| 01R25 |
RFM/UnN
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| Origin: |
To N from Oak Ridge National Laboratories, 1980. |
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| Diseases |
| Neoplastic (Spontaneous): |
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- Neoplastic diseases occurred in 88% of aging virgin females:
reticulum cell sarcoma (67%) and lung tumors (26%) were most common;
thymic lymphomas (8%), pituitary adenomas (7%), and Harderian gland
tumors (3%) were the only other tumors with an incidence greater
than 1%; mammary tumors were absent. (108)
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| Neoplastic (Induced): |
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- Murine myeloid leukemia was serially passaged by spleen cell
inoculation to provide a possible model for human acute myelocytic
leukemia; the original cell donor developed leukemia after irradiation.
Leukemic cells obtained early in the course of the disease were
less malignant than those obtained from preterminal mice. The
leukemia was most sensitive to alkytlating agents, but also responsive
to antimetabolites. (554)
- Antilymphocyte globulin administration reduced the incidence
and increased the latency of lymphomas induced by whole body
irradiation. (033)
- Corynebacterium parvum inoculation prolonged the
survival of RFM mice bearing myeloid leukemia induced by leukemia
cell
passage. Silica abrogated the effects
of C. parvum, and polyvinyl pyridine-N-oxide prevented the inhibitory effects
of silica, indicating a critical role for macrophages. (062)
- Tumors were induced more effectively with neutrons than with
gamma rays. Gamma rays increased the incidence of thymic lymphoma
and ovarian tumors,
but the
incidence of reticulum cell sarcoma and lung adenoma decreased. Neutron
irradiation effects
were similar, but lung adenomas were increased. (744)
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| Non-Neoplastic (Spontaneous): |
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- Glomerulosclerosis was found in almost all aging virgin females
and was severe in 90%; uterine hyperplasia (87%), mammary hyperplasia
(39%), adrenal cortical atrophy (52%), auricular thrombosis (35%),
hemopoietic hyperplasia (33%), arteriosclerosis (21%), and fatty
liver (21%) were the other diseases of moderate to high frequency.
(108)
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| Non-Neoplastic (Induced): |
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- A fatal host versus graft syndrome characterized by depletion
of peripheral T lymphocytes was initiated by perinatal inoculations
of (T6 X RFM)F1 spleen cells. The syndrome may serve as a model
for immunodeficiency syndromes of Nezelof type. (248)
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