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Volume 99(2);  January 22, 2002
Commentaries
Six blind men and the elephant—the many faces of heparan sulfate
Ajit Varki
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 543–545. doi: 10.1073/pnas.022649499.
PMCID: PMC117338
Deciphering genetic regulatory codes: A challenge for functional genomics
Alan M. Michelson
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 546–548. doi: 10.1073/pnas.032685999.
PMCID: PMC117339
Substance P, opioid, and catecholamine systems in the mouse central nervous system (CNS)
R. G. Hill
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 549–551. doi: 10.1073/pnas.032663599.
PMCID: PMC117340
Reaping of nitric oxide by sickle cell disease
Jack R. Lancaster, Jr.
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 552–553. doi: 10.1073/pnas.032633399.
PMCID: PMC117341
Ecological pork: Novel resources and the trophic reorganization of an ecosystem
Robert T. Paine and Daniel E. Schindler
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 554–555. doi: 10.1073/pnas.032685599.
PMCID: PMC117342
Chemical warfare from an ecological perspective
Richard E. Lenski and Margaret A. Riley
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 556–558. doi: 10.1073/pnas.022641999.
PMCID: PMC117343
Physical Sciences
Chemistry
A stochastic algorithm for global optimization and for best populations: A test case of side chains in proteins
Meir Glick, Anwar Rayan, and Amiram Goldblum
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 703–708. Published online 2002 January 15. doi: 10.1073/pnas.022418199.
PMCID: PMC117369
Geophysics
Redefinition of the mode Grüneisen parameter for polyatomic substances and thermodynamic implications
Anne M. Hofmeister and Ho-kwang Mao
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 559–564. doi: 10.1073/pnas.241631698.
PMCID: PMC117344
Mathematics
Generator problem for certain property T factors
Liming Ge and Junhao Shen
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 565–567. Published online 2002 January 15. doi: 10.1073/pnas.022593699.
PMCID: PMC117345
Biological Sciences
Applied Biological Sciences
Tumor cell surface heparan sulfate as cryptic promoters or inhibitors of tumor growth and metastasis
Dongfang Liu, Zachary Shriver, Ganesh Venkataraman, Yosuf El Shabrawi, and Ram Sasisekharan
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 568–573. doi: 10.1073/pnas.012578299.
PMCID: PMC117346
High throughput DNA sequencing with a microfabricated 96-lane capillary array electrophoresis bioprocessor
Brian M. Paegel, Charles A. Emrich, Gary J. Wedemayer, James R. Scherer, and Richard A. Mathies
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 574–579. Published online 2002 January 15. doi: 10.1073/pnas.012608699.
PMCID: PMC117347
Biochemistry
Abietadiene synthase catalysis: Mutational analysis of a prenyl diphosphate ionization-initiated cyclization and rearrangement
Reuben J. Peters and Rodney B. Croteau
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 580–584. doi: 10.1073/pnas.022627099.
PMCID: PMC117348
Blocking site-to-site translocation of a misactivated amino acid by mutation of a class I tRNA synthetase
Anthony C. Bishop, Tyzoon K. Nomanbhoy, and Paul Schimmel
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 585–590. Published online 2002 January 8. doi: 10.1073/pnas.012611299.
PMCID: PMC117349
From the Cover:
Snapshot of a key intermediate in enzymatic thiamin catalysis: Crystal structure of the α-carbanion of (α,β-dihydroxyethyl)-thiamin diphosphate in the active site of transketolase from Saccharomyces cerevisiae
Erik Fiedler, Stina Thorell, Tatyana Sandalova, Ralph Golbik, Stephan König, and Gunter Schneider
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 591–595. Published online 2002 January 2. doi: 10.1073/pnas.022510999.
PMCID: PMC117350
Archaeal dUTPase enhances PCR amplifications with archaeal DNA polymerases by preventing dUTP incorporation
Holly H. Hogrefe, Connie J. Hansen, Bradley R. Scott, and Kirk B. Nielson
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 596–601. Published online 2002 January 8. doi: 10.1073/pnas.012372799.
PMCID: PMC117351
Multiple hematopoietic defects and delayed globin switching in Ikaros null mice
Rocio A. Lopez, Stuti Schoetz, Kathryn DeAngelis, David O'Neill, and Arthur Bank
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 602–607. doi: 10.1073/pnas.022412699.
PMCID: PMC117352
Protein and ligand dynamics in 4-hydroxybenzoate hydroxylase
Jian Wang, Mariliz Ortiz-Maldonado, Barrie Entsch, Vincent Massey, David Ballou, and Domenico L. Gatti
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 608–613. doi: 10.1073/pnas.022640199.
PMCID: PMC117353
Combinatorial approaches: A new tool to search for highly structured β-hairpin peptides
Maria Teresa Pastor, Manuela López de la Paz, Emmanuel Lacroix, Luis Serrano, and Enrique Pérez-Payá
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 614–619. Published online 2002 January 8. doi: 10.1073/pnas.012583999.
PMCID: PMC117354
Gene characterized for membrane desaturase that produces (E)-11 isomers of mono- and diunsaturated fatty acids
Weitian Liu, Hongmei Jiao, Nancy C. Murray, Marion O'Connor, and Wendell L. Roelofs
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 620–624. doi: 10.1073/pnas.221601498.
PMCID: PMC117355
A mutation in the peroxisome proliferator-activated receptor γ-binding site in the gene for the cytosolic form of phosphoenolpyruvate carboxykinase reduces adipose tissue size and fat content in mice
Yael Olswang, Hannah Cohen, Orit Papo, Hanoch Cassuto, Colleen M. Croniger, Parvin Hakimi, Shirley M. Tilghman, Richard W. Hanson, and Lea Reshef
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 625–630. Published online 2002 January 15. doi: 10.1073/pnas.022616299.
PMCID: PMC117356
Herpes simplex virus 1-infected cell protein 0 contains two E3 ubiquitin ligase sites specific for different E2 ubiquitin-conjugating enzymes
Ryan Hagglund, Charles Van Sant, Pascal Lopez, and Bernard Roizman
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 631–636. doi: 10.1073/pnas.022531599.
PMCID: PMC117357
mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties
Dong-chul Kang, Rahul V. Gopalkrishnan, Qingping Wu, Eckhard Jankowsky, Anna Marie Pyle, and Paul B. Fisher
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 637–642. doi: 10.1073/pnas.022637199.
PMCID: PMC117358
Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptides
Lidija Covic, Amy L. Gresser, Joyce Talavera, Steven Swift, and Athan Kuliopulos
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 643–648. doi: 10.1073/pnas.022460899.
PMCID: PMC117359
Transcription-coupled repair in RNA polymerase I-transcribed genes of yeast
Antonio Conconi, Vyacheslav A. Bespalov, and Michael J. Smerdon
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 649–654. Published online 2002 January 8. doi: 10.1073/pnas.022373099.
PMCID: PMC117360
tRNA elements mediate the assembly of an icosahedral RNA virus
Yoon Gi Choi, Theo W. Dreher, and A. L. N. Rao
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 655–660. Published online 2002 January 8. doi: 10.1073/pnas.022618199.
PMCID: PMC117361
Supervillin associates with androgen receptor and modulates its transcriptional activity
Huei-Ju Ting, Shuyuan Yeh, Kazuo Nishimura, and Chawnshang Chang
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 661–666. Published online 2002 January 15. doi: 10.1073/pnas.022469899.
PMCID: PMC117362
Biophysics
From the Cover:
Self-assembly properties of a model RING domain
Alex Kentsis, Ronald E. Gordon, and Katherine L. B. Borden
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 667–672. Published online 2002 January 15. doi: 10.1073/pnas.012317299.
PMCID: PMC117363
Robustness of circadian rhythms with respect to molecular noise
Didier Gonze, José Halloy, and Albert Goldbeter
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 673–678. Published online 2002 January 15. doi: 10.1073/pnas.022628299.
PMCID: PMC117364
Synchronizing genetic relaxation oscillators by intercell signaling
David McMillen, Nancy Kopell, Jeff Hasty, and J. J. Collins
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 679–684. doi: 10.1073/pnas.022642299.
PMCID: PMC117365
Protein folding mediated by solvation: Water expulsion and formation of the hydrophobic core occur after the structural collapse
Margaret S. Cheung, Angel E. García, and José N. Onuchic
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 685–690. doi: 10.1073/pnas.022387699.
PMCID: PMC117366
Improved recognition of native-like protein structures using a family of designed sequences
Patrice Koehl and Michael Levitt
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 691–696. Published online 2002 January 8. doi: 10.1073/pnas.022408799.
PMCID: PMC117367
Function of the voltage gate of gap junction channels: Selective exclusion of molecules
Yang Qu and Gerhard Dahl
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 697–702. doi: 10.1073/pnas.022324499.
PMCID: PMC117368
A stochastic algorithm for global optimization and for best populations: A test case of side chains in proteins
Meir Glick, Anwar Rayan, and Amiram Goldblum
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 703–708. Published online 2002 January 15. doi: 10.1073/pnas.022418199.
PMCID: PMC117369
Real-time and equilibrium 19F-NMR studies reveal the role of domain–domain interactions in the folding of the chaperone PapD
James G. Bann, Jerome Pinkner, Scott J. Hultgren, and Carl Frieden
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 709–714. Published online 2002 January 15. doi: 10.1073/pnas.022649599.
PMCID: PMC117370
Cell Biology
Reactive oxygen generated by Nox1 triggers the angiogenic switch
Jack L. Arbiser, John Petros, Robert Klafter, Baskaran Govindajaran, Elizabeth R. McLaughlin, Lawrence F. Brown, Cynthia Cohen, Marsha Moses, Susan Kilroy, Rebecca S. Arnold, and J. David Lambeth
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 715–720. doi: 10.1073/pnas.022630199.
PMCID: PMC117371
Characterization of protein kinase C β isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization
Kiyoshi Suzuma, Noriko Takahara, Izumi Suzuma, Keiji Isshiki, Kohjiro Ueki, Michael Leitges, Lloyd Paul Aiello, and George L. King
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 721–726. doi: 10.1073/pnas.022644499.
PMCID: PMC117372
Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment
Paul J. Muchowski, Ke Ning, Crislyn D'Souza-Schorey, and Stanley Fields
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 727–732. Published online 2002 January 15. doi: 10.1073/pnas.022628699.
PMCID: PMC117373
Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration
Huaiyang Chen, Ian C. Duncan, Hormozd Bozorgchami, and Su Hao Lo
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 733–738. Published online 2002 January 15. doi: 10.1073/pnas.022518699.
PMCID: PMC117374
Activity of the TonEBP/OREBP transactivation domain varies directly with extracellular NaCl concentration
Joan D. Ferraris, Chester K. Williams, Prita Persaud, Zheng Zhang, Ye Chen, and Maurice B. Burg
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 739–744. Published online 2002 January 15. doi: 10.1073/pnas.241637298.
PMCID: PMC117375
Budding yeast Dsk2p is a polyubiquitin-binding protein that can interact with the proteasome
Minoru Funakoshi, Toru Sasaki, Takeharu Nishimoto, and Hideki Kobayashi
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 745–750. doi: 10.1073/pnas.012585199.
PMCID: PMC117376
Actin cable dynamics in budding yeast
Hyeong-Cheol Yang and Liza A. Pon
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 751–756. doi: 10.1073/pnas.022462899.
PMCID: PMC117377
Developmental Biology
Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genome
Benjamin P. Berman, Yutaka Nibu, Barret D. Pfeiffer, Pavel Tomancak, Susan E. Celniker, Michael Levine, Gerald M. Rubin, and Michael B. Eisen
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 757–762. doi: 10.1073/pnas.231608898.
PMCID: PMC117378
Genome-wide analysis of clustered Dorsal binding sites identifies putative target genes in the Drosophila embryo
Michele Markstein, Peter Markstein, Vicky Markstein, and Michael S. Levine
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 763–768. Published online 2001 December 18. doi: 10.1073/pnas.012591199.
PMCID: PMC117379
Evolution of germ-line signals that regulate growth and aging in nematodes
Mavji N. Patel, Christopher G. Knight, Constantina Karageorgi, and Armand M. Leroi
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 769–774. doi: 10.1073/pnas.012511099.
PMCID: PMC117380
APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos
Caroline Goutte, Makoto Tsunozaki, Valerie A. Hale, and James R. Priess
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 775–779. Published online 2002 January 15. doi: 10.1073/pnas.022523499.
PMCID: PMC117381
Genomic structure and functional control of the Dlx3-7 bigene cluster
Kenta Sumiyama, Steven Q. Irvine, David W. Stock, Kenneth M. Weiss, Kazuhiko Kawasaki, Nobuyoshi Shimizu, Cooduvalli S. Shashikant, Webb Miller, and Frank H. Ruddle
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 780–785. Published online 2002 January 15. doi: 10.1073/pnas.012584999.
PMCID: PMC117382
Ecology
Chemical warfare between microbes promotes biodiversity
Tamás L. Czárán, Rolf F. Hoekstra, and Ludo Pagie
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 786–790. Published online 2002 January 15. doi: 10.1073/pnas.012399899.
PMCID: PMC117383
From the Cover:
Golden eagles, feral pigs, and insular carnivores: How exotic species turn native predators into prey
Gary W. Roemer, C. Josh Donlan, and Franck Courchamp
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 791–796. Published online 2001 December 18. doi: 10.1073/pnas.012422499.
PMCID: PMC117384
Evolution
In silico chromosome staining: Reconstruction of Giemsa bands from the whole human genome sequence
Yoshihito Niimura and Takashi Gojobori
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 797–802. Published online 2002 January 15. doi: 10.1073/pnas.022437999.
PMCID: PMC117385
Mutation rates in mammalian genomes
Sudhir Kumar and Sankar Subramanian
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 803–808. Published online 2002 January 15. doi: 10.1073/pnas.022629899.
PMCID: PMC117386
Recombinatoric exploration of novel folded structures: A heteropolymer-based model of protein evolutionary landscapes
Yan Cui, Wing Hung Wong, Erich Bornberg-Bauer, and Hue Sun Chan
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 809–814. doi: 10.1073/pnas.022240299.
PMCID: PMC117387
Genetics
Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genome
Benjamin P. Berman, Yutaka Nibu, Barret D. Pfeiffer, Pavel Tomancak, Susan E. Celniker, Michael Levine, Gerald M. Rubin, and Michael B. Eisen
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 757–762. doi: 10.1073/pnas.231608898.
PMCID: PMC117378
Molecular analysis of mutations in DNA polymerase η in xeroderma pigmentosum-variant patients
Bernard C. Broughton, Agnes Cordonnier, Wim J. Kleijer, Nicolaas G. J. Jaspers, Heather Fawcett, Anja Raams, Victor H. Garritsen, Anne Stary, Marie-Françoise Avril, François Boudsocq, Chikahide Masutani, Fumio Hanaoka, Robert P. Fuchs, Alain Sarasin, and Alan R. Lehmann
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 815–820. Published online 2002 January 2. doi: 10.1073/pnas.022473899.
PMCID: PMC117388
Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
David D. Kline, Ying-Jie Peng, Dominador J. Manalo, Gregg L. Semenza, and Nanduri R. Prabhakar
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 821–826. Published online 2002 January 15. doi: 10.1073/pnas.022634199.
PMCID: PMC117389
From the Cover:
Evaluation of linkage of breast cancer to the putative BRCA3 locus on chromosome 13q21 in 128 multiple case families from the Breast Cancer Linkage Consortium
Deborah Thompson, Csilla I. Szabo, Jon Mangion, Rogier A. Oldenburg, Fabrice Odefrey, Sheila Seal, Rita Barfoot, Karin Kroeze-Jansema, Dawn Teare, Nazneen Rahman, Hélène Renard, KConFab Consortium, Graham Mann, John L. Hopper, Saundra S. Buys, Irene L. Andrulis, Ruby Senie, Mary B. Daly, Dee West, Elaine A. Ostrander, Ken Offit, Tamar Peretz, Ana Osorio, J. Benitez, Katherine L. Nathanson, Olga M. Sinilnikova, Edith Olàh, Yves-Jean Bignon, Pablo Ruiz, Michael D. Badzioch, Hans F. A. Vasen, Andrew P. Futreal, Catherine M. Phelan, Steven A. Narod, Henry T. Lynch, Bruce A. J. Ponder, Ros A. Eeles, Hanne Meijers-Heijboer, Dominique Stoppa-Lyonnet, Fergus J. Couch, Diana M. Eccles, D. Gareth Evans, Jenny Chang-Claude, Gilbert Lenoir, Barbara L. Weber, Peter Devilee, Douglas F. Easton, David E. Goldgar, and Michael R. Stratton
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 827–831. Published online 2002 January 15. doi: 10.1073/pnas.012584499.
PMCID: PMC117390
Ku86 is essential in human somatic cells
Gang Li, Caron Nelsen, and Eric A. Hendrickson
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 832–837. Published online 2002 January 15. doi: 10.1073/pnas.022649699.
PMCID: PMC117391
Life extension in Drosophila by feeding a drug
Hyung-Lyun Kang, Seymour Benzer, and Kyung-Tai Min
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 838–843. Published online 2002 January 15. doi: 10.1073/pnas.022631999.
PMCID: PMC117392
Functional annotation of mammalian genomic DNA sequence by chemical mutagenesis: A fine-structure genetic mutation map of a 1- to 2-cM segment of mouse chromosome 7 corresponding to human chromosome 11p14-p15
Eugene M. Rinchik, Donald A. Carpenter, and Dabney K. Johnson
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 844–849. Published online 2002 January 15. doi: 10.1073/pnas.022628199.
PMCID: PMC117393
Physical and genetic mapping of barley (Hordeum vulgare) germin-like cDNAs
Arnis Druka, David Kudrna, C. Gamini Kannangara, Diter von Wettstein, and Andris Kleinhofs
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 850–855. Published online 2002 January 15. doi: 10.1073/pnas.022627999.
PMCID: PMC117394
Association of human aging with a functional variant of klotho
Dan E. Arking, Alice Krebsova, Milan Macek, Sr., Milan Macek, Jr., Albert Arking, I. Saira Mian, Linda Fried, Ada Hamosh, Srabani Dey, Iain McIntosh, and Harry C. Dietz
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 856–861. Published online 2002 January 15. doi: 10.1073/pnas.022484299.
PMCID: PMC117395
Evidence for positive selection and population structure at the human MAO-A gene
Yoav Gilad, Shai Rosenberg, Molly Przeworski, Doron Lancet, and Karl Skorecki
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 862–867. doi: 10.1073/pnas.022614799.
PMCID: PMC117396
Immunology
Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation
Russell E. Vance, Amanda M. Jamieson, Dragana Cado, and David H. Raulet
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 868–873. Published online 2002 January 8. doi: 10.1073/pnas.022500599.
PMCID: PMC117397
Grafts of supplementary thymuses injected with allogeneic pancreatic islets protect nonobese diabetic mice against diabetes
J. Salaün, N. Simmenauer, P. Belo, A. Coutinho, and N. M. Le Douarin
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 874–877. Published online 2002 January 15. doi: 10.1073/pnas.012597499.
PMCID: PMC117398
Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice
Y. Zhang, S. F. Schlossman, R. A. Edwards, Ching-Nan Ou, J. Gu, and Mei X. Wu
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 878–883. Published online 2002 January 8. doi: 10.1073/pnas.022326699.
PMCID: PMC117399
Differential role of SLP-76 domains in T cell development and function
Lalit Kumar, Vadim Pivniouk, Miguel A. de la Fuente, Dhafer Laouini, and Raif S. Geha
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 884–889. Published online 2002 January 15. doi: 10.1073/pnas.022619199.
PMCID: PMC117400
Medical Sciences
Plasminogen activator inhibitor-1 is a major stress-regulated gene: Implications for stress-induced thrombosis in aged individuals
Koji Yamamoto, Kyosuke Takeshita, Takayoshi Shimokawa, Hong Yi, Ken-ichi Isobe, David J. Loskutoff, and Hidehiko Saito
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 890–895. Published online 2002 January 15. doi: 10.1073/pnas.022608799.
PMCID: PMC117401
Heat shock protein 90 catalyzes activation of the prekallikrein-kininogen complex in the absence of factor XII
Kusumam Joseph, Baby G. Tholanikunnel, and Allen P. Kaplan
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 896–900. Published online 2002 January 15. doi: 10.1073/pnas.022626899.
PMCID: PMC117402
Rescue of hereditary form of dilated cardiomyopathy by rAAV-mediated somatic gene therapy: Amelioration of morphological findings, sarcolemmal permeability, cardiac performances, and the prognosis of TO-2 hamsters
Tomie Kawada, Mikio Nakazawa, Sakura Nakauchi, Ken Yamazaki, Ryoichi Shimamoto, Masashi Urabe, Jumi Nakata, Chieko Hemmi, Fujiko Masui, Toshiaki Nakajima, Jun-Ichi Suzuki, John Monahan, Hiroshi Sato, Tomoh Masaki, Keiya Ozawa, and Teruhiko Toyo-oka
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 901–906. doi: 10.1073/pnas.022641799.
PMCID: PMC117403
Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo
Christopher L. Antos, Timothy A. McKinsey, Norbert Frey, William Kutschke, John McAnally, John M. Shelton, James A. Richardson, Joseph A. Hill, and Eric N. Olson
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 907–912. Published online 2002 January 8. doi: 10.1073/pnas.231619298.
PMCID: PMC117404
Ca2+-desensitizing effect of a deletion mutation ΔK210 in cardiac troponin T that causes familial dilated cardiomyopathy
S. Morimoto, Q.-W. Lu, K. Harada, F. Takahashi-Yanaga, R. Minakami, M. Ohta, T. Sasaguri, and I. Ohtsuki
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 913–918. Published online 2002 January 2. doi: 10.1073/pnas.022628899.
PMCID: PMC117405
Lymph nodal prion replication and neuroinvasion in mice devoid of follicular dendritic cells
Marco Prinz, Fabio Montrasio, Michael A. Klein, Petra Schwarz, Josef Priller, Bernhard Odermatt, Klaus Pfeffer, and Adriano Aguzzi
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 919–924. Published online 2002 January 15. doi: 10.1073/pnas.022626399.
PMCID: PMC117406
Missense mutations but not allelic variants alter the function of ATM by dominant interference in patients with breast cancer
Shaun P. Scott, Regina Bendix, Philip Chen, Raymond Clark, Thilo Dörk, and Martin F. Lavin
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 925–930. doi: 10.1073/pnas.012329699.
PMCID: PMC117407
Tumor lysate-pulsed dendritic cells can elicit an effective antitumor immune response during early lymphoid recovery
W. Asavaroengchai, Y. Kotera, and J. J. Mulé
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 931–936. Published online 2002 January 15. doi: 10.1073/pnas.022634999.
PMCID: PMC117408
A peptide that binds and stabilizes p53 core domain: Chaperone strategy for rescue of oncogenic mutants
Assaf Friedler, Lars O. Hansson, Dmitry B. Veprintsev, Stefan M. V. Freund, Thomas M. Rippin, Penka V. Nikolova, Mark R. Proctor, Stefan Rüdiger, and Alan R. Fersht
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 937–942. Published online 2002 January 8. doi: 10.1073/pnas.241629998.
PMCID: PMC117409
Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1)
Donald Metcalf, Sandra Mifsud, Ladina Di Rago, Nicos A. Nicola, Douglas J. Hilton, and Warren S. Alexander
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 943–948. Published online 2002 January 8. doi: 10.1073/pnas.022628499.
PMCID: PMC117410
Tumor necrosis factor-induced modulation of glyoxalase I activities through phosphorylation by PKA results in cell death and is accompanied by the formation of a specific methylglyoxal-derived AGE
Franky Van Herreweghe, Jianqiang Mao, Frank W. R. Chaplen, Johan Grooten, Kris Gevaert, Joël Vandekerckhove, and Katia Vancompernolle
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 949–954. Published online 2002 January 15. doi: 10.1073/pnas.012432399.
PMCID: PMC117411
Overexpression of the N-terminal domain of TSG101 inhibits HIV-1 budding by blocking late domain function
Dimiter G. Demirov, Akira Ono, Jan M. Orenstein, and Eric O. Freed
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 955–960. doi: 10.1073/pnas.032511899.
PMCID: PMC117412
Changes in subcellular distribution of pituitary receptors for luteinizing hormone-releasing hormone (LH-RH) after treatment with the LH-RH antagonist cetrorelix
Gabor Halmos and Andrew V. Schally
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 961–965. doi: 10.1073/pnas.012598399.
PMCID: PMC117413
Microbiology
A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae
Brian J. Akerley, Eric J. Rubin, Veronica L. Novick, Kensey Amaya, Nicholas Judson, and John J. Mekalanos
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 966–971. doi: 10.1073/pnas.012602299.
PMCID: PMC117414
Stereotyped and specific gene expression programs in human innate immune responses to bacteria
Jennifer C. Boldrick, Ash A. Alizadeh, Maximilian Diehn, Sandrine Dudoit, Chih Long Liu, Christopher E. Belcher, David Botstein, Louis M. Staudt, Patrick O. Brown, and David A. Relman
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 972–977. doi: 10.1073/pnas.231625398.
PMCID: PMC117415
Spontaneous molecular reactivation of herpes simplex virus type 1 latency in mice
Lawrence T. Feldman, Aaron R. Ellison, Cynthia C. Voytek, Li Yang, Philip Krause, and Todd P. Margolis
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 978–983. Published online 2002 January 2. doi: 10.1073/pnas.022301899.
PMCID: PMC117416
Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum
Sorel T. Fitz-Gibbon, Heidi Ladner, Ung-Jin Kim, Karl O. Stetter, Melvin I. Simon, and Jeffrey H. Miller
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 984–989. Published online 2002 January 15. doi: 10.1073/pnas.241636498.
PMCID: PMC117417
Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine
Ritu Banerjee, Jun Liu, Wandy Beatty, Lorraine Pelosof, Michael Klemba, and Daniel E. Goldberg
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 990–995. Published online 2002 January 8. doi: 10.1073/pnas.022630099.
PMCID: PMC117418
Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater
Tohru Shimizu, Kaori Ohtani, Hideki Hirakawa, Kenshiro Ohshima, Atsushi Yamashita, Tadayoshi Shiba, Naotake Ogasawara, Masahira Hattori, Satoru Kuhara, and Hideo Hayashi
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 996–1001. Published online 2002 January 15. doi: 10.1073/pnas.022493799.
PMCID: PMC117419
Neurobiology
Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity
Ali Khoshnan, Jan Ko, and Paul H. Patterson
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1002–1007. Published online 2002 January 15. doi: 10.1073/pnas.022631799.
PMCID: PMC117420
Role of a locus control region in the mutually exclusive expression of human red and green cone pigment genes
Philip M. Smallwood, Yanshu Wang, and Jeremy Nathans
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1008–1011. Published online 2002 January 2. doi: 10.1073/pnas.022629799.
PMCID: PMC117421
Synaptophysin regulates activity-dependent synapse formation in cultured hippocampal neurons
Leila Tarsa and Yukiko Goda
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1012–1016. Published online 2002 January 15. doi: 10.1073/pnas.022575999.
PMCID: PMC117422
Experience-dependent changes in cerebellar contributions to motor sequence learning
Julien Doyon, Allen W. Song, Avi Karni, François Lalonde, Michelle M. Adams, and Leslie G. Ungerleider
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1017–1022. doi: 10.1073/pnas.022615199.
PMCID: PMC117423
Costimulation of N-methyl-d-aspartate and muscarinic neuronal receptors modulates gap junctional communication in striatal astrocytes
N. Rouach, M. Tencé, J. Glowinski, and C. Giaume
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1023–1028. Published online 2002 January 15. doi: 10.1073/pnas.022257499.
PMCID: PMC117424
The NK1 receptor mediates both the hyperalgesia and the resistance to morphine in mice lacking noradrenaline
Luc Jasmin, Duc Tien, David Weinshenker, Richard D. Palmiter, Paul G. Green, Gabriella Janni, and Peter T. Ohara
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1029–1034. doi: 10.1073/pnas.012598599.
PMCID: PMC117425
Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain
Mats H. Holmqvist, Jie Cao, Ricardo Hernandez-Pineda, Michael D. Jacobson, Karen I. Carroll, M. Amy Sung, Maria Betty, Pei Ge, Kevin J. Gilbride, Melissa E. Brown, Mark E. Jurman, Deborah Lawson, Inmaculada Silos-Santiago, Yu Xie, Manuel Covarrubias, Kenneth J. Rhodes, Peter S. Distefano, and W. Frank An
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1035–1040. doi: 10.1073/pnas.022509299.
PMCID: PMC117799
Experience-dependent plasticity without long-term depression by type 2 metabotropic glutamate receptors in developing visual cortex
John J. Renger, Kenichi N. Hartman, Yoshiko Tsuchimoto, Mineto Yokoi, Shigetada Nakanishi, and Takao K. Hensch
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1041–1046. doi: 10.1073/pnas.022618799.
PMCID: PMC117426
Pharmacology
Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin
Todd A. Huffman, Isabelle Mothe-Satney, and John C. Lawrence, Jr.
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1047–1052. Published online 2002 January 15. doi: 10.1073/pnas.022634399.
PMCID: PMC117427
Physiology
Anti-inflammatory role in septic shock of pituitary adenylate cyclase-activating polypeptide receptor
Carmen Martinez, Catalina Abad, Mario Delgado, Alicia Arranz, Maria G. Juarranz, Nieves Rodriguez-Henche, Philippe Brabet, Javier Leceta, and Rosa P. Gomariz
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1053–1058. Published online 2002 January 15. doi: 10.1073/pnas.012367999.
PMCID: PMC117428
Decreased pulmonary vascular permeability in aquaporin-1-null humans
Landon S. King, Søren Nielsen, Peter Agre, and Robert H. Brown
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1059–1063. Published online 2002 January 2. doi: 10.1073/pnas.022626499.
PMCID: PMC117429
Plant Biology
The tomato Blind gene encodes a MYB transcription factor that controls the formation of lateral meristems
Gregor Schmitz, Edith Tillmann, Filomena Carriero, Carola Fiore, Francesco Cellini, and Klaus Theres
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1064–1069. doi: 10.1073/pnas.022516199.
PMCID: PMC117430
Directed molecular evolution of ADP-glucose pyrophosphorylase
Peter R. Salamone, I. Halil Kavakli, Casey J. Slattery, and Thomas W. Okita
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1070–1075. Published online 2002 January 2. doi: 10.1073/pnas.012603799.
PMCID: PMC117431
From the Cover:
Suppressors of transcriptional transgenic silencing in Chlamydomonas are sensitive to DNA-damaging agents and reactivate transposable elements
Byeong-ryool Jeong, Dancia Wu-Scharf, Chaomei Zhang, and Heriberto Cerutti
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1076–1081. Published online 2002 January 8. doi: 10.1073/pnas.022392999.
PMCID: PMC117432
Recombination rates between adjacent genic and retrotransposon regions in maize vary by 2 orders of magnitude
Huihua Fu, Zhenwei Zheng, and Hugo K. Dooner
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1082–1087. Published online 2002 January 15. doi: 10.1073/pnas.022635499.
PMCID: PMC117433
Impact of folivory on photosynthesis is greater than the sum of its holes
A. R. Zangerl, J. G. Hamilton, T. J. Miller, A. R. Crofts, K. Oxborough, M. R. Berenbaum, and E. H. de Lucia
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1088–1091. Published online 2002 January 15. doi: 10.1073/pnas.022647099.
PMCID: PMC117434
Evaluation of transgenic tomato plants expressing an additional phytoene synthase in a fruit-specific manner
Paul D. Fraser, Susanne Romer, Cathie A. Shipton, Philippa B. Mills, Joy W. Kiano, Norihiko Misawa, Rachel G. Drake, Wolfgang Schuch, and Peter M. Bramley
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1092–1097. doi: 10.1073/pnas.241374598.
PMCID: PMC117435
Corrections
Correction
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1098. Published online 2001 December 26. doi: 10.1073/pnas.032657499.
PMCID: PMC117334
Corrects: Hirofumi Komori, et al. Crystal structure of thermostable DNA photolyase: Pyrimidine-dimer recognition mechanism. Proc Natl Acad Sci U S A. 2001 November 20; 98(24): 13560–13565.
Correction
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1098. Published online 2002 January 8. doi: 10.1073/pnas.032605499.
PMCID: PMC117335
Corrects: Silvia Santamarina-Fojo, et al. Complete genomic sequence of the human ABCA1 gene: Analysis of the human and mouse ATP-binding cassette A promoter. Proc Natl Acad Sci U S A. 2000 July 5; 97(14): 7987–7992.
Correction
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1098. Published online 2002 January 2. doi: 10.1073/pnas.022616599.
PMCID: PMC117336
Corrects: Mitchell E. Garber, et al. Diversity of gene expression in adenocarcinoma of the lung. Proc Natl Acad Sci U S A. 2001 November 20; 98(24): 13784–13789.
Correction
Proc Natl Acad Sci U S A. 2002 January 22; 99(2): 1098. Published online 2002 January 2. doi: 10.1073/pnas.032656999.
PMCID: PMC117337
Corrects: Zhi-Li Huang, et al. Arousal effect of orexin A depends on activation of the histaminergic system. Proc Natl Acad Sci U S A. 2001 August 14; 98(17): 9965–9970.
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