| | This journal provides immediate access to some articles. Commentaries Six blind men and the elephant—the many faces of heparan sulfate Ajit Varki Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 543–545. doi: 10.1073/pnas.022649499.PMCID: PMC117338 Deciphering genetic regulatory codes: A challenge for functional genomics Alan M. Michelson Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 546–548. doi: 10.1073/pnas.032685999.PMCID: PMC117339 Substance P, opioid, and catecholamine systems in the mouse central nervous system (CNS) R. G. Hill Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 549–551. doi: 10.1073/pnas.032663599.PMCID: PMC117340 Reaping of nitric oxide by sickle cell disease Jack R. Lancaster, Jr. Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 552–553. doi: 10.1073/pnas.032633399.PMCID: PMC117341 Ecological pork: Novel resources and the trophic reorganization of an ecosystem Robert T. Paine and Daniel E. Schindler Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 554–555. doi: 10.1073/pnas.032685599.PMCID: PMC117342 Chemical warfare from an ecological perspective Richard E. Lenski and Margaret A. Riley Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 556–558. doi: 10.1073/pnas.022641999.PMCID: PMC117343 Physical Sciences Chemistry A stochastic algorithm for global optimization and for best populations: A test case of side chains in proteins Meir Glick, Anwar Rayan, and Amiram Goldblum Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 703–708. Published online 2002 January 15. doi: 10.1073/pnas.022418199.PMCID: PMC117369 Geophysics Redefinition of the mode Grüneisen parameter for polyatomic substances and thermodynamic implications Anne M. Hofmeister and Ho-kwang Mao Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 559–564. doi: 10.1073/pnas.241631698.PMCID: PMC117344 Mathematics Generator problem for certain property T factors Liming Ge and Junhao Shen Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 565–567. Published online 2002 January 15. doi: 10.1073/pnas.022593699.PMCID: PMC117345 Biological Sciences Applied Biological Sciences Tumor cell surface heparan sulfate as cryptic promoters or inhibitors of tumor growth and metastasis Dongfang Liu, Zachary Shriver, Ganesh Venkataraman, Yosuf El Shabrawi, and Ram Sasisekharan Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 568–573. doi: 10.1073/pnas.012578299.PMCID: PMC117346 High throughput DNA sequencing with a microfabricated 96-lane capillary array electrophoresis bioprocessor Brian M. Paegel, Charles A. Emrich, Gary J. Wedemayer, James R. Scherer, and Richard A. Mathies Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 574–579. Published online 2002 January 15. doi: 10.1073/pnas.012608699.PMCID: PMC117347 Biochemistry Abietadiene synthase catalysis: Mutational analysis of a prenyl diphosphate ionization-initiated cyclization and rearrangement Reuben J. Peters and Rodney B. Croteau Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 580–584. doi: 10.1073/pnas.022627099.PMCID: PMC117348 Blocking site-to-site translocation of a misactivated amino acid by mutation of a class I tRNA synthetase Anthony C. Bishop, Tyzoon K. Nomanbhoy, and Paul Schimmel Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 585–590. Published online 2002 January 8. doi: 10.1073/pnas.012611299.PMCID: PMC117349 From the Cover: Snapshot of a key intermediate in enzymatic thiamin catalysis: Crystal structure of the α-carbanion of (α,β-dihydroxyethyl)-thiamin diphosphate in the active site of transketolase from Saccharomyces cerevisiae Erik Fiedler, Stina Thorell, Tatyana Sandalova, Ralph Golbik, Stephan König, and Gunter Schneider Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 591–595. Published online 2002 January 2. doi: 10.1073/pnas.022510999.PMCID: PMC117350 Archaeal dUTPase enhances PCR amplifications with archaeal DNA polymerases by preventing dUTP incorporation Holly H. Hogrefe, Connie J. Hansen, Bradley R. Scott, and Kirk B. Nielson Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 596–601. Published online 2002 January 8. doi: 10.1073/pnas.012372799.PMCID: PMC117351 Multiple hematopoietic defects and delayed globin switching in Ikaros null mice Rocio A. Lopez, Stuti Schoetz, Kathryn DeAngelis, David O'Neill, and Arthur Bank Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 602–607. doi: 10.1073/pnas.022412699.PMCID: PMC117352 Protein and ligand dynamics in 4-hydroxybenzoate hydroxylase Jian Wang, Mariliz Ortiz-Maldonado, Barrie Entsch, Vincent Massey, David Ballou, and Domenico L. Gatti Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 608–613. doi: 10.1073/pnas.022640199.PMCID: PMC117353 Combinatorial approaches: A new tool to search for highly structured β-hairpin peptides Maria Teresa Pastor, Manuela López de la Paz, Emmanuel Lacroix, Luis Serrano, and Enrique Pérez-Payá Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 614–619. Published online 2002 January 8. doi: 10.1073/pnas.012583999.PMCID: PMC117354 Gene characterized for membrane desaturase that produces (E)-11 isomers of mono- and diunsaturated fatty acids Weitian Liu, Hongmei Jiao, Nancy C. Murray, Marion O'Connor, and Wendell L. Roelofs Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 620–624. doi: 10.1073/pnas.221601498.PMCID: PMC117355 A mutation in the peroxisome proliferator-activated receptor γ-binding site in the gene for the cytosolic form of phosphoenolpyruvate carboxykinase reduces adipose tissue size and fat content in mice Yael Olswang, Hannah Cohen, Orit Papo, Hanoch Cassuto, Colleen M. Croniger, Parvin Hakimi, Shirley M. Tilghman, Richard W. Hanson, and Lea Reshef Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 625–630. Published online 2002 January 15. doi: 10.1073/pnas.022616299.PMCID: PMC117356 Herpes simplex virus 1-infected cell protein 0 contains two E3 ubiquitin ligase sites specific for different E2 ubiquitin-conjugating enzymes Ryan Hagglund, Charles Van Sant, Pascal Lopez, and Bernard Roizman Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 631–636. doi: 10.1073/pnas.022531599.PMCID: PMC117357 mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties Dong-chul Kang, Rahul V. Gopalkrishnan, Qingping Wu, Eckhard Jankowsky, Anna Marie Pyle, and Paul B. Fisher Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 637–642. doi: 10.1073/pnas.022637199.PMCID: PMC117358 Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptides Lidija Covic, Amy L. Gresser, Joyce Talavera, Steven Swift, and Athan Kuliopulos Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 643–648. doi: 10.1073/pnas.022460899.PMCID: PMC117359 Transcription-coupled repair in RNA polymerase I-transcribed genes of yeast Antonio Conconi, Vyacheslav A. Bespalov, and Michael J. Smerdon Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 649–654. Published online 2002 January 8. doi: 10.1073/pnas.022373099.PMCID: PMC117360 tRNA elements mediate the assembly of an icosahedral RNA virus Yoon Gi Choi, Theo W. Dreher, and A. L. N. Rao Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 655–660. Published online 2002 January 8. doi: 10.1073/pnas.022618199.PMCID: PMC117361 Supervillin associates with androgen receptor and modulates its transcriptional activity Huei-Ju Ting, Shuyuan Yeh, Kazuo Nishimura, and Chawnshang Chang Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 661–666. Published online 2002 January 15. doi: 10.1073/pnas.022469899.PMCID: PMC117362 Biophysics From the Cover: Self-assembly properties of a model RING domain Alex Kentsis, Ronald E. Gordon, and Katherine L. B. Borden Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 667–672. Published online 2002 January 15. doi: 10.1073/pnas.012317299.PMCID: PMC117363 Robustness of circadian rhythms with respect to molecular noise Didier Gonze, José Halloy, and Albert Goldbeter Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 673–678. Published online 2002 January 15. doi: 10.1073/pnas.022628299.PMCID: PMC117364 Synchronizing genetic relaxation oscillators by intercell signaling David McMillen, Nancy Kopell, Jeff Hasty, and J. J. Collins Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 679–684. doi: 10.1073/pnas.022642299.PMCID: PMC117365 Protein folding mediated by solvation: Water expulsion and formation of the hydrophobic core occur after the structural collapse Margaret S. Cheung, Angel E. García, and José N. Onuchic Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 685–690. doi: 10.1073/pnas.022387699.PMCID: PMC117366 Improved recognition of native-like protein structures using a family of designed sequences Patrice Koehl and Michael Levitt Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 691–696. Published online 2002 January 8. doi: 10.1073/pnas.022408799.PMCID: PMC117367 Function of the voltage gate of gap junction channels: Selective exclusion of molecules Yang Qu and Gerhard Dahl Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 697–702. doi: 10.1073/pnas.022324499.PMCID: PMC117368 A stochastic algorithm for global optimization and for best populations: A test case of side chains in proteins Meir Glick, Anwar Rayan, and Amiram Goldblum Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 703–708. Published online 2002 January 15. doi: 10.1073/pnas.022418199.PMCID: PMC117369 Real-time and equilibrium 19F-NMR studies reveal the role of domain–domain interactions in the folding of the chaperone PapD James G. Bann, Jerome Pinkner, Scott J. Hultgren, and Carl Frieden Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 709–714. Published online 2002 January 15. doi: 10.1073/pnas.022649599.PMCID: PMC117370 Cell Biology Reactive oxygen generated by Nox1 triggers the angiogenic switch Jack L. Arbiser, John Petros, Robert Klafter, Baskaran Govindajaran, Elizabeth R. McLaughlin, Lawrence F. Brown, Cynthia Cohen, Marsha Moses, Susan Kilroy, Rebecca S. Arnold, and J. David Lambeth Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 715–720. doi: 10.1073/pnas.022630199.PMCID: PMC117371 Characterization of protein kinase C β isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization Kiyoshi Suzuma, Noriko Takahara, Izumi Suzuma, Keiji Isshiki, Kohjiro Ueki, Michael Leitges, Lloyd Paul Aiello, and George L. King Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 721–726. doi: 10.1073/pnas.022644499.PMCID: PMC117372 Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment Paul J. Muchowski, Ke Ning, Crislyn D'Souza-Schorey, and Stanley Fields Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 727–732. Published online 2002 January 15. doi: 10.1073/pnas.022628699.PMCID: PMC117373 Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration Huaiyang Chen, Ian C. Duncan, Hormozd Bozorgchami, and Su Hao Lo Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 733–738. Published online 2002 January 15. doi: 10.1073/pnas.022518699.PMCID: PMC117374 Activity of the TonEBP/OREBP transactivation domain varies directly with extracellular NaCl concentration Joan D. Ferraris, Chester K. Williams, Prita Persaud, Zheng Zhang, Ye Chen, and Maurice B. Burg Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 739–744. Published online 2002 January 15. doi: 10.1073/pnas.241637298.PMCID: PMC117375 Budding yeast Dsk2p is a polyubiquitin-binding protein that can interact with the proteasome Minoru Funakoshi, Toru Sasaki, Takeharu Nishimoto, and Hideki Kobayashi Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 745–750. doi: 10.1073/pnas.012585199.PMCID: PMC117376 Actin cable dynamics in budding yeast Hyeong-Cheol Yang and Liza A. Pon Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 751–756. doi: 10.1073/pnas.022462899.PMCID: PMC117377 Developmental Biology Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genome Benjamin P. Berman, Yutaka Nibu, Barret D. Pfeiffer, Pavel Tomancak, Susan E. Celniker, Michael Levine, Gerald M. Rubin, and Michael B. Eisen Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 757–762. doi: 10.1073/pnas.231608898.PMCID: PMC117378 Genome-wide analysis of clustered Dorsal binding sites identifies putative target genes in the Drosophila embryo Michele Markstein, Peter Markstein, Vicky Markstein, and Michael S. Levine Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 763–768. Published online 2001 December 18. doi: 10.1073/pnas.012591199.PMCID: PMC117379 Evolution of germ-line signals that regulate growth and aging in nematodes Mavji N. Patel, Christopher G. Knight, Constantina Karageorgi, and Armand M. Leroi Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 769–774. doi: 10.1073/pnas.012511099.PMCID: PMC117380 APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos Caroline Goutte, Makoto Tsunozaki, Valerie A. Hale, and James R. Priess Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 775–779. Published online 2002 January 15. doi: 10.1073/pnas.022523499.PMCID: PMC117381 Genomic structure and functional control of the Dlx3-7 bigene cluster Kenta Sumiyama, Steven Q. Irvine, David W. Stock, Kenneth M. Weiss, Kazuhiko Kawasaki, Nobuyoshi Shimizu, Cooduvalli S. Shashikant, Webb Miller, and Frank H. Ruddle Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 780–785. Published online 2002 January 15. doi: 10.1073/pnas.012584999.PMCID: PMC117382 Ecology Chemical warfare between microbes promotes biodiversity Tamás L. Czárán, Rolf F. Hoekstra, and Ludo Pagie Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 786–790. Published online 2002 January 15. doi: 10.1073/pnas.012399899.PMCID: PMC117383 From the Cover: Golden eagles, feral pigs, and insular carnivores: How exotic species turn native predators into prey Gary W. Roemer, C. Josh Donlan, and Franck Courchamp Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 791–796. Published online 2001 December 18. doi: 10.1073/pnas.012422499.PMCID: PMC117384 Evolution In silico chromosome staining: Reconstruction of Giemsa bands from the whole human genome sequence Yoshihito Niimura and Takashi Gojobori Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 797–802. Published online 2002 January 15. doi: 10.1073/pnas.022437999.PMCID: PMC117385 Mutation rates in mammalian genomes Sudhir Kumar and Sankar Subramanian Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 803–808. Published online 2002 January 15. doi: 10.1073/pnas.022629899.PMCID: PMC117386 Recombinatoric exploration of novel folded structures: A heteropolymer-based model of protein evolutionary landscapes Yan Cui, Wing Hung Wong, Erich Bornberg-Bauer, and Hue Sun Chan Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 809–814. doi: 10.1073/pnas.022240299.PMCID: PMC117387 Genetics Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genome Benjamin P. Berman, Yutaka Nibu, Barret D. Pfeiffer, Pavel Tomancak, Susan E. Celniker, Michael Levine, Gerald M. Rubin, and Michael B. Eisen Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 757–762. doi: 10.1073/pnas.231608898.PMCID: PMC117378 Molecular analysis of mutations in DNA polymerase η in xeroderma pigmentosum-variant patients Bernard C. Broughton, Agnes Cordonnier, Wim J. Kleijer, Nicolaas G. J. Jaspers, Heather Fawcett, Anja Raams, Victor H. Garritsen, Anne Stary, Marie-Françoise Avril, François Boudsocq, Chikahide Masutani, Fumio Hanaoka, Robert P. Fuchs, Alain Sarasin, and Alan R. Lehmann Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 815–820. Published online 2002 January 2. doi: 10.1073/pnas.022473899.PMCID: PMC117388 Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α David D. Kline, Ying-Jie Peng, Dominador J. Manalo, Gregg L. Semenza, and Nanduri R. Prabhakar Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 821–826. Published online 2002 January 15. doi: 10.1073/pnas.022634199.PMCID: PMC117389 From the Cover: Evaluation of linkage of breast cancer to the putative BRCA3 locus on chromosome 13q21 in 128 multiple case families from the Breast Cancer Linkage Consortium Deborah Thompson, Csilla I. Szabo, Jon Mangion, Rogier A. Oldenburg, Fabrice Odefrey, Sheila Seal, Rita Barfoot, Karin Kroeze-Jansema, Dawn Teare, Nazneen Rahman, Hélène Renard, KConFab Consortium, Graham Mann, John L. Hopper, Saundra S. Buys, Irene L. Andrulis, Ruby Senie, Mary B. Daly, Dee West, Elaine A. Ostrander, Ken Offit, Tamar Peretz, Ana Osorio, J. Benitez, Katherine L. Nathanson, Olga M. Sinilnikova, Edith Olàh, Yves-Jean Bignon, Pablo Ruiz, Michael D. Badzioch, Hans F. A. Vasen, Andrew P. Futreal, Catherine M. Phelan, Steven A. Narod, Henry T. Lynch, Bruce A. J. Ponder, Ros A. Eeles, Hanne Meijers-Heijboer, Dominique Stoppa-Lyonnet, Fergus J. Couch, Diana M. Eccles, D. Gareth Evans, Jenny Chang-Claude, Gilbert Lenoir, Barbara L. Weber, Peter Devilee, Douglas F. Easton, David E. Goldgar, and Michael R. Stratton Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 827–831. Published online 2002 January 15. doi: 10.1073/pnas.012584499.PMCID: PMC117390 Ku86 is essential in human somatic cells Gang Li, Caron Nelsen, and Eric A. Hendrickson Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 832–837. Published online 2002 January 15. doi: 10.1073/pnas.022649699.PMCID: PMC117391 Life extension in Drosophila by feeding a drug Hyung-Lyun Kang, Seymour Benzer, and Kyung-Tai Min Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 838–843. Published online 2002 January 15. doi: 10.1073/pnas.022631999.PMCID: PMC117392 Functional annotation of mammalian genomic DNA sequence by chemical mutagenesis: A fine-structure genetic mutation map of a 1- to 2-cM segment of mouse chromosome 7 corresponding to human chromosome 11p14-p15 Eugene M. Rinchik, Donald A. Carpenter, and Dabney K. Johnson Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 844–849. Published online 2002 January 15. doi: 10.1073/pnas.022628199.PMCID: PMC117393 Physical and genetic mapping of barley (Hordeum vulgare) germin-like cDNAs Arnis Druka, David Kudrna, C. Gamini Kannangara, Diter von Wettstein, and Andris Kleinhofs Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 850–855. Published online 2002 January 15. doi: 10.1073/pnas.022627999.PMCID: PMC117394 Association of human aging with a functional variant of klotho Dan E. Arking, Alice Krebsova, Milan Macek, Sr., Milan Macek, Jr., Albert Arking, I. Saira Mian, Linda Fried, Ada Hamosh, Srabani Dey, Iain McIntosh, and Harry C. Dietz Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 856–861. Published online 2002 January 15. doi: 10.1073/pnas.022484299.PMCID: PMC117395 Evidence for positive selection and population structure at the human MAO-A gene Yoav Gilad, Shai Rosenberg, Molly Przeworski, Doron Lancet, and Karl Skorecki Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 862–867. doi: 10.1073/pnas.022614799.PMCID: PMC117396 Immunology Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation Russell E. Vance, Amanda M. Jamieson, Dragana Cado, and David H. Raulet Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 868–873. Published online 2002 January 8. doi: 10.1073/pnas.022500599.PMCID: PMC117397 Grafts of supplementary thymuses injected with allogeneic pancreatic islets protect nonobese diabetic mice against diabetes J. Salaün, N. Simmenauer, P. Belo, A. Coutinho, and N. M. Le Douarin Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 874–877. Published online 2002 January 15. doi: 10.1073/pnas.012597499.PMCID: PMC117398 Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice Y. Zhang, S. F. Schlossman, R. A. Edwards, Ching-Nan Ou, J. Gu, and Mei X. Wu Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 878–883. Published online 2002 January 8. doi: 10.1073/pnas.022326699.PMCID: PMC117399 Differential role of SLP-76 domains in T cell development and function Lalit Kumar, Vadim Pivniouk, Miguel A. de la Fuente, Dhafer Laouini, and Raif S. Geha Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 884–889. Published online 2002 January 15. doi: 10.1073/pnas.022619199.PMCID: PMC117400 Medical Sciences Plasminogen activator inhibitor-1 is a major stress-regulated gene: Implications for stress-induced thrombosis in aged individuals Koji Yamamoto, Kyosuke Takeshita, Takayoshi Shimokawa, Hong Yi, Ken-ichi Isobe, David J. Loskutoff, and Hidehiko Saito Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 890–895. Published online 2002 January 15. doi: 10.1073/pnas.022608799.PMCID: PMC117401 Heat shock protein 90 catalyzes activation of the prekallikrein-kininogen complex in the absence of factor XII Kusumam Joseph, Baby G. Tholanikunnel, and Allen P. Kaplan Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 896–900. Published online 2002 January 15. doi: 10.1073/pnas.022626899.PMCID: PMC117402 Rescue of hereditary form of dilated cardiomyopathy by rAAV-mediated somatic gene therapy: Amelioration of morphological findings, sarcolemmal permeability, cardiac performances, and the prognosis of TO-2 hamsters Tomie Kawada, Mikio Nakazawa, Sakura Nakauchi, Ken Yamazaki, Ryoichi Shimamoto, Masashi Urabe, Jumi Nakata, Chieko Hemmi, Fujiko Masui, Toshiaki Nakajima, Jun-Ichi Suzuki, John Monahan, Hiroshi Sato, Tomoh Masaki, Keiya Ozawa, and Teruhiko Toyo-oka Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 901–906. doi: 10.1073/pnas.022641799.PMCID: PMC117403 Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo Christopher L. Antos, Timothy A. McKinsey, Norbert Frey, William Kutschke, John McAnally, John M. Shelton, James A. Richardson, Joseph A. Hill, and Eric N. Olson Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 907–912. Published online 2002 January 8. doi: 10.1073/pnas.231619298.PMCID: PMC117404 Ca2+-desensitizing effect of a deletion mutation ΔK210 in cardiac troponin T that causes familial dilated cardiomyopathy S. Morimoto, Q.-W. Lu, K. Harada, F. Takahashi-Yanaga, R. Minakami, M. Ohta, T. Sasaguri, and I. Ohtsuki Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 913–918. Published online 2002 January 2. doi: 10.1073/pnas.022628899.PMCID: PMC117405 Lymph nodal prion replication and neuroinvasion in mice devoid of follicular dendritic cells Marco Prinz, Fabio Montrasio, Michael A. Klein, Petra Schwarz, Josef Priller, Bernhard Odermatt, Klaus Pfeffer, and Adriano Aguzzi Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 919–924. Published online 2002 January 15. doi: 10.1073/pnas.022626399.PMCID: PMC117406 Missense mutations but not allelic variants alter the function of ATM by dominant interference in patients with breast cancer Shaun P. Scott, Regina Bendix, Philip Chen, Raymond Clark, Thilo Dörk, and Martin F. Lavin Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 925–930. doi: 10.1073/pnas.012329699.PMCID: PMC117407 Tumor lysate-pulsed dendritic cells can elicit an effective antitumor immune response during early lymphoid recovery W. Asavaroengchai, Y. Kotera, and J. J. Mulé Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 931–936. Published online 2002 January 15. doi: 10.1073/pnas.022634999.PMCID: PMC117408 A peptide that binds and stabilizes p53 core domain: Chaperone strategy for rescue of oncogenic mutants Assaf Friedler, Lars O. Hansson, Dmitry B. Veprintsev, Stefan M. V. Freund, Thomas M. Rippin, Penka V. Nikolova, Mark R. Proctor, Stefan Rüdiger, and Alan R. Fersht Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 937–942. Published online 2002 January 8. doi: 10.1073/pnas.241629998.PMCID: PMC117409 Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1) Donald Metcalf, Sandra Mifsud, Ladina Di Rago, Nicos A. Nicola, Douglas J. Hilton, and Warren S. Alexander Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 943–948. Published online 2002 January 8. doi: 10.1073/pnas.022628499.PMCID: PMC117410 Tumor necrosis factor-induced modulation of glyoxalase I activities through phosphorylation by PKA results in cell death and is accompanied by the formation of a specific methylglyoxal-derived AGE Franky Van Herreweghe, Jianqiang Mao, Frank W. R. Chaplen, Johan Grooten, Kris Gevaert, Joël Vandekerckhove, and Katia Vancompernolle Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 949–954. Published online 2002 January 15. doi: 10.1073/pnas.012432399.PMCID: PMC117411 Overexpression of the N-terminal domain of TSG101 inhibits HIV-1 budding by blocking late domain function Dimiter G. Demirov, Akira Ono, Jan M. Orenstein, and Eric O. Freed Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 955–960. doi: 10.1073/pnas.032511899.PMCID: PMC117412 Changes in subcellular distribution of pituitary receptors for luteinizing hormone-releasing hormone (LH-RH) after treatment with the LH-RH antagonist cetrorelix Gabor Halmos and Andrew V. Schally Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 961–965. doi: 10.1073/pnas.012598399.PMCID: PMC117413 Microbiology A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae Brian J. Akerley, Eric J. Rubin, Veronica L. Novick, Kensey Amaya, Nicholas Judson, and John J. Mekalanos Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 966–971. doi: 10.1073/pnas.012602299.PMCID: PMC117414 Stereotyped and specific gene expression programs in human innate immune responses to bacteria Jennifer C. Boldrick, Ash A. Alizadeh, Maximilian Diehn, Sandrine Dudoit, Chih Long Liu, Christopher E. Belcher, David Botstein, Louis M. Staudt, Patrick O. Brown, and David A. Relman Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 972–977. doi: 10.1073/pnas.231625398.PMCID: PMC117415 Spontaneous molecular reactivation of herpes simplex virus type 1 latency in mice Lawrence T. Feldman, Aaron R. Ellison, Cynthia C. Voytek, Li Yang, Philip Krause, and Todd P. Margolis Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 978–983. Published online 2002 January 2. doi: 10.1073/pnas.022301899.PMCID: PMC117416 Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum Sorel T. Fitz-Gibbon, Heidi Ladner, Ung-Jin Kim, Karl O. Stetter, Melvin I. Simon, and Jeffrey H. Miller Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 984–989. Published online 2002 January 15. doi: 10.1073/pnas.241636498.PMCID: PMC117417 Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine Ritu Banerjee, Jun Liu, Wandy Beatty, Lorraine Pelosof, Michael Klemba, and Daniel E. Goldberg Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 990–995. Published online 2002 January 8. doi: 10.1073/pnas.022630099.PMCID: PMC117418 Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater Tohru Shimizu, Kaori Ohtani, Hideki Hirakawa, Kenshiro Ohshima, Atsushi Yamashita, Tadayoshi Shiba, Naotake Ogasawara, Masahira Hattori, Satoru Kuhara, and Hideo Hayashi Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 996–1001. Published online 2002 January 15. doi: 10.1073/pnas.022493799.PMCID: PMC117419 Neurobiology Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity Ali Khoshnan, Jan Ko, and Paul H. Patterson Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1002–1007. Published online 2002 January 15. doi: 10.1073/pnas.022631799.PMCID: PMC117420 Role of a locus control region in the mutually exclusive expression of human red and green cone pigment genes Philip M. Smallwood, Yanshu Wang, and Jeremy Nathans Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1008–1011. Published online 2002 January 2. doi: 10.1073/pnas.022629799.PMCID: PMC117421 Synaptophysin regulates activity-dependent synapse formation in cultured hippocampal neurons Leila Tarsa and Yukiko Goda Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1012–1016. Published online 2002 January 15. doi: 10.1073/pnas.022575999.PMCID: PMC117422 Experience-dependent changes in cerebellar contributions to motor sequence learning Julien Doyon, Allen W. Song, Avi Karni, François Lalonde, Michelle M. Adams, and Leslie G. Ungerleider Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1017–1022. doi: 10.1073/pnas.022615199.PMCID: PMC117423 Costimulation of N-methyl-d-aspartate and muscarinic neuronal receptors modulates gap junctional communication in striatal astrocytes N. Rouach, M. Tencé, J. Glowinski, and C. Giaume Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1023–1028. Published online 2002 January 15. doi: 10.1073/pnas.022257499.PMCID: PMC117424 The NK1 receptor mediates both the hyperalgesia and the resistance to morphine in mice lacking noradrenaline Luc Jasmin, Duc Tien, David Weinshenker, Richard D. Palmiter, Paul G. Green, Gabriella Janni, and Peter T. Ohara Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1029–1034. doi: 10.1073/pnas.012598599.PMCID: PMC117425 Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain Mats H. Holmqvist, Jie Cao, Ricardo Hernandez-Pineda, Michael D. Jacobson, Karen I. Carroll, M. Amy Sung, Maria Betty, Pei Ge, Kevin J. Gilbride, Melissa E. Brown, Mark E. Jurman, Deborah Lawson, Inmaculada Silos-Santiago, Yu Xie, Manuel Covarrubias, Kenneth J. Rhodes, Peter S. Distefano, and W. Frank An Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1035–1040. doi: 10.1073/pnas.022509299.PMCID: PMC117799 Experience-dependent plasticity without long-term depression by type 2 metabotropic glutamate receptors in developing visual cortex John J. Renger, Kenichi N. Hartman, Yoshiko Tsuchimoto, Mineto Yokoi, Shigetada Nakanishi, and Takao K. Hensch Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1041–1046. doi: 10.1073/pnas.022618799.PMCID: PMC117426 Pharmacology Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin Todd A. Huffman, Isabelle Mothe-Satney, and John C. Lawrence, Jr. Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1047–1052. Published online 2002 January 15. doi: 10.1073/pnas.022634399.PMCID: PMC117427 Physiology Anti-inflammatory role in septic shock of pituitary adenylate cyclase-activating polypeptide receptor Carmen Martinez, Catalina Abad, Mario Delgado, Alicia Arranz, Maria G. Juarranz, Nieves Rodriguez-Henche, Philippe Brabet, Javier Leceta, and Rosa P. Gomariz Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1053–1058. Published online 2002 January 15. doi: 10.1073/pnas.012367999.PMCID: PMC117428 Decreased pulmonary vascular permeability in aquaporin-1-null humans Landon S. King, Søren Nielsen, Peter Agre, and Robert H. Brown Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1059–1063. Published online 2002 January 2. doi: 10.1073/pnas.022626499.PMCID: PMC117429 Plant Biology The tomato Blind gene encodes a MYB transcription factor that controls the formation of lateral meristems Gregor Schmitz, Edith Tillmann, Filomena Carriero, Carola Fiore, Francesco Cellini, and Klaus Theres Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1064–1069. doi: 10.1073/pnas.022516199.PMCID: PMC117430 Directed molecular evolution of ADP-glucose pyrophosphorylase Peter R. Salamone, I. Halil Kavakli, Casey J. Slattery, and Thomas W. Okita Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1070–1075. Published online 2002 January 2. doi: 10.1073/pnas.012603799.PMCID: PMC117431 From the Cover: Suppressors of transcriptional transgenic silencing in Chlamydomonas are sensitive to DNA-damaging agents and reactivate transposable elements Byeong-ryool Jeong, Dancia Wu-Scharf, Chaomei Zhang, and Heriberto Cerutti Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1076–1081. Published online 2002 January 8. doi: 10.1073/pnas.022392999.PMCID: PMC117432 Recombination rates between adjacent genic and retrotransposon regions in maize vary by 2 orders of magnitude Huihua Fu, Zhenwei Zheng, and Hugo K. Dooner Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1082–1087. Published online 2002 January 15. doi: 10.1073/pnas.022635499.PMCID: PMC117433 Impact of folivory on photosynthesis is greater than the sum of its holes A. R. Zangerl, J. G. Hamilton, T. J. Miller, A. R. Crofts, K. Oxborough, M. R. Berenbaum, and E. H. de Lucia Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1088–1091. Published online 2002 January 15. doi: 10.1073/pnas.022647099.PMCID: PMC117434 Evaluation of transgenic tomato plants expressing an additional phytoene synthase in a fruit-specific manner Paul D. Fraser, Susanne Romer, Cathie A. Shipton, Philippa B. Mills, Joy W. Kiano, Norihiko Misawa, Rachel G. Drake, Wolfgang Schuch, and Peter M. Bramley Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1092–1097. doi: 10.1073/pnas.241374598.PMCID: PMC117435 Corrections Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1098. Published online 2001 December 26. doi: 10.1073/pnas.032657499.PMCID: PMC117334 Corrects: Hirofumi Komori, et al. Crystal structure of thermostable DNA photolyase: Pyrimidine-dimer recognition mechanism. Proc Natl Acad Sci U S A. 2001 November 20; 98(24): 13560–13565. Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1098. Published online 2002 January 8. doi: 10.1073/pnas.032605499.PMCID: PMC117335 Corrects: Silvia Santamarina-Fojo, et al. Complete genomic sequence of the human ABCA1 gene: Analysis of the human and mouse ATP-binding cassette A promoter. Proc Natl Acad Sci U S A. 2000 July 5; 97(14): 7987–7992. Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1098. Published online 2002 January 2. doi: 10.1073/pnas.022616599.PMCID: PMC117336 Corrects: Mitchell E. Garber, et al. Diversity of gene expression in adenocarcinoma of the lung. Proc Natl Acad Sci U S A. 2001 November 20; 98(24): 13784–13789. Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1098. Published online 2002 January 2. doi: 10.1073/pnas.032656999.PMCID: PMC117337 Corrects: Zhi-Li Huang, et al. Arousal effect of orexin A depends on activation of the
histaminergic system. Proc Natl Acad Sci U S A. 2001 August 14; 98(17): 9965–9970. |