Project Number: 3635-31320-008-12
Project Type: Trust

Start Date: Feb 01, 2008
End Date: Sep 30, 2009

Objective:
1. Evaluation of whether the proposed integrative genomics approach is feasible and determination of the associated costs. 2. Determine whether differential gene expression might account for variation in MD incidence observed within and between commercial pure lines. 3. A list of genes and biological pathways associated with response to MDV challenge. 4. Determination of sequence variation within and between lines for ~200 genes that are differentially-expressed with respect to response to Marek¿s disease virus challenge. 5. Determination of MD incidence in two commercial pure lines under controlled conditions.

Approach:
Using MDV, identify genes that show allele-specific expression following MDV challenge, which also serves as a model for our integrative genomic approach to rapidly identify causative genes for complex traits.