| | This journal provides immediate access to some articles. Commentaries Viewing protein folding from many perspectives Charles L. Brooks, III Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1099–1100. doi: 10.1073/pnas.042708199.PMCID: PMC122148 Unstable molecules form stable tissues Anton V. Persikov and Barbara Brodsky Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1101–1103. doi: 10.1073/pnas.042707899.PMCID: PMC122149 The methylator meets the terminator Steven Clarke Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1104–1106. doi: 10.1073/pnas.042004099.PMCID: PMC122150 Antigen-presenting cells control T cell proliferation by regulating amino acid availability Aimee L. Edinger and Craig B. Thompson Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1107–1109. doi: 10.1073/pnas.042707999.PMCID: PMC122151 Location alters tRNA identity: Trypanosoma brucei's cytosolic elongator tRNAMet is both the initiator and elongator in mitochondria Nancy C. Martin Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1110–1112. doi: 10.1073/pnas.042011199.PMCID: PMC122152 Dissecting the molecular mechanisms of olfaction in a malaria-vector mosquito A. Nighorn and J. G. Hildebrand Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1113–1114. doi: 10.1073/pnas.042708099.PMCID: PMC122153 Review Calcium signaling: A tale for all seasons Ernesto Carafoli Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1115–1122. doi: 10.1073/pnas.032427999.PMCID: PMC122154 Physical Sciences Applied Mathematics Stochastic and mesoscopic models for tropical convection Andrew J. Majda and Boualem Khouider Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1123–1128. doi: 10.1073/pnas.032663199.PMCID: PMC123720 Physics The calculation of transport properties in quantum liquids using the maximum entropy numerical analytic continuation method: Application to liquid para-hydrogen Eran Rabani, David R. Reichman, Goran Krilov, and Bruce J. Berne Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1129–1133. doi: 10.1073/pnas.261540698.PMCID: PMC122155 Biological Sciences Anthropology The evolution and development of cranial form in Homo sapiens Daniel E. Lieberman, Brandeis M. McBratney, and Gail Krovitz Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1134–1139. Published online 2002 January 22. doi: 10.1073/pnas.022440799.PMCID: PMC122156 Applied Biological Sciences Testosterone prevents the heat shock-induced overactivation of glycogen synthase kinase-3β but not of cyclin-dependent kinase 5 and c-Jun NH2-terminal kinase and concomitantly abolishes hyperphosphorylation of τ: Implications for Alzheimer's disease Sozos Ch. Papasozomenos and Alikunju Shanavas Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1140–1145. Published online 2002 January 22. doi: 10.1073/pnas.032646799.PMCID: PMC122157 Biochemistry A direct role of SRY and SOX proteins in pre-mRNA splicing Kenji Ohe, Enzo Lalli, and Paolo Sassone-Corsi Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1146–1151. Published online 2002 January 29. doi: 10.1073/pnas.022645899.PMCID: PMC122158 Eukaryotic-type elongator tRNAMet of Trypanosoma brucei becomes formylated after import into mitochondria Timothy H. P. Tan, Natacha Bochud-Allemann, Elke K. Horn, and André Schneider Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1152–1157. Published online 2002 January 15. doi: 10.1073/pnas.022522299.PMCID: PMC122159 Studies on the nonmevalonate terpene biosynthetic pathway: Metabolic role of IspH (LytB) protein Felix Rohdich, Stefan Hecht, Katrin Gärtner, Petra Adam, Cornelia Krieger, Sabine Amslinger, Duilio Arigoni, Adelbert Bacher, and Wolfgang Eisenreich Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1158–1163. Published online 2002 January 29. doi: 10.1073/pnas.032658999.PMCID: PMC122160 Self-generated DNA termini relax the specificity of SgrAI restriction endonuclease Jurate Bitinaite and Ira Schildkraut Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1164–1169. Published online 2002 January 29. doi: 10.1073/pnas.022346799.PMCID: PMC122161 Product dependence and bifunctionality compromise the ultrasensitivity of signal transduction cascades Fernando Ortega, Luis Acerenza, Hans V. Westerhoff, Francesc Mas, and Marta Cascante Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1170–1175. doi: 10.1073/pnas.022267399.PMCID: PMC122162 The mechanism of catalysis of the chorismate to prephenate reaction by the Escherichia coli mutase enzyme Sun Hur and Thomas C. Bruice Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1176–1181. Published online 2002 January 29. doi: 10.1073/pnas.022628599.PMCID: PMC122163 Casein kinase I phosphorylates and destabilizes the β-catenin degradation complex Zhong-Hua Gao, Joni M. Seeling, Virginia Hill, April Yochum, and David M. Virshup Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1182–1187. Published online 2002 January 29. doi: 10.1073/pnas.032468199.PMCID: PMC122164 Structural basis for the conformational adaptability of apolipophorin III, a helix-bundle exchangeable apolipoprotein Jianjun Wang, Brian D. Sykes, and Robert O. Ryan Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1188–1193. Published online 2002 January 29. doi: 10.1073/pnas.032565999.PMCID: PMC122165 Discrimination against purine–pyrimidine mispairs in the polymerase active site of DNA polymerase I: A structural explanation Dana T. Minnick, Lixing Liu, Nigel D. F. Grindley, Thomas A. Kunkel, and Catherine M. Joyce Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1194–1199. doi: 10.1073/pnas.032457899.PMCID: PMC122166 Dynamic association of transcriptional activation domains and regulatory regions in Saccharomyces cerevisiae heat shock factor Tianxin Chen and Carl S. Parker Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1200–1205. Published online 2002 January 29. doi: 10.1073/pnas.032681299.PMCID: PMC122167 The regulatory role for the ERCC3 helicase of general transcription factor TFIIH during promoter escape in transcriptional activation Aya Fukuda, Yasuhisa Nogi, and Koji Hisatake Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1206–1211. Published online 2002 January 29. doi: 10.1073/pnas.251674198.PMCID: PMC122168 Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP Nobuo Maita, Kengo Okada, Kazuyuki Hatakeyama, and Toshio Hakoshima Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1212–1217. Published online 2002 January 29. doi: 10.1073/pnas.022646999.PMCID: PMC122169 Structural basis of transcription: α-Amanitin–RNA polymerase II cocrystal at 2.8 Å resolution David A. Bushnell, Patrick Cramer, and Roger D. Kornberg Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1218–1222. Published online 2002 January 22. doi: 10.1073/pnas.251664698.PMCID: PMC122170 Extracellular ubiquitination and proteasome-mediated degradation of the ascidian sperm receptor Hitoshi Sawada, Naoyuki Sakai, Yukichi Abe, Etsuko Tanaka, Youko Takahashi, Junko Fujino, Eri Kodama, Satoshi Takizawa, and Hideyoshi Yokosawa Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1223–1228. Published online 2002 January 29. doi: 10.1073/pnas.032389499.PMCID: PMC122171 Structural diversity of heparan sulfate binding domains in chemokines Hugues Lortat-Jacob, Aurélien Grosdidier, and Anne Imberty Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1229–1234. doi: 10.1073/pnas.032497699.PMCID: PMC122172 Subnuclear distribution of topoisomerase I is linked to ongoing transcription and p53 status Yinghui Mao, Issac R. Mehl, and Mark T. Muller Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1235–1240. Published online 2002 January 22. doi: 10.1073/pnas.022631899.PMCID: PMC122173 Human Elongator facilitates RNA polymerase II transcription through chromatin Jae-Hyun Kim, William S. Lane, and Danny Reinberg Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1241–1246. Published online 2002 January 29. doi: 10.1073/pnas.251672198.PMCID: PMC122174 The thioesterase domain from a nonribosomal peptide synthetase as a cyclization catalyst for integrin binding peptides Rahul M. Kohli, Junichi Takagi, and Christopher T. Walsh Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1247–1252. Published online 2002 January 22. doi: 10.1073/pnas.251668398.PMCID: PMC122175 Probing protein conformational changes in living cells by using designer binding proteins: Application to the estrogen receptor Akiko Koide, Stacy Abbatiello, Lisa Rothgery, and Shohei Koide Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1253–1258. Published online 2002 January 29. doi: 10.1073/pnas.032665299.PMCID: PMC122176 Cytochrome c release from mitochondria proceeds by a two-step process Martin Ott, John D. Robertson, Vladimir Gogvadze, Boris Zhivotovsky, and Sten Orrenius Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1259–1263. Published online 2002 January 29. doi: 10.1073/pnas.241655498.PMCID: PMC122177 From the Cover: γ-Glutamyl carboxylation: An extracellular posttranslational modification that antedates the divergence of molluscs, arthropods, and chordates Pradip K. Bandyopadhyay, James E. Garrett, Reshma P. Shetty, Tyler Keate, Craig S. Walker, and Baldomero M. Olivera Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1264–1269. Published online 2002 January 29. doi: 10.1073/pnas.022637099.PMCID: PMC122178 Biophysics Combinatorial computational method gives new picomolar ligands for a known enzyme Bartosz A. Grzybowski, Alexey V. Ishchenko, Chu-Young Kim, George Topalov, Robert Chapman, David W. Christianson, George M. Whitesides, and Eugene I. Shakhnovich Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1270–1273. Published online 2002 January 29. doi: 10.1073/pnas.032673399.PMCID: PMC122179 Flexibility and packing in proteins Bertil Halle Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1274–1279. Published online 2002 January 29. doi: 10.1073/pnas.032522499.PMCID: PMC122180 Protein topology and stability define the space of allowed sequences Patrice Koehl and Michael Levitt Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1280–1285. Published online 2002 January 22. doi: 10.1073/pnas.032405199.PMCID: PMC122181 Translocation of a functional protein by a voltage-dependent ion channel Stephen L. Slatin, Angèle Nardi, Karen S. Jakes, Daniel Baty, and Denis Duché Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1286–1291. doi: 10.1073/pnas.022480199.PMCID: PMC122182 Direct visualization at the single-cell level of electrically mediated gene delivery Muriel Golzio, Justin Teissié, and Marie-Pierre Rols Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1292–1297. Published online 2002 January 29. doi: 10.1073/pnas.022646499.PMCID: PMC122183 The enthalpy of the alanine peptide helix measured by isothermal titration calorimetry using metal-binding to induce helix formation Maria M. Lopez, Der-Hang Chin, Robert L. Baldwin, and George I. Makhatadze Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1298–1302. Published online 2002 January 29. doi: 10.1073/pnas.032665199.PMCID: PMC122184 Stable “zeta” peptides that act as potent antagonists of the high-affinity IgE receptor Gerald R. Nakamura, Mark E. Reynolds, Yvonne M. Chen, Melissa A. Starovasnik, and Henry B. Lowman Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1303–1308. doi: 10.1073/pnas.022635599.PMCID: PMC122185 Role of backbone solvation in determining thermodynamic β propensities of the amino acids Franc Avbelj and Robert L. Baldwin Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1309–1313. Published online 2002 January 22. doi: 10.1073/pnas.032665499.PMCID: PMC122186 From the Cover: Type I collagen is thermally unstable at body temperature E. Leikina, M. V. Mertts, N. Kuznetsova, and S. Leikin Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1314–1318. Published online 2002 January 22. doi: 10.1073/pnas.032307099.PMCID: PMC122187 Photoactivation of the flavin cofactor in Xenopus laevis (6–4) photolyase: Observation of a transient tyrosyl radical by time-resolved electron paramagnetic resonance Stefan Weber, Christopher W. M. Kay, Heike Mögling, Klaus Möbius, Kenichi Hitomi, and Takeshi Todo Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1319–1322. Published online 2002 January 22. doi: 10.1073/pnas.032469399.PMCID: PMC122188 Coherent infrared emission from myoglobin crystals: An electric field measurement Marie-Louise Groot, Marten H. Vos, Ilme Schlichting, Frank van Mourik, Manuel Joffre, Jean-Christophe Lambry, and Jean-Louis Martin Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1323–1328. Published online 2002 January 29. doi: 10.1073/pnas.251662698.PMCID: PMC122189 Conformational landscape of cytochrome c folding studied by microsecond-resolved small-angle x-ray scattering Shuji Akiyama, Satoshi Takahashi, Tetsunari Kimura, Koichiro Ishimori, Isao Morishima, Yukihiro Nishikawa, and Tetsuro Fujisawa Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1329–1334. Published online 2002 January 2. doi: 10.1073/pnas.012458999.PMCID: PMC122190 Cell Biology Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes Yih-Cherng Liou, Akihide Ryo, Han-Kuei Huang, Pei-Jung Lu, Roderick Bronson, Fumihiro Fujimori, Takafumi Uchida, Tony Hunter, and Kun Ping Lu Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1335–1340. Published online 2002 January 22. doi: 10.1073/pnas.032404099.PMCID: PMC122191 Muscle-derived hematopoietic stem cells are hematopoietic in origin Shannon L. McKinney-Freeman, Kathyjo A. Jackson, Fernando D. Camargo, Giuliana Ferrari, Fulvio Mavilio, and Margaret A. Goodell Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1341–1346. doi: 10.1073/pnas.032438799.PMCID: PMC122192 Analysis of Cdc6 function in the assembly of mammalian prereplication complexes Jeanette Gowen Cook, Chi-Hyun Park, Thomas W. Burke, Gustavo Leone, James DeGregori, Amber Engel, and Joseph R. Nevins Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1347–1352. Published online 2002 January 22. doi: 10.1073/pnas.032677499.PMCID: PMC122193 Formation of transitory intrachain and interchain disulfide bonds accompanies the folding and oligomerization of simian virus 40 Vp1 in the cytoplasm Peggy P. Li, Akira Nakanishi, Sean W. Clark, and Harumi Kasamatsu Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1353–1358. Published online 2002 January 22. doi: 10.1073/pnas.032668699.PMCID: PMC122194 The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R M. Resnati, I. Pallavicini, J. M. Wang, J. Oppenheim, C. N. Serhan, M. Romano, and F. Blasi Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1359–1364. Published online 2002 January 29. doi: 10.1073/pnas.022652999.PMCID: PMC122195 The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain Stefan F. Lichtenthaler, Dirk Beher, Heike S. Grimm, Rong Wang, Mark S. Shearman, Colin L. Masters, and Konrad Beyreuther Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1365–1370. Published online 2002 January 22. doi: 10.1073/pnas.032395699.PMCID: PMC122196 Developmental Biology A cell number-counting factor regulates the cytoskeleton and cell motility in Dictyostelium Lei Tang, Tong Gao, Catherine McCollum, Wonhee Jang, Michael G. Vicker, Robin R. Ammann, and Richard H. Gomer Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1371–1376. Published online 2002 January 29. doi: 10.1073/pnas.022516099.PMCID: PMC122197 Targeted gene expression in transgenic Xenopus using the binary Gal4-UAS system Katharine O. Hartley, Stephen L. Nutt, and Enrique Amaya Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1377–1382. Published online 2002 January 29. doi: 10.1073/pnas.022646899.PMCID: PMC122198 Adenovirus-mediated gene delivery and in vitro microinsemination produce offspring from infertile male mice Mito Kanatsu-Shinohara, Atsuo Ogura, Masaya Ikegawa, Kimiko Inoue, Narumi Ogonuki, Kei Tashiro, Shinya Toyokuni, Tasuku Honjo, and Takashi Shinohara Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1383–1388. Published online 2002 January 29. doi: 10.1073/pnas.022646399.PMCID: PMC122199 Ecology Projecting the future of the U.S. carbon sink G. C. Hurtt, S. W. Pacala, P. R. Moorcroft, J. Caspersen, E. Shevliakova, R. A. Houghton, and B. Moore, III Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1389–1394. doi: 10.1073/pnas.012249999.PMCID: PMC122200 Anthropogenic modification of New England salt marsh landscapes Mark D. Bertness, Patrick J. Ewanchuk, and Brian Reed Silliman Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1395–1398. Published online 2002 January 29. doi: 10.1073/pnas.022447299.PMCID: PMC122201 Evolution mtDNA from fossils reveals a radiation of Hawaiian geese recently derived from the Canada goose (Branta canadensis) Ellen E. Paxinos, Helen F. James, Storrs L. Olson, Michael D. Sorenson, Jennifer Jackson, and Robert C. Fleischer Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1399–1404. Published online 2002 January 29. doi: 10.1073/pnas.032166399.PMCID: PMC122202 Redundancy, antiredundancy, and the robustness of genomes David C. Krakauer and Joshua B. Plotkin Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1405–1409. Published online 2002 January 29. doi: 10.1073/pnas.032668599.PMCID: PMC122203 Spirochete and protist symbionts of a termite (Mastotermes electrodominicus) in Miocene amber Andrew Wier, Michael Dolan, David Grimaldi, Ricardo Guerrero, Jorge Wagensberg, and Lynn Margulis Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1410–1413. Published online 2002 January 29. doi: 10.1073/pnas.022643899.PMCID: PMC122204 The analysis of 100 genes supports the grouping of three highly divergent amoebae: Dictyostelium, Entamoeba, and Mastigamoeba Eric Bapteste, Henner Brinkmann, Jennifer A. Lee, Dorothy V. Moore, Christoph W. Sensen, Paul Gordon, Laure Duruflé, Terry Gaasterland, Philippe Lopez, Miklós Müller, and Hervé Philippe Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1414–1419. doi: 10.1073/pnas.032662799.PMCID: PMC122205 The origin of the eukaryotic cell: A genomic investigation Hyman Hartman and Alexei Fedorov Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1420–1425. Published online 2002 January 22. doi: 10.1073/pnas.032658599.PMCID: PMC122206 Molecular phylogenetic evidence for the independent evolutionary origin of an arthropod compound eye Todd H. Oakley and Clifford W. Cunningham Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1426–1430. Published online 2002 January 29. doi: 10.1073/pnas.032483599.PMCID: PMC122207 Microbat paraphyly and the convergent evolution of a key innovation in Old World rhinolophoid microbats Emma C. Teeling, Ole Madsen, Ronald A. Van Den Bussche, Wilfried W. de Jong, Michael J. Stanhope, and Mark S. Springer Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1431–1436. Published online 2002 January 22. doi: 10.1073/pnas.022477199.PMCID: PMC122208 Genetics The unexpected landscape of in vivo somatic mutation in a human epithelial cell lineage Lorel M. Colgin, Alden F. M. Hackmann, Mary J. Emond, and Raymond J. Monnat, Jr. Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1437–1442. Published online 2002 January 29. doi: 10.1073/pnas.032655699.PMCID: PMC122209 Stable suppression of gene expression by RNAi in mammalian cells Patrick J. Paddison, Amy A. Caudy, and Gregory J. Hannon Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1443–1448. Published online 2002 January 29. doi: 10.1073/pnas.032652399.PMCID: PMC122210 Recurrent evolution of DNA-binding motifs in the Drosophila centromeric histone Harmit S. Malik, Danielle Vermaak, and Steven Henikoff Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1449–1454. Published online 2002 January 22. doi: 10.1073/pnas.032664299.PMCID: PMC122211 Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice Mingjian James You, Diego H. Castrillon, Boris C. Bastian, Rónán C. O'Hagan, Marcus W. Bosenberg, Ramon Parsons, Lynda Chin, and Ronald A. DePinho Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1455–1460. Published online 2002 January 29. doi: 10.1073/pnas.022632099.PMCID: PMC122212 Complementary whole-genome technologies reveal the cellular response to proteasome inhibition by PS-341 James A. Fleming, Eric S. Lightcap, Seth Sadis, Vala Thoroddsen, Christine E. Bulawa, and Ronald K. Blackman Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1461–1466. doi: 10.1073/pnas.032516399.PMCID: PMC122213 Cho, a second endonuclease involved in Escherichia coli nucleotide excision repair Geri F. Moolenaar, Sari van Rossum-Fikkert, Marian van Kesteren, and Nora Goosen Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1467–1472. Published online 2002 January 29. doi: 10.1073/pnas.032584099.PMCID: PMC122214 From the Cover: HemK, a class of protein methyl transferase with similarity to DNA methyl transferases, methylates polypeptide chain release factors, and hemK knockout induces defects in translational termination Kenji Nakahigashi, Naoko Kubo, Shin-ichiro Narita, Takeshi Shimaoka, Simon Goto, Taku Oshima, Hirotada Mori, Maki Maeda, Chieko Wada, and Hachiro Inokuchi Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1473–1478. Published online 2002 January 22. doi: 10.1073/pnas.032488499.PMCID: PMC122215 Immunology The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness Alison A. Humbles, Bao Lu, Daniel S. Friend, Shoji Okinaga, Jose Lora, Amal Al-garawi, Thomas R. Martin, Norma P. Gerard, and Craig Gerard Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1479–1484. doi: 10.1073/pnas.261462598.PMCID: PMC122216 Conformational Abs recognizing a generic amyloid fibril epitope Brian O'Nuallain and Ronald Wetzel Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1485–1490. Published online 2002 January 29. doi: 10.1073/pnas.022662599.PMCID: PMC122217 From the Cover: Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation Giovanna Angelini, Stefania Gardella, Massimo Ardy, Maria Rosa Ciriolo, Giuseppe Filomeni, Giovanna Di Trapani, Frank Clarke, Roberto Sitia, and Anna Rubartelli Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1491–1496. Published online 2002 January 15. doi: 10.1073/pnas.022630299.PMCID: PMC122218 Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes Hajir Dadgostar, Brian Zarnegar, Alexander Hoffmann, Xiao-Feng Qin, Uyen Truong, Govinda Rao, David Baltimore, and Genhong Cheng Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1497–1502. doi: 10.1073/pnas.032665099.PMCID: PMC122219 Human macrophage activation programs induced by bacterial pathogens Gerard J. Nau, Joan F. L. Richmond, Ann Schlesinger, Ezra G. Jennings, Eric S. Lander, and Richard A. Young Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1503–1508. Published online 2002 January 22. doi: 10.1073/pnas.022649799.PMCID: PMC122220 IL-6 transgenic mouse model for extraosseous plasmacytoma Alexander L. Kovalchuk, Joong Su Kim, Sung Sup Park, Allen E. Coleman, Jerrold M. Ward, Herbert C. Morse, III, Tadamitsu Kishimoto, Michael Potter, and Siegfried Janz Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1509–1514. Published online 2002 January 22. doi: 10.1073/pnas.022643999.PMCID: PMC122221 Uncoating ATPase Hsc70 is recruited by invariant chain and controls the size of endocytic compartments Cécile Lagaudrière-Gesbert, Sherri L. Newmyer, Tone F. Gregers, Oddmund Bakke, and Hidde L. Ploegh Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1515–1520. Published online 2002 January 29. doi: 10.1073/pnas.042688099.PMCID: PMC122222 Medical Sciences Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis Reade B. Roberts, Lu Min, M. Kay Washington, Sandra J. Olsen, Stephen H. Settle, Robert J. Coffey, and David W. Threadgill Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1521–1526. Published online 2002 January 29. doi: 10.1073/pnas.032678499.PMCID: PMC122223 Targeting the prostate for destruction through a vascular address Wadih Arap, Wolfgang Haedicke, Michele Bernasconi, Renate Kain, Daniel Rajotte, Stanislaw Krajewski, H. Michael Ellerby, Dale E. Bredesen, Renata Pasqualini, and Erkki Ruoslahti Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1527–1531. doi: 10.1073/pnas.241655998.PMCID: PMC122224 Functional p53 chimeras containing the Epstein–Barr virus Gly-Ala repeat are protected from Mdm2- and HPV-E6-induced proteolysis Stijn Heessen, Ainars Leonchiks, Natalia Issaeva, Anatoly Sharipo, Galina Selivanova, Maria G. Masucci, and Nico P. Dantuma Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1532–1537. Published online 2002 January 22. doi: 10.1073/pnas.022306499.PMCID: PMC122225 Determinants of cluster distribution in the molecular epidemiology of tuberculosis Megan Murray Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1538–1543. Published online 2002 January 29. doi: 10.1073/pnas.022618299.PMCID: PMC122226 Microbiology The Brucella suis virB operon is induced intracellularly in macrophages Maria Laura Boschiroli, Safia Ouahrani-Bettache, Vincent Foulongne, Sylvie Michaux-Charachon, Gisele Bourg, Annick Allardet-Servent, Chantal Cazevieille, Jean Pierre Liautard, Michel Ramuz, and David O'Callaghan Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1544–1549. doi: 10.1073/pnas.032514299.PMCID: PMC122227 The murMN operon: A functional link between antibiotic resistance and antibiotic tolerance in Streptococcus pneumoniae Sergio R. Filipe, Elena Severina, and Alexander Tomasz Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1550–1555. doi: 10.1073/pnas.032671699.PMCID: PMC122228 Comparative genomic analysis of Vibrio cholerae: Genes that correlate with cholera endemic and pandemic disease Michelle Dziejman, Emmy Balon, Dana Boyd, Clare M. Fraser, John F. Heidelberg, and John J. Mekalanos Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1556–1561. Published online 2002 January 29. doi: 10.1073/pnas.042667999.PMCID: PMC122229 DNA microarray analysis of differential gene expression in Borrelia burgdorferi, the Lyme disease spirochete Andrew T. Revel, Adel M. Talaat, and Michael V. Norgard Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1562–1567. doi: 10.1073/pnas.032667699.PMCID: PMC122230 Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN Li Wu, Arman A. Bashirova, Thomas D. Martin, Loreley Villamide, Erin Mehlhop, Andrei O. Chertov, Derya Unutmaz, Melissa Pope, Mary Carrington, and Vineet N. KewalRamani Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1568–1573. Published online 2002 January 29. doi: 10.1073/pnas.032654399.PMCID: PMC122231 The capsular polysaccharide of Enterococcus faecalis and its relationship to other polysaccharides in the cell wall Lynn E. Hancock and Michael S. Gilmore Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1574–1579. doi: 10.1073/pnas.032448299.PMCID: PMC122232 Neurobiology Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity Hiroshi Kawasaki, Hirofumi Suemori, Kenji Mizuseki, Kiichi Watanabe, Fumi Urano, Hiroshi Ichinose, Masatoshi Haruta, Masayo Takahashi, Kanako Yoshikawa, Shin-Ichi Nishikawa, Norio Nakatsuji, and Yoshiki Sasai Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1580–1585. Published online 2002 January 29. doi: 10.1073/pnas.032662199.PMCID: PMC122233 Guiding the study of brain dynamics by using first-person data: Synchrony patterns correlate with ongoing conscious states during a simple visual task Antoine Lutz, Jean-Philippe Lachaux, Jacques Martinerie, and Francisco J. Varela Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1586–1591. Published online 2002 January 22. doi: 10.1073/pnas.032658199.PMCID: PMC122234 Cerebellar cortical inhibition and classical eyeblink conditioning Shaowen Bao, Lu Chen, Jeansok J. Kim, and Richard F. Thompson Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1592–1597. Published online 2002 January 22. doi: 10.1073/pnas.032655399.PMCID: PMC122235 Evidence of a mate-finding cue in the hermaphrodite nematode Caenorhabditis elegans Jasper M. Simon and Paul W. Sternberg Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1598–1603. Published online 2002 January 29. doi: 10.1073/pnas.032225799.PMCID: PMC122236 Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS) David S. Howland, Jian Liu, Yijin She, Beth Goad, Nicholas J. Maragakis, Benjamin Kim, Jamie Erickson, John Kulik, Lisa DeVito, George Psaltis, Louis J. DeGennaro, Don W. Cleveland, and Jeffrey D. Rothstein Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1604–1609. Published online 2002 January 29. doi: 10.1073/pnas.032539299.PMCID: PMC122237 β-Amyloid precursor protein transgenic mice that harbor diffuse Aβ deposits but do not form plaques show increased ischemic vulnerability: Role of inflammation Milla Koistinaho, Mikko I. Kettunen, Gundars Goldsteins, Riitta Keinänen, Antero Salminen, Michael Ort, Jan Bures, David Liu, Risto A. Kauppinen, Linda S. Higgins, and Jari Koistinaho Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1610–1615. Published online 2002 January 29. doi: 10.1073/pnas.032670899.PMCID: PMC122238 Oscillatory brain states and learning: Impact of hippocampal theta-contingent training Matthew A. Seager, Lynn D. Johnson, Elizabeth S. Chabot, Yukiko Asaka, and Stephen D. Berry Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1616–1620. Published online 2002 January 29. doi: 10.1073/pnas.032662099.PMCID: PMC122239 Cultured rat hippocampal neural progenitors generate spontaneously active neural networks Sanjay K. Mistry, Edward W. Keefer, Bruce A. Cunningham, Gerald M. Edelman, and Kathryn L. Crossin Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1621–1626. Published online 2002 January 29. doi: 10.1073/pnas.022646599.PMCID: PMC122240 The SNARE protein SNAP-25 is linked to fast calcium triggering of exocytosis Jakob B. Sørensen, Ulf Matti, Shun-Hui Wei, Ralf B. Nehring, Thomas Voets, Uri Ashery, Thomas Binz, Erwin Neher, and Jens Rettig Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1627–1632. doi: 10.1073/pnas.251673298.PMCID: PMC122241 From the Cover: Visual arrestins in olfactory pathways of Drosophila and the malaria vector mosquito Anopheles gambiae C. E. Merrill, J. Riesgo-Escovar, R. J. Pitts, F. C. Kafatos, J. R. Carlson, and L. J. Zwiebel Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1633–1638. Published online 2002 January 15. doi: 10.1073/pnas.022505499.PMCID: PMC122242 Dendritic spines elongate after stimulation of group 1 metabotropic glutamate receptors in cultured hippocampal neurons Peter W. Vanderklish and Gerald M. Edelman Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1639–1644. Published online 2002 January 29. doi: 10.1073/pnas.032681099.PMCID: PMC122243 Spatial frequency and orientation tuning dynamics in area V1 James A. Mazer, William E. Vinje, Josh McDermott, Peter H. Schiller, and Jack L. Gallant Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1645–1650. Published online 2002 January 29. doi: 10.1073/pnas.022638499.PMCID: PMC122244 Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception Arpad Dobolyi, Hiroshi Ueda, Hitoshi Uchida, Miklós Palkovits, and Ted B. Usdin Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1651–1656. Published online 2002 January 29. doi: 10.1073/pnas.042416199.PMCID: PMC122245 Neurotrophic factor intervention restores auditory function in deafened animals Takayuki Shinohara, Göran Bredberg, Mats Ulfendahl, Ilmari Pyykkö, N. Petri Olivius, Risto Kaksonen, Bo Lindström, Richard Altschuler, and Josef M. Miller Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1657–1660. Published online 2002 January 29. doi: 10.1073/pnas.032677999.PMCID: PMC122246 Selective up-regulation of dopamine D1 receptors in dendritic spines by NMDA receptor activation Lena Scott, Maria Sol Kruse, Hans Forssberg, Hjalmar Brismar, Paul Greengard, and Anita Aperia Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1661–1664. Published online 2002 January 29. doi: 10.1073/pnas.032654599.PMCID: PMC122247 C2A activates a cryptic Ca2+-triggered membrane penetration activity within the C2B domain of synaptotagmin I Jihong Bai, Ping Wang, and Edwin R. Chapman Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1665–1670. Published online 2002 January 22. doi: 10.1073/pnas.032541099.PMCID: PMC122248 Pharmacology Adenovirus-directed expression of Q227L-Gαs inhibits growth of established tumors of later-stage human breast cancer cells in athymic mice Tara Ann Santore, Yibang Chen, Martine J. Smit, and Ravi Iyengar Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1671–1676. Published online 2002 January 22. doi: 10.1073/pnas.032661999.PMCID: PMC122249 Potent antiarthritic properties of a glucocorticoid derivative, NCX-1015, in an experimental model of arthritis Mark J. Paul-Clark, Lucia Mancini, Piero Del Soldato, Roderick J. Flower, and Mauro Perretti Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1677–1682. Published online 2002 January 22. doi: 10.1073/pnas.022641099.PMCID: PMC122250 Generation of an activating Zn2+ switch in the dopamine transporter: Mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle Claus Juul Loland, Lene Norregaard, Thomas Litman, and Ulrik Gether Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1683–1688. Published online 2002 January 29. doi: 10.1073/pnas.032386299.PMCID: PMC122251 Efficacy and age-related effects of nitric oxide-releasing aspirin on experimental restenosis Claudio Napoli, Giancarlo Aldini, John L. Wallace, Filomena de Nigris, Roberto Maffei, Pasquale Abete, Domenico Bonaduce, Gianluigi Condorelli, Franco Rengo, Vincenzo Sica, Francesco P. D'Armiento, Chiara Mignogna, Gaetano de Rosa, Mario Condorelli, Lilach O. Lerman, and Louis J. Ignarro Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1689–1694. Published online 2002 January 29. doi: 10.1073/pnas.022639399.PMCID: PMC122252 Physiology Type 3 ryanodine receptors of skeletal muscle are segregated in a parajunctional position Edward Felder and Clara Franzini-Armstrong Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1695–1700. Published online 2002 January 29. doi: 10.1073/pnas.032657599.PMCID: PMC122253 Circulating relaxin acts on subfornical organ neurons to stimulate water drinking in the rat N. Sunn, M. Egli, T. C. D. Burazin, P. Burns, L. Colvill, P. Davern, D. A. Denton, B. J. Oldfield, R. S. Weisinger, M. Rauch, H. A. Schmid, and M. J. McKinley Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1701–1706. doi: 10.1073/pnas.022647699.PMCID: PMC122254 Cytosolic malate dehydrogenase confers selectivity of the nucleic acid-conducting channel Basil Hanss, Edgar Leal-Pinto, Avelino Teixeira, Robert E. Christian, Jeffery Shabanowitz, Donald F. Hunt, and Paul E. Klotman Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1707–1712. Published online 2002 January 22. doi: 10.1073/pnas.022355499.PMCID: PMC122255 Plant Biology Leaf-to-shoot apex movement of symplastic tracer is restricted coincident with flowering in Arabidopsis Andreas Gisel, Frederick D. Hempel, Sandra Barella, and Patricia Zambryski Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1713–1717. Published online 2002 January 29. doi: 10.1073/pnas.251675698.PMCID: PMC122256 A gene encoding a protein modified by the phytohormone indoleacetic acid Alexander Walz, Seijin Park, Janet P. Slovin, Jutta Ludwig-Müller, Yoshie S. Momonoki, and Jerry D. Cohen Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1718–1723. doi: 10.1073/pnas.032450399.PMCID: PMC122257 Enhanced ADP-glucose pyrophosphorylase activity in wheat endosperm increases seed yield Eric D. Smidansky, Maureen Clancy, Fletcher D. Meyer, Susan P. Lanning, Nancy K. Blake, Luther E. Talbert, and Michael J. Giroux Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1724–1729. doi: 10.1073/pnas.022635299.PMCID: PMC122258 Nitrogen assimilation and growth of wheat under elevated carbon dioxide Arnold J. Bloom, David R. Smart, Duy T. Nguyen, and Peter S. Searles Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1730–1735. Published online 2002 January 29. doi: 10.1073/pnas.022627299.PMCID: PMC122259 Psychology Dissociation in human prefrontal cortex of affective influences on working memory-related activity William M. Perlstein, Thomas Elbert, and V. Andrew Stenger Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1736–1741. Published online 2002 January 29. doi: 10.1073/pnas.241650598.PMCID: PMC122260 Social Sciences Psychology Global organization of the Wordnet lexicon Mariano Sigman and Guillermo A. Cecchi Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1742–1747. doi: 10.1073/pnas.022341799.PMCID: PMC122261 |