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CloseVolumes 1301 - 1304 (2007)
 You are entitled to access the full text of this documentVolume 1304 - selected
pp. 1-428 (1 November 2007)
The Interdisciplinary Conference on Tryptophan and Related Substances: Chemistry, Biology, and Medicine. Proceedings of the Eleventh Triennial Meeting of International Study Group for Tryptophan Research (ISTRY-2006 Tokyo) Sanjyo-Kaikan Conference Hall, The University of Tokyo, 4-7 July, 2006
 You are entitled to access the full text of this documentVolume 1303
pp. 1-176 (August 2007)
The metabolic syndrome: the road map from inflammation to cardiovascular disease. Proceedings of the 9th European symposium on Metabolism held in Padua, Italy, between 12 and 14 October 2006
 You are entitled to access the full text of this documentVolume 1302
pp. 1-168 (June 2007)
Molecular Biology and Pharmacology of Tissue Repair. Proceedings of the Esteve Foundation Symposium 12, held between 4 and 7 October 2006, S'Agaró (Girona), Spain
 You are entitled to access the full text of this documentVolume 1301
pp. 1-310 (July 2007)
Brain-Inspired IT III. Invited and selected papers of the 3rd International Conference on Brain-Inspired Information Technology “BrainIT 2006” held in Hibikino, Kitakyushu, Japan between 27 and 29 September 2006
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The Interdisciplinary Conference on Tryptophan and Related Substances: Chemistry, Biology, and Medicine. Proceedings of the Eleventh Triennial Meeting of International Study Group for Tryptophan Research (ISTRY-2006 Tokyo) Sanjyo-Kaikan Conference Hall, The University of Tokyo, 4-7 July, 2006
Edited by Katsuji Takai
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Editorial Board
Page iii
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Organ members (international/local)
Pages v-vii
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Acknowledgements
Page ix
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Interdisciplinary tryptophan research and its coherence in 2006
Pages xi-xvi
Katsuji Takai
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Contents
Pages xvii-xxiii
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 Updates on Chemistry of Indoles and Aromatic Metabolites Therefrom
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Indole, the aromatic element of tryptophan, as a pi-donor and amphiphilic headgroup
Pages 1-14
George W. Gokel
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 Structure and Dynamics of Ion Channels in the Membrane: Roles of Typtophan Residues
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The role of tryptophan cation–pi interactions on ammonia transport through the AmtB ammonia channel
Pages 15-21
William E.C. Harries, Shahram Khademi, Robert M. Stroud
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 Modified Tryptophan Residues by Reactive Nitrogen Species: 6-Nitro-tryptophan in Proteins
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Formation of 6-nitrotryptophan in purified proteins by reactive nitrogen species: A possible new biomarker
Pages 22-32
Fumiyuki Yamakura, Keiichi Ikeda, Takashi Matsumoto, Hikari Taka, Naoko Kaga
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Proteomic analysis of 6-nitrotryptophan-containing proteins in peroxynitrite-treated PC12 cells
Pages 33-40
Keiichi Ikeda, Hideaki Iwai, Takashi Matsumoto, Reiko Mineki, Hikari Taka, Kenji Takamori, Hideoki Ogawa, Fumiyuki Yamakura
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Post-translational modification of indoleamine 2,3-dioxygenase: N-terminal modification and nitration
Pages 41-45
Hidetsugu Fujigaki, Kanako Takahashi, Suwako Fujigaki, Junichi Masuda, Osamu Takikawa, Sanford P. Markey, Mitsuru Seishima, Kuniaki Saito
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 Natural Products from Tryptophan with Pharmacological Implications and Their Stereospecific Syntheses
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Variety of natural products derived from tryptophan and stereoselective synthesis of tetrahydro-β-carboline derivatives of pharmacological importance
Pages 46-59
Piotr Roszkowski, Stefan Czarnocki, Jan K. Maurin, Aleksandra Siwicka, Anna Zawadzka, Joanna Szawkało, Andrzej Leniewski, Zbigniew Czarnocki
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 The Bis-indole Indirubins: From Indigo Plant to Clinic
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Diversity of the intracellular mechanisms underlying the anti-tumor properties of indirubins
Pages 60-74
Laurent Meijer, Jessica Shearer, Karima Bettayeb, Yoan Ferandin
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 Tryptophan Permeases: A New Paradigm of Tryptophan
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Regulation and dynamics of yeast tryptophan permeases studied using hydrostatic pressure
Pages 75-84
Fumiyoshi Abe
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 Structural Biology of a Tryptophan-Ring Cleavage Enzyme
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X-ray structure and reaction mechanism of human indoleamine 2,3-dioxygenase
Pages 85-97
Hiroshi Sugimoto, Shun-ichiro Oda, Takashi Otsuki, Keiko Yotsuya, Tomoya Hino, Tadashi Yoshida, Yoshitsugu Shiro
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 Serotonin Neurons as Highly Complex Systems with Multi-Modal Nature
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Comparison of projections of the dorsal and median raphe nuclei, with some functional considerations
Pages 98-120
Robert P. Vertes, Stephanie B. Linley
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 Updates on the Nature and Nurture of Violence, and Possible Involvement of Tryptophan-Serotonin Axis
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Aetiology of antisocial behaviour
Pages 121-132
Essi Viding, Henrik Larsson
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The effect of tryptophan on quarrelsomeness, agreeableness, and mood in everyday life
Pages 133-143
Simon N. Young, Marije aan het Rot, Gilbert Pinard, Debbie S. Moskowitz
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The role of serotonin in risky choice and the acquisition of reciprocal cooperative behaviour: 2 investigations using tryptophan depletion
Pages 144-149
Robert D. Rogers
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 Systemic Tryptophan Depletion
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Tryptophan metabolism via serotonin in human CSF of different brain sites using a new neuroendoscopic technique
Pages 150-158
P. Longatti, S. Comai, A. Perin, A. Bertazzo, V. Rizzo, E. Ragazzi, C.V.L. Costa, G. Allegri
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The acute tryptophan depletion and loading tests: Specificity issues
Pages 159-166
Abdulla A.-B. Badawy, Christopher J. Morgan, Donald M. Dougherty, Dawn M. Marsh, Charles W. Mathias, Ashley A. Jagar, Meredith A. Addicott, F. Gerard Moeller
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Relationship between serum kynurenine concentration and exercise performance
Pages 167-170
Yasuhiro Itoh, Reiko Yonekura, Chiharu Kobayashi, Kuniaki Saito, Yoshito Oguri, Kaoru Kawai, Ryoji Teradaira, Yoichi Nagamura
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Characterization of tryptophan–niacin metabolism in rats fed with an excessive tryptophan diet
Pages 171-174
A. Okuno, T. Fukuwatari, R. Sasaki, K. Shibata
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Mental stress-induced changes in plasma serotonin, tryptophan, kynurenine concentrations in healthy participants
Pages 175-179
R. Teradaira, Y. Itoh, K. Kawai, H. Ishikawa, K. Ohashi, Y. Nagamura
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The effects of dietary tryptophan metabolism on the “vigor” and “confusion” factor of mood
Pages 180-183
Reiko Yonekura, Yasuhiro Itoh, Masami Asayama, Katsumi Shibata
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 Biochemistry and Molecular Biology of Tryptophan Metabolism
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Phthalate esters enhance quinolinate production by inhibiting amino-carboxymuconate-semialdehyde decarboxylase (ACMSD), a key enzyme of the tryptophan-niacin pathway
Pages 184-194
K. Shibata, T. Fukuwatari, R. Sasaki
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Dietary fat and peroxisome-proliferators affect production of quinolinate in rats, accompanied with suppression of gene expression of α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD)
Pages 195-199
Yukari Egashira, Hiroyuki Hashimato, Kuniaki Saito, Hiroo Sanada
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Up-regulation of indoleamine 2,3-dioxygenase by lipopolysaccharide is regulated through activation of p38 mitogen-activated protein kinase and nuclear factor-κB
Pages 200-204
Suwako Fujigaki, Kanako Takahashi, Hidetsugu Fujigaki, Masao Takemura, Mitsuru Seishima, Kuniaki Saito
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Trichloroacetic acid-triggered reaction of kynurenine with nitrite produced by bone marrow-derived myeloid dendritic cells stimulated with CpG
Pages 205-208
Toshiaki Hara, Rie Hiramatsu, Hidetoshi Akimoto, Osamu Takikawa, Tsutomu Kawabe, Fumihiko Nagase
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Enhancement of 3-hydroxyanthranilic acid-induced T cell apoptosis through cinnabarinic acid generation
Pages 209-212
Rie Hiramatsu, Toshiaki Hara, Hidetoshi Akimoto, Osamu Takikawa, Tsutomu Kawabe, Fumihiko Nagase
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Characterization of the kynurenine pathway in human oligodendrocytes
Pages 213-217
Chai K. Lim, George A. Smythe, Roland Stocker, Bruce J. Brew, Gilles J. Guillemin
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Down-regulation of α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase by polyunsaturated fatty acids in hepatocytes is not mediated by PPARα
Pages 218-221
Naho Sasaki, Yukari Egashira, Hiroo Sanada
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Peroxisome proliferators-activated receptor α controls tryptophan-NAD metabolism in rodents
Pages 222-226
M. Shin, C. Umezawa, K. Sano, F.J. Gonzalez
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Non-protein (free and protein-bound) tryptophan content in cereal and legume seed flours
Pages 227-232
S. Comai, A. Bertazzo, L. Bailoni, M. Zancato, C.V.L. Costa, G. Allegri
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 Implications of Tryptophan Catabolism in Default Modes and Pathologies
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The mouse epididymis: A site of strong and constitutive expression of the tryptophan metabolizing enzyme indoleamine 2,3-dioxygenase (IDO)
Pages 233-240
Shigenobu Toné, Aurore Britan, Aicha Jrad, Violette Maffre, Joël R. Drevet
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Tryptophan metabolism and non-hypoxic induction of hypoxia-inducible factor (HIF)
Pages 241-249
P. Fardin, M.B Manzari, A. Petretto, A. Ricciardi, L. Varesio
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Differential targeting of tryptophan catabolism in tumors and in tumor-draining lymph nodes by stereoisomers of the IDO inhibitor 1-methyl-tryptophan
Pages 250-261
Alexander J. Muller, Richard Metz, George C. Prendergast
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Ido serves as a marker of poor prognosis in gene expression profiles of serous ovarian cancer cells
Pages 262-273
Aikou Okamoto, Takashi Nikaido, Kazunori Ochiai, Satoshi Takakura, Miho Takao, Misato Saito, Yuko Aoki, Nobuya Ishii, Nozomu Yanaihara, Kyosuke Yamada, Osamu Takikawa, Rie Kawaguchi, Seiji Isonishi, Tadao Tanaka, Mitsuyoshi Urashima
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Tumoral immune resistance based on tryptophan degradation by indoleamine 2,3-dioxygenase
Pages 274-277
B.J. Van den Eynde, I. Théate, C. Uyttenhove, D. Colau, L. Pilotte, V. Stroobant
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The role of tryptophan and its derivatives for development of malaria parasite in vector mosquito
Pages 278-285
Hiroyuki Matsuoka, Meiji Arai, Hajime Yoshida, Ryuta Hattori, Yuichi Kasahara, Makoto Hirai
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Induction of indoleamine 2,3-dioxygenase in small intestine of mouse infected with parasitic helminth, Hymenolepis nana
Pages 286-289
F. Ohyama, S. Tone, T. Okamoto, K. Shimoda, Y. Minatogawa
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Clinical aspects of indoleamine 2,3-dioxygenase (IDO)-initiated tryptophan metabolism: IDO is a target of drug discovery for various diseases
Pages 290-297
O. Takikawa
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 Tryptophan-Kynurenine Pathway in the Central Nervous System and Periphery
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Pharmacology of the kynurenine pathway
Pages 298-304
Trevor W. Stone, L. Gail Darlington
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Kynurenic acid actions in brain and periphery
Pages 305-313
F. Moroni, S. Fossati, A. Chiarugi, A. Cozzi
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Inhibition of increased indoleamine 2,3-dioxygenase activity exacerbates neuronal cell death in various CNS disorders
Pages 314-323
Hidetsugu Fujigaki, Kuniaki Saito
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Chronic HIV infection leads to an Alzheimer's disease like illness. Involvement of the kynurenine pathway
Pages 324-334
Gilles J. Guillemin, Bruce J. Brew
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 Clinical Chemistry of Tryptophan Metabolism and Animal Models
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Assessment of the kynurenine pathway in humans: I. Normal plasma values, ethnic differences and their clinical implications
Pages 335-343
Abdulla A.-B. Badawy, Christopher J. Morgan, Jennifer A. Turner, Donald M. Dougherty, Dawn M. Marsh, Charles W. Mathias, Meredith A. Addicott, Ashley A. Jagar
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Tryptophan metabolites as potent inhibitors of aldehyde dehydrogenase activity and potential alcoholism-aversion therapeutic agents
Pages 344-351
Abdulla A.-B. Badawy, Christopher J. Morgan
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Down-regulation of the indoleamine 2,3-dioxygenase (IDO) transcription by tryptophan analogues
Pages 352-356
Takeaki Okamoto, Shigenobu Toné, Hiroaki Kanouchi, Fumio Ohyama, Yohsuke Minatogawa
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Up-regulation of the brain indoleamine 2,3-dioxygenase activity in a mouse model of Alzheimer's disease by systemic endotoxin challenge
Pages 357-361
Hidetoshi Akimoto, Akiko Yamada, Osamu Takikawa
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Changes in serum tryptophan during antiviral therapy with recombinant α-interferon in chronic hepatitis C
Pages 362-366
A. Bertazzo, S. Comai, L. Cavalletto, L. Chemello, S. Luise, C.V.L. Costa
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Interpretation of kynurenine pathway metabolism in osteoporosis
Pages 367-371
L. Gail Darlington, Caroline M. Forrest, Gillian M. Mackay, Lynn Oxford, Nicholas Stoy, Trevor W. Stone
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Effects of hepatic injury or kidney injury on the tryptophan–niacin metabolism in rats
Pages 372-376
Yukari Egashira, Shin Nagaki, Hiroo Sanada
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Analysis of Huntington's disease transgenic mice based on “Quinolinate Hypothesis”
Pages 377-379
T. Imai, K. Kobayashi, Y. Arii, E. Sugimoto, A. Okuno, K. Shibata, S.-I. Fukuoka
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Effect of melatonin on serum cholesterol status with formation of alpha-naphthylisothiocyanate-induced liver injury in rats
Pages 380-383
Yoshiji Ohta, Yoichiro Imai, Akira Kitagawa
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Effect of quinolinic acid on gene expression in human astrocytes: Implications for Alzheimer's disease
Pages 384-388
Ka Ka Ting, Bruce J. Brew, Gilles J. Guillemin
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 Analytical Chemistry
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Advancements in the rapid and sensitive analyses of tryptophan and its metabolites, by chromatography
Pages 389-403
Ibolya Molnár-Perl
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Mass spectrometric detection of quinolinic acid in microdissected Alzheimer's disease plaques
Pages 404-408
Gilles J. Guillemin, Bruce J. Brew, Claire E. Noonan, Toby G. Knight, George A. Smythe, Karen M. Cullen
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Hemin-mediated fluorometric determination of melatonin by high-performance liquid chromatography
Pages 409-414
H. Iizuka, K. Someya, T. Yajima
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Rapid, simple and simultaneous measurement of kynurenine and tryptophan in plasma by column switching-HPLC method
Pages 415-419
K. Kawai, H. Ishikawa, K. Ohashi, Y. Itoh, R. Teradaira
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Author Index
Pages 421-423
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Keyword Index
Pages 425-428
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