![](https://webarchive.library.unt.edu/eot2008/20090512223551im_/http://cognet.mit.edu/shared/images/wasterlain.jpg)
April 2006
ISBN 0-262-23245-6
8.5 x 11, 649 pp., 196 illus.
12-page color insert
$135.00/£87.95 (CLOTH)
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Status Epilepticus, Mechanisms and Management
Edited by Claude G. Wasterlain and David M. Treiman
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Interest in status epilepticus--the most extreme form of epilepsy, involving continuous seizures--has surged in the last 20 years. The book focuses on the two areas in which progress has been most rapid: basic mechanisms and treatment. After an overview of history, classification, and epidemiology, the contributors consider clinical phenomenology, biological markers, pathophysiology, brain damage, epileptogenesis, therapeutic principles, pharmacology, and therapeutic management.
Claude G. Wasterlain is Chief of the Department of Neurology at the West Los Angeles VA Medical Center and Distinguished Professor and Vice Chair of the Department of Neurology at UCLA.
David M. Treiman is Director of the Epilepsy Center at the Barrow Neurological Institute at St. Joseph's Hospital and Medical Center, Phoenix.
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Table of Contents |
| Abstract |
| Preface |
I. | STATUS EPILEPTICUS: HISTORY, DEFINITION, CLASSIFICATION, AND EPIDEMIOLOGY |
| 1. | Historical Overview
Brian S. Meldrum
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| 2. | Definition and Classification of Status Epilepticus
Claude G. Wasterlain and James W. Chen
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| 3. | Incidence and Causes of Status Epilepticus
Robert J. DeLorenzo
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| 4. | Prognosis after a First Episode of Status Epilepticus
Giancarlo Logroscino, Dale C. Hesdorffer, and W. Allen Hauser
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| 5. | Epidemiology of Childhood Status Epilepticus
Shlomo Shinnar
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II. | STATUS EPILEPTICUS: CLINICAL PHENOMENOLOGY |
| 6. | Generalized Convulsive Status Epilepticus
David M. Treiman
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| 7. | Simple and Complex Partial Status Epilepticus
Pierre Thomas, Benjamin Zifkin, and Frederick Andermann
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| 8. | Absence Status
Pierre Thomas, Benjamin Zifkin, and Frederick Andermann
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| 9. | The Two Faces of Electrographic Status Epilepticus: The Walking Wounded and the Ictally Comatose
Denson G. Fujikawa
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| 10. | Status Epilepticus in Infancy and Childhood
Joyce Y. Wu, Susan Koh, and Raman Sankar
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| 11. | Nonconvulsive Status Epilepticus in Children: With Special Reference to Electrical Status Epilepticus During Slow-Wave Sleep Syndrome (ESES Syndrome)
Shunsuke Ohtahara, Yasuko Yamatogi, Katsuhiro Kobayashi, and Naohiro Nishibayashi
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| 12. | Status Epilepticus in the Neonate
Eli M. Mizrahi
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III. | STATUS EPILEPTICUS: BIOLOGICAL MARKERS |
| 13. | Physiologic Responses to Status Epilepticus
Roger P. Simon
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| 14. | Clinical Neuropathology in Convulsive Status Epilepticus
Heinz-Joachim Meencke and Gerhard Veith
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| 15. | Neuron-Specific Enolase in Status Epilepticus
Christopher M. DeGiorgio, Adrian L. Rabinowicz, Jorge Correale, Christi Norton Heck, Peggy S. Gott, and Steven Schreiber
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| 16. | Brain Imaging in Status Epilepticus
Thomas R. Henry
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IV. | BASIC MECHANISMS: PATHOPHYSIOLOGY |
| 17. | Self-Sustaining Status Epilepticus
Andrey M. Mazarati, Hantao Liu, David E. Naylor, Lucie Suchomelová, Kerry W. Thompson, Anne Pereira de Vasconselos, Raman Sankar, Astrid Nehlig, and Claude G. Wasterlain
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| 18. | Pathophysiology of Seizure Circuitry in Status Epilepticus
Dan C. McIntyre, Mary Ellen Kelly, and William A. Staines
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| 19. | Neuroanatomy of Status Epilepticus
Adrian Handforth
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| 20. | Role of GABAA Receptors in Status Epilepticus
Robert L. Macdonald and Jaideep Kapur
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| 21. | Physiologic Mechanisms of Inhibition and Status Epilepticus
Igor Spigelman
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| 22. | Glutamate and Glutamate Receptors in Status Epilepticus
Astrid G. Chapman and Brian S. Meldrum
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| 23. | Metabotropic Receptors in Status Epilepticus
Brian S. Meldrum
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| 24. | The Role of Adenosine in Status Epilepticus
Deborah Young and Michael Dragunow
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V. | BASIC MECHANISMS: BRAIN DAMAGE |
| 25. | Excitotoxicity in Status Epilepticus
Luiz E. A. M. Mello, Luciene Covolan, Clement Hamani, and Ricardo Luis Smith
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| 26. | Seizure-Induced Damage in the Immature Brain: Overcoming the Burden of Proof
Kerry W. Thompson and Raman Sankar
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| 27. | Metabolic and Circulatory Adaptations to Status Epilepticus in the Immature Brain
Astrid Nehlig and Anne Pereira de Vasconcelos
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| 28. | Excitotoxicity and Seizures in the Immature Brain
Pavel Mareš
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| 29. | Age-Specific Mechanisms of Status Epilepticus
Jana Velíšková, Rina Wu, and Solomon L. Moshé
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| 30. | Developmental Differences in Seizure Susceptibility and Hippocampal Vulnerability: Molecular Correlates
Linda K. Friedman and Ellen F. Sperber
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| 31. | Seizures and Neurotrophic Factor Expression
Harley I. Kornblum and Christine M. Gall
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| 32. | Behavioral Consequences of Status Epilepticus in the Immature Brain
Gregory L. Holmes, Roustem Khazipov, Zhao Liu, Matthew R. Sarkisian, and Carl E. Stafstrom
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VI. | BASIC MECHANISMS: EPILEPTOGENESIS |
| 33. | Late Consequences of Status Epilepticus
João Pereira Leite, Alexandre Valotta da Silva, and Esper A. Cavalheiro
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| 34. | Epileptogenic Effects of Status Epilepticus
Yukiyoshi Shirasaka, Lucie Suchomelová, Andrey M. Mazarati, and Claude G. Wasterlain
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| 35. | Hippocampal Reactive Synaptogenesis from Status Epilepticus
Gary W. Mathern
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VII. | THERAPEUTIC PRINCIPLES |
| 36. | Neuroprotective Strategies in Status Epilepticus
Denson G. Fujikawa
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| 37. | Generalized Convulsive Status Epilepticus: Principles of Treatment
Edward Faught and Christopher M. DeGiorgio
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| 38. | Therapeutic Attitudes and Therapeutic Algorithms
Claude G. Wasterlain
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| 39. | Approach to the Management of Neonatal Status Epilepticus
Hoda Z. Abdel-Hamid and Michael J. Painter
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| 40. | Management of Status Epilepticus in Infants and Children
Philippe Evrard, Alexis Arzimanoglou, Isabelle Husson, Pierre Gressens, and Raman Sankar
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VIII. | PHARMACOTHERAPY |
| 41. | Benzodiazepines for Initial Treatment of Status Epilepticus
Brian K. Alldredge
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| 42. | Phenytoin in the Treatment of Status Epilepticus
Ilo E. Leppik
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| 43. | Phenytoin and Fosphenytoin
R. Eugene Ramsay and Flavia M. Pryor
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| 44. | Phenobarbital in the Treatment of Status Epilepticus
Edward Faught
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| 45. | Valproate
Sunita Dergalust, Roi Ann Wallis, and Kimberly L. Panizzon
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| 46. | Other Pharmacologic Therapy for Refractory Status Epilepticus
Alan G. Stein and Robert S. Fisher
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IX. | THERAPEUTIC MANAGEMENT |
| 47. | Approaches to Treating Status Epilepticus Outside the Hospital
John W. Miller and Gail D. Anderson
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| 48. | The Treatment of Status Epilepticus Patients in the Emergency Setting
Edward P. Sloan
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| 49. | Critical Care of the Status Epilepticus Patient
Thomas P. Bleck
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| 50. | The Impact of Status Epilepticus on Health Care Delivery Systems: Quality of Care and Access
Barbara G. Vickrey
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| 51. | Status Epilepticus: The Future
Claude G. Wasterlain and David M. Treiman
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| Contributors |
| Index |
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