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| Annual Reports in Medicinal Chemistry Page iii ![]() |
| Copyright page Page iv ![]() |
| Contributors Page xiii ![]() |
| Preface Pages xv-xvi ![]() |
Part I: Central Nervous System Diseases
| Chapter 1 Recent Advances in Corticotropin-Releasing Factor Receptor Antagonists Pages 3-23 Carolyn D. Dzierba, Richard A. Hartz, Joanne J. Bronson ![]() |
| Chapter 2 Recent Advances on the 5-HT5A, 5-HT6 and 5-HT7 Receptors Pages 25-42 Brock T. Shireman, Pascal Bonaventure, Nicholas I. Carruthers ![]() |
| Chapter 3 Recent Advances in Voltage-Gated Sodium Channel Blockers: Therapeutic Potential as Drug Targets in the CNS Pages 43-60 Andreas Termin, Esther Martinborough, Dean Wilson ![]() |
| Chapter 4 Medication Development for the Treatment of Substance Abuse Pages 61-72 Brian S. Fulton ![]() |
Part II: Cardiovascular and Metabolic Diseases
| Chapter 5 GPR40 (FFAR1) Modulators Pages 75-85 Julio C. Medina, Jonathan B. Houze ![]() |
| Chapter 6 Rho-Kinase Inhibitors for Cardiovascular Disease Pages 87-102 Robert A. Stavenger ![]() |
| Chapter 7 LXR Agonists for the Treatment of Atherosclerosis: Recent Highlights Pages 103-117, 565-566 Jonathan Bennett, Andrew Cooke, Heather J. McKinnon, Olaf Nimz ![]() |
| Chapter 8 Glucagon Receptor Antagonists for Type II Diabetes Pages 119-137 Duane E. DeMong, Michael W. Miller, Jean E. Lachowicz ![]() |
Part III: Inflammation/Pulmonary/GI
| Chapter 9 Advances Toward Dissociated Non-Steroidal Glucocorticoid Receptor Agonists Pages 141-154 John Regan, Hossein Razavi, David Thomson ![]() |
| Chapter 10 Advances in the Discovery of IκB Kinase Inhibitors Pages 155-170 William J. Pitts, James Kempson ![]() |
| Chapter 11 Protease Inhibitors for the Potential Treatment of Chronic Obstructive Pulmonary Disease and Asthma Pages 171-185 Weimin Liu, Eugene R. Hickey ![]() |
Part IV: Oncology
| Chapter 12 mTOR Inhibitors in Oncology Pages 189-202 Jeroen Verheijen, Ker Yu, Arie Zask ![]() |
| Chapter 13 Oncology Drug Targets in the Sphingomyelin-Signaling Pathway Pages 203-226 William Garland, Amy Cavalli, Geneviève Hansen ![]() |
Part V: Infectious Diseases
| Chapter 14 Inhibitors of Respiratory Syncytial Virus Pages 229-245, 567-569 Malcolm Carter, G. Stuart Cockerill ![]() |
| Chapter 15 Recent Developments in β-Lactamases and Inhibitors Pages 247-267 Tarek S. Mansour, Patricia A. Bradford, Aranapakam M. Venkatesan ![]() |
| Chapter 16 Recent Development in the Treatment of Clostridium difficile Associated Disease (CDAD) Pages 269-279 Xicheng Sun, Joseph Guiles, Nebojsa Janjic ![]() |
| Chapter 17 Recent Advances in the Discovery of Hybrid Antibacterial Agents Pages 281-290 Michael R. Barbachyn ![]() |
Part VI: Topics in Biology
| Chapter 18 Recent Renaissance of Prostaglandin Research Pages 293-309 Robert M. Burk ![]() |
| Chapter 19 Human Exposure and Dose Projections Pages 311-328 Punit H. Marathe, Christine Huang, A. David Rodrigues ![]() |
| Chapter 20 Modeling Networks of Glycolysis, Overall Energy Metabolism and Drug Metabolism under a Systems Biology Approach Pages 329-349 Zoltán Sarnyai, László G. Boros ![]() |
Part VII: Topics in Drug Design and Discovery
| Chapter 21 Contrasting the Gastrointestinal Tracts of Mammals: Factors that Influence Absorption Pages 353-371 John M. DeSesso, Amy Lavin Williams ![]() |
| Chapter 22 The Emerging Utility of Co-Crystals in Drug Discovery and Development Pages 373-404 Nicholas A. Meanwell ![]() |
| Chapter 23 Pregnane X Receptor: Prediction and Attenuation of Human CYP3A4 Enzyme Induction and Drug–Drug Interactions Pages 405-418 Michael W. Sinz ![]() |
| Chapter 24 Formulation in Drug Discovery Pages 419-451 Robert G. Strickley ![]() |
Part VIII: Trends and Perspectives
| Chapter 25 To Market, To Market — 2007 Pages 455-497 Shridhar Hegde, Michelle Schmidt ![]() |
| Compound Name, Code Number and Subject Index, Volume 43 Pages 499-504 ![]() |
| Cumulative Chapter Titles Keyword Index, Volume 1–43 Pages 505-523 ![]() |
| Cumulative Nce Introduction Index, 1983–2007 Pages 525-544 ![]() |
| Cumulative Nce Introduction Index, 1983–2007 (By Indication) Pages 545-564 ![]() |
articles 1 - 33 |