Dion E, Valantin MA, Biligui A, Grenier P, Katlama C, Costagliola D; IAS Conference on HIV Pathogenesis and Treatment (2nd : 2003 : Paris, France).

Antivir Ther. 2003; 8 (Suppl.1): abstract no. 728.

Departement de Radiologie, Hopital Pitie-Salpetriere

OBJECTIVE: Lipoatrophy is a frequent complication in HIV-infected patients treated with antiretroviral therapy. Morphologic evaluation is based on clinical examination but objective end-points are needed to evaluate therapeutic interventions. The thighs are a specific location of lipoatrophy. In severe cases, fat cannot be measurable on a CT single slice. We report a three-dimensional volumetric fat evaluation of the thighs. Patients : CT scans were performed on 10 HIV-infected patients (seven males, three females) with clinical lipoatrophy (HIV+ LA+) and on 10 sex-matched volunteers (HIV-). The 10 HIV-infected patients were included in the NONUKE ANRS 108 randomized ongoing trial evaluating the impact on lipoatrophy of two different antiretroviral strategies (NRTI-sparing regimens versus NRTI containing combinations). METHOD: Helical CT scans of the two thighs were acquired in both groups, twice within 1 month, over a height of 10 cm taken at 10 cm below the lesser trochanter (39 slices). Three-dimensional reconstructions were obtained using a 3D-analysis software package on a General Electric Advantage workstation. Fat volume calculations were repeated twice for each time point. Fat volume reported is the mean value of the two evaluations. RESULTS: In HIV+LA+ male patients mean value is 37 +/-26 cm3 vs 957 +/-242 cm3 for HIV- males (reduction of 96%). In women the difference was less striking (684 +/-476 cm3 for HIV+LA+ vs 1509 +/-121 cm3 for HIV-, reduction of 55%). The standard deviation of the variation of fat volume within 1 month was 41 in HIV- men and 172 cm3 in HIV-women while corresponding figures were 5 and 81 cm3 in HIV+LA+ men and women, respectively. CONCLUSION: 3D CT acquisition is suitable for evaluation of lipoatrophy of the thighs even in patients with severe lipoatrophy. If used as an end-point in a clinical trial, stratification on sex is advisable.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Case-Control Studies
• Female
• HIV Infections
• HIV Seropositivity
• Humans
• Lipodystrophy
• Male
• Tomography, Spiral Computed
• Tomography, X-Ray Computed
• radiography

Other ID:

• GWAIDS0023383

UI: 102263007

From Meeting Abstracts