| | This journal provides immediate access to some articles. Letters The burden of proof: A response to Rosi-Marshall et al. Roger N. Beachy, Nina V. Fedoroff, Robert B. Goldberg, and Alan McHughen Proc Natl Acad Sci U S A. 2008 February 19; 105(7): E9. doi: 10.1073/pnas.0711431105.PMCID: PMC2268211 Study of Bt impact on caddisflies overstates its conclusions: Response to Rosi-Marshall et al. Wayne Parrott Proc Natl Acad Sci U S A. 2008 February 19; 105(7): E10. doi: 10.1073/pnas.0711284105.PMCID: PMC2268209 Reply to Beachy et al. and Parrott: Study indicates Bt corn may affect caddisflies Emma J. Rosi-Marshall, Jennifer L. Tank, Todd V. Royer, and Matt R. Whiles Proc Natl Acad Sci U S A. 2008 February 19; 105(7): E11. doi: 10.1073/pnas.0712192105.PMCID: PMC2268210 This Week in PNAS Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2255–2256. doi: 10.1073/iti0708105.PMCID: PMC2268119 Commentaries An emerging link between general anesthesia and sleep Ravi Allada Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2257–2258. doi: 10.1073/pnas.0711532105.PMCID: PMC2268120 Cell cycle regulation, neurogenesis, and depression Kathryn A. Cunningham and Cheryl S. Watson Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2259–2260. doi: 10.1073/pnas.0800029105.PMCID: PMC2268121 Gambling for global goods Anna Dreber and Martin A. Nowak Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2261–2262. doi: 10.1073/pnas.0800033105.PMCID: PMC2268122 Profile Profile of Richard Dixon Melissa Marino Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2263–2265. doi: 10.1073/pnas.0800273105.PMCID: PMC2268123 Physical Sciences Applied Physical Sciences Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST) Wen Ling, Ravinder R. Regatte, Gil Navon, and Alexej Jerschow Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2266–2270. doi: 10.1073/pnas.0707666105.PMCID: PMC2268124 Remote detection of nuclear magnetic resonance with an anisotropic magnetoresistive sensor F. Verpillat, M. P. Ledbetter, S. Xu, D. J. Michalak, C. Hilty, L.-S. Bouchard, S. Antonijevic, D. Budker, and A. Pines Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2271–2273. doi: 10.1073/pnas.0712129105.PMCID: PMC2268125 Chemistry Hydrophobicity of protein surfaces: Separating geometry from chemistry Nicolas Giovambattista, Carlos F. Lopez, Peter J. Rossky, and Pablo G. Debenedetti Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2274–2279. doi: 10.1073/pnas.0708088105.PMCID: PMC2268126 Electroactive controlled release thin films Kris C. Wood, Nicole S. Zacharia, Daniel J. Schmidt, Stefani N. Wrightman, Brian J. Andaya, and Paula T. Hammond Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2280–2285. doi: 10.1073/pnas.0706994105.PMCID: PMC2268127 An experimental survey of the transition between two-state and downhill protein folding scenarios Feng Liu, Deguo Du, Amelia A. Fuller, Jennifer E. Davoren, Peter Wipf, Jeffery W. Kelly, and Martin Gruebele Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2369–2374. doi: 10.1073/pnas.0711908105.PMCID: PMC2268143 A chemical method for fast and sensitive detection of DNA synthesis in vivo Adrian Salic and Timothy J. Mitchison Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2415–2420. doi: 10.1073/pnas.0712168105.PMCID: PMC2268151 Engineering From the Cover: Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers Frank Gu, Liangfang Zhang, Benjamin A. Teply, Nina Mann, Andrew Wang, Aleksandar F. Radovic-Moreno, Robert Langer, and Omid C. Farokhzad Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2586–2591. doi: 10.1073/pnas.0711714105.PMCID: PMC2268180 Physics Zero-field remote detection of NMR with a microfabricated atomic magnetometer M. P. Ledbetter, I. M. Savukov, D. Budker, V. Shah, S. Knappe, J. Kitching, D. J. Michalak, S. Xu, and A. Pines Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2286–2290. doi: 10.1073/pnas.0711505105.PMCID: PMC2268128 Biological Sciences Applied Biological Sciences From the Cover: A biodegradable and biocompatible gecko-inspired tissue adhesive Alborz Mahdavi, Lino Ferreira, Cathryn Sundback, Jason W. Nichol, Edwin P. Chan, David J. D. Carter, Chris J. Bettinger, Siamrut Patanavanich, Loice Chignozha, Eli Ben-Joseph, Alex Galakatos, Howard Pryor, Irina Pomerantseva, Peter T. Masiakos, William Faquin, Andreas Zumbuehl, Seungpyo Hong, Jeffrey Borenstein, Joseph Vacanti, Robert Langer, and Jeffrey M. Karp Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2307–2312. doi: 10.1073/pnas.0712117105.PMCID: PMC2268132 The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8 Wolf Wrasidlo, Ainhoa Mielgo, Vicente A. Torres, Simone Barbero, Konstantin Stoletov, Takashi L. Suyama, Richard L. Klemke, William H. Gerwick, Dennis A. Carson, and Dwayne G. Stupack Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2313–2318. doi: 10.1073/pnas.0712198105.PMCID: PMC2268133 Assessing the potential of mutational strategies to elicit new phenotypes in industrial strains Daniel Klein-Marcuschamer and Gregory Stephanopoulos Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2319–2324. doi: 10.1073/pnas.0712177105.PMCID: PMC2268134 Biochemistry From the Cover: Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction Kevin J. Pearson, Kaitlyn N. Lewis, Nathan L. Price, Joy W. Chang, Evelyn Perez, Maria Victoria Cascajo, Kellie L. Tamashiro, Suresh Poosala, Anna Csiszar, Zoltan Ungvari, Thomas W. Kensler, Masayuki Yamamoto, Josephine M. Egan, Dan L. Longo, Donald K. Ingram, Placido Navas, and Rafael de Cabo Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2325–2330. doi: 10.1073/pnas.0712162105.PMCID: PMC2268135 Crystal structure of tetrameric form of human lysyl-tRNA synthetase: Implications for multisynthetase complex formation Min Guo, Michael Ignatov, Karin Musier-Forsyth, Paul Schimmel, and Xiang-Lei Yang Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2331–2336. doi: 10.1073/pnas.0712072105.PMCID: PMC2268136 Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn Adam R. Mezo, Kevin A. McDonnell, Cristina A. Tan Hehir, Susan C. Low, Vito J. Palombella, James M. Stattel, George D. Kamphaus, Cara Fraley, Yixia Zhang, Jennifer A. Dumont, and Alan J. Bitonti Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2337–2342. doi: 10.1073/pnas.0708960105.PMCID: PMC2268137 Transitive homology-guided structural studies lead to discovery of Cro proteins with 40% sequence identity but different folds Christian G. Roessler, Branwen M. Hall, William J. Anderson, Wendy M. Ingram, Sue A. Roberts, William R. Montfort, and Matthew H. J. Cordes Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2343–2348. doi: 10.1073/pnas.0711589105.PMCID: PMC2268138 Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis Rashna Bhandari, Krishna R. Juluri, Adam C. Resnick, and Solomon H. Snyder Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2349–2353. doi: 10.1073/pnas.0712227105.PMCID: PMC2268139 Rapid selection of accessible and cleavable sites in RNA by Escherichia coli RNase P and random external guide sequences Eirik W. Lundblad, Gaoping Xiao, Jae-hyeong Ko, and Sidney Altman Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2354–2357. doi: 10.1073/pnas.0711977105.PMCID: PMC2268140 Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells Muhammad Emaduddin, David C. Bicknell, Walter F. Bodmer, and Stephan M. Feller Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2358–2362. doi: 10.1073/pnas.0712176105.PMCID: PMC2268141 The same mutation in Gsα and transducin α reveals behavioral differences between these highly homologous G protein α-subunits Adolfo R. Zurita and Lutz Birnbaumer Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2363–2368. doi: 10.1073/pnas.0712261105.PMCID: PMC2268142 Biophysics An experimental survey of the transition between two-state and downhill protein folding scenarios Feng Liu, Deguo Du, Amelia A. Fuller, Jennifer E. Davoren, Peter Wipf, Jeffery W. Kelly, and Martin Gruebele Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2369–2374. doi: 10.1073/pnas.0711908105.PMCID: PMC2268143 Insights into bunyavirus architecture from electron cryotomography of Uukuniemi virus A. K. Överby, R. F. Pettersson, K. Grünewald, and J. T. Huiskonen Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2375–2379. doi: 10.1073/pnas.0708738105.PMCID: PMC2268144 SNAREpin/Munc18 promotes adhesion and fusion of large vesicles to giant membranes David Tareste, Jingshi Shen, Thomas J. Melia, and James E. Rothman Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2380–2385. doi: 10.1073/pnas.0712125105.PMCID: PMC2268145 Three-dimensional structure of vertebrate cardiac muscle myosin filaments Maria E. Zoghbi, John L. Woodhead, Richard L. Moss, and Roger Craig Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2386–2390. doi: 10.1073/pnas.0708912105.PMCID: PMC2268146 Structural and biochemical insights into the dicing mechanism of mouse Dicer: A conserved lysine is critical for dsRNA cleavage Zhihua Du, John K. Lee, Richard Tjhen, Robert M. Stroud, and Thomas L. James Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2391–2396. doi: 10.1073/pnas.0711506105.PMCID: PMC2268147 Cooperative folding kinetics of BBL protein and peripheral subunit-binding domain homologues Wookyung Yu, Kwanghoon Chung, Mookyung Cheon, Muyoung Heo, Kyou-Hoon Han, Sihyun Ham, and Iksoo Chang Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2397–2402. doi: 10.1073/pnas.0708480105.PMCID: PMC2268148 Amyloid of Rnq1p, the basis of the [PIN+] prion, has a parallel in-register β-sheet structure Reed B. Wickner, Fred Dyda, and Robert Tycko Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2403–2408. doi: 10.1073/pnas.0712032105.PMCID: PMC2268149 Mechanisms of prion protein assembly into amyloid Jan Stöhr, Nicole Weinmann, Holger Wille, Tina Kaimann, Luitgard Nagel-Steger, Eva Birkmann, Giannantonio Panza, Stanley B. Prusiner, Manfred Eigen, and Detlev Riesner Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2409–2414. doi: 10.1073/pnas.0712036105.PMCID: PMC2268150 Cell Biology A chemical method for fast and sensitive detection of DNA synthesis in vivo Adrian Salic and Timothy J. Mitchison Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2415–2420. doi: 10.1073/pnas.0712168105.PMCID: PMC2268151 The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis Zhao Xu, Songtao Yu, Chung-Hsin Hsu, Jun Eguchi, and Evan D. Rosen Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2421–2426. doi: 10.1073/pnas.0707082105.PMCID: PMC2268152 Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis Tania Szado, Veerle Vanderheyden, Jan B. Parys, Humbert De Smedt, Katja Rietdorf, Larissa Kotelevets, Eric Chastre, Farid Khan, Ulf Landegren, Ola Söderberg, Martin D. Bootman, and H. Llewelyn Roderick Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2427–2432. doi: 10.1073/pnas.0711324105.PMCID: PMC2268153 Sterility and absence of histopathological defects in nonreproductive organs of a mouse ERβ-null mutant Maria Cristina Antal, Andrée Krust, Pierre Chambon, and Manuel Mark Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2433–2438. doi: 10.1073/pnas.0712029105.PMCID: PMC2268154 Anthrax lethal toxin induces cell death-independent permeability in zebrafish vasculature Robert E. Bolcome, III, Sarah E. Sullivan, René Zeller, Adam P. Barker, R. John Collier, and Joanne Chan Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2439–2444. doi: 10.1073/pnas.0712195105.PMCID: PMC2268155 Progenitor/stem cells give rise to liver cancer due to aberrant TGF-β and IL-6 signaling Yi Tang, Krit Kitisin, Wilma Jogunoori, Cuiling Li, Chu-Xia Deng, Susette C. Mueller, Habtom W. Ressom, Asif Rashid, Aiwu Ruth He, Jonathan S. Mendelson, John M. Jessup, Kirti Shetty, Michael Zasloff, Bibhuti Mishra, E. P. Reddy, Lynt Johnson, and Lopa Mishra Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2445–2450. doi: 10.1073/pnas.0705395105.PMCID: PMC2268156 Dissection of the insulin signaling pathway via quantitative phosphoproteomics Marcus Krüger, Irina Kratchmarova, Blagoy Blagoev, Yu-Hua Tseng, C. Ronald Kahn, and Matthias Mann Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2451–2456. doi: 10.1073/pnas.0711713105.PMCID: PMC2268157 A promoter-hijack strategy for conditional shutdown of multiply spliced essential cell cycle genes Kumiko Samejima, Hiromi Ogawa, Carol A. Cooke, Damien Hudson, Fiona MacIsaac, Susana A. Ribeiro, Paola Vagnarelli, Stefano Cardinale, Alastair Kerr, Fan Lai, Sandrine Ruchaud, Zuojun Yue, and William C. Earnshaw Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2457–2462. doi: 10.1073/pnas.0712083105.PMCID: PMC2268158 Four distinct pathways of hemoglobin uptake in the malaria parasite Plasmodium falciparum David A. Elliott, Michael T. McIntosh, H. Dean Hosgood, III, Shuo Chen, Gina Zhang, Pavlina Baevova, and Keith A. Joiner Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2463–2468. doi: 10.1073/pnas.0711067105.PMCID: PMC2268159 Developmental Biology A W-linked DM-domain gene, DM-W, participates in primary ovary development in Xenopus laevis Shin Yoshimoto, Ema Okada, Hirohito Umemoto, Kei Tamura, Yoshinobu Uno, Chizuko Nishida-Umehara, Yoichi Matsuda, Nobuhiko Takamatsu, Tadayoshi Shiba, and Michihiko Ito Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2469–2474. doi: 10.1073/pnas.0712244105.PMCID: PMC2268160 Cellular components and signals required for the cardiac outflow tract assembly in Drosophila Monika Zmojdzian, Jean Philippe Da Ponte, and Krzysztof Jagla Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2475–2480. doi: 10.1073/pnas.0706402105.PMCID: PMC2268161 Atbf1 is required for the Pit1 gene early activation Yingchuan Qi, Jeffrey A. Ranish, Xiaoyan Zhu, Anna Krones, Jie Zhang, Ruedi Aebersold, David W. Rose, Michael G. Rosenfeld, and Catherine Carrière Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2481–2486. doi: 10.1073/pnas.0712196105.PMCID: PMC2268162 IKKα is a critical coregulator of a Smad4-independent TGFβ-Smad2/3 signaling pathway that controls keratinocyte differentiation Pascal Descargues, Alok K. Sil, Yuji Sano, Olexandr Korchynskyi, Gangwen Han, Philip Owens, Xiao-Jing Wang, and Michael Karin Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2487–2492. doi: 10.1073/pnas.0712044105.PMCID: PMC2268163 Ecology King penguin population threatened by Southern Ocean warming Céline Le Bohec, Joël M. Durant, Michel Gauthier-Clerc, Nils C. Stenseth, Young-Hyang Park, Roger Pradel, David Grémillet, Jean-Paul Gendner, and Yvon Le Maho Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2493–2497. doi: 10.1073/pnas.0712031105.PMCID: PMC2268164 Lifespan and reproduction in Drosophila: New insights from nutritional geometry Kwang Pum Lee, Stephen J. Simpson, Fiona J. Clissold, Robert Brooks, J. William O. Ballard, Phil W. Taylor, Nazaneen Soran, and David Raubenheimer Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2498–2503. doi: 10.1073/pnas.0710787105.PMCID: PMC2268165 Environmental Sciences Evidence for a fundamental and pervasive shift away from nature-based recreation Oliver R. W. Pergams and Patricia A. Zaradic Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2295–2300. doi: 10.1073/pnas.0709893105.PMCID: PMC2268130 Evolution Identifying the fundamental units of bacterial diversity: A paradigm shift to incorporate ecology into bacterial systematics Alexander Koeppel, Elizabeth B. Perry, Johannes Sikorski, Danny Krizanc, Andrew Warner, David M. Ward, Alejandro P. Rooney, Evelyne Brambilla, Nora Connor, Rodney M. Ratcliff, Eviatar Nevo, and Frederick M. Cohan Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2504–2509. doi: 10.1073/pnas.0712205105.PMCID: PMC2268166 Genome evolution in cyanobacteria: The stable core and the variable shell Tuo Shi and Paul G. Falkowski Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2510–2515. doi: 10.1073/pnas.0711165105.PMCID: PMC2268167 Distribution of cytotoxic and DNA ADP-ribosylating activity in crude extracts from butterflies among the family Pieridae Yasuko Matsumoto, Tsuyoshi Nakano, Masafumi Yamamoto, Yuko Matsushima-Hibiya, Ken-Ichi Odagiri, Osamu Yata, Kotaro Koyama, Takashi Sugimura, and Keiji Wakabayashi Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2516–2520. doi: 10.1073/pnas.0712221105.PMCID: PMC2268168 Genetics Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma Chandrahas Koumar Ratnacaram, Marius Teletin, Ming Jiang, Xiangjun Meng, Pierre Chambon, and Daniel Metzger Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2521–2526. doi: 10.1073/pnas.0712021105.PMCID: PMC2268169 Discovering gapped binding sites of yeast transcription factors Chien-Yu Chen, Huai-Kuang Tsai, Chen-Ming Hsu, Mei-Ju May Chen, Hao-Geng Hung, Grace Tzu-Wei Huang, and Wen-Hsiung Li Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2527–2532. doi: 10.1073/pnas.0712188105.PMCID: PMC2268170 Enzymes of the shikimic acid pathway encoded in the genome of a basal metazoan, Nematostella vectensis, have microbial origins Antonio Starcevic, Shamima Akthar, Walter C. Dunlap, J. Malcolm Shick, Daslav Hranueli, John Cullum, and Paul F. Long Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2533–2537. doi: 10.1073/pnas.0707388105.PMCID: PMC2268171 Mutations in FN1 cause glomerulopathy with fibronectin deposits Federica Castelletti, Roberta Donadelli, Federica Banterla, Friedhelm Hildebrandt, Peter F. Zipfel, Elena Bresin, Edgar Otto, Christine Skerka, Alessandra Renieri, Marta Todeschini, Jessica Caprioli, Rosa Maria Caruso, Rosangela Artuso, Giuseppe Remuzzi, and Marina Noris Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2538–2543. doi: 10.1073/pnas.0707730105.PMCID: PMC2268172 A multimetric approach to analysis of genome-wide association by single markers and composite likelihood Jane Gibson, William Tapper, David Cox, Weihua Zhang, Arne Pfeufer, Christian Gieger, H.-Erich Wichmann, Stefan Kääb, Andrew R. Collins, Thomas Meitinger, and Newton Morton Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2592–2597. doi: 10.1073/pnas.0711903105.PMCID: PMC2268181 Immunology ATF3 regulates MCMV infection in mice by modulating IFN-γ expression in natural killer cells Carrie M. Rosenberger, April E. Clark, Piper M. Treuting, Carrie D. Johnson, and Alan Aderem Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2544–2549. doi: 10.1073/pnas.0712182105.PMCID: PMC2268173 Human regulatory T cells inhibit polarization of T helper cells toward antigen-presenting cells via a TGF-β-dependent mechanism Michael Esquerré, Baptiste Tauzin, Martine Guiraud, Sabina Müller, Abdelhadi Saoudi, and Salvatore Valitutti Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2550–2555. doi: 10.1073/pnas.0708350105.PMCID: PMC2268174 A cell-type-specific requirement for IFN regulatory factor 5 (IRF5) in Fas-induced apoptosis Arnaud Couzinet, Kaoru Tamura, Hui-min Chen, Keishiro Nishimura, ZhiChao Wang, Yasuyuki Morishita, Kazuyoshi Takeda, Hideo Yagita, Hideyuki Yanai, Tadatsugu Taniguchi, and Tomohiko Tamura Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2556–2561. doi: 10.1073/pnas.0712295105.PMCID: PMC2268175 Pseudomonas aeruginosa activates caspase 1 through Ipaf Edward A. Miao, Robert K. Ernst, Monica Dors, Dat P. Mao, and Alan Aderem Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2562–2567. doi: 10.1073/pnas.0712183105.PMCID: PMC2268176 WIP is essential for lytic granule polarization and NK cell cytotoxicity Konrad Krzewski, Xi Chen, and Jack L. Strominger Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2568–2573. doi: 10.1073/pnas.0711593105.PMCID: PMC2268177 The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine Christine Trumpfheller, Marina Caskey, Godwin Nchinda, Maria Paula Longhi, Olga Mizenina, Yaoxing Huang, Sarah J. Schlesinger, Marco Colonna, and Ralph M. Steinman Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2574–2579. doi: 10.1073/pnas.0711976105.PMCID: PMC2268178 Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms Niti Puri and Paul A. Roche Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2580–2585. doi: 10.1073/pnas.0707854105.PMCID: PMC2268179 Medical Sciences Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST) Wen Ling, Ravinder R. Regatte, Gil Navon, and Alexej Jerschow Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2266–2270. doi: 10.1073/pnas.0707666105.PMCID: PMC2268124 From the Cover: Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers Frank Gu, Liangfang Zhang, Benjamin A. Teply, Nina Mann, Andrew Wang, Aleksandar F. Radovic-Moreno, Robert Langer, and Omid C. Farokhzad Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2586–2591. doi: 10.1073/pnas.0711714105.PMCID: PMC2268180 A multimetric approach to analysis of genome-wide association by single markers and composite likelihood Jane Gibson, William Tapper, David Cox, Weihua Zhang, Arne Pfeufer, Christian Gieger, H.-Erich Wichmann, Stefan Kääb, Andrew R. Collins, Thomas Meitinger, and Newton Morton Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2592–2597. doi: 10.1073/pnas.0711903105.PMCID: PMC2268181 Arterial calcifications and increased expression of vitamin D receptor targets in mice lacking TIF1α Mihaela Ignat, Marius Teletin, Johan Tisserand, Konstantin Khetchoumian, Christine Dennefeld, Pierre Chambon, Régine Losson, and Manuel Mark Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2598–2603. doi: 10.1073/pnas.0712030105.PMCID: PMC2268182 The genome landscape of ERα- and ERβ-binding DNA regions Yawen Liu, Hui Gao, Troels Torben Marstrand, Anders Ström, Eivind Valen, Albin Sandelin, Jan-Åke Gustafsson, and Karin Dahlman-Wright Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2604–2609. doi: 10.1073/pnas.0712085105.PMCID: PMC2268183 Heart failure drug digitoxin induces calcium uptake into cells by forming transmembrane calcium channels Nelson Arispe, Juan Carlos Diaz, Olga Simakova, and Harvey B. Pollard Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2610–2615. doi: 10.1073/pnas.0712270105.PMCID: PMC2268184 Chemically modified β-glucuronidase crosses blood–brain barrier and clears neuronal storage in murine mucopolysaccharidosis VII Jeffrey H. Grubb, Carole Vogler, Beth Levy, Nancy Galvin, Yun Tan, and William S. Sly Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2616–2621. doi: 10.1073/pnas.0712147105.PMCID: PMC2268185 PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a) Brooke M. Emerling, Frank Weinberg, Juinn-Lin Liu, Tak W. Mak, and Navdeep S. Chandel Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2622–2627. doi: 10.1073/pnas.0706790105.PMCID: PMC2268186 Wound angiogenesis as a function of tissue oxygen tension: A mathematical model Richard C. Schugart, Avner Friedman, Rui Zhao, and Chandan K. Sen Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2628–2633. doi: 10.1073/pnas.0711642105.PMCID: PMC2268187 High levels of erythropoietin are associated with protection against neurological sequelae in African children with cerebral malaria Climent Casals-Pascual, Richard Idro, Nimmo Gicheru, Samson Gwer, Barnes Kitsao, Evelyn Gitau, Robert Mwakesi, David J. Roberts, and Charles R. J. C. Newton Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2634–2639. doi: 10.1073/pnas.0709715105.PMCID: PMC2268188 Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression Farbod Shojaei, Mallika Singh, Jennifer D. Thompson, and Napoleone Ferrara Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2640–2645. doi: 10.1073/pnas.0712185105.PMCID: PMC2268189 Expanded CTG repeats within the DMPK 3′ UTR causes severe skeletal muscle wasting in an inducible mouse model for myotonic dystrophy James P. Orengo, Pierre Chambon, Daniel Metzger, Dennis R. Mosier, G. Jackson Snipes, and Thomas A. Cooper Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2646–2651. doi: 10.1073/pnas.0708519105.PMCID: PMC2268190 Helical domain and kinase domain mutations in p110α of phosphatidylinositol 3-kinase induce gain of function by different mechanisms Li Zhao and Peter K. Vogt Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2652–2657. doi: 10.1073/pnas.0712169105.PMCID: PMC2268191 Microbiology The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum Eszter Lázár-Molnár, Attila Gácser, Gordon J. Freeman, Steven C. Almo, Stanley G. Nathenson, and Joshua D. Nosanchuk Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2658–2663. doi: 10.1073/pnas.0711918105.PMCID: PMC2268192 Receptor determinants of zoonotic transmission of New World hemorrhagic fever arenaviruses Sheli R. Radoshitzky, Jens H. Kuhn, Christina F. Spiropoulou, César G. Albariño, Dan P. Nguyen, Jorge Salazar-Bravo, Tatyana Dorfman, Amy S. Lee, Enxiu Wang, Susan R. Ross, Hyeryun Choe, and Michael Farzan Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2664–2669. doi: 10.1073/pnas.0709254105.PMCID: PMC2268193 A cell–cell signaling sensor is required for virulence and insect transmission of Xylella fastidiosa Subhadeep Chatterjee, Christina Wistrom, and Steven E. Lindow Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2670–2675. doi: 10.1073/pnas.0712236105.PMCID: PMC2268194 Neuroscience From the Cover: Detailed recollection of remote autobiographical memory after damage to the medial temporal lobe C. Brock Kirwan, Peter J. Bayley, Veronica V. Galván, and Larry R. Squire Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2676–2680. doi: 10.1073/pnas.0712155105.PMCID: PMC2268195 Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Aβ toxicity Joel N. Buxbaum, Zhengyi Ye, Natàlia Reixach, Linsey Friske, Coree Levy, Pritam Das, Todd Golde, Eliezer Masliah, Amanda R. Roberts, and Tamas Bartfai Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2681–2686. doi: 10.1073/pnas.0712197105.PMCID: PMC2268196 Starvation after AgRP neuron ablation is independent of melanocortin signaling Qi Wu, Maureen P. Howell, Michael A. Cowley, and Richard D. Palmiter Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2687–2692. doi: 10.1073/pnas.0712062105.PMCID: PMC2268197 A Drosophila model for LRRK2-linked parkinsonism Zhaohui Liu, Xiaoyue Wang, Yi Yu, Xueping Li, Tao Wang, Haibing Jiang, Qiuting Ren, Yuchen Jiao, Akira Sawa, Timothy Moran, Christopher A. Ross, Craig Montell, and Wanli W. Smith Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2693–2698. doi: 10.1073/pnas.0708452105.PMCID: PMC2268198 GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current Jane E. Lauckner, Jill B. Jensen, Huei-Ying Chen, Hui-Chen Lu, Bertil Hille, and Ken Mackie Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2699–2704. doi: 10.1073/pnas.0711278105.PMCID: PMC2268199 Anti-Ca2+ channel antibody attenuates Ca2+ currents and mimics cerebellar ataxia in vivo Yaping Joyce Liao, Parsa Safa, Yi-Ren Chen, Raymond A. Sobel, Edward S. Boyden, and Richard W. Tsien Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2705–2710. doi: 10.1073/pnas.0710771105.PMCID: PMC2268200 BDNF is essential to promote persistence of long-term memory storage Pedro Bekinschtein, Martín Cammarota, Cynthia Katche, Leandro Slipczuk, Janine I. Rossato, Andrea Goldin, Ivan Izquierdo, and Jorge H. Medina Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2711–2716. doi: 10.1073/pnas.0711863105.PMCID: PMC2268201 Galanin decreases proliferation of PC12 cells and induces apoptosis via its subtype 2 receptor (GalR2) R. Tofighi, B. Joseph, S. Xia, Z.-Q. D. Xu, B. Hamberger, T. Hökfelt, and S. Ceccatelli Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2717–2722. doi: 10.1073/pnas.0712300105.PMCID: PMC2268202 Pharmacology IL-33 mediates antigen-induced cutaneous and articular hypernociception in mice Waldiceu A. Verri, Jr., Ana T. G. Guerrero, Sandra Y. Fukada, Daniel A. Valerio, Thiago M. Cunha, Damo Xu, Sérgio H. Ferreira, Foo Y. Liew, and Fernando Q. Cunha Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2723–2728. doi: 10.1073/pnas.0712116105.PMCID: PMC2268203 Physiology Reverse wave propagation in the cochlea Wenxuan He, Anders Fridberger, Edward Porsov, Karl Grosh, and Tianying Ren Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2729–2733. doi: 10.1073/pnas.0708103105.PMCID: PMC2268204 Plant Biology Structural insight into the reaction mechanism and evolution of cytokinin biosynthesis Hajime Sugawara, Nanae Ueda, Mikiko Kojima, Nobue Makita, Tomoyuki Yamaya, and Hitoshi Sakakibara Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2734–2739. doi: 10.1073/pnas.0707374105.PMCID: PMC2268205 Population Biology Reanalyses of Gulf of Mexico fisheries data: Landings can be misleading in assessments of fisheries and fisheries ecosystems Kim de Mutsert, James H. Cowan, Jr., Timothy E. Essington, and Ray Hilborn Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2740–2744. doi: 10.1073/pnas.0704354105.PMCID: PMC2268206 Psychology Bayesian learning of visual chunks by human observers Gergő Orbán, József Fiser, Richard N. Aslin, and Máté Lengyel Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2745–2750. doi: 10.1073/pnas.0708424105.PMCID: PMC2268207 Social Sciences Environmental Sciences From the Cover: The collective-risk social dilemma and the prevention of simulated dangerous climate change Manfred Milinski, Ralf D. Sommerfeld, Hans-Jürgen Krambeck, Floyd A. Reed, and Jochem Marotzke Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2291–2294. doi: 10.1073/pnas.0709546105.PMCID: PMC2268129 Evidence for a fundamental and pervasive shift away from nature-based recreation Oliver R. W. Pergams and Patricia A. Zaradic Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2295–2300. doi: 10.1073/pnas.0709893105.PMCID: PMC2268130 Temporal and spatial changes in social vulnerability to natural hazards Susan L. Cutter and Christina Finch Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2301–2306. doi: 10.1073/pnas.0710375105.PMCID: PMC2268131 Sustainability Science Temporal and spatial changes in social vulnerability to natural hazards Susan L. Cutter and Christina Finch Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2301–2306. doi: 10.1073/pnas.0710375105.PMCID: PMC2268131 Correction Correction for Turner et al., Land Change Science Special Feature: The emergence of land change science for global environmental change and sustainability Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2751. doi: 10.1073/pnas.0800052105.PMCID: PMC2268208 Corrects: B. L. Turner, II, et al. 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