HSCL-25), are decreased with therapy that improves DFS of these patients .
5. Determine whether the incremental gain in DFS outweighs decrements in the generic domains of HRQOL (i.e., mobility, self care, usual activities, pain/discomfort, and anxiety/depression) in patients treated with these regimens.
6. Conduct a cost-utility analysis of hypofractionated 3D-CRT or IMRT as a prostate cancer therapy if this regimen is shown to be as effective as conventionally fractionated 3D-CRT or IMRT in improving DFS.

Entry Criteria

Disease Characteristics:

• Histologically confirmed adenocarcinoma of the prostate within the past 6 months
  • Clinical stage T1-2c



• Combined Gleason score 2-6



• Prostate-specific antigen (PSA) < 10 ng/mL within the past 6 months
  • No PSA measurement for ≥ 10 days after prostate biopsy
  • No PSA measurement for ≥ 30 days after discontinuation of finasteride (90 days after discontinuation of dutasteride)



• No regional lymph node involvement



• No distant metastases

Prior/Concurrent Therapy:

• See Disease Characteristics
• No prior radical prostatectomy or cryosurgery for prostate cancer
• No prior hormonal therapy, including any of the following:
  • Luteinizing hormone-releasing hormone agonists (e.g., goserelin or leuprolide)
  • Antiandrogens (e.g., flutamide or bicalutamide)
  • Estrogens (e.g., diethylstilbestrol [DES])
  • Surgical castration (bilateral orchiectomy)
• No prior pelvic radiotherapy or prostate brachytherapy
• No prior or concurrent cytotoxic chemotherapy for prostate cancer
• At least 30 days since prior finasteride
• At least 90 days since prior dutasteride
• No concurrent neoadjuvant or adjuvant hormonal therapy
• Concurrent warfarin or other blood-thinning agents allowed

Patient Characteristics:

• Zubrod performance status 0-1
• No unstable angina and/or congestive heart failure requiring hospitalization within the past 6 months
• No transmural myocardial infarction within the past 6 months
• No acute bacterial or fungal infection requiring IV antibiotics
• No chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study treatment
• No hepatic insufficiency resulting in clinical jaundice and/or coagulation defects
• No known AIDS
• No prior or concurrent lymphomatous/hematogenous malignancy or other invasive malignancy except nonmelanomatous skin cancer or any other cancer for which the patient has been continually disease-free for ≥ 5 years (e.g., carcinoma in situ of the bladder or oral cavity)
• No other severe, active comorbidity

Expected Enrollment

A total of 1,067 patients will be accrued to this study.

Outcomes

Disease-free survival at 5 years as measured by Kaplan-Meier

Time to failure

Outline

This is a randomized, controlled, multicenter study. Patients are stratified according to Gleason score (2-4 vs 5-6), prostate-specific antigen (PSA) level (< 4 ng/mL vs 4-9 ng/mL), and planned radiotherapy modality (three-dimensional conformal radiotherapy [3D-CRT] vs intensity-modulated radiotherapy [IMRT]). Patients are randomized to 1 of 2 treatment arms.

• Arm I: Patients undergo conventionally fractionated 3D-CRT or IMRT once daily 5 days a week for 8.2 weeks (total of 41 treatments).



• Arm II: Patients undergo hypofractionated 3D-CRT or IMRT once daily 5 days a week for 5.6 weeks (total of 28 treatments).

Quality of life, anxiety, and depression are assessed at baseline and then at 6 months and 1, 2, and 5 years after the start of radiotherapy.

After completion of study treatment, patients are followed every 3 months for 2 years, every 6 months for 3 years, and then annually thereafter.

Trial Contact Information

Trial Lead Organizations

Radiation Therapy Oncology Group

W. Robert Lee, MD, Protocol chair		Ph: 919-668-7342

U.S.A.
Alabama
	Mobile
	Mobile Infirmary Medical Center
		Clinical Trials Office - Mobile Infirmary Medical Center	Ph:  251-435-3942
Arizona
	Phoenix
	Arizona Oncology Services Foundation
		David Brachman, MD, FACRO	Ph:  602-406-3170
	Scottsdale
	Mayo Clinic Scottsdale
		Clinical Trials Office - All Mayo Clinic Locations	Ph:  507-538-7623
	Tucson
	Arizona Oncology - Tucson
		Vivek Kavadi	Ph:  520-797-4468
California
	Auburn
	Auburn Radiation Oncology
		Christopher Jones, MD	Ph:  916-888-1266
	Berkeley
	Alta Bates Summit Comprehensive Cancer Center
		Clinical Trials Office - Alta Bates Summit Comprehensive Cancer Center	Ph:  510-204-3428
	Burbank
	Providence Saint Joseph Medical Center - Burbank
		Clinical Trials Office - Providence Saint Joseph Medical Center - Burbank	Ph:  818-847-3220
	Burlingame
	Peninsula Medical Center
		David Irwin, MD	Ph:  510-204-2866
	Cameron Park
	Radiation Oncology Centers - Cameron Park
		Christopher Jones, MD	Ph:  916-622-9700
	Carmichael
	Mercy Cancer Center at Mercy San Juan Medical Center
		Christopher Jones, MD	Ph:  916-904-3440
	Castro Valley
	East Bay Radiation Oncology Center
		James Feusner, MD	Ph:  510-428-3689
	Valley Medical Oncology Consultants - Castro Valley
		James Feusner, MD	Ph:  510-428-3689
	Fremont
	Valley Medical Oncology
		James Feusner, MD	Ph:  510-428-3689
	Washington Township Hospital
		Byron Wilson, MD	Ph:  510-797-1111
	Greenbrae
	Marin Cancer Institute at Marin General Hospital
		David Irwin, MD	Ph:  510-204-2866
	Sutter Health - Western Division Cancer Research Group
		David Irwin, MD	Ph:  510-204-2866
	Hayward
	Kaiser Permanente Medical Center - Hayward
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Los Angeles
	Kaiser Permanente Medical Center - Los Angeles
		Michael Girvigian	Ph:  323-667-4011 800-954-8000
	Oakland
	Alta Bates Summit Medical Center - Summit Campus
		Clinical Trials Office - Alta Bates Summit Medical Center - Summit Campus	Ph:  510-204-1414
	Bay Area Breast Surgeons, Incorporated
		James Feusner, MD	Ph:  510-428-3689
	CCOP - Bay Area Tumor Institute
		James Feusner, MD	Ph:  510-428-3689
	Kaiser Permanente Medical Center - Oakland
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Larry G Strieff MD Medical Corporation
		James Feusner, MD	Ph:  510-428-3689
	Tom K Lee, Incorporated
		James Feusner, MD	Ph:  510-428-3689
	Pleasanton
	Valley Medical Oncology Consultants - Pleasanton
		James Feusner, MD	Ph:  510-428-3689
	Redwood City
	Kaiser Permanente Medical Center - Redwood City
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Richmond
	Kaiser Permanente Medical Center - Richmond
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Roseville
	Kaiser Permanente Medical Center - Roseville
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Radiation Oncology Center - Roseville
		Christopher Jones, MD	Ph:  916-969-4422
	Sacramento
	Kaiser Permanente Medical Center - Sacramento
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Mercy General Hospital
		Christopher Jones, MD	Ph:  916-453-4453
	Radiological Associates of Sacramento Medical Group, Incorporated
		Christopher Jones, MD	Ph:  916-646-8300
	San Francisco
	California Pacific Medical Center - California Campus
		David Irwin, MD	Ph:  510-204-2866
	Kaiser Permanente Medical Center - San Francisco Geary Campus
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	UCSF Helen Diller Family Comprehensive Cancer Center
		Clinical Trials Office - UCSF Helen Diller Family Comprehensive Cancer Center	Ph:  877-827-3222
	San Jose
	Kaiser Permanente Medical Center - Santa Teresa
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	San Pablo
	Doctors Medical Center - San Pablo Campus
		James Feusner, MD	Ph:  510-428-3689
	San Rafael
	Kaiser Foundation Hospital - San Rafael
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Santa Clara
	Kaiser Permanente Medical Center - Santa Clara Kiely Campus
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Santa Rosa
	Kaiser Permanente Medical Center - Santa Rosa
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	South San Francisco
	Kaiser Permanente Medical Center - South San Francisco
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Torrance
	Torrance Memorial Medical Center
		Thyra Endicott, MD	Ph:  310-325-9110
	Travis AFB
	General Robert Huyser Cancer Center at David Grant Medical Center
		Roland Engel, MD	Ph:  707-423-5129
	Vacaville
	Solano Radiation Oncology Center
		Christopher Jones, MD	Ph:  707-447-0400
	Vallejo
	Sutter Solano Medical Center
		David Irwin, MD	Ph:  510-204-2866
	Walnut Creek
	Kaiser Permanente Medical Center - Walnut Creek
		Louis Fehrenbacher, MD	Ph:  707-651-2577
Colorado
	Aurora
	Aurora Presbyterian Hospital
		Eduardo Pajon, MD	Ph:  303-777-2663
	Rocky Mountain Cancer Centers - Aurora
		Vivek Kavadi	Ph:  303-418-7600
	University of Colorado Cancer Center at UC Health Sciences Center
		Clinical Trials Office - University of Colorado Cancer Center	Ph:  720-848-0650
	Boulder
	Boulder Community Hospital
		Clinical Trials Office - Boulder Community Hospital	Ph:  303-938-5253
	Colorado Springs
	Penrose Cancer Center at Penrose Hospital
		Clinical Trials Office - Penrose Cancer Center	Ph:  719-776-5275
	Denver
	Porter Adventist Hospital
		Eduardo Pajon, MD	Ph:  303-777-2663
	Presbyterian - St. Luke's Medical Center
		Clinical Trials Office - Presbyterian - St. Luke's Medical Center	Ph:  303-839-6000
	St. Joseph Hospital
		Eduardo Pajon, MD	Ph:  303-777-2663
	Veterans Affairs Medical Center - Denver
		Rachel Rabinovitch, MD	Ph:  720-848-0116
	Englewood
	Swedish Medical Center
		Eduardo Pajon, MD	Ph:  303-777-2663
	Fort Collins
	Poudre Valley Radiation Oncology
		C. Kelley Simpson, MD	Ph:  970-482-3328
	Grand Junction
	St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
		Eduardo Pajon, MD	Ph:  303-777-2663
	Greeley
	North Colorado Medical Center
		Eduardo Pajon, MD	Ph:  303-777-2663
	Lone Tree
	Sky Ridge Medical Center
		Eduardo Pajon, MD	Ph:  303-777-2663
	Longmont
	Hope Cancer Care Center at Longmont United Hospital
		Eduardo Pajon, MD	Ph:  303-777-2663
	Loveland
	McKee Medical Center
		Eduardo Pajon, MD	Ph:  303-777-2663
	Pueblo
	St. Mary - Corwin Regional Medical Center
		Eduardo Pajon, MD	Ph:  303-777-2663
	Thornton
	North Suburban Medical Center
		Eduardo Pajon, MD	Ph:  303-777-2663
	Wheat Ridge
	Exempla Lutheran Medical Center
		Clinical Trials Office - Exempla Lutheran Medical Center	Ph:  303-403-3605
Delaware
	Newark
	CCOP - Christiana Care Health Services
		Clinical Trial Office - CCOP - Christiana Care Health Services	Ph:  302-733-6227
Florida
	Gainesville
	University of Florida Shands Cancer Center
		Clinical Trials Office - University of Florida Shands Cancer Center	Ph:  888-254-7581
	Jacksonville
	Mayo Clinic - Jacksonville
		Clinical Trials Office - All Mayo Clinic Locations	Ph:  507-538-7623
	Miami
	Baptist-South Miami Regional Cancer Program
		Andre Abitbol, MD	Ph:  786-596-6566
	Panama City
	Bay Medical
		Hasan Murshed	Ph:  850-747-6972
Georgia
	Altanta
	Winship Cancer Institute of Emory University
		Ashesh Jani	Ph:  404-778-5180 888-946-7447
	Decatur
	Veterans Affairs Medical Center - Atlanta (Decatur)
		Scott Edelman	Ph:  404-728-7680
Illinois
	Alton
	Saint Anthony's Hospital at Saint Anthony's Health Center
		Bethany Sleckman, MD	Ph:  314-251-6573
	Bloomington
	St. Joseph Medical Center
		John Kugler, MD	Ph:  309-243-3000
	Chicago
	University of Chicago Cancer Research Center
		Clinical Trials Office - University of Chicago Cancer Research Center	Ph:  773-834-7424
	Decatur
	Decatur Memorial Hospital Cancer Care Institute
		Clinical Trials Office - Decatur Memorial Hospital Cancer Care Institute	Ph:  217-876-6601
	Galesburg
	InterCommunity Cancer Center of Western Illinois
		John Kugler, MD	Ph:  309-243-3000
	Normal
	BroMenn Regional Medical Center
		John Kugler, MD	Ph:  309-243-3000
	Community Cancer Center
		John Kugler, MD	Ph:  309-243-3000
	Olympia Fields
	Saint James Hospital and Health Centers Comprehensive Cancer Institute - Olympia Fields
		Clinical Trials Office - Saint James Hospital and Health Centers Comprehensive Cancer Institute - Olympia Fields	Ph:  708-679-2217
	Pekin
	Cancer Treatment Center at Pekin Hospital
		John Kugler, MD	Ph:  309-243-3000
	Peoria
	CCOP - Illinois Oncology Research Association
		John Kugler, MD	Ph:  309-243-3000
	Methodist Medical Center of Illinois
		Clinical Trials Office - Methodist Medical Center of Illinois	Ph:  309-243-3000
	Oncology Hematology Associates of Central Illinois, PC - Peoria
		John Kugler, MD	Ph:  309-243-3000
	OSF St. Francis Medical Center
		John Kugler, MD	Ph:  309-243-3000
		John Kugler, MD	Ph:  309-243-3000
	Spring Valley
	Valley Cancer Center
		John Kugler, MD	Ph:  309-243-3000
Indiana
	Indianapolis
	Central Indiana Cancer Centers - East
		Vivek Kavadi	Ph:  317-964-5200
	Methodist Cancer Center at Methodist Hospital
		Contact Person	Ph:  317-962-8288 800-265-3220
	Muncie
	Cancer Center at Ball Memorial Hospital
		Clinical Trials Office - Cancer Center at Ball Memorial Hospital	Ph:  765-281-2107
Iowa
	Ames
	McFarland Clinic, PC
		Clinical Trials Office - McFarland Clinic, PC	Ph:  515-239-2621
	Iowa City
	Holden Comprehensive Cancer Center at University of Iowa
		Cancer Information Service	Ph:  800-237-1225
	Mason City
	Mercy Cancer Center at Mercy Medical Center - North Iowa
		Clinical Trials Office - Mercy Cancer Center at Mercy Medical Center - North Iowa	Ph:  641-422-6304
	Sioux City
	Siouxland Hematology-Oncology Associates, LLP
		Donald Wender, MD, PhD	Ph:  712-252-9326
Kansas
	Kansas City
	Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center
		Clinical Trials Office - Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center	Ph:  913-588-4709
	Overland Park
	Kansas City Cancer Centers - Southwest
		Vivek Kavadi	Ph:  913-234-0400
Kentucky
	Louisville
	James Graham Brown Cancer Center at University of Louisville
		William Spanos, Jr.	Ph:  502-562-4158 866-530-5516
Maryland
	Baltimore
	Greenebaum Cancer Center at University of Maryland Medical Center
		Clinical Trials Office - Greenebaum Cancer Center at University of Maryladn Medical Center	Ph:  800-888-8823
	Columbia
	Central Maryland Oncology Center
		Young Kwok	Ph:  410-964-2212
Massachusetts
	Boston
	Boston University Cancer Research Center
		Clinical Trials Office - Boston University Cancer Research Center	Ph:  617-353-7571
	Massachusetts General Hospital
		Clinical Trials Office - Massachusetts General Hospital	Ph:  877-726-5130
	Fall River
	Hudner Oncology Center at Saint Anne's Hospital - Fall River
		Clinical Trials Office - Hudner Oncology Center at Saint Anne's Hospital - Fall River	Ph:  508-674-5600 ext. 2019
	Framingham
	MetroWest Medical Center - Framingham Union Hospital
		Allison Sacher, MD	Ph:  508-383-1000
Michigan
	Ann Arbor
	University of Michigan Comprehensive Cancer Center
		Clinical Trials Office - University of Michigan Comprehensive Cancer Center	Ph:  800-865-1125
	Veterans Affairs Medical Center - Ann Arbor
		Shruti Jolly	Ph:  734-769-7100
	Detroit
	Barbara Ann Karmanos Cancer Institute
		Clinical Trials Office - Barbara Ann Karmanos Cancer Institute	Ph:  313-576-9363
	Josephine Ford Cancer Center at Henry Ford Hospital
		Eleanor Walker, MD	Ph:  313-916-1850 888-734-5322
	Flint
	Great Lakes Cancer Institute at McLaren Regional Medical Center
		Clinical Trials Office - Great Lakes Cancer Institute at McLaren Regional Medical Center	Ph:  810-342-4071
	Grand Rapids
	CCOP - Grand Rapids
		Marianne Lange, MD	Ph:  616-391-1230
	Lacks Cancer Center at Saint Mary's Health Care
		Marianne Lange, MD	Ph:  616-752-5222
	Iron Mountain
	Dickinson County Healthcare System
		Nelson Adamson	Ph:  906-774-1313
	Kalamazoo
	Borgess Medical Center
		Raymond Lord, MD	Ph:  269-373-7488
	Bronson Methodist Hospital
		Raymond Lord, MD	Ph:  269-373-7488
	West Michigan Cancer Center
		Clinical Trials Office - West Michigan Cancer Center	Ph:  269-373-7458
Minnesota
	Bemidji
	MeritCare Bemidji
		Preston Steen, MD	Ph:  701-234-2397
	Burnsville
	Fairview Ridges Hospital
		Patrick Flynn, MD	Ph:  612-863-8585
	Coon Rapids
	Mercy and Unity Cancer Center at Mercy Hospital
		Patrick Flynn, MD	Ph:  612-863-8585
	Duluth
	St. Luke's Hospital Cancer Care Center
		Steven Bonin	Ph:  218-249-7800 877-249-7800
	Edina
	Fairview Southdale Hospital
		Clinical Trials Office - Fairview Southdale Hospital	Ph:  612-625-3650
	Fridley
	Mercy and Unity Cancer Center at Unity Hospital
		Patrick Flynn, MD	Ph:  612-863-8585
	Mankato
	Immanuel St. Joseph's
		Ron Smith	Ph:  507-345-2929
	Maplewood
	HealthEast Cancer Care at St. John's Hospital
		Daniel Anderson	Ph:  651-232-7970
	Minnesota Oncology Hematology, PA - Maplewood
		Patrick Flynn, MD	Ph:  612-863-8585
	Minneapolis
	Hennepin County Medical Center - Minneapolis
		Clinical Trials Office - Hennepin County Medical Center - Minneapolis	Ph:  612-873-5911
	Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
		Clinical Trials Office - Virginia Piper Cancer Institute	Ph:  612-863-5654
	Robbinsdale
	Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center
		Clinical Trials Office - Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center	Ph:  763-520-1893
	Rochester
	Mayo Clinic Cancer Center
		Clinical Trials Office - All Mayo Clinic Locations	Ph:  507-538-7623
	Saint Cloud
	CentraCare Clinic - River Campus
		Barbi Kaplan-Frenkel, DO	Ph:  320-252-5131
	Coborn Cancer Center
		Barbi Kaplan-Frenkel, DO	Ph:  320-229-4907 877-229-4907
	Saint Louis Park
	CCOP - Metro-Minnesota
		Patrick Flynn, MD	Ph:  612-863-8585
	Park Nicollet Cancer Center
		Patrick Flynn, MD	Ph:  612-863-8585
	Saint Paul
	HealthEast Cancer Care at St. Joseph's Hospital
		Daniel Anderson	Ph:  651-232-7970
	United Hospital
		Patrick Flynn, MD	Ph:  612-863-8585
	Shakopee
	St. Francis Cancer Center at St. Francis Medical Center
		Daniel Anderson	Ph:  952-403-2031
	St. Paul
	Regions Hospital Cancer Care Center
		Clinical Trials Office - Regions Hospital Cancer Care Center	Ph:  651-254-1517
	Waconia
	Ridgeview Medical Center
		Patrick Flynn, MD	Ph:  612-863-8585
Missouri
	Cape Girardeau
	Saint Francis Medical Center
		Bethany Sleckman, MD	Ph:  314-251-6573
	Gape Girardeau
	Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital
		Bethany Sleckman, MD	Ph:  314-251-6573
	Joplin
	St. John's Regional Medical Center
		Clinical Trials Office - St. John's Regional Medical Center	Ph:  417-625-2488 ext. 2949
	Kansas City
	CCOP - Kansas City
		Rakesh Gaur, MD	Ph:  816-823-0555
	Kansas City Cancer Centers - North
		Vivek Kavadi	Ph:  816-746-4570
	Kansas City Cancer Centers - South
		Vivek Kavadi	Ph:  816-333-1326
	Research Medical Center
		Rakesh Gaur, MD	Ph:  816-276-4000
	Saint Louis
	CCOP - St. Louis-Cape Girardeau
		Bethany Sleckman, MD	Ph:  314-251-6573
	David C. Pratt Cancer Center at St. John's Mercy
		Clinical Trials Office - David C. Pratt Cancer Center at St. John's Mercy	Ph:  314-251-6770
	Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
		Jeff Michalski, MD	Ph:  314-362-8566
	Saint Peters
	Siteman Cancer Center at Barnes-Jewish St. Peters Hospital - St. Peters
		Jeff Michalski, MD	Ph:  314-362-8566
Montana
	Billings
	Billings Clinic - Downtown
		Clinical Trials Office - Billings Clinic - Downtown	Ph:  800-996-2663
			Email: research@billingsclinic.org
	CCOP - Montana Cancer Consortium
		Benjamin Marchello, MD	Ph:  406-259-2245 800-361-3239
	Northern Rockies Radiation Oncology Center
		Benjamin Marchello, MD	Ph:  406-248-2212 800-358-8818
	Bozeman
	Bozeman Deaconess Cancer Center
		Benjamin Marchello, MD	Ph:  406-585-5070
	Great Falls
		Benjamin Marchello, MD
	Big Sky Oncology
		Clinical Trail Office - Big Sky Oncology	Ph:  406-731-8217
	Great Falls Clinic - Main Facility
		Benjamin Marchello, MD	Ph:  406-454-2171 800-421-1649
	Sletten Cancer Institute at Benefis Healthcare
		Grant Harrer, MD, FACP, CCTI	Ph:  406-455-2820
Nebraska
	Omaha
	Methodist Estabrook Cancer Center
		Tien-Shew Huang	Ph:  402-354-5890 877-850-3212
Nevada
	Las Vegas
	CCOP - Nevada Cancer Research Foundation
		John Ellerton, MD, CM	Ph:  702-384-0013
New Hampshire
	Concord
	Dartmouth - Hitchcock Concord
		Thomas Sheldon	Ph:  603-226-2200
New Jersey
	Camden
	Cancer Institute of New Jersey at Cooper University Hospital - Camden
		Clinical Trial Office - Cancer Institute of New Jersey at Cooper Uniersity Hospital	Ph:  856-325-6757
	Livingston
	St. Barnabas Medical Center Cancer Center
		Clinical Trials Office - St. Barnabas Medical Center Cancer Center	Ph:  973-322-2470
	Marlton
	Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton
		Clinical Trials Office - Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton	Ph:  888-847-8823
	New Brunswick
	Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School
		Clinical Trials Office - Cancer Institute of New Jersey	Ph:  732-235-8675
	Sparta
	Frederick R. and Betty M. Smith Cancer Treatment Center
		Richard Valicenti, MD	Ph:  215-955-5936
	Toms River
	J. Phillip Citta Regional Cancer Center at Community Medical Center
		Clinical Trials Office - J. Phillip Citta Regional Cancer Center at Community Medical Center	Ph:  732-818-3882
	Trenton
	Capital Health Regional Cancer Center
		Daniel Fram, MD	Ph:  609-394-4244
	Voorhees
	Cancer Institute of New Jersey at Cooper - Voorhees
		Clinical Trials Office - Cancer Institute of New Jersey at Cooper University Hospital - Voorhees	Ph:  856-325-6757
New Mexico
	Albuquerque
	Lovelace Medical Center - Downtown
		Benny Liem, MD	Ph:  505-727-8000
	Radiation Oncology Associates, PA
		Benny Liem, MD	Ph:  505-889-9639
	University of New Mexico Cancer Center
		Clinical Trials Office - University of New Mexico Cancer Center	Ph:  505-272-6972
	Santa Fe
	Cancer Institute of New Mexico
		Clinical Trials Office - Cancer Institute of New Mexico	Ph:  505-955-7910
New York
	Albany
	New York Oncology Hematology, PC at Albany Regional Cancer Care
		Vivek Kavadi	Ph:  518-489-2607
	Binghamton
	Lourdes Regional Cancer Center
		Michael Fallon	Ph:  607-798-5230
	Buffalo
	Roswell Park Cancer Institute
		Clinical Trials Office - Roswell Park Cancer Institute	Ph:  877-275-7724
	East Syracuse
	CCOP - Hematology-Oncology Associates of Central New York
		Jeffrey Kirshner, MD	Ph:  315-472-7504
	Ithaca
	Cayuga Medical Center of Ithaca
		David Cho	Ph:  607-274-4011
	Manhasset
	CCOP - North Shore University Hospital
		Louis Potters, MD, FACR	Ph:  516-734-8954
	Don Monti Comprehensive Cancer Center at North Shore University Hospital
		Clinical Trials Office - Don Monti Comprehensive Cancer Center at North Shore University Hospital	Ph:  516-734-8900
	New Hyde Park
	Long Island Jewish Medical Center
		Louis Potters, MD, FACR	Ph:  718-470-7000 800-371-7111
	Poughkeepsie
	Hudson Valley Oncology Associates
		Richard Valicenti, MD	Ph:  215-955-5936
	Syracuse
	SUNY Upstate Medical University Hospital
		Clinical Trials Office - SUNY Upstate Medical University Hospital	Ph:  315-464-5476
North Carolina
	Durham
	Duke Comprehensive Cancer Center
		Clinical Trials Office - Duke Comprehensive Cancer Center	Ph:  888-275-3853
	Gastonia
	CaroMont Cancer Center at Gaston Memorial Hospital
		Clinical Trials Office - CaroMont Cancer Center at Gaston Memorial Hospital	Ph:  704-834-2932
	Rutherfordton
	Rutherford Hospital
		James Bearden, MD	Ph:  864-560-6812
	Wilmington
	New Hanover Radiation Oncology, PA
		Martin Meyerson, MD	Ph:  910-251-1839
North Dakota
	Bismarck
	Bismarck Cancer Center
		Edward Wos, DO	Ph:  701-323-5741
	Medcenter One Hospital Cancer Care Center
		Edward Wos, DO	Ph:  701-323-5741
	Mid Dakota Clinic, PC
		Clinical Trials Office - Mid Dakota Clinic, PC	Ph:  701-530-6950
	St. Alexius Medical Center Cancer Center
		Clinical Trials Office - St. Alexius Medical Center Cancer Center	Ph:  701-530-6950
	Fargo
	CCOP - MeritCare Hospital
		Preston Steen, MD	Ph:  701-234-2397
	MeritCare Broadway
		Preston Steen, MD	Ph:  701-234-2397
Ohio
	Akron
	McDowell Cancer Center at Akron General Medical Center
		Mitchell Fromm, MD	Ph:  330-344-6448
	Summa Center for Cancer Care at Akron City Hospital
		Clinical Trials Office - Akron City Hospital	Ph:  330-375-6101
	Cincinnati
	Charles M. Barrett Cancer Center at University Hospital
		Kevin Redmond, MD	Ph:  513-584-9089
	Cleveland
	Cleveland Clinic Cancer Center at Fairview Hospital
		Clinical Trials Office - Cleveland Clinic Cancer Center at Fairview Hospital	Ph:  216-476-9362
	Cleveland Clinic Taussig Cancer Center
		Clinical Trials Office - Cleveland Clinic Taussig Cancer Center	Ph:  866-223-8100
	Mayfield Heights
	Hillcrest Cancer Center at Hillcrest Hospital
		Arul Mahadevan	Ph:  440-312-4500
	Salem
	Cancer Research UK Medical Oncology Unit at Churchill Hospital & Weatherall Institute of Molecular Medicine - Oxford
		William Demas, MD	Ph:  330-375-3557
	West Chester
	Precision Radiotherapy at University Pointe
		Kevin Redmond, MD	Ph:  513-584-9089
	Wooster
	Cancer Treatment Center
		Clinical Trials Office - Cancer Treatment Center	Ph:  330-375-4221
	Cleveland Clinic - Wooster
		Clinical Trials Office - Cleveland Clinic - Wooster	Ph:  800-862-7798
Oklahoma
	Oklahoma City
	Oklahoma University Cancer Institute
		Terence Herman	Ph:  405-271-6822
	Tulsa
	Natalie Warren Bryant Cancer Center at St. Francis Hospital
		Robert Swanson, MD	Ph:  918-494-1585
Oregon
	Eugene
	Willamette Valley Cancer Center - Eugene
		Vivek Kavadi	Ph:  541-683-5001
Pennsylvania
	Abington
	Rosenfeld Cancer Center at Abington Memorial Hospital
		Clinical Trials Office - Rosenfeld Cancer Center at Abington Memorial Hospital	Ph:  215-481-2402
	Bryn Mawr
	Bryn Mawr Hospital
		Clinical Trials Office - Bryn Mawr Hospital	Ph:  610-645-2680
	Danville
	Geisinger Cancer Institute at Geisinger Health
		Clinical Trials Office - Geisinger Cancer Institute	Ph:  570-271-5251
	Darby
	Mercy Fitzgerald Hospital
		Clinical Trials Office - Mercy Fitzgerald Hospital	Ph:  610-237-4982
	Dunmore
	Northeast Radiation Oncology Center
		Richard Valicenti, MD	Ph:  215-955-5936
	Langhorne
	St. Mary Regional Cancer Center
		Clinical Trials Office - St. Mary Regional Cancer Center	Ph:  215-710-4585
	Paoli
	Cancer Center of Paoli Memorial Hospital
		Clinical Trials Office - Cancer Center of Paoli Memorial Hospital	Ph:  610-648-1637
	Philadelphia
	Fox Chase Cancer Center - Philadelphia
		Clinical Trials Office - Fox Chase Cancer Center - Philadelphia	Ph:  215-728-4790
	Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
		Clinical Trials Office - Kimmel Cancer Center at Thomas Jefferson University - Philadelphia	Ph:  215-955-6084
	MNAP Oncologic Center
		Steven DiBiase	Ph:  215-673-9260
	Sayre
	Guthrie Cancer Center at Guthrie Clinic Sayre
		Clinical Trials Office - Guthrie Cancer Center at Guthrie Clinic Sayre	Ph:  800-836-0388
	Wilkes-Barre
	Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
		Clinical Trials Office - Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center	Ph:  570-271-5251
	Wynnewood
	CCOP - Main Line Health
		Paul Gilman, MD	Ph:  610-645-2649
	Lankenau Cancer Center at Lankenau Hospital
		Paul Gilman, MD	Ph:  610-645-2000
	York
	York Cancer Center at Apple Hill Medical Center
		Amit Shah	Ph:  717-741-8180
South Carolina
	Anderson
	AnMed Cancer Center
		Clinical Trials Office - AnMed Cancer Center	Ph:  864-512-1000
	Myrtle Beach
	Carolina Regional Cancer Center
		Todd Williams, MD	Ph:  843-449-9415 877-449-9415
	Spartanburg
	CCOP - Upstate Carolina
		Clinical Trials Office - CCOP - Upstate Carolina	Ph:  800-486-5941
	Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
		Clinical Trials Office - Gibbs Regional Cancer Center	Ph:  800-486-5941
South Dakota
	Rapid City
	Rapid City Regional Hospital
		Eric Eastmo, MD	Ph:  605-719-2360
Texas
	Bedford
	Texas Oncology, PA at Harris Center HEB
		Vivek Kavadi	Ph:  817-359-9000
	Bryan
	St. Joseph Regional Cancer Center
		Scott Goble, MD	Ph:  979-774-0808
	Dallas
	Medical City Dallas Hospital
		Vivek Kavadi	Ph:  972-566-7000
	Texas Oncology, PA at Texas Cancer Center Dallas Southwest
		Vivek Kavadi	Ph:  972-709-2580
	Fort Sam Houston
	Brooke Army Medical Center
		Clinical Trials Office - Brooke Army Medical Center	Ph:  210-916-4837
	Fort Worth
	Klabzuba Cancer Center at Harris Methodist Fort Worth Hospital
		Vivek Kavadi	Ph:  817-820-4820
	Lackland AFB
	Wilford Hall Medical Center
		Michael Dullea, MD	Ph:  210-292-7100
	San Antonio
	Cancer Therapy and Research Center
		Clinical Trials Office - Cancer Therapy and Research Center	Ph:  210- 616-5798
	University of Texas Health Science Center at San Antonio
		Gregory Swanson, MD	Ph:  210-567-4777
	Sherman
	Texas Oncology, PA at Texas Cancer Center - Sherman
		Vivek Kavadi	Ph:  903-892-9455
	Sugar Land
	Texas Oncology, PA at Texas Oncology Cancer Center Sugar Land
		Vivek Kavadi	Ph:  281-277-5200
Utah
	Salt Lake City
	Huntsman Cancer Institute at University of Utah
		Clinical Trials Office - Huntsman Cancer Institute at University of Utah	Ph:  801-581-4477
			Email: clinical.trials@hci.utah.edu
Vermont
	Burlington
	Fletcher Allen Health Care - University Health Center Campus
		Clinical Trials Office - Fletcher Allen Health Care	Ph:  802-656-8990
Virginia
	Danville
	Danville Regional Medical Center
		Clinical Trials Office - Danville Regional Medical Center	Ph:  434-799-3753
	Norfolk
	Sentara Cancer Institute at Sentara Norfolk General Hospital
		Clinical Trials Office - Sentara Cancer Institute at Sentara Norfolk General Hospital	Ph:  757-388-2406
	Richmond
	Veterans Affairs Medical Center - Richmond
		Clinical Trials Office - Veterans Affairs Medical Center - Richmond	Ph:  804-675-5646
Washington
	Bremerton
	Harrison Medical Center
		Stephen Springate	Ph:  360-792-6605
Wisconsin
	Appleton
	Theda Care Cancer Institute
		Clinical Trials Office - Theda Care Cancer Institute	Ph:  920-380-1500
	La Crosse
	Franciscan Skemp Healthcare - La Crosse Campus
		Kernan Minehan, MD	Ph:  608-791-9510
	Menomonee Falls
	Community Memorial Hospital Cancer Care Center
		Colleen Lawton, MD	Ph:  414-805-4472
	Mequon
	Columbia Saint Mary's Hospital - Ozaukee
		Carl Olson, MD	Ph:  414-961-3850
	Milwaukee
	Columbia-Saint Mary's Cancer Care Center
		Clinical Trials Office - Columbia-St. Mary's Cancer Care Center	Ph:  414-326-1739
	Medical College of Wisconsin Cancer Center
		Clinical Trials Office - Medical College of Wisconsin Cancer Center	Ph:  414-805-4380
	Veterans Affairs Medical Center - Milwaukee
		Elizabeth Gore, MD	Ph:  414-805-4465
	Racine
	All Saints Cancer Center at Wheaton Franciscan Healthcare
		James Taylor, MD	Ph:  262-687-5000
Wyoming
	Sheridan
	Welch Cancer Center at Sheridan Memorial Hospital
		Benjamin Marchello, MD	Ph:  307-674-6022
Canada
Alberta
	Calgary
	Tom Baker Cancer Centre - Calgary
		Alexander Balogh	Ph:  403-521-3701
New Brunswick
	Saint John
	Saint John Regional Hospital
		John Carson, MD	Ph:  506-648-6884
Nova Scotia
	Halifax
	Nova Scotia Cancer Centre
		Derek Wilke	Ph:  902-473-6000
Ontario
	Hamilton
	Margaret and Charles Juravinski Cancer Centre
		Ian Dayes	Ph:  905-387-9495
	London
	London Regional Cancer Program at London Health Sciences Centre
		Glenn Bauman	Ph:  519-685-8615
	Ottawa
	Ottawa Hospital Regional Cancer Centre - General Campus
		Shawn Malone	Ph:  613-737-7700 ext. 70209 888-627-5346
	Sudbury
	Northeastern Ontario Regional Cancer Centre
		Randall Bissett	Ph:  705-522-6237
	Thunder Bay
	Cancer Care Program at Thunder Bay Regional Health Sciences
		Sunil Premial Gulavita	Ph:  807-684-7200
Quebec
	Montreal
	Hopital Notre-Dame du CHUM
		Carole Lambert	Ph:  514-281-6000
	McGill Cancer Centre at McGill University
		Sergio Faria	Ph:  514-398-1444
	Quebec City
	Centre Hospitalier Universitaire de Quebec
		Lucie Blondeau	Ph:  418-525-4444
Saskatchewan
	Regina
	Allan Blair Cancer Centre at Pasqua Hospital
		Evgeny Sadikov	Ph:  306-766-2203
	Saskatoon
	Saskatoon Cancer Centre at the University of Saskatchewan
		Iain MacLennan	Ph:  306-655-2662