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Volume 105(7);  February 19, 2008
Letters
The burden of proof: A response to Rosi-Marshall et al.
Roger N. Beachy, Nina V. Fedoroff, Robert B. Goldberg, and Alan McHughen
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): E9. doi: 10.1073/pnas.0711431105.
PMCID: PMC2268211
Study of Bt impact on caddisflies overstates its conclusions: Response to Rosi-Marshall et al.
Wayne Parrott
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): E10. doi: 10.1073/pnas.0711284105.
PMCID: PMC2268209
Reply to Beachy et al. and Parrott: Study indicates Bt corn may affect caddisflies
Emma J. Rosi-Marshall, Jennifer L. Tank, Todd V. Royer, and Matt R. Whiles
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): E11. doi: 10.1073/pnas.0712192105.
PMCID: PMC2268210
This Week in PNAS
In This Issue
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2255–2256. doi: 10.1073/iti0708105.
PMCID: PMC2268119
Commentaries
An emerging link between general anesthesia and sleep
Ravi Allada
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2257–2258. doi: 10.1073/pnas.0711532105.
PMCID: PMC2268120
Cell cycle regulation, neurogenesis, and depression
Kathryn A. Cunningham and Cheryl S. Watson
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2259–2260. doi: 10.1073/pnas.0800029105.
PMCID: PMC2268121
Gambling for global goods
Anna Dreber and Martin A. Nowak
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2261–2262. doi: 10.1073/pnas.0800033105.
PMCID: PMC2268122
Profile
Profile of Richard Dixon
Melissa Marino
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2263–2265. doi: 10.1073/pnas.0800273105.
PMCID: PMC2268123
Physical Sciences
Applied Physical Sciences
Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST)
Wen Ling, Ravinder R. Regatte, Gil Navon, and Alexej Jerschow
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2266–2270. doi: 10.1073/pnas.0707666105.
PMCID: PMC2268124
Remote detection of nuclear magnetic resonance with an anisotropic magnetoresistive sensor
F. Verpillat, M. P. Ledbetter, S. Xu, D. J. Michalak, C. Hilty, L.-S. Bouchard, S. Antonijevic, D. Budker, and A. Pines
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2271–2273. doi: 10.1073/pnas.0712129105.
PMCID: PMC2268125
Chemistry
Hydrophobicity of protein surfaces: Separating geometry from chemistry
Nicolas Giovambattista, Carlos F. Lopez, Peter J. Rossky, and Pablo G. Debenedetti
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2274–2279. doi: 10.1073/pnas.0708088105.
PMCID: PMC2268126
Electroactive controlled release thin films
Kris C. Wood, Nicole S. Zacharia, Daniel J. Schmidt, Stefani N. Wrightman, Brian J. Andaya, and Paula T. Hammond
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2280–2285. doi: 10.1073/pnas.0706994105.
PMCID: PMC2268127
An experimental survey of the transition between two-state and downhill protein folding scenarios
Feng Liu, Deguo Du, Amelia A. Fuller, Jennifer E. Davoren, Peter Wipf, Jeffery W. Kelly, and Martin Gruebele
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2369–2374. doi: 10.1073/pnas.0711908105.
PMCID: PMC2268143
A chemical method for fast and sensitive detection of DNA synthesis in vivo
Adrian Salic and Timothy J. Mitchison
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2415–2420. doi: 10.1073/pnas.0712168105.
PMCID: PMC2268151
Engineering
From the Cover:
Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers
Frank Gu, Liangfang Zhang, Benjamin A. Teply, Nina Mann, Andrew Wang, Aleksandar F. Radovic-Moreno, Robert Langer, and Omid C. Farokhzad
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2586–2591. doi: 10.1073/pnas.0711714105.
PMCID: PMC2268180
Physics
Zero-field remote detection of NMR with a microfabricated atomic magnetometer
M. P. Ledbetter, I. M. Savukov, D. Budker, V. Shah, S. Knappe, J. Kitching, D. J. Michalak, S. Xu, and A. Pines
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2286–2290. doi: 10.1073/pnas.0711505105.
PMCID: PMC2268128
Biological Sciences
Applied Biological Sciences
From the Cover:
A biodegradable and biocompatible gecko-inspired tissue adhesive
Alborz Mahdavi, Lino Ferreira, Cathryn Sundback, Jason W. Nichol, Edwin P. Chan, David J. D. Carter, Chris J. Bettinger, Siamrut Patanavanich, Loice Chignozha, Eli Ben-Joseph, Alex Galakatos, Howard Pryor, Irina Pomerantseva, Peter T. Masiakos, William Faquin, Andreas Zumbuehl, Seungpyo Hong, Jeffrey Borenstein, Joseph Vacanti, Robert Langer, and Jeffrey M. Karp
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2307–2312. doi: 10.1073/pnas.0712117105.
PMCID: PMC2268132
The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8
Wolf Wrasidlo, Ainhoa Mielgo, Vicente A. Torres, Simone Barbero, Konstantin Stoletov, Takashi L. Suyama, Richard L. Klemke, William H. Gerwick, Dennis A. Carson, and Dwayne G. Stupack
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2313–2318. doi: 10.1073/pnas.0712198105.
PMCID: PMC2268133
Assessing the potential of mutational strategies to elicit new phenotypes in industrial strains
Daniel Klein-Marcuschamer and Gregory Stephanopoulos
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2319–2324. doi: 10.1073/pnas.0712177105.
PMCID: PMC2268134
Biochemistry
From the Cover:
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction
Kevin J. Pearson, Kaitlyn N. Lewis, Nathan L. Price, Joy W. Chang, Evelyn Perez, Maria Victoria Cascajo, Kellie L. Tamashiro, Suresh Poosala, Anna Csiszar, Zoltan Ungvari, Thomas W. Kensler, Masayuki Yamamoto, Josephine M. Egan, Dan L. Longo, Donald K. Ingram, Placido Navas, and Rafael de Cabo
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2325–2330. doi: 10.1073/pnas.0712162105.
PMCID: PMC2268135
Crystal structure of tetrameric form of human lysyl-tRNA synthetase: Implications for multisynthetase complex formation
Min Guo, Michael Ignatov, Karin Musier-Forsyth, Paul Schimmel, and Xiang-Lei Yang
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2331–2336. doi: 10.1073/pnas.0712072105.
PMCID: PMC2268136
Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn
Adam R. Mezo, Kevin A. McDonnell, Cristina A. Tan Hehir, Susan C. Low, Vito J. Palombella, James M. Stattel, George D. Kamphaus, Cara Fraley, Yixia Zhang, Jennifer A. Dumont, and Alan J. Bitonti
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2337–2342. doi: 10.1073/pnas.0708960105.
PMCID: PMC2268137
Transitive homology-guided structural studies lead to discovery of Cro proteins with 40% sequence identity but different folds
Christian G. Roessler, Branwen M. Hall, William J. Anderson, Wendy M. Ingram, Sue A. Roberts, William R. Montfort, and Matthew H. J. Cordes
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2343–2348. doi: 10.1073/pnas.0711589105.
PMCID: PMC2268138
Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis
Rashna Bhandari, Krishna R. Juluri, Adam C. Resnick, and Solomon H. Snyder
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2349–2353. doi: 10.1073/pnas.0712227105.
PMCID: PMC2268139
Rapid selection of accessible and cleavable sites in RNA by Escherichia coli RNase P and random external guide sequences
Eirik W. Lundblad, Gaoping Xiao, Jae-hyeong Ko, and Sidney Altman
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2354–2357. doi: 10.1073/pnas.0711977105.
PMCID: PMC2268140
Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells
Muhammad Emaduddin, David C. Bicknell, Walter F. Bodmer, and Stephan M. Feller
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2358–2362. doi: 10.1073/pnas.0712176105.
PMCID: PMC2268141
The same mutation in Gsα and transducin α reveals behavioral differences between these highly homologous G protein α-subunits
Adolfo R. Zurita and Lutz Birnbaumer
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2363–2368. doi: 10.1073/pnas.0712261105.
PMCID: PMC2268142
Biophysics
An experimental survey of the transition between two-state and downhill protein folding scenarios
Feng Liu, Deguo Du, Amelia A. Fuller, Jennifer E. Davoren, Peter Wipf, Jeffery W. Kelly, and Martin Gruebele
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2369–2374. doi: 10.1073/pnas.0711908105.
PMCID: PMC2268143
Insights into bunyavirus architecture from electron cryotomography of Uukuniemi virus
A. K. Överby, R. F. Pettersson, K. Grünewald, and J. T. Huiskonen
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2375–2379. doi: 10.1073/pnas.0708738105.
PMCID: PMC2268144
SNAREpin/Munc18 promotes adhesion and fusion of large vesicles to giant membranes
David Tareste, Jingshi Shen, Thomas J. Melia, and James E. Rothman
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2380–2385. doi: 10.1073/pnas.0712125105.
PMCID: PMC2268145
Three-dimensional structure of vertebrate cardiac muscle myosin filaments
Maria E. Zoghbi, John L. Woodhead, Richard L. Moss, and Roger Craig
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2386–2390. doi: 10.1073/pnas.0708912105.
PMCID: PMC2268146
Structural and biochemical insights into the dicing mechanism of mouse Dicer: A conserved lysine is critical for dsRNA cleavage
Zhihua Du, John K. Lee, Richard Tjhen, Robert M. Stroud, and Thomas L. James
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2391–2396. doi: 10.1073/pnas.0711506105.
PMCID: PMC2268147
Cooperative folding kinetics of BBL protein and peripheral subunit-binding domain homologues
Wookyung Yu, Kwanghoon Chung, Mookyung Cheon, Muyoung Heo, Kyou-Hoon Han, Sihyun Ham, and Iksoo Chang
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2397–2402. doi: 10.1073/pnas.0708480105.
PMCID: PMC2268148
Amyloid of Rnq1p, the basis of the [PIN+] prion, has a parallel in-register β-sheet structure
Reed B. Wickner, Fred Dyda, and Robert Tycko
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2403–2408. doi: 10.1073/pnas.0712032105.
PMCID: PMC2268149
Mechanisms of prion protein assembly into amyloid
Jan Stöhr, Nicole Weinmann, Holger Wille, Tina Kaimann, Luitgard Nagel-Steger, Eva Birkmann, Giannantonio Panza, Stanley B. Prusiner, Manfred Eigen, and Detlev Riesner
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2409–2414. doi: 10.1073/pnas.0712036105.
PMCID: PMC2268150
Cell Biology
A chemical method for fast and sensitive detection of DNA synthesis in vivo
Adrian Salic and Timothy J. Mitchison
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2415–2420. doi: 10.1073/pnas.0712168105.
PMCID: PMC2268151
The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis
Zhao Xu, Songtao Yu, Chung-Hsin Hsu, Jun Eguchi, and Evan D. Rosen
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2421–2426. doi: 10.1073/pnas.0707082105.
PMCID: PMC2268152
Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis
Tania Szado, Veerle Vanderheyden, Jan B. Parys, Humbert De Smedt, Katja Rietdorf, Larissa Kotelevets, Eric Chastre, Farid Khan, Ulf Landegren, Ola Söderberg, Martin D. Bootman, and H. Llewelyn Roderick
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2427–2432. doi: 10.1073/pnas.0711324105.
PMCID: PMC2268153
Sterility and absence of histopathological defects in nonreproductive organs of a mouse ERβ-null mutant
Maria Cristina Antal, Andrée Krust, Pierre Chambon, and Manuel Mark
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2433–2438. doi: 10.1073/pnas.0712029105.
PMCID: PMC2268154
Anthrax lethal toxin induces cell death-independent permeability in zebrafish vasculature
Robert E. Bolcome, III, Sarah E. Sullivan, René Zeller, Adam P. Barker, R. John Collier, and Joanne Chan
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2439–2444. doi: 10.1073/pnas.0712195105.
PMCID: PMC2268155
Progenitor/stem cells give rise to liver cancer due to aberrant TGF-β and IL-6 signaling
Yi Tang, Krit Kitisin, Wilma Jogunoori, Cuiling Li, Chu-Xia Deng, Susette C. Mueller, Habtom W. Ressom, Asif Rashid, Aiwu Ruth He, Jonathan S. Mendelson, John M. Jessup, Kirti Shetty, Michael Zasloff, Bibhuti Mishra, E. P. Reddy, Lynt Johnson, and Lopa Mishra
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2445–2450. doi: 10.1073/pnas.0705395105.
PMCID: PMC2268156
Dissection of the insulin signaling pathway via quantitative phosphoproteomics
Marcus Krüger, Irina Kratchmarova, Blagoy Blagoev, Yu-Hua Tseng, C. Ronald Kahn, and Matthias Mann
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2451–2456. doi: 10.1073/pnas.0711713105.
PMCID: PMC2268157
A promoter-hijack strategy for conditional shutdown of multiply spliced essential cell cycle genes
Kumiko Samejima, Hiromi Ogawa, Carol A. Cooke, Damien Hudson, Fiona MacIsaac, Susana A. Ribeiro, Paola Vagnarelli, Stefano Cardinale, Alastair Kerr, Fan Lai, Sandrine Ruchaud, Zuojun Yue, and William C. Earnshaw
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2457–2462. doi: 10.1073/pnas.0712083105.
PMCID: PMC2268158
Four distinct pathways of hemoglobin uptake in the malaria parasite Plasmodium falciparum
David A. Elliott, Michael T. McIntosh, H. Dean Hosgood, III, Shuo Chen, Gina Zhang, Pavlina Baevova, and Keith A. Joiner
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2463–2468. doi: 10.1073/pnas.0711067105.
PMCID: PMC2268159
Developmental Biology
A W-linked DM-domain gene, DM-W, participates in primary ovary development in Xenopus laevis
Shin Yoshimoto, Ema Okada, Hirohito Umemoto, Kei Tamura, Yoshinobu Uno, Chizuko Nishida-Umehara, Yoichi Matsuda, Nobuhiko Takamatsu, Tadayoshi Shiba, and Michihiko Ito
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2469–2474. doi: 10.1073/pnas.0712244105.
PMCID: PMC2268160
Cellular components and signals required for the cardiac outflow tract assembly in Drosophila
Monika Zmojdzian, Jean Philippe Da Ponte, and Krzysztof Jagla
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2475–2480. doi: 10.1073/pnas.0706402105.
PMCID: PMC2268161
Atbf1 is required for the Pit1 gene early activation
Yingchuan Qi, Jeffrey A. Ranish, Xiaoyan Zhu, Anna Krones, Jie Zhang, Ruedi Aebersold, David W. Rose, Michael G. Rosenfeld, and Catherine Carrière
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2481–2486. doi: 10.1073/pnas.0712196105.
PMCID: PMC2268162
IKKα is a critical coregulator of a Smad4-independent TGFβ-Smad2/3 signaling pathway that controls keratinocyte differentiation
Pascal Descargues, Alok K. Sil, Yuji Sano, Olexandr Korchynskyi, Gangwen Han, Philip Owens, Xiao-Jing Wang, and Michael Karin
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2487–2492. doi: 10.1073/pnas.0712044105.
PMCID: PMC2268163
Ecology
King penguin population threatened by Southern Ocean warming
Céline Le Bohec, Joël M. Durant, Michel Gauthier-Clerc, Nils C. Stenseth, Young-Hyang Park, Roger Pradel, David Grémillet, Jean-Paul Gendner, and Yvon Le Maho
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2493–2497. doi: 10.1073/pnas.0712031105.
PMCID: PMC2268164
Lifespan and reproduction in Drosophila: New insights from nutritional geometry
Kwang Pum Lee, Stephen J. Simpson, Fiona J. Clissold, Robert Brooks, J. William O. Ballard, Phil W. Taylor, Nazaneen Soran, and David Raubenheimer
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2498–2503. doi: 10.1073/pnas.0710787105.
PMCID: PMC2268165
Environmental Sciences
Evidence for a fundamental and pervasive shift away from nature-based recreation
Oliver R. W. Pergams and Patricia A. Zaradic
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2295–2300. doi: 10.1073/pnas.0709893105.
PMCID: PMC2268130
Evolution
Identifying the fundamental units of bacterial diversity: A paradigm shift to incorporate ecology into bacterial systematics
Alexander Koeppel, Elizabeth B. Perry, Johannes Sikorski, Danny Krizanc, Andrew Warner, David M. Ward, Alejandro P. Rooney, Evelyne Brambilla, Nora Connor, Rodney M. Ratcliff, Eviatar Nevo, and Frederick M. Cohan
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2504–2509. doi: 10.1073/pnas.0712205105.
PMCID: PMC2268166
Genome evolution in cyanobacteria: The stable core and the variable shell
Tuo Shi and Paul G. Falkowski
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2510–2515. doi: 10.1073/pnas.0711165105.
PMCID: PMC2268167
Distribution of cytotoxic and DNA ADP-ribosylating activity in crude extracts from butterflies among the family Pieridae
Yasuko Matsumoto, Tsuyoshi Nakano, Masafumi Yamamoto, Yuko Matsushima-Hibiya, Ken-Ichi Odagiri, Osamu Yata, Kotaro Koyama, Takashi Sugimura, and Keiji Wakabayashi
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2516–2520. doi: 10.1073/pnas.0712221105.
PMCID: PMC2268168
Genetics
Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma
Chandrahas Koumar Ratnacaram, Marius Teletin, Ming Jiang, Xiangjun Meng, Pierre Chambon, and Daniel Metzger
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2521–2526. doi: 10.1073/pnas.0712021105.
PMCID: PMC2268169
Discovering gapped binding sites of yeast transcription factors
Chien-Yu Chen, Huai-Kuang Tsai, Chen-Ming Hsu, Mei-Ju May Chen, Hao-Geng Hung, Grace Tzu-Wei Huang, and Wen-Hsiung Li
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2527–2532. doi: 10.1073/pnas.0712188105.
PMCID: PMC2268170
Enzymes of the shikimic acid pathway encoded in the genome of a basal metazoan, Nematostella vectensis, have microbial origins
Antonio Starcevic, Shamima Akthar, Walter C. Dunlap, J. Malcolm Shick, Daslav Hranueli, John Cullum, and Paul F. Long
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2533–2537. doi: 10.1073/pnas.0707388105.
PMCID: PMC2268171
Mutations in FN1 cause glomerulopathy with fibronectin deposits
Federica Castelletti, Roberta Donadelli, Federica Banterla, Friedhelm Hildebrandt, Peter F. Zipfel, Elena Bresin, Edgar Otto, Christine Skerka, Alessandra Renieri, Marta Todeschini, Jessica Caprioli, Rosa Maria Caruso, Rosangela Artuso, Giuseppe Remuzzi, and Marina Noris
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2538–2543. doi: 10.1073/pnas.0707730105.
PMCID: PMC2268172
A multimetric approach to analysis of genome-wide association by single markers and composite likelihood
Jane Gibson, William Tapper, David Cox, Weihua Zhang, Arne Pfeufer, Christian Gieger, H.-Erich Wichmann, Stefan Kääb, Andrew R. Collins, Thomas Meitinger, and Newton Morton
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2592–2597. doi: 10.1073/pnas.0711903105.
PMCID: PMC2268181
Immunology
ATF3 regulates MCMV infection in mice by modulating IFN-γ expression in natural killer cells
Carrie M. Rosenberger, April E. Clark, Piper M. Treuting, Carrie D. Johnson, and Alan Aderem
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2544–2549. doi: 10.1073/pnas.0712182105.
PMCID: PMC2268173
Human regulatory T cells inhibit polarization of T helper cells toward antigen-presenting cells via a TGF-β-dependent mechanism
Michael Esquerré, Baptiste Tauzin, Martine Guiraud, Sabina Müller, Abdelhadi Saoudi, and Salvatore Valitutti
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2550–2555. doi: 10.1073/pnas.0708350105.
PMCID: PMC2268174
A cell-type-specific requirement for IFN regulatory factor 5 (IRF5) in Fas-induced apoptosis
Arnaud Couzinet, Kaoru Tamura, Hui-min Chen, Keishiro Nishimura, ZhiChao Wang, Yasuyuki Morishita, Kazuyoshi Takeda, Hideo Yagita, Hideyuki Yanai, Tadatsugu Taniguchi, and Tomohiko Tamura
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2556–2561. doi: 10.1073/pnas.0712295105.
PMCID: PMC2268175
Pseudomonas aeruginosa activates caspase 1 through Ipaf
Edward A. Miao, Robert K. Ernst, Monica Dors, Dat P. Mao, and Alan Aderem
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2562–2567. doi: 10.1073/pnas.0712183105.
PMCID: PMC2268176
WIP is essential for lytic granule polarization and NK cell cytotoxicity
Konrad Krzewski, Xi Chen, and Jack L. Strominger
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2568–2573. doi: 10.1073/pnas.0711593105.
PMCID: PMC2268177
The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine
Christine Trumpfheller, Marina Caskey, Godwin Nchinda, Maria Paula Longhi, Olga Mizenina, Yaoxing Huang, Sarah J. Schlesinger, Marco Colonna, and Ralph M. Steinman
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2574–2579. doi: 10.1073/pnas.0711976105.
PMCID: PMC2268178
Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms
Niti Puri and Paul A. Roche
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2580–2585. doi: 10.1073/pnas.0707854105.
PMCID: PMC2268179
Medical Sciences
Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST)
Wen Ling, Ravinder R. Regatte, Gil Navon, and Alexej Jerschow
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2266–2270. doi: 10.1073/pnas.0707666105.
PMCID: PMC2268124
From the Cover:
Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers
Frank Gu, Liangfang Zhang, Benjamin A. Teply, Nina Mann, Andrew Wang, Aleksandar F. Radovic-Moreno, Robert Langer, and Omid C. Farokhzad
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2586–2591. doi: 10.1073/pnas.0711714105.
PMCID: PMC2268180
A multimetric approach to analysis of genome-wide association by single markers and composite likelihood
Jane Gibson, William Tapper, David Cox, Weihua Zhang, Arne Pfeufer, Christian Gieger, H.-Erich Wichmann, Stefan Kääb, Andrew R. Collins, Thomas Meitinger, and Newton Morton
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2592–2597. doi: 10.1073/pnas.0711903105.
PMCID: PMC2268181
Arterial calcifications and increased expression of vitamin D receptor targets in mice lacking TIF1α
Mihaela Ignat, Marius Teletin, Johan Tisserand, Konstantin Khetchoumian, Christine Dennefeld, Pierre Chambon, Régine Losson, and Manuel Mark
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2598–2603. doi: 10.1073/pnas.0712030105.
PMCID: PMC2268182
The genome landscape of ERα- and ERβ-binding DNA regions
Yawen Liu, Hui Gao, Troels Torben Marstrand, Anders Ström, Eivind Valen, Albin Sandelin, Jan-Åke Gustafsson, and Karin Dahlman-Wright
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2604–2609. doi: 10.1073/pnas.0712085105.
PMCID: PMC2268183
Heart failure drug digitoxin induces calcium uptake into cells by forming transmembrane calcium channels
Nelson Arispe, Juan Carlos Diaz, Olga Simakova, and Harvey B. Pollard
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2610–2615. doi: 10.1073/pnas.0712270105.
PMCID: PMC2268184
Chemically modified β-glucuronidase crosses blood–brain barrier and clears neuronal storage in murine mucopolysaccharidosis VII
Jeffrey H. Grubb, Carole Vogler, Beth Levy, Nancy Galvin, Yun Tan, and William S. Sly
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2616–2621. doi: 10.1073/pnas.0712147105.
PMCID: PMC2268185
PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a)
Brooke M. Emerling, Frank Weinberg, Juinn-Lin Liu, Tak W. Mak, and Navdeep S. Chandel
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2622–2627. doi: 10.1073/pnas.0706790105.
PMCID: PMC2268186
Wound angiogenesis as a function of tissue oxygen tension: A mathematical model
Richard C. Schugart, Avner Friedman, Rui Zhao, and Chandan K. Sen
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2628–2633. doi: 10.1073/pnas.0711642105.
PMCID: PMC2268187
High levels of erythropoietin are associated with protection against neurological sequelae in African children with cerebral malaria
Climent Casals-Pascual, Richard Idro, Nimmo Gicheru, Samson Gwer, Barnes Kitsao, Evelyn Gitau, Robert Mwakesi, David J. Roberts, and Charles R. J. C. Newton
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2634–2639. doi: 10.1073/pnas.0709715105.
PMCID: PMC2268188
Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression
Farbod Shojaei, Mallika Singh, Jennifer D. Thompson, and Napoleone Ferrara
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2640–2645. doi: 10.1073/pnas.0712185105.
PMCID: PMC2268189
Expanded CTG repeats within the DMPK 3′ UTR causes severe skeletal muscle wasting in an inducible mouse model for myotonic dystrophy
James P. Orengo, Pierre Chambon, Daniel Metzger, Dennis R. Mosier, G. Jackson Snipes, and Thomas A. Cooper
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2646–2651. doi: 10.1073/pnas.0708519105.
PMCID: PMC2268190
Helical domain and kinase domain mutations in p110α of phosphatidylinositol 3-kinase induce gain of function by different mechanisms
Li Zhao and Peter K. Vogt
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2652–2657. doi: 10.1073/pnas.0712169105.
PMCID: PMC2268191
Microbiology
The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum
Eszter Lázár-Molnár, Attila Gácser, Gordon J. Freeman, Steven C. Almo, Stanley G. Nathenson, and Joshua D. Nosanchuk
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2658–2663. doi: 10.1073/pnas.0711918105.
PMCID: PMC2268192
Receptor determinants of zoonotic transmission of New World hemorrhagic fever arenaviruses
Sheli R. Radoshitzky, Jens H. Kuhn, Christina F. Spiropoulou, César G. Albariño, Dan P. Nguyen, Jorge Salazar-Bravo, Tatyana Dorfman, Amy S. Lee, Enxiu Wang, Susan R. Ross, Hyeryun Choe, and Michael Farzan
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2664–2669. doi: 10.1073/pnas.0709254105.
PMCID: PMC2268193
A cell–cell signaling sensor is required for virulence and insect transmission of Xylella fastidiosa
Subhadeep Chatterjee, Christina Wistrom, and Steven E. Lindow
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2670–2675. doi: 10.1073/pnas.0712236105.
PMCID: PMC2268194
Neuroscience
From the Cover:
Detailed recollection of remote autobiographical memory after damage to the medial temporal lobe
C. Brock Kirwan, Peter J. Bayley, Veronica V. Galván, and Larry R. Squire
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2676–2680. doi: 10.1073/pnas.0712155105.
PMCID: PMC2268195
Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Aβ toxicity
Joel N. Buxbaum, Zhengyi Ye, Natàlia Reixach, Linsey Friske, Coree Levy, Pritam Das, Todd Golde, Eliezer Masliah, Amanda R. Roberts, and Tamas Bartfai
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2681–2686. doi: 10.1073/pnas.0712197105.
PMCID: PMC2268196
Starvation after AgRP neuron ablation is independent of melanocortin signaling
Qi Wu, Maureen P. Howell, Michael A. Cowley, and Richard D. Palmiter
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2687–2692. doi: 10.1073/pnas.0712062105.
PMCID: PMC2268197
A Drosophila model for LRRK2-linked parkinsonism
Zhaohui Liu, Xiaoyue Wang, Yi Yu, Xueping Li, Tao Wang, Haibing Jiang, Qiuting Ren, Yuchen Jiao, Akira Sawa, Timothy Moran, Christopher A. Ross, Craig Montell, and Wanli W. Smith
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2693–2698. doi: 10.1073/pnas.0708452105.
PMCID: PMC2268198
GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current
Jane E. Lauckner, Jill B. Jensen, Huei-Ying Chen, Hui-Chen Lu, Bertil Hille, and Ken Mackie
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2699–2704. doi: 10.1073/pnas.0711278105.
PMCID: PMC2268199
Anti-Ca2+ channel antibody attenuates Ca2+ currents and mimics cerebellar ataxia in vivo
Yaping Joyce Liao, Parsa Safa, Yi-Ren Chen, Raymond A. Sobel, Edward S. Boyden, and Richard W. Tsien
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2705–2710. doi: 10.1073/pnas.0710771105.
PMCID: PMC2268200
BDNF is essential to promote persistence of long-term memory storage
Pedro Bekinschtein, Martín Cammarota, Cynthia Katche, Leandro Slipczuk, Janine I. Rossato, Andrea Goldin, Ivan Izquierdo, and Jorge H. Medina
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2711–2716. doi: 10.1073/pnas.0711863105.
PMCID: PMC2268201
Galanin decreases proliferation of PC12 cells and induces apoptosis via its subtype 2 receptor (GalR2)
R. Tofighi, B. Joseph, S. Xia, Z.-Q. D. Xu, B. Hamberger, T. Hökfelt, and S. Ceccatelli
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2717–2722. doi: 10.1073/pnas.0712300105.
PMCID: PMC2268202
Pharmacology
IL-33 mediates antigen-induced cutaneous and articular hypernociception in mice
Waldiceu A. Verri, Jr., Ana T. G. Guerrero, Sandra Y. Fukada, Daniel A. Valerio, Thiago M. Cunha, Damo Xu, Sérgio H. Ferreira, Foo Y. Liew, and Fernando Q. Cunha
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2723–2728. doi: 10.1073/pnas.0712116105.
PMCID: PMC2268203
Physiology
Reverse wave propagation in the cochlea
Wenxuan He, Anders Fridberger, Edward Porsov, Karl Grosh, and Tianying Ren
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2729–2733. doi: 10.1073/pnas.0708103105.
PMCID: PMC2268204
Plant Biology
Structural insight into the reaction mechanism and evolution of cytokinin biosynthesis
Hajime Sugawara, Nanae Ueda, Mikiko Kojima, Nobue Makita, Tomoyuki Yamaya, and Hitoshi Sakakibara
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2734–2739. doi: 10.1073/pnas.0707374105.
PMCID: PMC2268205
Population Biology
Reanalyses of Gulf of Mexico fisheries data: Landings can be misleading in assessments of fisheries and fisheries ecosystems
Kim de Mutsert, James H. Cowan, Jr., Timothy E. Essington, and Ray Hilborn
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2740–2744. doi: 10.1073/pnas.0704354105.
PMCID: PMC2268206
Psychology
Bayesian learning of visual chunks by human observers
Gergő Orbán, József Fiser, Richard N. Aslin, and Máté Lengyel
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2745–2750. doi: 10.1073/pnas.0708424105.
PMCID: PMC2268207
Social Sciences
Environmental Sciences
From the Cover:
The collective-risk social dilemma and the prevention of simulated dangerous climate change
Manfred Milinski, Ralf D. Sommerfeld, Hans-Jürgen Krambeck, Floyd A. Reed, and Jochem Marotzke
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2291–2294. doi: 10.1073/pnas.0709546105.
PMCID: PMC2268129
Evidence for a fundamental and pervasive shift away from nature-based recreation
Oliver R. W. Pergams and Patricia A. Zaradic
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2295–2300. doi: 10.1073/pnas.0709893105.
PMCID: PMC2268130
Temporal and spatial changes in social vulnerability to natural hazards
Susan L. Cutter and Christina Finch
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2301–2306. doi: 10.1073/pnas.0710375105.
PMCID: PMC2268131
Sustainability Science
Temporal and spatial changes in social vulnerability to natural hazards
Susan L. Cutter and Christina Finch
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2301–2306. doi: 10.1073/pnas.0710375105.
PMCID: PMC2268131
Correction
Correction for Turner et al., Land Change Science Special Feature: The emergence of land change science for global environmental change and sustainability
Proc Natl Acad Sci U S A. 2008 February 19; 105(7): 2751. doi: 10.1073/pnas.0800052105.
PMCID: PMC2268208
Corrects: B. L. Turner, II, et al. From The Cover:Land Change Science Special Feature:
The emergence of land change science for global environmental change and sustainability.
Proc Natl Acad Sci U S A. 2007 December 26; 104(52): 20666–20671.
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