Ally (CASRN 74223-64-6)
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0288
Ally;
CASRN 74223-64-6
Health assessment information on a chemical substance is included in IRIS
only after a comprehensive review of chronic toxicity data by U.S. EPA
health scientists from several Program Offices and the Office of Research
and Development. The summaries presented in Sections I and II represent
a consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR Ally
File First On-Line 06/30/1988
Category (section) |
Status |
Last Revised |
---|---|---|
Oral RfD Assessment (I.A.) | on-line | 06/30/1988 |
Inhalation RfC Assessment (I.B.) | no data | |
Carcinogenicity Assessment (II.) | no data |
_I. Chronic Health Hazard Assessments for Noncarcinogenic Effects
_I.A. Reference Dose for Chronic Oral Exposure (RfD)
Substance Name — Ally
CASRN — 74223-64-6
Last Revised — 06/30/1988
The oral Reference Dose (RfD) is based on the assumption that thresholds
exist for certain toxic effects such as cellular necrosis. It is expressed
in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty
spanning perhaps an order of magnitude) of a daily exposure to the human
population (including sensitive subgroups) that is likely to be without
an appreciable risk of deleterious effects during a lifetime. Please refer
to the Background Document for an elaboration of these concepts. RfDs
can also be derived for the noncarcinogenic health effects of substances
that are also carcinogens. Therefore, it is essential to refer to other
sources of information concerning the carcinogenicity of this substance.
If the U.S. EPA has evaluated this substance for potential human carcinogenicity,
a summary of that evaluation will be contained in Section II of this file.
__I.A.1. Oral RfD Summary
Critical Effect |
Experimental Doses* |
UF |
MF |
RfD |
---|---|---|---|---|
Decreased body 2-Year Rat Feeding/ duPont, 1985a |
NOEL: 500 ppm (25 LEL: 5000 ppm (250 |
100
|
1
|
2.5E-1
mg/kg/day |
*Conversion Factors -- 1 ppm = 0.05 mg/kg/day (assumed rat food consumption)
__I.A.2. Principal and Supporting Studies (Oral RfD)
E.I. duPont de Nemours and Company, Inc. 1985a. MRID No. 00125931, 00151029, 00154477. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Groups of 90 male and 90 female Sprague-Dawley rats were fed diets containing the test material at levels of 0, 5, 25, 500, or 5000 ppm for 2 years. Twenty animals/sex/group were removed from the chronic study at 11 weeks for the reproductive phase of the study and put back into the chronic phase at week 32. The LEL for systemic chronic toxicity is considered to be 5000 ppm based on body weights. The NOEL has been determined to be 500 ppm.
Groups of 19 or 20 female rabbits were administered 2 mL portions of ally in 0.5% aqueous methocel by gavage during days 6 to 18 of gestation, at doses of either 25, 100, 300, or 700 mg/kg/day. Developmental toxicity was not demonstrated. Maternal toxicity was shown by a dose-related increase in mortality and decrease in body weight at doses of 100 mg/kg/day or higher. The 25 mg/kg/day dose was a NOEL. These results are consistent with those of the primary study.
__I.A.3. Uncertainty and Modifying Factors (Oral RfD)
UF — An uncertainty factor of 100 was used to account for the inter- and intraspecies differences.
MF — None
__I.A.4. Additional Studies/Comments (Oral RfD)
Data Considered for Establishing the RfD:
1) 2-Year Feeding (oncogenic) - rat: Principal study - see previous description; core grade minimum
2) 1-Year Feeding - dog: NOEL=5000 ppm (125 mg/kg/day) (no effect at the HDT); core grade minimum (duPont, 1984)
3) 2-Generation Reproduction - rat: Maternal NOEL=500 ppm (25 mg/kg/day); Maternal LEL=5000 ppm (250 mg/kg/day) (decreased weight gain); Reproductive NOEL=5000 ppm (HDT); Fetotoxic NOEL=5000 ppm (HDT); core grade minimum (duPont, 1985b)
4) Teratology - rat: Teratogenic NOEL=1000 mg/kg/day (HDT); Fetotoxic NOEL=1000 mg/kg/day; Maternal toxic NOEL=none; Maternal toxic LEL=40 mg/kg/day (hyperactivity, ungroomed coat); core grade minimum (duPont, 1982)
5) Teratology - rabbit: Maternal toxic NOEL=25 mg/kg/day; Maternal toxic LEL=100 mg/kg/day (decreased weight gain and death); Teratogenic NOEL=700 mg/kg/day; Fetotoxic NOEL=700 mg/kg/day (HDT); core grade minimum (duPont, 1985c)
Data Gap(s): None
__I.A.5. Confidence in the Oral RfD
Study — High
Database — High
RfD — High
The critical study is of good quality and and is given a high confidence rating. Additional studies are also of good quality; therefore, the database is given a high confidence rating. High confidence in the RfD follows.
__I.A.6. EPA Documentation and Review of the Oral RfD
Source Document — This assessment is not presented in any existing U.S. EPA document.
Other EPA Documentation — Pesticide Registration Files
Agency Work Group Review — 04/22/1986, 08/12/1987
Verification Date — 08/12/1987
Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the RfD for Ally conducted in September 2002 did not identify any critical new studies. IRIS users who know of important new studies may provide that information to the IRIS Hotline at hotline.iris@epa.gov or (202)566-1676.
__I.A.7. EPA Contacts (Oral RfD)
Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).
_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)
Substance Name — Ally
CASRN — 74223-64-6
Not available at this time.
_II. Carcinogenicity Assessment for Lifetime Exposure
Substance Name — Ally
CASRN — 74223-64-6
This substance/agent has not undergone a complete evaluation and determination under US EPA's IRIS program for evidence of human carcinogenic potential.
_III.
[reserved]
_IV. [reserved]
_V. [reserved]
_VI. Bibliography
Substance Name — Ally
CASRN — 74223-64-6
Last Revised — 11/01/1989
_VI.A. Oral RfD References
E.I. duPont de Nemours and Company, Inc. 1982. MRID No. 00125835. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
E.I. duPont de Nemours and Company, Inc. 1984. MRID No. 00141821. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
E.I. duPont de Nemours and Company, Inc. 1985a. MRID No. 00125931, 00151029, 00154477. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
E.I. duPont de Nemours and Company, Inc. 1985b. MRID No. 00151028. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
E.I. duPont de Nemours and Company, Inc. 1985c. MRID No. 00151028. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
_VI.B. Inhalation RfD References
None
_VI.C. Carcinogenicity Assessment References
None
_VII. Revision History
Substance Name — Ally
CASRN — 74223-64-6
Date |
Section |
Description |
---|---|---|
11/01/1989 | VI. | Bibliography on-line |
04/01/1997 | III., IV., V. | Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information. |
12/03/2002 | I.A.6. | Screening-Level Literature Review Findings message has been added. |
_VIII. Synonyms
Substance Name — Ally
CASRN — 74223-64-6
Last Revised — 06/30/1988
- 74223-64-6
- Ally
- Benzoic acid, 2-(((((4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino)- carbonyl)amino)sulfonyl)-, methyl ester
- Benzoic acid, 2-(((((4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino)carbonyl)amino)sulfonyl)-, methyl ester (9CI)
- Caswell No. 419H
- DPD 63760M
- DPX 6376
- DPX T6376
- EPA Pesticide Chemical Code 122010
- Gropper
- Methyl-2-((((4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino)carbonyl)amino)sulfonyl)benzoate
- Metsulfuron-methyl
- Metsulfuron methyl ester [ANSI]