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The Cancer Chromosome Aberration Project (CCAP)
What is CCAP?
The Cancer Chromosome Aberration Project (CCAP) is a CGAP Initiative designed to develop a
set of "tools" to define and characterize the distinct
chromosomal alterations that are associated with malignant transformation.
Both the National Cancer Institute and the National Center for Biotechnology
Information (NCBI) support the project.
Why CCAP?
Identifying chromosomal abnormalities can be useful to the clinician,
enabling the diagnosis, classification, and
treatment selection of a given cancer.
The Goals of CCAP
- To integrate the cytogenetic (defined at the level of an entire
chromosome) and physical (structural) maps of the human genome.
- To generate a clone repository of genetically and physically mapped
sequence ready DNA *BAC (bacterial artificial chromosome) clones
at a resolution of 1-2 Mb across the human genome.
- To develop a FISH-mapped BAC clone database to provide
a platform for correlation with parallel databases of cancer-associated
chromosome aberrations and clinical, histopathologic information.
- To refine the descriptive nomenclature that
defines karyotypic aberrations (insertions,
amplifications, deletions, and translocations) in cancer cells. This
refinement is designed to supplement and complement
conventional descriptions of chromosomes based on "banding"
patterns by integrating and formatting the
three data streams of state-of-the-art cytogenetic analyses:
- Spectral
karyotyping (SKY)
- Comparative genomic hybridization
(CGH)
- Fluorescent in situ hybridization (FISH).
* BAC clones provide valuable tools for mapping studies because they
contain large inserts of human DNA and can be fluorescently labeled
to allow localization of genes and identification of regions
involved in cancer chromosomal aberrations.
Go to the BAC to Chromosome Map Viewer.
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