Hypophosphatasia
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Q&A	More Detailed Information	Support Groups	NLM Gateway

My daughter has hypophosphatasia. She will soon be 7 years-old and has already lost eleven of her first teeth. Two of her adult teeth have come in. Will she loose these too?

• Can hypophosphatasia cause the early loss of adult (or secondary) teeth?

• Can hypophosphatasia cause the early loss of adult (or secondary) teeth? (Back to Top)

• Yes. Hypophosphatasia is a disorder that disrupts a process called mineralization, in which minerals such as calcium and phosphorus are deposited in developing bones and teeth. Mineralization is critical for the formation of teeth that can withstand chewing and grinding. Hypophosphatasia is characterized by the early loss of baby (or deciduous) teeth. While not as common, children and adults with hypophosphatasia may also have additional issues with their adult or permanent teeth. Problems may include cavity prone teeth and early loss of teeth.^[1][2] Children and adults with hypophosphatasia benefit from consultations with an appropriate specialist for care of dentition (tooth) complications.
  
• Last Reviewed: 5/6/2009

References  (Back)

1. Hypophosphatasia. Genetics Home Reference (GHR). 2008 Available at: http://ghr.nlm.nih.gov/condition=hypophosphatasia. Accessed February 22, 2008.
2. Mornet E, Nunes ME. Hypophosphatasia . GeneReviews. 2007 Available at: http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=hops. Accessed May 6, 2009.