| | This journal provides immediate access to some articles. In This Issue Proc Natl Acad Sci U S A. 2005 January 18; 102(3): 517–518. doi: 10.1073/iti0305102.PMCID: PMC548599 Commentary Accessorizing natural products: Adding to nature's toolbox Sherry S. Lamb and Gerard D. Wright PMCID: PMC545579 Biography INAUGURAL ARTICLE by a Recently Elected Academy Member: Biography of William T. Newsome Emma Hitt PMCID: PMC545564 Physical Sciences Chemistry The fluorescence resonance energy transfer (FRET) gate: A time-resolved study Qing-Hua Xu, Shu Wang, Dmitry Korystov, Alexander Mikhailovsky, Guillermo C. Bazan, Daniel Moses, and Alan J. Heeger PMCID: PMC545565 Physics Formation and structure of ramified charge transportation networks in an electromechanical system Joseph K. Jun and Alfred H. Hübler PMCID: PMC545530 Biological Sciences Agricultural Sciences Enhanced in vivo fitness of fluoroquinolone-resistant Campylobacter jejuni in the absence of antibiotic selection pressure Naidan Luo, Sonia Pereira, Orhan Sahin, Jun Lin, Shouxiong Huang, Linda Michel, and Qijing Zhang PMCID: PMC545549 Applied Biological Sciences Profiling the humoral immune response to infection by using proteome microarrays: High-throughput vaccine and diagnostic antigen discovery D. Huw Davies, Xiaowu Liang, Jenny E. Hernandez, Arlo Randall, Siddiqua Hirst, Yunxiang Mu, Kimberly M. Romero, Toai T. Nguyen, Mina Kalantari-Dehaghi, Shane Crotty, Pierre Baldi, Luis P. Villarreal, and Philip L. Felgner PMCID: PMC545576 Biochemistry The carboligation reaction of acetohydroxyacid synthase II: Steady-state intermediate distributions in wild type and mutants by NMR Kai Tittmann, Maria Vyazmensky, Gerhard Hübner, Ze'ev Barak, and David M. Chipman PMCID: PMC545553 Altered pharmacology and distinct coactivator usage for estrogen receptor-dependent transcription through activating protein-1 Edwin Cheung, Mari Luz Acevedo, Philip A. Cole, and W. Lee Kraus PMCID: PMC545529 The Birc6 (Bruce) gene regulates p53 and the mitochondrial pathway of apoptosis and is essential for mouse embryonic development Jinyu Ren, Mingan Shi, Renshui Liu, Qi-Heng Yang, Teri Johnson, William C. Skarnes, and Chunying Du PMCID: PMC543482 From the Cover:
In vitro characterization of IroB, a pathogen-associated C-glycosyltransferase Michael A. Fischbach, Hening Lin, David R. Liu, and Christopher T. Walsh PMCID: PMC545562 Active site restructuring regulates ligand recognition in class A penicillin-binding proteins Pauline Macheboeuf, Anne Marie Di Guilmi, Viviana Job, Thierry Vernet, Otto Dideberg, and Andréa Dessen PMCID: PMC545533 Zinc fingers as protein recognition motifs: Structural basis for the GATA-1/Friend of GATA interaction Chu Kong Liew, Raina J. Y. Simpson, Ann H. Y. Kwan, Linda A. Crofts, Fionna E. Loughlin, Jacqueline M. Matthews, Merlin Crossley, and Joel P. Mackay PMCID: PMC545545 Methods for strand-specific DNA detection with cationic conjugated polymers suitable for incorporation into DNA chips and microarrays Bin Liu and Guillermo C. Bazan PMCID: PMC545563 Heme-assisted S-nitrosation of a proximal thiolate in a nitric oxide transport protein Andrzej Weichsel, Estelle M. Maes, John F. Andersen, Jesus G. Valenzuela, Tatjana Kh. Shokhireva, F. Ann Walker, and William R. Montfort PMCID: PMC545542 Insights into the action of the superfamily of cholesterol-dependent cytolysins from studies of intermedilysin Galina Polekhina, Kara Sue Giddings, Rodney K. Tweten, and Michael W. Parker PMCID: PMC545513 Thermodynamic prediction of protein neutrality Jesse D. Bloom, Jonathan J. Silberg, Claus O. Wilke, D. Allan Drummond, Christoph Adami, and Frances H. Arnold PMCID: PMC545518 Biophysics From the Cover:
Conformational changes during the nanosecond-to-millisecond unfolding of ubiquitin Hoi Sung Chung, Munira Khalil, Adam W. Smith, Ziad Ganim, and Andrei Tokmakoff PMCID: PMC545570 Protein conformational space in higher order ϕ-Ψ maps Gregory E. Sims, In-Geol Choi, and Sung-Hou Kim PMCID: PMC543483 Solution NMR-derived global fold of a monomeric 82-kDa enzyme Vitali Tugarinov, Wing-Yiu Choy, Vladislav Yu. Orekhov, and Lewis E. Kay PMCID: PMC545550 Φ-Value analysis by molecular dynamics simulations of reversible folding Giovanni Settanni, Francesco Rao, and Amedeo Caflisch PMCID: PMC545520 From the Cover:
An interlocked dimeric parallel-stranded DNA quadruplex: A potent inhibitor of HIV-1 integrase Anh Tuân Phan, Vitaly Kuryavyi, Jin-Biao Ma, Aurélie Faure, Marie-Line Andréola, and Dinshaw J. Patel PMCID: PMC545538 Prion protein NMR structures of cats, dogs, pigs, and sheep Dominikus A. Lysek, Christian Schorn, Lucas G. Nivon, Vicent Esteve-Moya, Barbara Christen, Luigi Calzolai, Christine von Schroetter, Francesco Fiorito, Torsten Herrmann, Peter Güntert, and Kurt Wüthrich PMCID: PMC545531 Prion protein NMR structures of elk and of mouse/elk hybrids Alvar D. Gossert, Sophie Bonjour, Dominikus A. Lysek, Francesco Fiorito, and Kurt Wüthrich PMCID: PMC545551 Prion protein NMR structures of chickens, turtles, and frogs Luigi Calzolai, Dominikus A. Lysek, Daniel R. Pérez, Peter Güntert, and Kurt Wüthrich PMCID: PMC545536 Mini-thin filaments regulated by troponin–tropomyosin Huiyu Gong, Victoria Hatch, Laith Ali, William Lehman, Roger Craig, and Larry S. Tobacman PMCID: PMC545539 Cell Biology Mg2+ as activator of uridine phosphorylation in coordination with other cellular responses to growth factors Charles Vidair and Harry Rubin PMCID: PMC545559 Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors Bryan A. Ballif, Philippe P. Roux, Scott A. Gerber, Jeffrey P. MacKeigan, John Blenis, and Steven P. Gygi PMCID: PMC545566 Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors J. S. Ungerstedt, Y. Sowa, W.-S. Xu, Y. Shao, M. Dokmanovic, G. Perez, L. Ngo, A. Holmgren, X. Jiang, and P. A. Marks PMCID: PMC543461 Developmental Biology A saturation screen for cis-acting regulatory DNA in the Hox genes of Ciona intestinalis David N. Keys, Byung-in Lee, Anna Di Gregorio, Naoe Harafuji, J. Chris Detter, Mei Wang, Orsalem Kahsai, Sylvia Ahn, Cindy Zhang, Sharon A. Doyle, Noriyuki Satoh, Yutaka Satou, Hidetoshi Saiga, Allen T. Christian, Dan S. Rokhsar, Trevor L. Hawkins, Mike Levine, and Paul M. Richardson PMCID: PMC544341 Ecology Body sizes of hosts and parasitoids in individual feeding relationships Joel E. Cohen, Tomas Jonsson, Christine B. Müller, H. C. J. Godfray, and Van M. Savage PMCID: PMC545575 Carbon starvation in glacial trees recovered from the La Brea tar pits, southern California Joy K. Ward, John M. Harris, Thure E. Cerling, Alex Wiedenhoeft, Michael J. Lott, Maria-Denise Dearing, Joan B. Coltrain, and James R. Ehleringer PMCID: PMC544040 Diversity–productivity relationships: Initial effects, long-term patterns, and underlying mechanisms Jasper van Ruijven and Frank Berendse PMCID: PMC545547 Environmental Sciences Enantioselectivity in environmental safety of current chiral insecticides Weiping Liu, Jianying Gan, Daniel Schlenk, and William A. Jury PMCID: PMC545578 Evolution Rapid evolution of expression and regulatory divergences after yeast gene duplication Xun Gu, Zhongqi Zhang, and Wei Huang PMCID: PMC545572 The pattern of intron loss Scott W. Roy and Walter Gilbert PMCID: PMC545554 Genetics mtDNA mutations increase tumorigenicity in prostate cancer John A. Petros, Amanda K. Baumann, Eduardo Ruiz-Pesini, Mahul B. Amin, Carrie Qi Sun, John Hall, SoDug Lim, Muta M. Issa, W. Dana Flanders, Seyed H. Hosseini, Fray F. Marshall, and Douglas C. Wallace PMCID: PMC545582 Syncytin-A and syncytin-B, two fusogenic placenta-specific murine envelope genes of retroviral origin conserved in Muridae Anne Dupressoir, Geoffroy Marceau, Cécile Vernochet, Laurence Bénit, Colette Kanellopoulos, Vincent Sapin, and Thierry Heidmann PMCID: PMC545540 The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma Andrew Slack, Zaowen Chen, Roberto Tonelli, Martin Pule, Lisa Hunt, Andrea Pession, and Jason M. Shohet PMCID: PMC545522 Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants Monica Di Giacomo, Marco Barchi, Frédéric Baudat, Winfried Edelmann, Scott Keeney, and Maria Jasin PMCID: PMC545532 Two cleavage products of the Drosophila accessory gland protein ovulin can independently induce ovulation Yael Heifetz, Laura N. Vandenberg, Heather I. Cohn, and Mariana F. Wolfner PMCID: PMC545548 Medical Sciences Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors Thomas A. Milne, Christina M. Hughes, Ricardo Lloyd, Zhaohai Yang, Orit Rozenblatt-Rosen, Yali Dou, Robert W. Schnepp, Cynthia Krankel, Virginia A. LiVolsi, Denise Gibbs, Xianxin Hua, Robert G. Roeder, Matthew Meyerson, and Jay L. Hess PMCID: PMC545577 Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium Ming Zhao, Meng Yang, Xiao-Ming Li, Ping Jiang, Eugene Baranov, Shukuan Li, Mingxu Xu, Sheldon Penman, and Robert M. Hoffman PMCID: PMC545558 Dissecting the molecular control of endothelial NO synthase by caveolin-1 using cell-permeable peptides Pascal N. Bernatchez, Philip M. Bauer, Jun Yu, Jay S. Prendergast, Pingnian He, and William C. Sessa PMCID: PMC545535 Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells Matt X. G. Shao and Jay A. Nadel PMCID: PMC545521 Clearance of hepatitis B virus from the liver of transgenic mice by short hairpin RNAs Susan L. Uprichard, Bryan Boyd, Alana Althage, and Francis V. Chisari PMCID: PMC545555 Use of targeted glycoproteomics to identify serum glycoproteins that correlate with liver cancer in woodchucks and humans Timothy M. Block, Mary Ann Comunale, Melissa Lowman, Laura F. Steel, Patrick R. Romano, Claus Fimmel, Bud C. Tennant, W. Thomas London, Alison A. Evans, Baruch S. Blumberg, Raymond A. Dwek, Tajinder S. Mattu, and Anand S. Mehta PMCID: PMC545516 Hypertension in mice lacking the proatrial natriuretic peptide convertase corin Joyce C. Y. Chan, Ole Knudson, Faye Wu, John Morser, William P. Dole, and Qingyu Wu PMCID: PMC545541 From the Cover:
Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory elementbinding protein-1c Bronwyn D. Hegarty, Alexandre Bobard, Isabelle Hainault, Pascal Ferré, Pascale Bossard, and Fabienne Foufelle PMCID: PMC545517 Evasion of antibody neutralization in emerging severe acute respiratory syndrome coronaviruses Zhi-yong Yang, Heidi C. Werner, Wing-pui Kong, Kwanyee Leung, Elisabetta Traggiai, Antonio Lanzavecchia, and Gary J. Nabel PMCID: PMC545557 Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic Sohye Kang, Andreas G. Bader, and Peter K. Vogt PMCID: PMC545580 ATP flux through creatine kinase in the normal, stressed, and failing human heart Robert G. Weiss, Gary Gerstenblith, and Paul A. Bottomley PMCID: PMC545546 Microbiology A genetic approach to the de novo identification of targets of strain-specific immunity in malaria parasites Axel Martinelli, Sandra Cheesman, Paul Hunt, Richard Culleton, Ahmed Raza, Margaret Mackinnon, and Richard Carter PMCID: PMC545519 Epstein-Barr virus nuclear antigen 1 does not induce lymphoma in transgenic FVB mice Myung-Soo Kang, Hongxiang Lu, Teruhito Yasui, Arlene Sharpe, Henry Warren, Ellen Cahir-McFarland, Roderick Bronson, Siu Chun Hung, and Elliott Kieff PMCID: PMC545574 A C-terminal translocation signal required for Dot/Icm-dependent delivery of the Legionella RalF protein to host cells Hiroki Nagai, Eric D. Cambronne, Jonathan C. Kagan, Juan Carlos Amor, Richard A. Kahn, and Craig R. Roy PMCID: PMC545534 Positive charge is an important feature of the C-terminal transport signal of the VirB/D4-translocated proteins of Agrobacterium Annette C. Vergunst, Miranda C. M. van Lier, Amke den Dulk-Ras, Thomas A. Grosse Stüve, Anette Ouwehand, and Paul J. J. Hooykaas PMCID: PMC545537 The genome of the heartwater agent Ehrlichia ruminantium contains multiple tandem repeats of actively variable copy number Nicola E. Collins, Junita Liebenberg, Etienne P. de Villiers, Kelly A. Brayton, Elmarié Louw, Alri Pretorius, F. Erika Faber, Henriette van Heerden, Antoinette Josemans, Mirinda van Kleef, Helena C. Steyn, M. Fransie van Strijp, Erich Zweygarth, Frans Jongejan, Jean Charles Maillard, David Berthier, Marli Botha, Fourie Joubert, Craig H. Corton, Nicholas R. Thomson, Maria T. Allsopp, and Basil A. Allsopp PMCID: PMC545511 Complete genome sequencing of Anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins Kelly A. Brayton, Lowell S. Kappmeyer, David R. Herndon, Michael J. Dark, David L. Tibbals, Guy H. Palmer, Travis C. McGuire, and Donald P. Knowles, Jr. PMCID: PMC545514 Discovery of a free-living chlorophyll d-producing cyanobacterium with a hybrid proteobacterial/cyanobacterial small-subunit rRNA gene Scott R. Miller, Sunny Augustine, Tien Le Olson, Robert E. Blankenship, Jeanne Selker, and A. Michelle Wood PMCID: PMC545527 A bipartite signal mediates the transfer of type IV secretion substrates of Bartonella henselae into human cells Ralf Schulein, Patrick Guye, Thomas A. Rhomberg, Michael C. Schmid, Gunnar Schröder, Annette C. Vergunst, Ilaria Carena, and Christoph Dehio PMCID: PMC545523 Neuroscience INAUGURAL ARTICLE by a Recently Elected Academy Member: Microstimulation of the superior colliculus focuses attention without moving the eyes James R. Müller, Marios G. Philiastides, and William T. Newsome PMCID: PMC545556 A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain Hannelore Ehrenreich, Martin Hasselblatt, Friederike Knerlich, Nico von Ahsen, Sonja Jacob, Swetlana Sperling, Helge Woldt, Katalin Vehmeyer, Klaus-Armin Nave, and Anna-Leena Sirén PMCID: PMC545528 Calcineurin/NFAT-induced up-regulation of the Fas ligand/Fas death pathway is involved in methamphetamine-induced neuronal apoptosis Subramaniam Jayanthi, Xiaolin Deng, Bruce Ladenheim, Michael T. McCoy, Andrew Cluster, Ning-sheng Cai, and Jean Lud Cadet PMCID: PMC545515 A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus Xiaoying Lu, Alasdair M. Barr, Jefferson W. Kinney, Pietro Sanna, Bruno Conti, M. Margarita Behrens, and Tamas Bartfai PMCID: PMC545581 The neocortical microcircuit as a tabula rasa Nir Kalisman, Gilad Silberberg, and Henry Markram PMCID: PMC545526 Notch-1 activation and dendritic atrophy in prion disease Nako Ishikura, Jared L. Clever, Essia Bouzamondo-Bernstein, Erik Samayoa, Stanley B. Prusiner, Eric J. Huang, and Stephen J. DeArmond PMCID: PMC545568 A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo Xiaoqian Zhang, Donna L. Smith, Anatoli B. Meriin, Sabine Engemann, Deborah E. Russel, Margo Roark, Shetia L. Washington, Michele M. Maxwell, J. Lawrence Marsh, Leslie Michels Thompson, Erich E. Wanker, Anne B. Young, David E. Housman, Gillian P. Bates, Michael Y. Sherman, and Aleksey G. Kazantsev PMCID: PMC545525 A cortico-cortical mechanism mediating object-driven grasp in humans L. Cattaneo, M. Voss, T. Brochier, G. Prabhu, D. M. Wolpert, and R. N. Lemon PMCID: PMC545569 Pharmacology Endothelial nitric oxide synthase activation is critical for vascular leakage during acute inflammation in vivo Mariarosaria Bucci, Fiorentina Roviezzo, Inmaculada Posadas, Jun Yu, Luca Parente, William C. Sessa, Louis J. Ignarro, and Giuseppe Cirino PMCID: PMC545512 Phosphodiesterase 4D is required for β2 adrenoceptor subtype-specific signaling in cardiac myocytes Yang Xiang, Fabio Naro, Maria Zoudilova, S.-L. Catherine Jin, Marco Conti, and Brian Kobilka PMCID: PMC544184 Different GABAA receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates James K. Rowlett, Donna M. Platt, Snjezana Lelas, John R. Atack, and Gerard R. Dawson PMCID: PMC545524 Physiology Fluorescent imaging of Cl- in Amphiuma red blood cells: How the nuclear exclusion of Cl- affects the plasma membrane potential Joseph F. Hoffman and John P. Geibel PMCID: PMC545567 Rapid hyperosmotic coinduction of two tilapia (Oreochromis mossambicus) transcription factors in gill cells Diego F. Fiol and Dietmar Kültz PMCID: PMC545544 Plant Biology From the Cover:
The nonmevalonate pathway supports both monoterpene and sesquiterpene formation in snapdragon flowers Natalia Dudareva, Susanna Andersson, Irina Orlova, Nathalie Gatto, Michael Reichelt, David Rhodes, Wilhelm Boland, and Jonathan Gershenzon PMCID: PMC545543 Psychology Visual extrapolation of contour geometry Manish Singh and Jacqueline M. Fulvio PMCID: PMC545560 Social Sciences Economic Sciences A simple test of expected utility theory using professional traders John A. List and Michael S. Haigh PMCID: PMC545552 Environmental Sciences Maize diversity and ethnolinguistic diversity in Chiapas, Mexico Hugo R. Perales, Bruce F. Benz, and Stephen B. Brush PMCID: PMC545571 Corrections Proc Natl Acad Sci U S A. 2005 January 18; 102(3): 955. doi: 10.1073/pnas.0409105101.PMCID: PMC545561 Corrects: Blaise R. Boles, et al. From the Cover:
Self-generated diversity produces “insurance effects” in biofilm communities. Proc Natl Acad Sci U S A. 2004 November 23; 101(47): 16630–16635. Proc Natl Acad Sci U S A. 2005 January 18; 102(3): 955. doi: 10.1073/pnas.0409392102.PMCID: PMC545573 Corrects: David W. Colby, et al. Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody. Proc Natl Acad Sci U S A. 2004 December 21; 101(51): 17616–17621. |
