| | This journal provides immediate access to some articles. This Week in PNAS Proc Natl Acad Sci U S A. 2006 November 7; 103(45): 16617–16618. doi: 10.1073/iti4506103.PMCID: PMC1636502 Commentaries A boost for hearing in mosquitoes Ron Hoy PMCID: PMC1636503 A surprising METamorphosis: Autism genetics finds a common functional variant Matthew W. State PMCID: PMC1636504 Perspective A backbone-based theory of protein folding George D. Rose, Patrick J. Fleming, Jayanth R. Banavar, and Amos Maritan PMCID: PMC1636505 Profile Profile of F. Stuart Chapin III Philip Downey PMCID: PMC1636506 Physical Sciences Chemistry Photoprotection of human retinal pigment epithelium cells against blue light-induced apoptosis by melanin free radicals from Sepia officinalis Brandon-Luke L. Seagle, Elzbieta M. Gasyna, William F. Mieler, and James R. Norris, Jr. PMCID: PMC1636508 A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas Cameron C. Lee, Elizabeth R. Gillies, Megan E. Fox, Steven J. Guillaudeu, Jean M. J. Fréchet, Edward E. Dy, and Francis C. Szoka PMCID: PMC1636509 Photoreactivation of DNA by an Archaeal nucleoprotein Sso7d Ryu Tashiro, Andrew H.-J. Wang, and Hiroshi Sugiyama PMCID: PMC1636510 Engineering Universal scaling for polymer chain scission in turbulence Siva A. Vanapalli, Steven L. Ceccio, and Michael J. Solomon PMCID: PMC1636511 Geology Confirmation of Romer's Gap as a low oxygen interval constraining the timing of initial arthropod and vertebrate terrestrialization Peter Ward, Conrad Labandeira, Michel Laurin, and Robert A. Berner PMCID: PMC1636538 Medical Sciences Cardiac myosin binding protein c phosphorylation is cardioprotective Sakthivel Sadayappan, Hanna Osinska, Raisa Klevitsky, John N. Lorenz, Michelle Sargent, Jeffrey D. Molkentin, Christine E. Seidman, Jonathan G. Seidman, and Jeffrey Robbins PMCID: PMC1636554 Biological Sciences Agricultural Sciences Impacts of genetic bottlenecks on soybean genome diversity David L. Hyten, Qijian Song, Youlin Zhu, Ik-Young Choi, Randall L. Nelson, Jose M. Costa, James E. Specht, Randy C. Shoemaker, and Perry B. Cregan PMCID: PMC1624862 Changing green leaf volatile biosynthesis in plants: An approach for improving plant resistance against both herbivores and pathogens Kaori Shiojiri, Kyutaro Kishimoto, Rika Ozawa, Soichi Kugimiya, Soichi Urashimo, Genichiro Arimura, Junichiro Horiuchi, Takaaki Nishioka, Kenji Matsui, and Junji Takabayashi PMCID: PMC1636513 Applied Biological Sciences Single-step electronic detection of femtomolar DNA by target-induced strand displacement in an electrode-bound duplex Yi Xiao, Arica A. Lubin, Brian R. Baker, Kevin W. Plaxco, and Alan J. Heeger PMCID: PMC1622927 A neuroinductive biomaterial based on dopamine Jin Gao, Yu Mi Kim, Herna Coe, Blaine Zern, Barbara Sheppard, and Yadong Wang PMCID: PMC1636515 Biochemistry The 39-kDa poly(ADP-ribose) glycohydrolase ARH3 hydrolyzes O-acetyl-ADP-ribose, a product of the Sir2 family of acetyl-histone deacetylases Tohru Ono, Atsushi Kasamatsu, Shunya Oka, and Joel Moss PMCID: PMC1636516 A Ras-induced conformational switch in the Ras activator Son of sevenless Tanya S. Freedman, Holger Sondermann, Gregory D. Friedland, Tanja Kortemme, Dafna Bar-Sagi, Susan Marqusee, and John Kuriyan PMCID: PMC1629002 Nonspecific binding to structured RNA and preferential unwinding of an exposed helix by the CYT-19 protein, a DEAD-box RNA chaperone Pilar Tijerina, Hari Bhaskaran, and Rick Russell PMCID: PMC1636518 Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum Yoshihiro Baba, Kenji Hayashi, Yoko Fujii, Akiko Mizushima, Hiroshi Watarai, Minoru Wakamori, Takuro Numaga, Yasuo Mori, Masamitsu Iino, Masaki Hikida, and Tomohiro Kurosaki PMCID: PMC1636519 Combinatorial methods for small-molecule placement in computational enzyme design Jonathan Kyle Lassila, Heidi K. Privett, Benjamin D. Allen, and Stephen L. Mayo PMCID: PMC1636520 Haploinsufficiency of the corepressor of estrogen receptor activity (REA) enhances estrogen receptor function in the mammary gland Paola Mussi, Lan Liao, Seong-Eun Park, Paolo Ciana, Adriana Maggi, Benita S. Katzenellenbogen, Jianming Xu, and Bert W. O'Malley PMCID: PMC1636521 Disulfide cross-linking indicates that FlgM-bound and free σ28 adopt similar conformations Margareta K. Sorenson and Seth A. Darst PMCID: PMC1636522 Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase Jason M. Crawford, Blair C. R. Dancy, Eric A. Hill, Daniel W. Udwary, and Craig A. Townsend PMCID: PMC1636523 Biophysics From the Cover:
Nonlinear auditory mechanism enhances female sounds for male mosquitoes Joseph C. Jackson and Daniel Robert PMCID: PMC1636524 Amide vibrations are delocalized across the hydrophobic interface of a transmembrane helix dimer Chong Fang, Alessandro Senes, Lidia Cristian, William F. DeGrado, and Robin M. Hochstrasser PMCID: PMC1636525 Phase knowledge enables rational screens for protein crystallization Megan J. Anderson, Carl L. Hansen, and Stephen R. Quake PMCID: PMC1636526 Statistics of cellular signal transduction as a race to the nucleus by multiple random walkers in compartment/phosphorylation space Ting Lu, Tongye Shen, Chenghang Zong, Jeff Hasty, and Peter G. Wolynes PMCID: PMC1636527 Modeling dual pathways for the metazoan spindle assembly checkpoint Richard P. Sear and Martin Howard PMCID: PMC1636528 Fluorescence correlation spectroscopy shows that monomeric polyglutamine molecules form collapsed structures in aqueous solutions Scott L. Crick, Murali Jayaraman, Carl Frieden, Ronald Wetzel, and Rohit V. Pappu PMCID: PMC1629004 Cell Biology From the Cover:
An in vitro assay reveals a role for the diaphragm protein PV-1 in endothelial fenestra morphogenesis Sofia Ioannidou, Katrin Deinhardt, Jadwiga Miotla, John Bradley, Eunice Cheung, Steven Samuelsson, Yin-Shan Ng, and David T. Shima PMCID: PMC1636530 Essential role of RGS-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamics Bin Zheng, Tingdong Tang, Nan Tang, Krystyna Kudlicka, Kazuaki Ohtsubo, Phuong Ma, Jamey D. Marth, Marilyn G. Farquhar, and Eero Lehtonen PMCID: PMC1636531 Developmental Biology Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex Melissa M. Harrison, Craig J. Ceol, Xiaowei Lu, and H. Robert Horvitz PMCID: PMC1636532 Molecular interactions between Tbx3 and Bmp4 and a model for dorsoventral positioning of mammary gland development Kyoung-Won Cho, Jae-Young Kim, Soo-Jin Song, Elizabeth Farrell, Maxwell C. Eblaghie, Hee-Jin Kim, Cheryll Tickle, and Han-Sung Jung PMCID: PMC1636533 Mutation of TweedleD, a member of an unconventional cuticle protein family, alters body shape in Drosophila Xiao Guan, Brooke W. Middlebrooks, Sherry Alexander, and Steven A. Wasserman PMCID: PMC1636534 Vertebrate MAX-1 is required for vascular patterning in zebrafish Hanbing Zhong, Xinrong Wu, Haigen Huang, Qichang Fan, Zuoyan Zhu, and Shuo Lin PMCID: PMC1636535 Wnt and TGF-β signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells Paul Gadue, Tara L. Huber, Patrick J. Paddison, and Gordon M. Keller PMCID: PMC1636536 Ecology Modern Quaternary plant lineages promote diversity through facilitation of ancient Tertiary lineages Alfonso Valiente-Banuet, Adolfo Vital Rumebe, Miguel Verdú, and Ragan M. Callaway PMCID: PMC1636537 Evolution Confirmation of Romer's Gap as a low oxygen interval constraining the timing of initial arthropod and vertebrate terrestrialization Peter Ward, Conrad Labandeira, Michel Laurin, and Robert A. Berner PMCID: PMC1636538 The dynamics of Machiavellian intelligence Sergey Gavrilets and Aaron Vose PMCID: PMC1636539 Hagfish and lancelet fibrillar collagens reveal that type II collagen-based cartilage evolved in stem vertebrates GuangJun Zhang and Martin J. Cohn PMCID: PMC1636540 Genetics From the Cover:
A genetic variant that disrupts MET transcription is associated with autism Daniel B. Campbell, James S. Sutcliffe, Philip J. Ebert, Roberto Militerni, Carmela Bravaccio, Simona Trillo, Maurizio Elia, Cindy Schneider, Raun Melmed, Roberto Sacco, Antonio M. Persico, and Pat Levitt PMCID: PMC1838551 Template disruptions and failure of double Holliday junction dissolution during double-strand break repair in Drosophila BLM mutants Dena Johnson-Schlitz and William R. Engels PMCID: PMC1636541 Immunology Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response Nadia Anikeeva, Tatiana Lebedeva, Aaron R. Clapp, Ellen R. Goldman, Michael L. Dustin, Hedi Mattoussi, and Yuri Sykulev PMCID: PMC1636542 Responses of IL-18- and IL-18 receptor-deficient pancreatic islets with convergence of positive and negative signals for the IL-18 receptor Eli C. Lewis and Charles A. Dinarello PMCID: PMC1636543 Increased melanizing activity in Anopheles gambiae does not affect development of Plasmodium falciparum Kristin Michel, Chansak Suwanchaichinda, Isabelle Morlais, Louis Lambrechts, Anna Cohuet, Parfait H. Awono-Ambene, Frederic Simard, Didier Fontenille, Michael R. Kanost, and Fotis C. Kafatos PMCID: PMC1636544 Medical Sciences Photoprotection of human retinal pigment epithelium cells against blue light-induced apoptosis by melanin free radicals from Sepia officinalis Brandon-Luke L. Seagle, Elzbieta M. Gasyna, William F. Mieler, and James R. Norris, Jr. PMCID: PMC1636508 Fibrosis, not cell size, delineates β-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo Kumar Pandya, Hyung-Suk Kim, and Oliver Smithies PMCID: PMC1624863 Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice Yiguo Hu, Sarah Swerdlow, Theodore M. Duffy, Roberto Weinmann, Francis Y. Lee, and Shaoguang Li PMCID: PMC1629087 From the Cover:
Depression induces bone loss through stimulation of the sympathetic nervous system Raz Yirmiya, Inbal Goshen, Alon Bajayo, Tirzah Kreisel, Sharon Feldman, Joseph Tam, Victoria Trembovler, Valér Csernus, Esther Shohami, and Itai Bab PMCID: PMC1636547 Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase Jean S. Oak, Jonathan A. Deane, Michael G. Kharas, Ji Luo, Thomas E. Lane, Lewis C. Cantley, and David A. Fruman PMCID: PMC1636548 CLA-1 and its splicing variant CLA-2 mediate bacterial adhesion and cytosolic bacterial invasion in mammalian cells Tatyana G. Vishnyakova, Roger Kurlander, Alexander V. Bocharov, Irina N. Baranova, Zhigang Chen, Mones S. Abu-Asab, Maria Tsokos, Daniela Malide, Federica Basso, Alan Remaley, Gyorgy Csako, Thomas L. Eggerman, and Amy P. Patterson PMCID: PMC1636549 Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes Guo-Yun Chen, Hirotaka Osada, Luis F. Santamaria-Babi, and Reiji Kannagi PMCID: PMC1629005 The role of platelet adhesion receptor GPIbα far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis Wolfgang Bergmeier, Crystal L. Piffath, Tobias Goerge, Stephen M. Cifuni, Zaverio M. Ruggeri, Jerry Ware, and Denisa D. Wagner PMCID: PMC1636551 Akt1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning Wen-Sung Lai, Bin Xu, Koen G. C. Westphal, Marta Paterlini, Berend Olivier, Paul Pavlidis, Maria Karayiorgou, and Joseph A. Gogos PMCID: PMC1636552 Vitamin C mediates chemical aging of lens crystallins by the Maillard reaction in a humanized mouse model Xingjun Fan, Lixing W. Reneker, Mark E. Obrenovich, Christopher Strauch, Rongzhu Cheng, Simon M. Jarvis, Beryl J. Ortwerth, and Vincent M. Monnier PMCID: PMC1636553 Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model Dimple Bansal, Claudia Scholl, Stefan Fröhling, Elizabeth McDowell, Benjamin H. Lee, Konstanze Döhner, Patricia Ernst, Alan J. Davidson, George Q. Daley, Leonard I. Zon, D. Gary Gilliland, and Brian J. P. Huntly PMCID: PMC1636555 Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivo J. A. Kennedy, F. Barabé, B. J. Patterson, J. Bayani, J. A. Squire, D. L. Barber, and J. E. Dick PMCID: PMC1629449 Microbiology Emergence and predominance of an H5N1 influenza variant in China G. J. D. Smith, X. H. Fan, J. Wang, K. S. Li, K. Qin, J. X. Zhang, D. Vijaykrishna, C. L. Cheung, K. Huang, J. M. Rayner, J. S. M. Peiris, H. Chen, R. G. Webster, and Y. Guan PMCID: PMC1636557 Vaccine assembly from surface proteins of Staphylococcus aureus Yukiko K. Stranger-Jones, Taeok Bae, and Olaf Schneewind PMCID: PMC1636558 A structurally unrelated mimic of a Pseudomonas aeruginosa acyl-homoserine lactone quorum-sensing signal Ute Müh, Brian J. Hare, Breck A. Duerkop, Martin Schuster, Brian L. Hanzelka, Roger Heim, Eric R. Olson, and E. Peter Greenberg PMCID: PMC1636559 Legionella pneumophila glucosyltransferase inhibits host elongation factor 1A Yury Belyi, Ricarda Niggeweg, Bastian Opitz, Martin Vogelsgesang, Stefan Hippenstiel, Matthias Wilm, and Klaus Aktories PMCID: PMC1636560 Generation of HIV-1 derivatives that productively infect macaque monkey lymphoid cells Kazuya Kamada, Tatsuhiko Igarashi, Malcolm A. Martin, Boonruang Khamsri, Kazuki Hatcho, Tomoki Yamashita, Mikako Fujita, Tsuneo Uchiyama, and Akio Adachi PMCID: PMC1622925 Neuroscience Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors Antoine Taly, Pierre-Jean Corringer, Thomas Grutter, Lia Prado de Carvalho, Martin Karplus, and Jean-Pierre Changeux PMCID: PMC1629088 NMDA receptors promote survival in somatosensory relay nuclei by inhibiting Bax-dependent developmental cell death Juan Carlos de Rivero Vaccari, Gregory P. Casey, Salman Aleem, Won-Mee Park, and Roderick A. Corriveau PMCID: PMC1636563 Activity-dependent gene regulation in skeletal muscle is mediated by a histone deacetylase (HDAC)-Dach2-myogenin signal transduction cascade Huibin Tang and Daniel Goldman PMCID: PMC1636564 Activation of estrogen receptor α increases and estrogen receptor β decreases apolipoprotein E expression in hippocampus in vitro and in vivo Jun Ming Wang, Ronald W. Irwin, and Roberta Diaz Brinton PMCID: PMC1636565 Use of polysialic acid in repair of the central nervous system Abderrahman El Maarouf, Athanasios K. Petridis, and Urs Rutishauser PMCID: PMC1636566 MyoD expression restores defective myogenic differentiation of human mesoangioblasts from inclusion-body myositis muscle Roberta Morosetti, Massimiliano Mirabella, Carla Gliubizzi, Aldobrando Broccolini, Luciana De Angelis, Enrico Tagliafico, Maurilio Sampaolesi, Teresa Gidaro, Manuela Papacci, Enrica Roncaglia, Sergio Rutella, Stefano Ferrari, Pietro Attilio Tonali, Enzo Ricci, and Giulio Cossu PMCID: PMC1636567 Navigation-associated medial parietal neurons in monkeys Nobuya Sato, Hideo Sakata, Yuji L. Tanaka, and Masato Taira PMCID: PMC1624861 Cognitive enhancement with central thalamic electrical stimulation Prasad Shirvalkar, Malika Seth, Nicholas D. Schiff, and Daniel G. Herrera PMCID: PMC1622923 Valence-sensitive neurons exhibit divergent functional profiles in gregarious and asocial species James L. Goodson and Yiwei Wang PMCID: PMC1636570 Pharmacology A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas Cameron C. Lee, Elizabeth R. Gillies, Megan E. Fox, Steven J. Guillaudeu, Jean M. J. Fréchet, Edward E. Dy, and Francis C. Szoka PMCID: PMC1636509 Endothelial cellular senescence is inhibited by nitric oxide: Implications in atherosclerosis associated with menopause and diabetes Toshio Hayashi, Hisako Matsui-Hirai, Asaka Miyazaki-Akita, Akiko Fukatsu, Jun Funami, Qun-Fang Ding, Sumitra Kamalanathan, Yuichi Hattori, Louis J. Ignarro, and Akihisa Iguchi PMCID: PMC1629003 Atherosclerosis-related molecular alteration of the human CaV1.2 calcium channel α1C subunit Swasti Tiwari, Yuwei Zhang, Jennifer Heller, Darrell R. Abernethy, and Nikolai M. Soldatov PMCID: PMC1636572 μO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits J. Ekberg, A. Jayamanne, C. W. Vaughan, S. Aslan, L. Thomas, J. Mould, R. Drinkwater, M. D. Baker, B. Abrahamsen, J. N. Wood, D. J. Adams, M. J. Christie, and R. J. Lewis PMCID: PMC1629086 Plant Biology Cryptochrome-1-dependent execution of programmed cell death induced by singlet oxygen in Arabidopsis thaliana Antoine Danon, Núria Sánchez Coll, and Klaus Apel PMCID: PMC1636574 Cloning of DOG1, a quantitative trait locus controlling seed dormancy in Arabidopsis Leónie Bentsink, Jemma Jowett, Corrie J. Hanhart, and Maarten Koornneef PMCID: PMC1636575 Psychology A gender- and sexual orientation-dependent spatial attentional effect of invisible images Yi Jiang, Patricia Costello, Fang Fang, Miner Huang, and Sheng He PMCID: PMC1636576 From the Cover:
Self-recognition in an Asian elephant Joshua M. Plotnik, Frans B. M. de Waal, and Diana Reiss PMCID: PMC1636577 Sustainability Science INAUGURAL ARTICLE by a Recently Elected Academy Member: Policy strategies to address sustainability of Alaskan boreal forests in response to a directionally changing climate F. Stuart Chapin, III, Amy L. Lovecraft, Erika S. Zavaleta, Joanna Nelson, Martin D. Robards, Gary P. Kofinas, Sarah F. Trainor, Garry D. Peterson, Henry P. Huntington, and Rosamond L. Naylor PMCID: PMC1636507 Social Sciences Psychology A gender- and sexual orientation-dependent spatial attentional effect of invisible images Yi Jiang, Patricia Costello, Fang Fang, Miner Huang, and Sheng He PMCID: PMC1636576 Day-to-day dynamics of experience–cortisol associations in a population-based sample of older adults Emma K. Adam, Louise C. Hawkley, Brigitte M. Kudielka, and John T. Cacioppo PMCID: PMC1636578 Sustainability Science INAUGURAL ARTICLE by a Recently Elected Academy Member: Policy strategies to address sustainability of Alaskan boreal forests in response to a directionally changing climate F. Stuart Chapin, III, Amy L. Lovecraft, Erika S. Zavaleta, Joanna Nelson, Martin D. Robards, Gary P. Kofinas, Sarah F. Trainor, Garry D. Peterson, Henry P. Huntington, and Rosamond L. Naylor PMCID: PMC1636507 Corrections Correction for Wada et al., A molecular neuroethological approach for identifying and characterizing a cascade of behaviorally regulated genes PMCID: PMC1636579 Corrects: Kazuhiro Wada, et al. A molecular neuroethological approach for identifying and characterizing a cascade of behaviorally regulated genes. Proc Natl Acad Sci U S A. 2006 October 10; 103(41): 15212–15217. Correction for Street et al., A molecular mechanism for osmolyte-induced protein stability PMCID: PMC1636580 Corrects: Timothy O. Street, et al. A molecular mechanism for osmolyte-induced protein stability. Proc Natl Acad Sci U S A. 2006 September 19; 103(38): 13997–14002. Correction for Kadener et al., Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in Drosophila PMCID: PMC1636581 Corrects: Sebastian Kadener, et al. Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in Drosophila. Proc Natl Acad Sci U S A. 2006 September 5; 103(36): 13537–13542. Correction for Deshpande et al., A bio-chemo-mechanical model for cell contractility PMCID: PMC1636582 Corrects: Vikram S. Deshpande, et al. A bio-chemo-mechanical model for cell contractility. Proc Natl Acad Sci U S A. 2006 September 19; 103(38): 14015–14020. |
