| | This journal provides immediate access to some articles. Commentaries Two by two: The pairings of P-selectin and P-selectin glycoprotein ligand 1 Guy A. Zimmerman Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10023–10024. doi: 10.1073/pnas.191367898.PMCID: PMC56905 Making sense (and antisense) of the X inactivation center Huntington F. Willard and Laura Carrel Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10025–10027. doi: 10.1073/pnas.191380198.PMCID: PMC56906 Targeted therapies for killing tumor cells Adi F. Gazdar and John D. Minna Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10028–10030. doi: 10.1073/pnas.191379998.PMCID: PMC56907 Linking molecular therapeutics to molecular diagnostics: Inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo Gordon B. Mills, Yiling Lu, and Elise C. Kohn Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10031–10033. doi: 10.1073/pnas.191379498.PMCID: PMC56908 CmC(a/t)GG methylation: A new epigenetic mark in mammalian DNA? Matthew C. Lorincz and Mark Groudine Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10034–10036. doi: 10.1073/pnas.201392598.PMCID: PMC56909 Physical Sciences Applied Mathematics The coreceptor mutation CCR5Δ32 influences the dynamics of HIV epidemics and is selected for by HIV Amy D. Sullivan, Janis Wigginton, and Denise Kirschner Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10214–10219. Published online 2001 August 21. doi: 10.1073/pnas.181325198.PMCID: PMC56941 Chemistry Electrostatics of nanosystems: Application to microtubules and the ribosome Nathan A. Baker, David Sept, Simpson Joseph, Michael J. Holst, and J. Andrew McCammon Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10037–10041. Published online 2001 August 21. doi: 10.1073/pnas.181342398.PMCID: PMC56910 Chiral exciton coupling of merocyanine dyes within a well defined hydrogen-bonded assembly Leonard J. Prins, Christoph Thalacker, Frank Würthner, Peter Timmerman, and David N. Reinhoudt Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10042–10045. doi: 10.1073/pnas.171131398.PMCID: PMC56911 Biological Sciences Applied Biological Sciences The see-through medaka: A fish model that is transparent throughout life Yuko Wakamatsu, Sergey Pristyazhnyuk, Masato Kinoshita, Minoru Tanaka, and Kenjiro Ozato Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10046–10050. doi: 10.1073/pnas.181204298.PMCID: PMC56912 From the Cover: INAUGURAL ARTICLE by a Recently Elected Academy Member: The interplay of biology and technology Stanley Fields Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10051–10054. Published online 2001 August 21. doi: 10.1073/pnas.191380098.PMCID: PMC56913 Biochemistry Symmetrical dimer of the human dopamine transporter revealed by cross-linking Cys-306 at the extracellular end of the sixth transmembrane segment Hanne Hastrup, Arthur Karlin, and Jonathan A. Javitch Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10055–10060. doi: 10.1073/pnas.181344298.PMCID: PMC56914 Phospholamban domain IB forms an interaction site with the loop between transmembrane helices M6 and M7 of sarco(endo)plasmic reticulum Ca2+ ATPases Michio Asahi, N. Michael Green, Kazimierz Kurzydlowski, Michihiko Tada, and David H. MacLennan Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10061–10066. doi: 10.1073/pnas.181348298.PMCID: PMC56915 Why multiple small subunits (Y2 and Y4) for yeast ribonucleotide reductase? Toward understanding the role of Y4 Jie Ge, Deborah L. Perlstein, Hiep-Hoa Nguyen, Galit Bar, Robert G. Griffin, and JoAnne Stubbe Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10067–10072. doi: 10.1073/pnas.181336498.PMCID: PMC56916 Structure of the yeast ribonucleotide reductase Y2Y4 heterodimer Walter C. Voegtli, Jie Ge, Deborah L. Perlstein, JoAnne Stubbe, and Amy C. Rosenzweig Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10073–10078. doi: 10.1073/pnas.181336398.PMCID: PMC56917 Modifications of cellulose synthase confer resistance to isoxaben and thiazolidinone herbicides in Arabidopsis Ixr1 mutants Wolf-Rüdiger Scheible, Ravit Eshed, Todd Richmond, Deborah Delmer, and Chris Somerville Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10079–10084. Published online 2001 August 21. doi: 10.1073/pnas.191361598.PMCID: PMC56918 Human DNA replication initiation factors, ORC and MCM, associate with oriP of Epstein–Barr virus Biswendu Chaudhuri, Hongzhan Xu, Ivan Todorov, Anindya Dutta, and John L. Yates Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10085–10089. Published online 2001 August 21. doi: 10.1073/pnas.181347998.PMCID: PMC56919 DNA binding induces dissociation of the multimeric form of HIV-1 integrase: A time-resolved fluorescence anisotropy study Eric Deprez, Patrick Tauc, Hervé Leh, Jean-François Mouscadet, Christian Auclair, Mary E. Hawkins, and Jean-Claude Brochon Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10090–10095. Published online 2001 August 14. doi: 10.1073/pnas.181024498.PMCID: PMC56920 From the Cover: A conformational change in the ribosomal peptidyl transferase center upon active/inactive transition Mark A. Bayfield, Albert E. Dahlberg, Ulrike Schulmeister, Silke Dorner, and Andrea Barta Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10096–10101. Published online 2001 August 21. doi: 10.1073/pnas.171319598.PMCID: PMC56921 Glucagon receptor activates extracellular signal-regulated protein kinase 1/2 via cAMP-dependent protein kinase Youwei Jiang, Aaron M. Cypess, Evan D. Muse, Cui-Rong Wu, Cecilia G. Unson, R. B. Merrifield, and Thomas P. Sakmar Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10102–10107. Published online 2001 August 21. doi: 10.1073/pnas.131200398.PMCID: PMC56922 Flavohemoglobin denitrosylase catalyzes the reaction of a nitroxyl equivalent with molecular oxygen Alfred Hausladen, Andrew Gow, and Jonathan S. Stamler Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10108–10112. Published online 2001 August 21. doi: 10.1073/pnas.181199698.PMCID: PMC56923 DNA repair of a single UV photoproduct in a designed nucleosome Joseph V. Kosmoski, Eric J. Ackerman, and Michael J. Smerdon Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10113–10118. Published online 2001 August 21. doi: 10.1073/pnas.181073398.PMCID: PMC56924 A hemoglobin from plants homologous to truncated hemoglobins of microorganisms R. A. Watts, P. W. Hunt, A. N. Hvitved, M. S. Hargrove, W. J. Peacock, and E. S. Dennis Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10119–10124. doi: 10.1073/pnas.191349198.PMCID: PMC56925 Biophysics Electrostatics of nanosystems: Application to microtubules and the ribosome Nathan A. Baker, David Sept, Simpson Joseph, Michael J. Holst, and J. Andrew McCammon Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10037–10041. Published online 2001 August 21. doi: 10.1073/pnas.181342398.PMCID: PMC56910 TOUCHSTONE: An ab initio protein structure prediction method that uses threading-based tertiary restraints Daisuke Kihara, Hui Lu, Andrzej Kolinski, and Jeffrey Skolnick Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10125–10130. Published online 2001 August 14. doi: 10.1073/pnas.181328398.PMCID: PMC56926 X-ray structure of sensory rhodopsin II at 2.1-Å resolution Antoine Royant, Peter Nollert, Karl Edman, Richard Neutze, Ehud M. Landau, Eva Pebay-Peyroula, and Javier Navarro Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10131–10136. Published online 2001 August 14. doi: 10.1073/pnas.181203898.PMCID: PMC56927 Partitioning of a polymer into a nanoscopic protein pore obeys a simple scaling law Liviu Movileanu and Hagan Bayley Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10137–10141. Published online 2001 August 14. doi: 10.1073/pnas.181089798.PMCID: PMC56928 Cell Biology HIV envelope gp120 activates human arterial smooth muscle cells Alison D. Schecter, Adriane B. Berman, Lin Yi, Arevik Mosoian, Carrie M. McManus, Joan W. Berman, Mary E. Klotman, and Mark B. Taubman Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10142–10147. Published online 2001 August 14. doi: 10.1073/pnas.181328798.PMCID: PMC56929 Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation Seiji Ura, Norihisa Masuyama, Jonathan D. Graves, and Yukiko Gotoh Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10148–10153. Published online 2001 August 21. doi: 10.1073/pnas.181161698.PMCID: PMC56930 Transportin-SR2 mediates nuclear import of phosphorylated SR proteins Ming-Chih Lai, Ru-Inn Lin, and Woan-Yuh Tarn Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10154–10159. Published online 2001 August 21. doi: 10.1073/pnas.181354098.PMCID: PMC56931 Self-organization of a radial microtubule array by dynein-dependent nucleation of microtubules Ivan Vorobjev, Viacheslav Malikov, and Vladimir Rodionov Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10160–10165. Published online 2001 August 14. doi: 10.1073/pnas.181354198.PMCID: PMC56932 From the Cover: Dimerization of a selectin and its ligand stabilizes cell rolling and enhances tether strength in shear flow Vishwanath Ramachandran, Tadayuki Yago, Terry Kay Epperson, Marcin M. A. Kobzdej, Matthias U. Nollert, Richard D. Cummings, Cheng Zhu, and Rodger P. McEver Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10166–10171. Published online 2001 July 31. doi: 10.1073/pnas.171248098.PMCID: PMC56933 Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis Anatoly V. Grishin, Olga Azhipa, Igor Semenov, and Seth J. Corey Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10172–10177. Published online 2001 August 21. doi: 10.1073/pnas.191130798.PMCID: PMC56934 A cell-based system that recapitulates the dynamic light-dependent regulation of the vertebrate clock Matthew P. Pando, Anna B. Pinchak, Nicolas Cermakian, and Paolo Sassone-Corsi Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10178–10183. Published online 2001 August 21. doi: 10.1073/pnas.181228598.PMCID: PMC56935 Developmental Biology Regulation of SR protein localization during development Jeremy R. Sanford and James P. Bruzik Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10184–10189. doi: 10.1073/pnas.181340498.PMCID: PMC56936 Hemocytes are essential for wing maturation in Drosophila melanogaster John A. Kiger, Jr., Jeanette E. Natzle, and M. M. Green Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10190–10195. Published online 2001 August 14. doi: 10.1073/pnas.181338998.PMCID: PMC56937 Evolution Expression and phylogeny of claudins in vertebrate primordia Richard Kollmar, Shashi Karia Nakamura, James A. Kappler, and A. J. Hudspeth Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10196–10201. Published online 2001 August 21. doi: 10.1073/pnas.171325898.PMCID: PMC56938 Molecular phylogenetic analyses of the mitochondrial ADP-ATP carriers: The Plantae/Fungi/Metazoa trichotomy revisited Ari Löytynoja and Michel C. Milinkovitch Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10202–10207. Published online 2001 August 21. doi: 10.1073/pnas.181187698.PMCID: PMC56939 From the Cover: Accelerated regulatory gene evolution in an adaptive radiation Marianne Barrier, Robert H. Robichaux, and Michael D. Purugganan Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10208–10213. Published online 2001 August 21. doi: 10.1073/pnas.181257698.PMCID: PMC56940 Genetics The coreceptor mutation CCR5Δ32 influences the dynamics of HIV epidemics and is selected for by HIV Amy D. Sullivan, Janis Wigginton, and Denise Kirschner Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10214–10219. Published online 2001 August 21. doi: 10.1073/pnas.181325198.PMCID: PMC56941 The tRNA function of SsrA contributes to controlling repression of bacteriophage Mu prophage Caroline Ranquet, Johannes Geiselmann, and Ariane Toussaint Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10220–10225. Published online 2001 August 21. doi: 10.1073/pnas.171620598.PMCID: PMC56942 Activation of β-major globin gene transcription is associated with recruitment of NF-E2 to the β-globin LCR and gene promoter Tomoyuki Sawado, Kazuhiko Igarashi, and Mark Groudine Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10226–10231. Published online 2001 August 21. doi: 10.1073/pnas.181344198.PMCID: PMC56943 A functional role for Tsix transcription in blocking Xist RNA accumulation but not in X-chromosome choice Nicholas Stavropoulos, Naifung Lu, and Jeannie T. Lee Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10232–10237. Published online 2001 July 31. doi: 10.1073/pnas.171243598.PMCID: PMC56944 Mutations in Mlph, encoding a member of the Rab effector family, cause the melanosome transport defects observed in leaden mice Lydia E. Matesic, Richard Yip, Andreé E. Reuss, Deborah A. Swing, T. Norene O'Sullivan, Colin F. Fletcher, Neal G. Copeland, and Nancy A. Jenkins Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10238–10243. Published online 2001 August 14. doi: 10.1073/pnas.181336698.PMCID: PMC56945 The Eurasian Heartland: A continental perspective on Y-chromosome diversity R. Spencer Wells, Nadira Yuldasheva, Ruslan Ruzibakiev, Peter A. Underhill, Irina Evseeva, Jason Blue-Smith, Li Jin, Bing Su, Ramasamy Pitchappan, Sadagopal Shanmugalakshmi, Karuppiah Balakrishnan, Mark Read, Nathaniel M. Pearson, Tatiana Zerjal, Matthew T. Webster, Irakli Zholoshvili, Elena Jamarjashvili, Spartak Gambarov, Behrouz Nikbin, Ashur Dostiev, Ogonazar Aknazarov, Pierre Zalloua, Igor Tsoy, Mikhail Kitaev, Mirsaid Mirrakhimov, Ashir Chariev, and Walter F. Bodmer Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10244–10249. doi: 10.1073/pnas.171305098.PMCID: PMC56946 The tumor spectrum in FHIT-deficient mice Nicola Zanesi, Vincenzo Fidanza, Louise Y. Fong, Rita Mancini, Teresa Druck, Mauro Valtieri, Thomas Rüdiger, Peter A. McCue, Carlo M. Croce, and Kay Huebner Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10250–10255. Published online 2001 August 21. doi: 10.1073/pnas.191345898.PMCID: PMC56947 Antibody targeting studies in a transgenic murine model of spontaneous colorectal tumors Robert W. Wilkinson, Elizabeth L. Ross, Richard Poulsom, Mohammad Ilyas, Josef Straub, David Snary, Walter F. Bodmer, and Stephen J. Mather Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10256–10260. Published online 2001 August 21. doi: 10.1073/pnas.181353498.PMCID: PMC56948 Immunology Attributes of γδ intraepithelial lymphocytes as suggested by their transcriptional profile Aude M. Fahrer, Yves Konigshofer, Elizabeth M. Kerr, Ghassan Ghandour, David H. Mack, Mark M. Davis, and Yueh-hsiu Chien Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10261–10266. doi: 10.1073/pnas.171320798.PMCID: PMC56949 Notch1 confers a resistance to glucocorticoid-induced apoptosis on developing thymocytes by down-regulating SRG3 expression Young I. Choi, Sung H. Jeon, Jiho Jang, Sunmi Han, Joong K. Kim, Heekyoung Chung, Han W. Lee, Hee-Y. Chung, Sang D. Park, and Rho H. Seong Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10267–10272. Published online 2001 August 14. doi: 10.1073/pnas.181076198.PMCID: PMC56950 Immune hyporesponsiveness to amyloid β-peptide in amyloid precursor protein transgenic mice: Implications for the pathogenesis and treatment of Alzheimer's disease Alon Monsonego, Ruth Maron, Victor Zota, Dennis J. Selkoe, and Howard L. Weiner Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10273–10278. Published online 2001 August 21. doi: 10.1073/pnas.191118298.PMCID: PMC56951 Germinal center-associated nuclear protein (GANP) has a phosphorylation-dependent DNA-primase activity that is up-regulated in germinal center regions Kazuhiko Kuwahara, Shinjirou Tomiyasu, Satoru Fujimura, Kazumi Nomura, Yan Xing, Noriko Nishiyama, Michio Ogawa, Shinobu Imajoh-Ohmi, Shunji Izuta, and Nobuo Sakaguchi Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10279–10283. doi: 10.1073/pnas.181335698.PMCID: PMC56952 Cell adhesion regulates gene expression at translational checkpoints in human myeloid leukocytes Tracey S. Mahoney, Andrew S. Weyrich, Dan A. Dixon, Thomas McIntyre, Stephen M. Prescott, and Guy A. Zimmerman Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10284–10289. Published online 2001 August 21. doi: 10.1073/pnas.181201398.PMCID: PMC56953 A monoclonal cytolytic T-lymphocyte response observed in a melanoma patient vaccinated with a tumor-specific antigenic peptide encoded by gene MAGE-3 Pierre G. Coulie, Vaios Karanikas, Didier Colau, Christophe Lurquin, Claire Landry, Marie Marchand, Thierry Dorval, Vincent Brichard, and Thierry Boon Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10290–10295. Published online 2001 August 21. doi: 10.1073/pnas.161260098.PMCID: PMC56954 The principle of delivery of T cell epitopes to antigen-presenting cells applied to peptides from influenza virus, ovalbumin, and hen egg lysozyme: Implications for peptide vaccination Ingunn B. Rasmussen, Elin Lunde, Terje E. Michaelsen, Bjarne Bogen, and Inger Sandlie Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10296–10301. Published online 2001 August 21. doi: 10.1073/pnas.181336898.PMCID: PMC56955 Discrepancy between ELISPOT IFN-γ secretion and binding of A2/peptide multimers to TCR reveals interclonal dissociation of CTL effector function from TCR-peptide/MHC complexes half-life Verena Rubio-Godoy, Valerie Dutoit, Donata Rimoldi, Danielle Lienard, Ferdy Lejeune, Daniel Speiser, Philippe Guillaume, Jean-Charles Cerottini, Pedro Romero, and Danila Valmori Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10302–10307. Published online 2001 August 21. doi: 10.1073/pnas.181348898.PMCID: PMC56956 Medical Sciences Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival Hidemasa Oh, George E. Taffet, Keith A. Youker, Mark L. Entman, Paul A. Overbeek, Lloyd H. Michael, and Michael D. Schneider Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10308–10313. Published online 2001 August 21. doi: 10.1073/pnas.191169098.PMCID: PMC56957 Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR Mehran S. Neshat, Ingo K. Mellinghoff, Chris Tran, Bangyan Stiles, George Thomas, Roseann Petersen, Philip Frost, James J. Gibbons, Hong Wu, and Charles L. Sawyers Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10314–10319. Published online 2001 August 14. doi: 10.1073/pnas.171076798.PMCID: PMC56958 An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/− mice Katrina Podsypanina, Richard T. Lee, Chris Politis, Ian Hennessy, Allison Crane, Janusz Puc, Mehran Neshat, Hong Wang, Lin Yang, Jay Gibbons, Phil Frost, Valley Dreisbach, John Blenis, Zbigniew Gaciong, Peter Fisher, Charles Sawyers, Lora Hedrick-Ellenson, and Ramon Parsons Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10320–10325. Published online 2001 August 14. doi: 10.1073/pnas.171060098.PMCID: PMC56959 Furin inhibition results in absent or decreased invasiveness and tumorigenicity of human cancer cells Daniel E. Bassi, Ricardo Lopez De Cicco, Haleh Mahloogi, Stanley Zucker, Gary Thomas, and Andres J. P. Klein-Szanto Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10326–10331. Published online 2001 August 21. doi: 10.1073/pnas.191199198.PMCID: PMC56960 A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cells Zao-zhong Su, Irina V. Lebedeva, Rahul V. Gopalkrishnan, Neil I. Goldstein, C. A. Stein, John C. Reed, Paul Dent, and Paul B. Fisher Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10332–10337. doi: 10.1073/pnas.171315198.PMCID: PMC56961 Molecular emergence of acute myeloid leukemia during treatment for acute lymphoblastic leukemia Javier G. Blanco, Thierry Dervieux, Mathew J. Edick, Perdeep K. Mehta, Jeffrey E. Rubnitz, Sheila Shurtleff, Susana C. Raimondi, Frederick G. Behm, Ching-Hon Pui, and Mary V. Relling Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10338–10343. doi: 10.1073/pnas.181199898.PMCID: PMC56962 Mobilized bone marrow cells repair the infarcted heart, improving function and survival Donald Orlic, Jan Kajstura, Stefano Chimenti, Federica Limana, Igor Jakoniuk, Federico Quaini, Bernardo Nadal-Ginard, David M. Bodine, Annarosa Leri, and Piero Anversa Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10344–10349. Published online 2001 August 14. doi: 10.1073/pnas.181177898.PMCID: PMC56963 Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols Sanjay Gupta, Kedar Hastak, Nihal Ahmad, Jonathan S. Lewin, and Hasan Mukhtar Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10350–10355. Published online 2001 August 14. doi: 10.1073/pnas.171326098.PMCID: PMC56964 Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment Thomas Brabletz, Andreas Jung, Simone Reu, Marc Porzner, Falk Hlubek, Leoni A. Kunz-Schughart, Ruth Knuechel, and Thomas Kirchner Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10356–10361. doi: 10.1073/pnas.171610498.PMCID: PMC56965 HIV-1 induces phenotypic and functional perturbations of B cells in chronically infected individuals Susan Moir, Angela Malaspina, Kisani M. Ogwaro, Eileen T. Donoghue, Claire W. Hallahan, Linda A. Ehler, Shuying Liu, Joseph Adelsberger, Réjean Lapointe, Patrick Hwu, Michael Baseler, Jan M. Orenstein, Tae-Wook Chun, Jo Ann M. Mican, and Anthony S. Fauci Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10362–10367. Published online 2001 August 14. doi: 10.1073/pnas.181347898.PMCID: PMC56966 An anti-angiogenic state in mice and humans with retinal photoreceptor cell degeneration Johanna Lahdenranta, Renata Pasqualini, Reinier O. Schlingemann, Martin Hagedorn, William B. Stallcup, Corazon D. Bucana, Richard L. Sidman, and Wadih Arap Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10368–10373. doi: 10.1073/pnas.181329198.PMCID: PMC56967 FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis Hideshi Ishii, Andrea Vecchione, Yoshiki Murakumo, Gustavo Baldassarre, Shinichiro Numata, Francesco Trapasso, Hansjuerg Alder, Raffaele Baffa, and Carlo M. Croce Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10374–10379. Published online 2001 August 14. doi: 10.1073/pnas.181222898.PMCID: PMC56968 Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function Yijun Zhu, Chao Qi, Wen-Qing Cao, Anjana V. Yeldandi, M. Sambasiva Rao, and Janardan K. Reddy Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10380–10385. Published online 2001 August 21. doi: 10.1073/pnas.181347498.PMCID: PMC56969 The nuclear factor kappa B (NF-κB): A potential therapeutic target for estrogen receptor negative breast cancers Debajit K. Biswas, Sun-Chun Dai, Antonio Cruz, Barbara Weiser, Edgard Graner, and Arthur B. Pardee Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10386–10391. Published online 2001 August 21. doi: 10.1073/pnas.151257998.PMCID: PMC56970 Characterization of key residues in the subdomain encoded by exons 8 and 9 of human inducible nitric oxide synthase: A critical role for Asp-280 in substrate binding and subunit interactions Dipak K. Ghosh, Mohammad B. Rashid, Brian Crane, Varsha Taskar, Molly Mast, Mary A. Misukonis, J. Brice Weinberg, and N. Tony Eissa Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10392–10397. Published online 2001 August 21. doi: 10.1073/pnas.181251298.PMCID: PMC56971 AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations Youzhong Yuan, Liming Zhou, Toshihiro Miyamoto, Hiromi Iwasaki, Nari Harakawa, Christopher J. Hetherington, Sebastien A. Burel, Eric Lagasse, Irving L. Weissman, Koichi Akashi, and Dong-Er Zhang Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10398–10403. doi: 10.1073/pnas.171321298.PMCID: PMC56972 CmC(A/T)GG DNA methylation in mature B cell lymphoma gene silencing Cindy Sue Malone, Maurine D. Miner, Jeanette R. Doerr, James P. Jackson, Steven E. Jacobsen, Randolph Wall, and Michael Teitell Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10404–10409. Published online 2001 August 14. doi: 10.1073/pnas.181206898.PMCID: PMC56973 Microbiology The US3 protein kinase of herpes simplex virus 1 mediates the posttranslational modification of BAD and prevents BAD-induced programmed cell death in the absence of other viral proteins Joshua Munger and Bernard Roizman Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10410–10415. Published online 2001 August 21. doi: 10.1073/pnas.181344498.PMCID: PMC56974 Global differential gene expression in response to growth temperature alteration in group A Streptococcus Laura M. Smoot, James C. Smoot, Morag R. Graham, Greg A. Somerville, Daniel E. Sturdevant, Cristi A. Lux Migliaccio, Gail L. Sylva, and James M. Musser Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10416–10421. Published online 2001 August 21. doi: 10.1073/pnas.191267598.PMCID: PMC56975 Molecular characterization of a mannoprotein with homology to chitin deacetylases that stimulates T cell responses to Cryptococcus neoformans Stuart M. Levitz, Shu-hua Nong, Michael K. Mansour, Chao Huang, and Charles A. Specht Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10422–10427. Published online 2001 August 14. doi: 10.1073/pnas.181331398.PMCID: PMC56976 Neurobiology Glutamate-induced transient modification of the postsynaptic density Ayse Dosemeci, Jung-Hwa Tao-Cheng, Lucia Vinade, Christine A. Winters, Lucas Pozzo-Miller, and Thomas S. Reese Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10428–10432. Published online 2001 August 21. doi: 10.1073/pnas.181336998.PMCID: PMC56977 Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease Xu Gang Xia, Thomas Harding, Michael Weller, Alison Bieneman, James B. Uney, and Jörg B. Schulz Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10433–10438. Published online 2001 August 14. doi: 10.1073/pnas.181182298.PMCID: PMC56978 Failed retrograde transport of NGF in a mouse model of Down's syndrome: Reversal of cholinergic neurodegenerative phenotypes following NGF infusion Jonathan D. Cooper, Ahmad Salehi, Jean-Dominique Delcroix, Charles L. Howe, Pavel V. Belichenko, Jane Chua-Couzens, Joshua F. Kilbridge, Elaine J. Carlson, Charles J. Epstein, and William C. Mobley Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10439–10444. Published online 2001 August 14. doi: 10.1073/pnas.181219298.PMCID: PMC56979 Control of Drosophila perineurial glial growth by interacting neurotransmitter-mediated signaling pathways James Yager, Stephen Richards, Daria S. Hekmat-Scafe, Daryl D. Hurd, Vanathi Sundaresan, David R. Caprette, William M. Saxton, John R. Carlson, and Michael Stern Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10445–10450. Published online 2001 August 21. doi: 10.1073/pnas.191107698.PMCID: PMC56980 Induction of stereotypy in dopamine-deficient mice requires striatal D1 receptor activation Elena H. Chartoff, Brett T. Marck, Alvin M. Matsumoto, Daniel M. Dorsa, and Richard D. Palmiter Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10451–10456. Published online 2001 August 21. doi: 10.1073/pnas.181356498.PMCID: PMC56981 Noninvasive neuroelectronic interfacing with synaptically connected snail neurons immobilized on a semiconductor chip Günther Zeck and Peter Fromherz Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10457–10462. doi: 10.1073/pnas.181348698.PMCID: PMC56982 Plastic neural changes and reading improvement caused by audiovisual training in reading-impaired children T. Kujala, K. Karma, R. Ceponiene, S. Belitz, P. Turkkila, M. Tervaniemi, and R. Näätänen Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10509–10514. Published online 2001 August 21. doi: 10.1073/pnas.181589198.PMCID: PMC56991 Pharmacology Nitroxyl anion exerts redox-sensitive positive cardiac inotropy in vivo by calcitonin gene-related peptide signaling Nazareno Paolocci, Walter F. Saavedra, Katrina M. Miranda, Cristian Martignani, Takayoshi Isoda, Joshua M. Hare, Michael G. Espey, Jon M. Fukuto, Martin Feelisch, David A. Wink, and David A. Kass Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10463–10468. Published online 2001 August 21. doi: 10.1073/pnas.181191198.PMCID: PMC56983 Physiology Does oxidative damage to DNA increase with age? Michelle L. Hamilton, Holly Van Remmen, Jessica A. Drake, Hong Yang, Zhong Mao Guo, Kristen Kewitt, Christi A. Walter, and Arlan Richardson Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10469–10474. Published online 2001 August 21. doi: 10.1073/pnas.171202698.PMCID: PMC56984 Basolateral membrane expression of a K+ channel, Kir 2.3, is directed by a cytoplasmic COOH-terminal domain Sophie Le Maout, Paul A. Welling, Manuel Brejon, Olav Olsen, and Jean Merot Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10475–10480. Published online 2001 August 14. doi: 10.1073/pnas.181481098.PMCID: PMC56985 Plant Biology cAMP acts as a second messenger in pollen tube growth and reorientation Ana Moutinho, Patrick J. Hussey, Anthony J. Trewavas, and Rui Malhó Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10481–10486. Published online 2001 August 21. doi: 10.1073/pnas.171104598.PMCID: PMC56986 Regulation of plant growth by cytokinin Tomáš Werner, Václav Motyka, Miroslav Strnad, and Thomas Schmülling Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10487–10492. Published online 2001 August 14. doi: 10.1073/pnas.171304098.PMCID: PMC56987 Intragenic recombination generated two distinct Cf genes that mediate AVR9 recognition in the natural population of Lycopersicon pimpinellifolium Renier A. L. Van der Hoorn, Marco Kruijt, Ronelle Roth, Bas F. Brandwagt, Matthieu H. A. J. Joosten, and Pierre J. G. M. De Wit Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10493–10498. Published online 2001 August 21. doi: 10.1073/pnas.181241798.PMCID: PMC56988 An essential role of a TatC homologue of a ΔpH- dependent protein transporter in thylakoid membrane formation during chloroplast development in Arabidopsis thaliana Reiko Motohashi, Noriko Nagata, Takuya Ito, Seiji Takahashi, Tokunori Hobo, Shigeo Yoshida, and Kazuo Shinozaki Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10499–10504. doi: 10.1073/pnas.181304598.PMCID: PMC56989 Population Biology From the Cover: A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4 Annibale A. Puca, Mark J. Daly, Stephanie J. Brewster, Tara C. Matise, Jeffrey Barrett, Maureen Shea-Drinkwater, Sammy Kang, Erin Joyce, Julie Nicoli, Erica Benson, Louis M. Kunkel, and Thomas Perls Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10505–10508. Published online 2001 August 27. doi: 10.1073/pnas.181337598.PMCID: PMC56990 Social Sciences Psychology Plastic neural changes and reading improvement caused by audiovisual training in reading-impaired children T. Kujala, K. Karma, R. Ceponiene, S. Belitz, P. Turkkila, M. Tervaniemi, and R. Näätänen Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10509–10514. Published online 2001 August 21. doi: 10.1073/pnas.181589198.PMCID: PMC56991 Corrections Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10515. Published online 2001 August 21. PMCID: PMC56992 Corrects: P. D. Calvert, et al. Phototransduction in transgenic mice after targeted deletion of
the rod transducin α-subunit. Proc Natl Acad Sci U S A. 2000 December 5; 97(25): 13913–13918. Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10515. Published online 2001 August 14. PMCID: PMC56993 Corrects: Virginia Goss Tusher, et al. Significance analysis of microarrays applied to the ionizing
radiation response. Proc Natl Acad Sci U S A. 2001 April 24; 98(9): 5116–5121. Proc Natl Acad Sci U S A. 2001 August 28; 98(18): 10515. Published online 2001 August 14. PMCID: PMC56994 Corrects: Takashi Sugawara, et al. A missense mutation of the Na+ channel
αII subunit gene
Nav1.2 in a patient with
febrile and afebrile seizures causes channel dysfunction. Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6384–6389. |