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Found 330 studies with search of: "Sirolimus"
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Rank Status Study
1 Recruiting A Dose-Ranging Clinical Study to Assess the Safety and Efficacy of Subconjunctival Injection of Sirolimus in Patients With Dry Eye in the Controlled Adverse Environmental (CAE) Model
Condition: Dry Eye
Interventions: Drug: Sirolimus;   Drug: Sirolimus;   Drug: Sirolimus;   Drug: Sirolimus
2 Recruiting Dose Ranging Study of an Ocular Sirolimus (Rapamycin) Formulation in Patients With Diabetic Macular Edema
Condition: Diabetic Macular Edema
Interventions: Drug: Sirolimus;   Drug: Placebo;   Drug: Sirolimus;   Drug: Sirolimus
3 Completed Pharmacokinetic Drug Interaction Between Ezetimibe and Sirolimus After Single Dose Administration in Healthy Subjects
Conditions: Pharmacokinetics;   Drug Interactions;   Hypercholesterolemia;   Immunosuppression
Interventions: Drug: 1 tablet Ezetrol(R) (ezetimibe), MSD Sharp & Dohme GmbH, Germany;   Drug: 1 tablet Rapamune(R) (sirolimus), Wyeth Pharma, Germany;   Drug: 1 tablet Ezetrol(R) + 1 tablet Rapamune(R)
4 Completed Oral Sirolimus for In-Stent Restenosis
Condition: Coronary Restenosis
Interventions: Drug: Sirolimus;   Drug: Sirolimus;   Drug: Placebo
5 Recruiting A Phase II Study of the mTOR Inhibitor Sirolimus in Neurofibromatosis Type 1 Related Plexiform Neurofibromas
Condition: Neurofibromatosis Type 1
Intervention: Drug: Sirolimus, Rapamycin
6 Active, not recruiting Phase 1/2 Study of an Ocular Sirolimus (Rapamycin) Formulation in Patients With Age-Related Macular Degeneration
Conditions: Age-Related Macular Degeneration;   Choroidal Neovascularization
Interventions: Drug: Sirolimus;   Drug: Sirolimus
7 Recruiting Phase 2 Study of an Ocular Sirolimus (Rapamycin) Formulation in Combination With Lucentis® in Patients With Age-Related Macular Degeneration
Conditions: Age-Related Macular Degeneration;   Choroidal Neovascularization
Interventions: Drug: Sirolimus in combination with ranibizumab;   Drug: Sirolimus in combination with ranibizumab;   Drug: Placebo in combination with ranibizumab
8 Active, not recruiting Trial of Efficacy and Safety of Sirolimus in Tuberous Sclerosis and LAM
Conditions: Tuberous Sclerosis;   Lymphangioleiomyomatosis
Intervention: Drug: sirolimus
9 Recruiting A Phase II Study of Oral Cyclophosphamide and Sirolimus (OCR) in Advanced Sarcoma
Condition: Osteosarcoma
Intervention: Drug: Cyclophosphamide and Sirolimus
10 Active, not recruiting Sirolimus (Rapamune®) for Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Condition: Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Interventions: Drug: Sirolimus;   Other: Standard
11 Recruiting Study Evaluating Conversion From Tacrolimus to Sirolimus in Stable Kidney Transplant Recipients Receiving Myfortic
Condition: Kidney Transplantation
Intervention: Drug: sirolimus
12 Recruiting Sirolimus for Autoimmune Disease of Blood Cells
Conditions: Autoimmune Cytopenias;   Autoimmune Lymphoproliferative Syndrome (ALPS);   Evans Syndrome;   Idiopathic Thrombocytopenic Purpura;   Anemia, Hemolytic, Autoimmune;   Autoimmune Neutropenia;   Lupus;   Inflammatory Bowel Disease;   Rheumatoid Arthritis
Intervention: Drug: sirolimus
13 Recruiting Pediatric Kidney Transplant Study of Sirolimus, Mycophenolate Mofetil, and Corticosteroids vs Calcineurin Inhibitor Based Immunosuppression
Condition: Renal Transplant
Intervention: Drug: Sirolimus
14 Completed Study Evaluating Sirolimus in Kidney Transplant Recipients.
Conditions: Kidney Failure;   Graft vs Host Disease
Interventions: Drug: Cyclosporine;   Drug: Steroids;   Drug: Rapamune (Sirolimus)
15 Completed Tacrolimus/Sirolimus Versus Tacrolimus/Mycophenolate Mofetil (MMF) Versus Neoral/Sirolimus in Adult, Primary Kidney Transplantation
Condition: Adult Primary Kidney Transplantation
Interventions: Drug: Tacrolimus/Sirolimus;   Drug: Tacrolimus/MMF;   Drug: Neoral/Sirolimus
16 Recruiting A Study of the mTOR Inhibitor Rapamycin (Rapamune, Sirolimus) in Combination With Abraxane in Advanced Solid Cancers
Condition: Advanced Solid Cancers
Interventions: Drug: Rapamune;   Drug: Abraxane
17 Recruiting Sirolimus/Tacrolimus Versus Tacrolimus/Methotrexate for Preventing Graft-Versus-Host Disease (GVHD)
Conditions: Leukemia, Myelocytic, Acute;   Leukemia, Lymphocytic, Acute;   Leukemia, Myeloid, Chronic;   Myelodysplastic Syndromes
Interventions: Drug: Tacrolimus/methotrexate;   Drug: Tacrolimus/sirolimus
18 Active, not recruiting Ph II Erlotinib + Sirolimus for Pts w Recurrent Malignant Glioma Multiforme
Conditions: Glioblastoma;   Gliosarcoma
Intervention: Drug: Erlotinib, Sirolimus
19 Recruiting Sirolimus in Combination With MEC in High Risk Myeloid Leukemias
Conditions: Myeloid Leukemias;   AML;   Leukemia;   CML
Interventions: Drug: Rapamycin, Mitoxantrone, Etoposide, Cytarabine;   Drug: Rapamycin + MEC
20 Active, not recruiting Multicentre 2x2 Factorial Randomised Study Comparing Tirofiban Versus Abciximab and SES Versus BMS in AMI
Condition: Myocardial Infarction
Interventions: Other: abciximab followed by implantation of bare metal stent;   Other: abciximab and Sirolimus eluting stent;   Other: tirofiban and bare metal stent;   Other: tirofiban and sirolimus-eluting stent

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