| | This journal provides immediate access to some articles. Commentaries Reliability of axonal propagation: The spike doesn't stop here John R. Huguenard PMCID: PMC34025 Resolving the relationships of resolving enzymes David M. J. Lilley and Malcolm F. White PMCID: PMC34026 Synthesis of organs: In vitro or
in vivo? Ioannis V. Yannas PMCID: PMC34027 A large step for myosin Toshio Yanagida and Atsuko H. Iwane PMCID: PMC34028 Ions, cell volume, and apoptosis Shan Ping Yu and Dennis W. Choi PMCID: PMC34029 Immunoactive cannabinoids: Therapeutic prospects for
marijuana constituents Stephen E. Straus PMCID: PMC34030 Heritability at the ecosystem level Charles J. Goodnight PMCID: PMC34031 Physical Sciences Chemistry Site-directed ligand discovery Daniel A. Erlanson, Andrew C. Braisted, Darren R. Raphael, Mike Randal, Robert M. Stroud, Eric M. Gordon, and James A. Wells PMCID: PMC16870 Structure-based design of an osteoclast-selective, nonpeptide Src homology 2 inhibitor with in vivo antiresorptive activity William Shakespeare, Michael Yang, Regine Bohacek, Franklin Cerasoli, Karin Stebbins, Raji Sundaramoorthi, Mihai Azimioara, Chi Vu, Selvi Pradeepan, Chester Metcalf, III, Chad Haraldson, Taylor Merry, David Dalgarno, Surinder Narula, Marcos Hatada, Xiaode Lu, Marie Rose van Schravendijk, Susan Adams, Shelia Violette, Jeremy Smith, Wei Guan, Catherine Bartlett, Jay Herson, John Iuliucci, Manfred Weigele, and Tomi Sawyer PMCID: PMC16871 Computational evidence in favor of a two-state, two-mode model of the retinal chromophore photoisomerization Remedios González-Luque, Marco Garavelli, Fernando Bernardi, Manuela Merchán, Michael A. Robb, and Massimo Olivucci PMCID: PMC16872 Engineering Molecular mechanism of endothelial growth arrest by laminar shear stress Kurt Lin, Pin-Pin Hsu, Benjamin P. Chen, Suli Yuan, Shunichi Usami, John Y.-J. Shyy, Yi-Shuan Li, and Shu Chien PMCID: PMC16873 Biological Sciences Applied Biological Sciences Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology Steven P. Gygi, Garry L. Corthals, Yanni Zhang, Yvan Rochon, and Ruedi Aebersold PMCID: PMC16874 Biochemistry A retroviral RNA kissing complex containing only two G ![[center dot]](corehtml/pmc/pmcents/middot.gif) C base pairs Chul-Hyun Kim and Ignacio Tinoco, Jr. PMCID: PMC16875 A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion Darren F. Seals, Gary Eitzen, Nathan Margolis, William T. Wickner, and Albert Price PMCID: PMC16876 Redesign of substrate-selectivity determining modules of glutathione transferase A1–1 installs high catalytic efficiency with toxic alkenal products of lipid peroxidation Lisa O. Nilsson, Ann Gustafsson, and Bengt Mannervik PMCID: PMC16877 The crystal structure of d-lactate dehydrogenase, a peripheral membrane respiratory enzyme Orly Dym, Elizabeth Ann Pratt, Chien Ho, and David Eisenberg PMCID: PMC16878 Analysis of topoisomerase function in bacterial replication fork movement: Use of DNA microarrays Arkady B. Khodursky, Brian J. Peter, Molly B. Schmid, Joseph DeRisi, David Botstein, Patrick O. Brown, and Nicholas R. Cozzarelli PMCID: PMC16879 Autocatalytic proteolysis of the transcription factor-coactivator C1 (HCF): A potential role for proteolytic regulation of coactivator function Jodi L. Vogel and Thomas M. Kristie PMCID: PMC16880 A distinctive role for the Yersinia protein kinase: Actin binding, kinase activation, and cytoskeleton disruption Stephen J. Juris, Amy E. Rudolph, Don Huddler, Kim Orth, and Jack E. Dixon PMCID: PMC16881 TARP: A nuclear protein expressed in prostate and breast cancer cells derived from an alternate reading frame of the T cell receptor γ chain locus Curt D. Wolfgang, Magnus Essand, James J. Vincent, Byungkook Lee, and Ira Pastan PMCID: PMC16882 Intramolecular control of transcriptional activity by the NK2-specific domain in NK-2 homeodomain proteins Hirotaka Watada, Raghavendra G. Mirmira, Julie Kalamaras, and Michael S. German PMCID: PMC16883 A Δ9 desaturase gene with a different substrate specificity is responsible for the cuticular diene hydrocarbon polymorphism in Drosophila melanogaster Renaud Dallerac, Carole Labeur, Jean-Marc Jallon, Douglas C. Knipple, Wendell L. Roelofs, and Claude Wicker-Thomas PMCID: PMC16884 Inversion of stereospecificity of vanillyl-alcohol oxidase Robert H. H. van den Heuvel, Marco W. Fraaije, Miriam Ferrer, Andrea Mattevi, and Willem J. H. van Berkel PMCID: PMC16885 Biophysics Computational evidence in favor of a two-state, two-mode model of the retinal chromophore photoisomerization Remedios González-Luque, Marco Garavelli, Fernando Bernardi, Manuela Merchán, Michael A. Robb, and Massimo Olivucci PMCID: PMC16872 Ultrahigh-resolution multicolor colocalization of single fluorescent probes Thilo D. Lacoste, Xavier Michalet, Fabien Pinaud, Daniel S. Chemla, A. Paul Alivisatos, and Shimon Weiss PMCID: PMC16886 Cell sorting is analogous to phase ordering in fluids D. A. Beysens, G. Forgacs, and J. A. Glazier PMCID: PMC16887 Evidence of nonspecific surface interactions between laser-polarized xenon and myoglobin in solution Seth M. Rubin, Megan M. Spence, Boyd M. Goodson, David E. Wemmer, and Alexander Pines PMCID: PMC16888 A DNA–porphyrin minor-groove complex at atomic resolution: The structural consequences of porphyrin ruffling Matthew Bennett, Alexander Krah, Frank Wien, Elspeth Garman, Robert Mckenna, Mark Sanderson, and Stephen Neidle PMCID: PMC16889 Myosin-V stepping kinetics: A molecular model for processivity Matthias Rief, Ronald S. Rock, Amit D. Mehta, Mark S. Mooseker, Richard E. Cheney, and James A. Spudich PMCID: PMC16890 Cell Biology From the Cover:
Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis Emi Maeno, Yasuki Ishizaki, Toku Kanaseki, Akihiro Hazama, and Yasunobu Okada PMCID: PMC16891 Kinetochore reproduction in animal evolution: Cell biological explanation of karyotypic fission theory Robin L. Kolnicki PMCID: PMC16892 A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor β-induced cell-cycle arrest Gisela F. Claassen and Stephen R. Hann PMCID: PMC16893 Gene inactivation by multiphoton-targeted photochemistry Michael W. Berns, Zifu Wang, Andrew Dunn, Vincent Wallace, and Vasan Venugopalan PMCID: PMC16894 Developmental Biology Serotonin 2B receptor is required for heart development Canan G. Nebigil, Doo-Sup Choi, Andrée Dierich, Pierre Hickel, Marianne Le Meur, Nadia Messaddeq, Jean-Marie Launay, and Luc Maroteaux PMCID: PMC16895 A sea urchin genome project: Sequence scan, virtual map, and additional resources R. Andrew Cameron, Gregory Mahairas, Jonathan P. Rast, Pedro Martinez, Ted R. Biondi, Steven Swartzell, James C. Wallace, Albert J. Poustka, Brian T. Livingston, Gregory A. Wray, Charles A. Ettensohn, Hans Lehrach, Roy J. Britten, Eric H. Davidson, and Leroy Hood PMCID: PMC16896 The E23 early gene of Drosophila encodes an ecdysone-inducible ATP-binding cassette transporter capable of repressing ecdysone-mediated gene activation Tommy Hock, Tracy Cottrill, John Keegan, and Dan Garza PMCID: PMC16897 INAUGURAL ARTICLE by a Recently Elected Academy Member: The basic helix–loop–helix transcription factor capsulin controls spleen organogenesis JianRong Lu, Priscilla Chang, James A. Richardson, Lin Gan, Hartmut Weiler, and Eric N. Olson PMCID: PMC16898 Genetics A gene encoding a sphingolipid biosynthesis enzyme determines the sensitivity of Saccharomyces cerevisiae to an antifungal plant defensin from dahlia (Dahlia merckii) Karin Thevissen, Bruno P. A. Cammue, Katleen Lemaire, Joris Winderickx, Robert C. Dickson, Robert L. Lester, Kathelijne K. A. Ferket, Frederic Van Even, Annabel H. A. Parret, and Willem F. Broekaert PMCID: PMC16899 Restriction of ectopic recombination by interhomolog interactions during Saccharomyces cerevisiae meiosis Alastair S. H. Goldman and Michael Lichten PMCID: PMC16900 Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning R.-M. Hu, Z.-G. Han, H.-D. Song, Y.-D. Peng, Q.-H. Huang, S.-X. Ren, Y.-J. Gu, C.-H. Huang, Y.-B. Li, C.-L. Jiang, G. Fu, Q.-H. Zhang, B.-W. Gu, M. Dai, Y.-F. Mao, G.-F. Gao, R. Rong, M. Ye, J. Zhou, S.-H. Xu, J. Gu, J.-X. Shi, W.-R. Jin, C.-K. Zhang, T.-M. Wu, G.-Y. Huang, Z. Chen, M.-D. Chen, and J.-L. Chen PMCID: PMC16901 Voltage-sensor sodium channel mutations cause hypokalemic
periodic paralysis type 2 by enhanced inactivation and reduced current Karin Jurkat-Rott, Nenad Mitrovic, Chao Hang, Alexei Kouzmenkine, Paul Iaizzo, Jürgen Herzog, Holger Lerche, Sophie Nicole, Jose Vale-Santos, Dominique Chauveau, Bertrand Fontaine, and Frank Lehmann-Horn PMCID: PMC16902 Immunology Purified hematopoietic stem cell grafts induce tolerance to alloantigens and can mediate positive and negative T cell selection Judith A. Shizuru, Irving L. Weissman, Rachel Kernoff, Marilyn Masek, and Yolanda C. Scheffold PMCID: PMC16903 From the Cover:
The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis A. M. Malfait, R. Gallily, P. F. Sumariwalla, A. S. Malik, E. Andreakos, R. Mechoulam, and M. Feldmann PMCID: PMC16904 T6BP, a TRAF6-interacting protein involved in IL-1 signaling Lei Ling and David V. Goeddel PMCID: PMC16905 Inhibition of IL-2-induced Jak-STAT signaling by glucocorticoids Marina Bianchi, Charis Meng, and Lionel B. Ivashkiv PMCID: PMC16906 Medical Sciences Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype Minoru Matsui, Daisuke Motomura, Hiroshi Karasawa, Toru Fujikawa, Jian Jiang, Yuriko Komiya, Shin-ichi Takahashi, and Makoto M. Taketo PMCID: PMC16907 The human VASA gene is specifically expressed in the germ cell lineage Diego H. Castrillon, Bradley J. Quade, T. Y. Wang, Catherine Quigley, and Christopher P. Crum PMCID: PMC16908 Restoration of hemoglobin A synthesis in erythroid cells from peripheral blood of thalassemic patients Giuseppina Lacerra, Halina Sierakowska, Clementina Carestia, Suthat Fucharoen, James Summerton, Dwight Weller, and Ryszard Kole PMCID: PMC16909 Panhandle PCR for cDNA: A rapid method for isolation of MLL fusion transcripts involving unknown partner genes Maureen D. Megonigal, Eric F. Rappaport, Robert B. Wilson, Douglas H. Jones, James A. Whitlock, Jorge A. Ortega, Diana J. Slater, Peter C. Nowell, and Carolyn A. Felix PMCID: PMC16910 Somatic deletions in hereditary breast cancers implicate 13q21 as a putative novel breast cancer susceptibility locus Tommi Kainu, Suh-Hang Hank Juo, Richard Desper, Alejandro A. Schäffer, Elizabeth Gillanders, Ester Rozenblum, Diana Freas-Lutz, Don Weaver, Dietrich Stephan, Joan Bailey-Wilson, Olli-P. Kallioniemi, Mika Tirkkonen, Kirsi Syrjäkoski, Tuula Kuukasjärvi, Pasi Koivisto, Ritva Karhu, Kaija Holli, Adalgeir Arason, Gudrun Johannesdottir, Jon Thor Bergthorsson, Hrefna Johannsdottir, Valgardur Egilsson, Rosa Björk Barkardottir, Oskar Johannsson, Karin Haraldsson, Therese Sandberg, Eva Holmberg, Henrik Grönberg, Håkan Olsson, Åke Borg, Paula Vehmanen, Hannaleena Eerola, Päivi Heikkilä, Seppo Pyrhönen, and Heli Nevanlinna PMCID: PMC16911 Blockade of the epidermal growth factor receptor tyrosine kinase suppresses tumorigenesis in MMTV/Neu + MMTV/TGF-α bigenic mice Anne E. G. Lenferink, Jean F. Simpson, Laura K. Shawver, Robert J. Coffey, James T. Forbes, and Carlos L. Arteaga PMCID: PMC16912 Scan statistics to scan markers for susceptibility genes J. Hoh and J. Ott PMCID: PMC16913 Htra2-β1 stimulates an exonic splicing enhancer and can restore full-length SMN expression to survival motor neuron 2 (SMN2) Yvonne Hofmann, Christian L. Lorson, Stefan Stamm, Elliot J. Androphy, and Brunhilde Wirth PMCID: PMC16914 Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis Irmgard Schwarte-Waldhoff, Olga V. Volpert, Noël P. Bouck, Bence Sipos, Stephan A. Hahn, Susanne Klein-Scory, Jutta Lüttges, Günter Klöppel, Ulrich Graeven, Christina Eilert-Micus, Annette Hintelmann, and Wolff Schmiegel PMCID: PMC16915 Microbiology Mosaicism in the alpha-like protein genes of group B streptococci C. S. Lachenauer, R. Creti, J. L. Michel, and L. C. Madoff PMCID: PMC16916 Polyphosphate kinase is essential for biofilm development, quorum sensing, and virulence of Pseudomonas aeruginosa M. Harunur Rashid, Kendra Rumbaugh, Luciano Passador, David G. Davies, Abdul N. Hamood, Barbara H. Iglewski, and Arthur Kornberg PMCID: PMC16917 Genomewide insertional mutagenesis in Streptomyces coelicolor reveals additional genes involved in morphological differentiation Amy M. Gehring, Justin R. Nodwell, Stephen M. Beverley, and Richard Losick PMCID: PMC16918 Two Plasmodium falciparum genes express merozoite proteins that are related to Plasmodium vivax and Plasmodium yoelii adhesive proteins involved in host cell selection and invasion Julian C. Rayner, Mary R. Galinski, Paul Ingravallo, and John W. Barnwell PMCID: PMC16919 Avian-to-human transmission of H9N2 subtype influenza A viruses: Relationship between H9N2 and H5N1 human isolates Y. P. Lin, M. Shaw, V. Gregory, K. Cameron, W. Lim, A. Klimov, K. Subbarao, Y. Guan, S. Krauss, K. Shortridge, R. Webster, N. Cox, and A. Hay PMCID: PMC16920 Interaction of Pseudomonas aeruginosa with epithelial cells: Identification of differentially regulated genes by expression microarray analysis of human cDNAs Jeffrey K. Ichikawa, Anne Norris, M. Gita Bangera, Gary K. Geiss, Angélique B. van 't Wout, Roger E. Bumgarner, and Stephen Lory PMCID: PMC16921 In vivo transposon mutagenesis of the methanogenic archaeon Methanosarcina acetivorans C2A using a modified version of the insect mariner-family transposable element Himar1 J. K. Zhang, M. A. Pritchett, D. J. Lampe, H. M. Robertson, and W. W. Metcalf PMCID: PMC16922 Identification of type II restriction and modification systems in Helicobacter pylori reveals their substantial diversity among strains Qing Xu, Richard D. Morgan, Richard J. Roberts, and Martin J. Blaser PMCID: PMC16923 Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis Andrea E. DeBarber, Khisimuzi Mdluli, Marlein Bosman, Linda-Gail Bekker, and Clifton E. Barry, 3rd PMCID: PMC16924 Neurobiology Neurotrophin-3 promotes the cholinergic differentiation of sympathetic neurons Claude Brodski, Harald Schnürch, and Georg Dechant PMCID: PMC16925 Transgenic overexpression of caveolin-3 in skeletal muscle fibers induces a Duchenne-like muscular dystrophy phenotype Ferruccio Galbiati, Daniela Volonté, Jeffrey B. Chu, Maomi Li, Samson W. Fine, Maofu Fu, Jorge Bermudez, Marina Pedemonte, Karen M. Weidenheim, Richard G. Pestell, Carlo Minetti, and Michael P. Lisanti PMCID: PMC16926 Ca2+-dependent regulation of synaptic SNARE complex assembly via a calmodulin- and phospholipid-binding domain of synaptobrevin Stephanie Quetglas, Christian Leveque, Raymond Miquelis, Kazuki Sato, and Michael Seagar PMCID: PMC16927 Bacterial and yeast chaperones reduce both aggregate formation and cell death in mammalian cell models of Huntington's disease Jenny Carmichael, Jean Chatellier, Adrian Woolfson, César Milstein, Alan R. Fersht, and David C. Rubinsztein PMCID: PMC16928 Glutamate translocation of the neuronal glutamate transporter EAAC1 occurs within milliseconds Christof Grewer, Natalie Watzke, Michael Wiessner, and Thomas Rauen PMCID: PMC16929 BACE2, a β-secretase homolog, cleaves at the β site and within the amyloid-β region of the amyloid-β precursor protein Michael Farzan, Christine E. Schnitzler, Natalya Vasilieva, Doris Leung, and Hyeryun Choe PMCID: PMC16930 Functional MRI at 1.5 tesla: A comparison of the blood oxygenation level-dependent signal and electrophysiology Elizabeth A. Disbrow, Daniel A. Slutsky, Timothy P. L. Roberts, and Leah A. Krubitzer PMCID: PMC16931 From the Cover:
Action potentials reliably invade axonal arbors of rat neocortical neurons Charles L. Cox, Winfried Denk, David W. Tank, and Karel Svoboda PMCID: PMC16932 Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody Naoko Utsunomiya-Tate, Ken-ichiro Kubo, Shin-ichi Tate, Masatsune Kainosho, Eisaku Katayama, Kazunori Nakajima, and Katsuhiko Mikoshiba PMCID: PMC16933 Aβ1–40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation Kiyoshi Niwa, Linda Younkin, Christine Ebeling, Sherry K. Turner, David Westaway, Steven Younkin, Karen Hsiao Ashe, George A. Carlson, and Costantino Iadecola PMCID: PMC16934 Silent synapses in the developing hippocampus: Lack of functional AMPA receptors or low probability of glutamate release? Sonia Gasparini, Chiara Saviane, Leon L. Voronin, and Enrico Cherubini PMCID: PMC16935 Pharmacology An endothelium-derived hyperpolarizing factor distinct from NO and prostacyclin is a major endothelium-dependent vasodilator in resistance vessels of wild-type and endothelial NO synthase knockout mice Ralf P. Brandes, Friedrich-Hubertus Schmitz-Winnenthal, Michel Félétou, Axel Gödecke, Paul L. Huang, Paul M. Vanhoutte, Ingrid Fleming, and Rudi Busse PMCID: PMC16936 Inactivation of catecholamines by superoxide gives new insights on the pathogenesis of septic shock Heather Macarthur, Thomas C. Westfall, Dennis P. Riley, Thomas P. Misko, and Daniela Salvemini PMCID: PMC16937 Physiology Coordinated regulation of fetal and maternal prostaglandins directs successful birth and postnatal adaptation in the mouse Jeff Reese, Bibhash C. Paria, Naoko Brown, Xuemei Zhao, Jason D. Morrow, and Sudhansu K. Dey PMCID: PMC16938 Cyclosporine A-induced hypertension involves synapsin in renal sensory nerve endings Weiguo Zhang, Jia-Ling Li, Masahiro Hosaka, Roger Janz, John M. Shelton, George M. Albright, James A. Richardson, Thomas C. Südhof, and Ronald G. Victor PMCID: PMC16939 Activation and inhibition of G protein-coupled inwardly rectifying potassium (Kir3) channels by G protein βγ subunits Qiubo Lei, Miller B. Jones, Edmund M. Talley, Andrew D. Schrier, William E. McIntire, James C. Garrison, and Douglas A. Bayliss PMCID: PMC16940 Visuo-tactile cross-modal associations in cortical somatosensory cells Yong-Di Zhou and Joaquín M. Fuster PMCID: PMC16941 Plant Biology From the Cover:
Altered expression of expansin modulates leaf growth and pedicel abscission in Arabidopsis thaliana Hyung-Taeg Cho and Daniel J. Cosgrove PMCID: PMC16942 GIGANTEA is a nuclear protein involved in phytochrome signaling in Arabidopsis Enamul Huq, James M. Tepperman, and Peter H. Quail PMCID: PMC16943 A second, substrate-dependent site of protein import into chloroplasts Steffen Reinbothe, Regis Mache, and Christiane Reinbothe PMCID: PMC16944 Hyperpolarization-activated calcium channels at the tip of Arabidopsis root hairs Anne-Aliénor Véry and Julia M. Davies PMCID: PMC16945 The virulence factor AvrXa7 of Xanthomonas oryzae pv. oryzae is a type III secretion pathway-dependent nuclear-localized double-stranded DNA-binding protein Bing Yang, Weiguang Zhu, Lowell B. Johnson, and Frank F. White PMCID: PMC16946 Requirement for either a host- or pectin-induced pectate lyase
for infection of Pisum sativum by
Nectria hematococca Linda M. Rogers, Yeon-Ki Kim, Wenjin Guo, Luis González-Candelas, Daoxin Li, and Pappachan E. Kolattukudy PMCID: PMC16947 Corrections Proc Natl Acad Sci U S A. 2000 August 15; 97(17): 9819. PMCID: PMC56063 Corrects: Dmitriy A. Yablonskiy, et al. Coupling between changes in human brain temperature and oxidative metabolism during prolonged visual stimulation. Proc Natl Acad Sci U S A. 2000 June 20; 97(13): 7603–7608. Proc Natl Acad Sci U S A. 2000 August 15; 97(17): 9819. PMCID: PMC56064 Corrects: Koichi Murakami, et al. Pregnenolone binds to microtubule-associated protein 2 and stimulates microtubule assembly. Proc Natl Acad Sci U S A. 2000 March 28; 97(7): 3579–3584. Proc Natl Acad Sci U S A. 2000 August 15; 97(17): 9819. PMCID: PMC56065 Corrects: Juan Llopis, et al. Ligand-dependent interactions of coactivators steroid receptor coactivator-1 and peroxisome proliferator-activated receptor binding protein with nuclear hormone receptors can be imaged in live cells and are required for transcription. Proc Natl Acad Sci U S A. 2000 April 11; 97(8): 4363–4368. |
