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Editor-in-Chief Melissa Norton, MD
Biology Editor Penelope Webb, PhD
In-house Editor Matthew Kaiser
Welcome to BMC Chemical Biology published by BioMed Central
BMC Chemical Biology is an open access journal publishing original peer-reviewed research articles in the application of chemistry to the investigation of biology and drug design.
BMC Chemical Biology (ISSN 1472-6769) is indexed/tracked/covered by PubMed, BIOSIS, CAS, Scopus, EMBASE and Google Scholar.
BMC Chemical Biology 2009, 9 :4
The effect of different drugs on metabolic interaction networks varies in scope from localized to systemic, supporting the use of a system-wide approach when exploring drug actions.
BMC Chemical Biology 2009, 9 :3
New synthetic analogs of cyclic AMP (cAMP) can be used for affinity enrichment and purification of cAMP-dependent protein kinase (PKA) and other cAMP binding proteins and also have potential for other applications in chemical proteomics.
BMC Chemical Biology 2009, 9 :1
The discovery of a novel catalytic inhibitor of human topoisomerase II ATPase activity, quinonoline aminopurine compound 1 (QAP1), demonstrates the potential for the development of anti-cancer drugs utilizing this mechanism.
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Research article
Local and global modes of drug action in biochemical networks Jean-Marc Schwartz, Jose C Nacher BMC Chemical Biology 2009, 9 :4 (7 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Methodology article
Chemical tools selectively target components of the PKA system Daniela Bertinetti, Sonja Schweinsberg, Susanne E Hanke, Frank Schwede, Oliver Bertinetti, Stephan Drewianka, Hans-Gottfried Genieser, Friedrich W Herberg BMC Chemical Biology 2009, 9 :3 (12 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus John Paul Pezacki, Selena M Sagan, Angela M Tonary, Yanouchka Rouleau, Sylvie B BMC Chemical Biology 2009, 9 :2 (16 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue Patrick Ch BMC Chemical Biology 2009, 9 :1 (7 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Chemogenetic fingerprinting by analysis of cellular growth dynamics Jonas Warringer, Dragi Anevski, Beidong Liu, Anders Blomberg BMC Chemical Biology 2008, 8 :3 (22 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II Maria H BMC Chemical Biology 2008, 8 :2 (1 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Identification of cellular pathways affected by Sortin2, a synthetic compound that affects protein targeting to the vacuole in Saccharomyces cerevisiae Lorena Norambuena, Jan Zouhar, Glenn R Hicks, Natasha V Raikhel BMC Chemical Biology 2008, 8 :1 (7 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Enhancement of intracellular Yuichiro Tanaka, Leslie A Lesoon Wood, Robert V Cooney BMC Chemical Biology 2007, 7 :2 (3 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
The effect of amino acid deletions and substitutions in the longest loop of GFP Gabriela Flores-Ram BMC Chemical Biology 2007, 7 :1 (26 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Studies on the synthesis, characterization, binding with DNA and activities of two cis -planaramineplatinum(II) complexes of the form: cis -PtL(NH3 )Cl2 where L = 3-hydroxypyridine and 2,3-diaminopyridine Ahmed Abdullah, Fazlul Huq, Ashraf Chowdhury, Hasan Tayyem, Philip Beale, Keith Fisher BMC Chemical Biology 2006, 6 :3 (13 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Herbal therapy associated with antibiotic therapy: potentiation of the antibiotic activity against methicillin - resistant Staphylococcus aureus by Turnera ulmifolia L. Henrique DM Coutinho, Jose GM Costa, Edeltrudes O Lima, Vivyanne S Falcao-Silva, Jose P Siqueira-Junior BMC Complementary and Alternative Medicine 2009, 9 :13 (8 [Abstract ] [Provisional PDF ]
Research article
The cytochrome P450 (CYP) gene superfamily in Daphnia pulex William S Baldwin, Peter B Marko, David R Nelson BMC Genomics 2009, 10 :169 (21 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Small molecule inhibitors of the Yersinia type III secretion system impair the development of Chlamydia after entry into host cells Sandra Muschiol, Staffan Normark, Birgitta Henriques-Normark, Agathe Subtil BMC Microbiology 2009, 9 :75 (21 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Charge effect on the photoinactivation of Gram-negative and Gram-positive bacteria by cationic meso -substituted porphyrins Eliana Alves, Liliana Costa, Carla MB Carvalho, Jo BMC Microbiology 2009, 9 :70 (15 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Methodology
Proteomic analysis of phosphoproteins sensitive to a phosphatidylinositol 3-kinase inhibitor, ZSTK474, by using SELDI-TOF MS Tetsuyuki Akashi, Takao Yamori Proteome Science 2009, 7 :14 (31 [Abstract ] [Full Text ] [PDF ] [PubMed ] [Related articles ]
Research article
Photo-activation of the hydrophobic probe iodonaphthylazide in cells alters membrane protein function leading to cell death Mathias Viard, Himanshu Garg, Robert Blumenthal, Yossef Raviv BMC Cell Biology 2009, 10 :21 (26 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research
Caveolin-1 enhances resveratrol-mediated cytotoxicity and transport in a hepatocellular carcinoma model Hui-ling Yang, Wei-qiong Chen, Xuan Cao, Andrea Worschech, Li-fen Du, Wei-yi Fang, Yang-yan Xu, David F Stroncek, Xin Li, Ena Wang, Francesco M Marincola Journal of Translational Medicine 2009, 7 :22 (25 [Abstract ] [Full Text ] [PDF ] [PubMed ] [Related articles ]
Review
Applicability of non-invasively collected matrices for human biomonitoring Roel Smolders, Karl-Werner Schramm, Marc Nickmilder, Greet Schoeters Environmental Health 2009, 8 :8 (9 [Abstract ] [Full Text ] [PDF ] [PubMed ] [Related articles ]
Methodology article
Using multiplexed regulation of luciferase activity and GFP translocation to screen for FOXO modulators Fabian Zanella, Aranzaz BMC Cell Biology 2009, 10 :14 (25 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research
Spatiotemporal expression of histone acetyltransferases, p300 and CBP, in developing embryonic hearts Guozhen Chen, Jing Zhu, Tiewei Lv, Gang Wu, Huichao Sun, Xupei Huang, Jie Tian Journal of Biomedical Science 2009, 16 :24 (23 [Abstract ] [Full Text ] [PDF ] [PubMed ] [Related articles ]
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