| | This journal provides immediate access to some articles. This Week in PNAS Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16059–16060. doi: 10.1073/iti4406103.PMCID: PMC1637534 Commentaries Skirting the transition state, a new paradigm in reaction rate theory Joel M. Bowman Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16061–16062. Published online 2006 October 23. doi: 10.1073/pnas.0607810103.PMCID: PMC1637535 Discovery of principles of nature from mathematical modeling of DNA microarray data Orly Alter Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16063–16064. Published online 2006 October 23. doi: 10.1073/pnas.0607650103.PMCID: PMC1637536 Profile Profile of Gene E. Robinson Nick Zagorski Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16065–16067. Published online 2006 October 25. doi: 10.1073/pnas.0608392103.PMCID: PMC1637537 Physical Sciences Applied Physical Sciences Acceleration of the recognition rate between grafted ligands and receptors with magnetic forces J. Baudry, C. Rouzeau, C. Goubault, C. Robic, L. Cohen-Tannoudji, A. Koenig, E. Bertrand, and J. Bibette Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16076–16078. Published online 2006 October 18. doi: 10.1073/pnas.0607991103.PMCID: PMC1637538 Chemistry From the Cover: Photodissociation of acetaldehyde as a second example of the roaming mechanism P. L. Houston and S. H. Kable Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16079–16082. Published online 2006 October 17. doi: 10.1073/pnas.0604441103.PMCID: PMC1637539 Folding of the C-terminal bacterial binding domain in statherin upon adsorption onto hydroxyapatite crystals Gil Goobes, Rivka Goobes, Ora Schueler-Furman, David Baker, Patrick S. Stayton, and Gary P. Drobny Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16083–16088. Published online 2006 October 23. doi: 10.1073/pnas.0607193103.PMCID: PMC1637540 The limitations on organic detection in Mars-like soils by thermal volatilization–gas chromatography–MS and their implications for the Viking results Rafael Navarro-González, Karina F. Navarro, José de la Rosa, Enrique Iñiguez, Paola Molina, Luis D. Miranda, Pedro Morales, Edith Cienfuegos, Patrice Coll, François Raulin, Ricardo Amils, and Christopher P. McKay Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16089–16094. Published online 2006 October 23. doi: 10.1073/pnas.0604210103.PMCID: PMC1621051 Engineering Anisotropic mechanosensing by mesenchymal stem cells Kyle Kurpinski, Julia Chu, Craig Hashi, and Song Li Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16095–16100. Published online 2006 October 23. doi: 10.1073/pnas.0604182103.PMCID: PMC1637542 Physics Liquid–crystalline aqueous clay suspensions Laurent J. Michot, Isabelle Bihannic, Solange Maddi, Sérgio S. Funari, Christophe Baravian, Pierre Levitz, and Patrick Davidson Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16101–16104. Published online 2006 October 23. doi: 10.1073/pnas.0605201103.PMCID: PMC1637543 Breaking resolution limits in ultrafast electron diffraction and microscopy Peter Baum and Ahmed H. Zewail Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16105–16110. Published online 2006 October 20. doi: 10.1073/pnas.0607451103.PMCID: PMC1637544 Sustainability Science Exploring the engine of anthropogenic iron cycles Daniel B. Müller, Tao Wang, Benjamin Duval, and T. E. Graedel Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16111–16116. Published online 2006 October 19. doi: 10.1073/pnas.0603375103.PMCID: PMC1637545 Biological Sciences Applied Biological Sciences Anisotropic mechanosensing by mesenchymal stem cells Kyle Kurpinski, Julia Chu, Craig Hashi, and Song Li Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16095–16100. Published online 2006 October 23. doi: 10.1073/pnas.0604182103.PMCID: PMC1637542 Biochemistry Identification of conserved lipid/detergent-binding sites in a high-resolution structure of the membrane protein cytochrome c oxidase Ling Qin, Carrie Hiser, Anne Mulichak, R. Michael Garavito, and Shelagh Ferguson-Miller Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16117–16122. Published online 2006 October 18. doi: 10.1073/pnas.0606149103.PMCID: PMC1616942 Crystal structure of a photoactivated deprotonated intermediate of rhodopsin David Salom, David T. Lodowski, Ronald E. Stenkamp, Isolde Le Trong, Marcin Golczak, Beata Jastrzebska, Tim Harris, Juan A. Ballesteros, and Krzysztof Palczewski Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16123–16128. Published online 2006 October 23. doi: 10.1073/pnas.0608022103.PMCID: PMC1637547 Three strategically placed hydrogen-bonding residues convert a proton pump into a sensory receptor Yuki Sudo and John L. Spudich Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16129–16134. Published online 2006 October 18. doi: 10.1073/pnas.0607467103.PMCID: PMC1637548 Identification of a histidine-tyrosine cross-link in the active site of the cbb3-type cytochrome c oxidase from Rhodobacter sphaeroides Virve Rauhamäki, Marc Baumann, Rabah Soliymani, Anne Puustinen, and Mårten Wikström Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16135–16140. Published online 2006 October 23. doi: 10.1073/pnas.0606254103.PMCID: PMC1637549 Reaction mechanism of guanidinoacetate methyltransferase, concerted or step-wise Xiaodong Zhang and Thomas C. Bruice Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16141–16146. Published online 2006 October 19. doi: 10.1073/pnas.0607503103.PMCID: PMC1637550 Functional reconstitution and characterization of Pyrococcus furiosus RNase P Hsin-Yue Tsai, Dileep K. Pulukkunat, Walter K. Woznick, and Venkat Gopalan Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16147–16152. Published online 2006 October 19. doi: 10.1073/pnas.0608000103.PMCID: PMC1637551 Isoelectric focusing technology quantifies protein signaling in 25 cells Roger A. O'Neill, Arunashree Bhamidipati, Xiahui Bi, Debabrita Deb-Basu, Linda Cahill, Jason Ferrante, Erik Gentalen, Marc Glazer, John Gossett, Kevin Hacker, Celeste Kirby, James Knittle, Robert Loder, Catherine Mastroieni, Michael MacLaren, Thomas Mills, Uyen Nguyen, Nineveh Parker, Audie Rice, David Roach, Daniel Suich, David Voehringer, Karl Voss, Jade Yang, Tom Yang, and Peter B. Vander Horn Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16153–16158. Published online 2006 October 19. doi: 10.1073/pnas.0607973103.PMCID: PMC1618307 Different modes of SecY–SecA interactions revealed by site-directed in vivo photo-cross-linking Hiroyuki Mori and Koreaki Ito Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16159–16164. Published online 2006 October 23. doi: 10.1073/pnas.0606390103.PMCID: PMC1621050 Enzyme–microbe synergy during cellulose hydrolysis by Clostridium thermocellum Yanpin Lu, Yi-Heng Percival Zhang, and Lee R. Lynd Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16165–16169. Published online 2006 October 23. doi: 10.1073/pnas.0605381103.PMCID: PMC1637554 Definition of the mitochondrial proteome by measurement of molecular masses of membrane proteins Joe Carroll, Ian M. Fearnley, and John E. Walker Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16170–16175. Published online 2006 October 23. doi: 10.1073/pnas.0607719103.PMCID: PMC1621045 Independent and simultaneous translocation of two substrates by a nucleotide sugar transporter Carolina E. Caffaro, Carlos B. Hirschberg, and Patricia M. Berninsone Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16176–16181. Published online 2006 October 23. doi: 10.1073/pnas.0608159103.PMCID: PMC1621047 Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium Jilin Zhou, Young Pyo Jang, So Ra Kim, and Janet R. Sparrow Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16182–16187. Published online 2006 October 23. doi: 10.1073/pnas.0604255103.PMCID: PMC1637557 Impaired nucleotide excision repair upon macrophage differentiation is corrected by E1 ubiquitin-activating enzyme Thierry Nouspikel and Philip C. Hanawalt Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16188–16193. Published online 2006 October 23. doi: 10.1073/pnas.0607769103.PMCID: PMC1621053 Biophysics Acceleration of the recognition rate between grafted ligands and receptors with magnetic forces J. Baudry, C. Rouzeau, C. Goubault, C. Robic, L. Cohen-Tannoudji, A. Koenig, E. Bertrand, and J. Bibette Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16076–16078. Published online 2006 October 18. doi: 10.1073/pnas.0607991103.PMCID: PMC1637538 Folding of the C-terminal bacterial binding domain in statherin upon adsorption onto hydroxyapatite crystals Gil Goobes, Rivka Goobes, Ora Schueler-Furman, David Baker, Patrick S. Stayton, and Gary P. Drobny Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16083–16088. Published online 2006 October 23. doi: 10.1073/pnas.0607193103.PMCID: PMC1637540 Structural and dynamical changes in an α-subunit of a heterotrimeric G protein along the activation pathway Ned Van Eps, William M. Oldham, Heidi E. Hamm, and Wayne L. Hubbell Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16194–16199. Published online 2006 October 19. doi: 10.1073/pnas.0607972103.PMCID: PMC1637559 On structural transitions, thermodynamic equilibrium, and the phase diagram of DNA and RNA duplexes under torque and tension Jeff Wereszczynski and Ioan Andricioaei Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16200–16205. Published online 2006 October 23. doi: 10.1073/pnas.0603850103.PMCID: PMC1637560 Monitoring intermediate filament assembly by small-angle x-ray scattering reveals the molecular architecture of assembly intermediates Anna V. Sokolova, Laurent Kreplak, Tatjana Wedig, Norbert Mücke, Dmitri I. Svergun, Harald Herrmann, Ueli Aebi, and Sergei V. Strelkov Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16206–16211. Published online 2006 October 18. doi: 10.1073/pnas.0603629103.PMCID: PMC1637561 Structure of electron transfer flavoprotein-ubiquinone oxidoreductase and electron transfer to the mitochondrial ubiquinone pool Jian Zhang, Frank E. Frerman, and Jung-Ja P. Kim Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16212–16217. Published online 2006 October 18. doi: 10.1073/pnas.0604567103.PMCID: PMC1637562 Structure of phosphorylated enzyme I, the phosphoenolpyruvate:sugar phosphotransferase system sugar translocation signal protein Alexey Teplyakov, Kap Lim, Peng-Peng Zhu, Geeta Kapadia, Celia C. H. Chen, Jennifer Schwartz, Andrew Howard, Prasad T. Reddy, Alan Peterkofsky, and Osnat Herzberg Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16218–16223. Published online 2006 October 19. doi: 10.1073/pnas.0607587103.PMCID: PMC1618308 Yeast mitochondrial ADP/ATP carriers are monomeric in detergents Lisa Bamber, Marilyn Harding, P. Jonathan G. Butler, and Edmund R. S. Kunji Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16224–16229. Published online 2006 October 20. doi: 10.1073/pnas.0607640103.PMCID: PMC1618811 An approach to crystallizing proteins by synthetic symmetrization D. Rey Banatao, Duilio Cascio, Christopher S. Crowley, Mark R. Fleissner, Heather L. Tienson, and Todd O. Yeates Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16230–16235. Published online 2006 October 18. doi: 10.1073/pnas.0607674103.PMCID: PMC1637565 Role of histone tails in chromatin folding revealed by a mesoscopic oligonucleosome model Gaurav Arya and Tamar Schlick Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16236–16241. Published online 2006 October 23. doi: 10.1073/pnas.0604817103.PMCID: PMC1637566 Membrane-dependent oligomeric structure and pore formation of a β-hairpin antimicrobial peptide in lipid bilayers from solid-state NMR Rajeswari Mani, Sarah D. Cady, Ming Tang, Alan J. Waring, Robert I. Lehrer, and Mei Hong Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16242–16247. Published online 2006 October 23. doi: 10.1073/pnas.0605079103.PMCID: PMC1637567 General structural motifs of amyloid protofilaments Neil Ferguson, Johanna Becker, Henning Tidow, Sandra Tremmel, Timothy D. Sharpe, Gerd Krause, Jeremy Flinders, Miriana Petrovich, John Berriman, Hartmut Oschkinat, and Alan R. Fersht Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16248–16253. Published online 2006 October 23. doi: 10.1073/pnas.0607815103.PMCID: PMC1637568 Cell Biology From the Cover: A rapid genome-scale response of the transcriptional oscillator to perturbation reveals a period-doubling path to phenotypic change Caroline M. Li and Robert R. Klevecz Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16254–16259. Published online 2006 October 16. doi: 10.1073/pnas.0604860103.PMCID: PMC1613231 PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription Marco Sandri, Jiandie Lin, Christoph Handschin, Wenli Yang, Zoltan P. Arany, Stewart H. Lecker, Alfred L. Goldberg, and Bruce M. Spiegelman Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16260–16265. Published online 2006 October 19. doi: 10.1073/pnas.0607795103.PMCID: PMC1637570 Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch Sylvie Giuriato, Sandra Ryeom, Alice C. Fan, Pavan Bachireddy, Ryan C. Lynch, Matthew J. Rioth, Jan van Riggelen, Andrew M. Kopelman, Emmanuelle Passegué, Flora Tang, Judah Folkman, and Dean W. Felsher Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16266–16271. Published online 2006 October 20. doi: 10.1073/pnas.0608017103.PMCID: PMC1637571 Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone Marius C. Jones, Luca Fusi, Jenny H. Higham, Hany Abdel-Hafiz, Kathryn B. Horwitz, Eric W.-F. Lam, and Jan J. Brosens Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16272–16277. Published online 2006 October 19. doi: 10.1073/pnas.0603002103.PMCID: PMC1637572 Macrophage inhibitory cytokine 1 mediates a p53-dependent protective arrest in S phase in response to starvation for DNA precursors Mukesh K. Agarwal, Kedar Hastak, Mark W. Jackson, Samuel N. Breit, George R. Stark, and Munna L. Agarwal Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16278–16283. Published online 2006 October 18. doi: 10.1073/pnas.0607210103.PMCID: PMC1637573 β-Arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes Keshava Rajagopal, Erin J. Whalen, Jonathan D. Violin, Jonathan A. Stiber, Paul B. Rosenberg, Richard T. Premont, Thomas M. Coffman, Howard A. Rockman, and Robert J. Lefkowitz Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16284–16289. Published online 2006 October 23. doi: 10.1073/pnas.0607583103.PMCID: PMC1637574 Pds1/Esp1-dependent and -independent sister chromatid separation in mutants defective for protein phosphatase 2A Xianying Tang and Yanchang Wang Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16290–16295. Published online 2006 October 18. doi: 10.1073/pnas.0607856103.PMCID: PMC1637575 The p110α isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation Jean J. Zhao, Hailing Cheng, Shidong Jia, Li Wang, Ole V. Gjoerup, Aki Mikami, and Thomas M. Roberts Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16296–16300. Published online 2006 October 23. doi: 10.1073/pnas.0607899103.PMCID: PMC1637576 Stimulatory effect of voluntary exercise or fat removal (partial lipectomy) on apoptosis in the skin of UVB light-irradiated mice Yao-Ping Lu, You-Rong Lou, Bonnie Nolan, Qing-Yun Peng, Jian-Guo Xie, George C. Wagner, and Allan H. Conney Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16301–16306. Published online 2006 October 23. doi: 10.1073/pnas.0607789103.PMCID: PMC1637577 Developmental Biology Sog/Chordin is required for ventral-to-dorsal Dpp/BMP transport and head formation in a short germ insect Maurijn van der Zee, Oliver Stockhammer, Cornelia von Levetzow, Rodrigo Nunes da Fonseca, and Siegfried Roth Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16307–16312. Published online 2006 October 18. doi: 10.1073/pnas.0605154103.PMCID: PMC1637578 Jun NH2-terminal kinase (JNK) prevents nuclear β-catenin accumulation and regulates axis formation in Xenopus embryos Guanghong Liao, Qinghua Tao, Matthew Kofron, Juei-Suei Chen, Aryn Schloemer, Roger J. Davis, Jen-Chih Hsieh, Chris Wylie, Janet Heasman, and Chia-Yi Kuan Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16313–16318. Published online 2006 October 23. doi: 10.1073/pnas.0602557103.PMCID: PMC1637579 Murine inner cell mass-derived lineages depend on Sall4 function Ulrich Elling, Christian Klasen, Tobias Eisenberger, Katrin Anlag, and Mathias Treier Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16319–16324. Published online 2006 October 23. doi: 10.1073/pnas.0607884103.PMCID: PMC1637580 Establishment of stable cell lines of Drosophila germ-line stem cells Yuzo Niki, Takafumi Yamaguchi, and Anthony P. Mahowald Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16325–16330. Published online 2006 October 20. doi: 10.1073/pnas.0607435103.PMCID: PMC1637581 Evolution Ancient polymorphism and functional variation in the primate MHC-DQA1 5′ cis-regulatory region Dagan A. Loisel, Matthew V. Rockman, Gregory A. Wray, Jeanne Altmann, and Susan C. Alberts Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16331–16336. Published online 2006 October 19. doi: 10.1073/pnas.0607662103.PMCID: PMC1637582 Evolution of complexity in signaling pathways Orkun S. Soyer and Sebastian Bonhoeffer Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16337–16342. Published online 2006 October 23. doi: 10.1073/pnas.0604449103.PMCID: PMC1621048 Good genes sexual selection in nature John A. Byers and Lisette Waits Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16343–16345. Published online 2006 October 23. doi: 10.1073/pnas.0608184103.PMCID: PMC1637584 From the Cover: Evolutionary trade-off between weapons and testes Leigh W. Simmons and Douglas J. Emlen Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16346–16351. Published online 2006 October 19. doi: 10.1073/pnas.0603474103.PMCID: PMC1637585 Genome scan for cis-regulatory DNA motifs associated with social behavior in honey bees Saurabh Sinha, Xu Ling, Charles W. Whitfield, Chengxiang Zhai, and Gene E. Robinson Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16352–16357. Published online 2006 October 25. doi: 10.1073/pnas.0607448103.PMCID: PMC1637586 Genetics Caspar, a suppressor of antibacterial immunity in Drosophila Myungjin Kim, Jun Hee Lee, Soo Young Lee, Eunhee Kim, and Jongkyeong Chung Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16358–16363. Published online 2006 October 18. doi: 10.1073/pnas.0603238103.PMCID: PMC1637587 From the Cover: Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades Douglas Wahlsten, Alexander Bachmanov, Deborah A. Finn, and John C. Crabbe Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16364–16369. Published online 2006 October 19. doi: 10.1073/pnas.0605342103.PMCID: PMC1618164 Induction and repair of zinc-finger nuclease-targeted double-strand breaks in Caenorhabditis elegans somatic cells Jason Morton, M. Wayne Davis, Erik M. Jorgensen, and Dana Carroll Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16370–16375. Published online 2006 October 23. doi: 10.1073/pnas.0605633103.PMCID: PMC1637589 Ubiquitin-associated domain of Mex67 synchronizes recruitment of the mRNA export machinery with transcription Carole Gwizdek, Nahid Iglesias, Manuel S. Rodriguez, Batool Ossareh-Nazari, Maria Hobeika, Gilles Divita, Françoise Stutz, and Catherine Dargemont Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16376–16381. Published online 2006 October 20. doi: 10.1073/pnas.0607941103.PMCID: PMC1637590 Hypersensitivity to oxygen and shortened lifespan in a Drosophila mitochondrial complex II mutant David W. Walker, Petr Hájek, Julien Muffat, Dan Knoepfle, Stephanie Cornelison, Giuseppe Attardi, and Seymour Benzer Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16382–16387. Published online 2006 October 20. doi: 10.1073/pnas.0607918103.PMCID: PMC1618815 Immunology Differential requirement for Lck during primary and memory CD8+ T cell responses Kavita Tewari, Jane Walent, John Svaren, Rose Zamoyska, and M. Suresh Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16388–16393. Published online 2006 October 23. doi: 10.1073/pnas.0602565103.PMCID: PMC1637592 Role of ABCC1 in export of sphingosine-1-phosphate from mast cells Poulami Mitra, Carole A. Oskeritzian, Shawn G. Payne, Michael A. Beaven, Sheldon Milstien, and Sarah Spiegel Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16394–16399. Published online 2006 October 18. doi: 10.1073/pnas.0603734103.PMCID: PMC1637593 Modeling CTLA4-linked autoimmunity with RNA interference in mice Zhibin Chen, John Stockton, Diane Mathis, and Christophe Benoist Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16400–16405. Published online 2006 October 23. doi: 10.1073/pnas.0607854103.PMCID: PMC1637594 Complete correction of murine Artemis immunodeficiency by lentiviral vector-mediated gene transfer Gustavo Mostoslavsky, Attila J. Fabian, Sean Rooney, Frederick W. Alt, and Richard C. Mulligan Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16406–16411. Published online 2006 October 24. doi: 10.1073/pnas.0608130103.PMCID: PMC1637595 Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d) Mitsunori Shiroishi, Kimiko Kuroki, Linda Rasubala, Kouhei Tsumoto, Izumi Kumagai, Eiji Kurimoto, Koichi Kato, Daisuke Kohda, and Katsumi Maenaka Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16412–16417. Published online 2006 October 20. doi: 10.1073/pnas.0605228103.PMCID: PMC1637596 A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation Patricia C. Fulkerson, Christine A. Fischetti, Melissa L. McBride, Lynn M. Hassman, Simon P. Hogan, and Marc E. Rothenberg Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16418–16423. Published online 2006 October 23. doi: 10.1073/pnas.0607863103.PMCID: PMC1637597 Rel/NF-κB double mutants reveal that cellular immunity is central to Drosophila host defense Nina Matova and Kathryn V. Anderson Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16424–16429. Published online 2006 October 23. doi: 10.1073/pnas.0605721103.PMCID: PMC1637598 Proinsulin is encoded by an RNA splice variant in human blood myeloid cells Parth Narendran, Alana M. Neale, Bo Han Lee, Katrina Ngui, Raymond J. Steptoe, Grant Morahan, Ole Madsen, James A. Dromey, Kent P. Jensen, and Leonard C. Harrison Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16430–16435. Published online 2006 October 19. doi: 10.1073/pnas.0607380103.PMCID: PMC1618309 Medical Sciences Radiolabeled somatostatin receptor antagonists are preferable to agonists for in vivo peptide receptor targeting of tumors Mihaela Ginj, Hanwen Zhang, Beatrice Waser, Renzo Cescato, Damian Wild, Xuejuan Wang, Judit Erchegyi, Jean Rivier, Helmut R. Mäcke, and Jean Claude Reubi Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16436–16441. Published online 2006 October 20. doi: 10.1073/pnas.0607761103.PMCID: PMC1618814 Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene Warren S. Alexander, Elizabeth M. Viney, Jian-Guo Zhang, Donald Metcalf, Maria Kauppi, Craig D. Hyland, Marina R. Carpinelli, William Stevenson, Ben A. Croker, Adrienne A. Hilton, Sarah Ellis, Carly Selan, Harshal H. Nandurkar, Christopher C. Goodnow, Benjamin T. Kile, Nicos A. Nicola, Andrew W. Roberts, and Douglas J. Hilton Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16442–16447. Published online 2006 October 24. doi: 10.1073/pnas.0607872103.PMCID: PMC1637601 RIG-G as a key mediator of the antiproliferative activity of interferon-related pathways through enhancing p21 and p27 proteins Shu Xiao, Dong Li, Hai-Qing Zhu, Man-Gen Song, Xiao-Rong Pan, Pei-Min Jia, Lin-Ling Peng, Ai-Xia Dou, Guo-Qiang Chen, Sai-Juan Chen, Zhu Chen, and Jian-Hua Tong Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16448–16453. Published online 2006 October 18. doi: 10.1073/pnas.0607830103.PMCID: PMC1637602 Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates Giovanni Solinas, Willscott Naugler, Francesco Galimi, Myung-Shik Lee, and Michael Karin Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16454–16459. Published online 2006 October 18. doi: 10.1073/pnas.0607626103.PMCID: PMC1637603 Enforced expression of the homeobox gene Mixl1 impairs hematopoietic differentiation and results in acute myeloid leukemia Stefan Glaser, Donald Metcalf, Li Wu, Adam H. Hart, Ladina DiRago, Sandra Mifsud, Angela D'Amico, Samantha Dagger, Chiara Campo, Angela C. Chan, David J. Izon, and Lorraine Robb Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16460–16465. Published online 2006 October 23. doi: 10.1073/pnas.0607776103.PMCID: PMC1637604 Angiogenesis-independent tumor growth mediated by stem-like cancer cells Per Ø. Sakariassen, Lars Prestegarden, Jian Wang, Kai-Ove Skaftnesmo, Rupavathana Mahesparan, Carla Molthoff, Peter Sminia, Eirik Sundlisæter, Anjan Misra, Berit Bølge Tysnes, Martha Chekenya, Hans Peters, Gabriel Lende, Karl Henning Kalland, Anne M. Øyan, Kjell Petersen, Inge Jonassen, Albert van der Kogel, Burt G. Feuerstein, A. Jorge A. Terzis, Rolf Bjerkvig, and Per Øyvind Enger Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16466–16471. Published online 2006 October 20. doi: 10.1073/pnas.0607668103.PMCID: PMC1618812 The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis Gong Yang, Daniel G. Rosen, Zhihong Zhang, Robert C. Bast, Jr., Gordon B. Mills, Justin A. Colacino, Imelda Mercado-Uribe, and Jinsong Liu Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16472–16477. Published online 2006 October 23. doi: 10.1073/pnas.0605752103.PMCID: PMC1637606 Microbiology Terminal organelle development in the cell wall-less bacterium Mycoplasma pneumoniae Benjamin M. Hasselbring, Jarrat L. Jordan, Robert W. Krause, and Duncan C. Krause Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16478–16483. Published online 2006 October 24. doi: 10.1073/pnas.0608051103.PMCID: PMC1637607 Cryo-EM visualization of transfer messenger RNA with two SmpBs in a stalled ribosome Sukhjit Kaur, Reynald Gillet, Wen Li, Richard Gursky, and Joachim Frank Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16484–16489. Published online 2006 October 20. doi: 10.1073/pnas.0607438103.PMCID: PMC1618813 Secretion signal recognition by YscN, the Yersinia type III secretion ATPase Joseph A. Sorg, Bill Blaylock, and Olaf Schneewind Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16490–16495. Published online 2006 October 18. doi: 10.1073/pnas.0605974103.PMCID: PMC1637609 Mammalian reovirus, a nonfusogenic nonenveloped virus, forms size-selective pores in a model membrane Melina A. Agosto, Tijana Ivanovic, and Max L. Nibert Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16496–16501. Published online 2006 October 19. doi: 10.1073/pnas.0605835103.PMCID: PMC1637610 The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2 Michael A. Fischbach, Hening Lin, Lu Zhou, Yang Yu, Rebecca J. Abergel, David R. Liu, Kenneth N. Raymond, Barry L. Wanner, Roland K. Strong, Christopher T. Walsh, Alan Aderem, and Kelly D. Smith Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16502–16507. Published online 2006 October 23. doi: 10.1073/pnas.0604636103.PMCID: PMC1637611 Establishment of a Nipah virus rescue system Misako Yoneda, Vanessa Guillaume, Fusako Ikeda, Yuki Sakuma, Hiroki Sato, T. Fabian Wild, and Chieko Kai Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16508–16513. Published online 2006 October 19. doi: 10.1073/pnas.0606972103.PMCID: PMC1618306 A B lymphocyte mitogen is a Brucella abortus virulence factor required for persistent infection Juan Manuel Spera, Juan Esteban Ugalde, Juan Mucci, Diego J. Comerci, and Rodolfo Augusto Ugalde Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16514–16519. Published online 2006 October 19. doi: 10.1073/pnas.0603362103.PMCID: PMC1637613 Neuroscience Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly Lei Chen, Guanghong Liao, Linda Yang, Kenneth Campbell, Masato Nakafuku, Chia-Yi Kuan, and Yi Zheng Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16520–16525. Published online 2006 October 18. doi: 10.1073/pnas.0603533103.PMCID: PMC1637614 A homeostatic rule for inhibitory synapses promotes temporal sharpening and cortical reorganization Samat B. Moldakarimov, James L. McClelland, and G. Bard Ermentrout Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16526–16531. Published online 2006 October 18. doi: 10.1073/pnas.0607589103.PMCID: PMC1637615 A peptide zipcode sufficient for anterograde transport within amyloid precursor protein Prasanna Satpute-Krishnan, Joseph A. DeGiorgis, Michael P. Conley, Marcus Jang, and Elaine L. Bearer Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16532–16537. Published online 2006 October 24. doi: 10.1073/pnas.0607527103.PMCID: PMC1621108 Pheromone reception in fruit flies expressing a moth's odorant receptor Zainulabeuddin Syed, Yuko Ishida, Katherine Taylor, Deborah A. Kimbrell, and Walter S. Leal Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16538–16543. Published online 2006 October 23. doi: 10.1073/pnas.0607874103.PMCID: PMC1621046 Tactile guidance of prey capture in Etruscan shrews Farzana Anjum, Hendrik Turni, Paul G. H. Mulder, Johannes van der Burg, and Michael Brecht Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16544–16549. Published online 2006 October 23. doi: 10.1073/pnas.0605573103.PMCID: PMC1621049 Somatomotor and oculomotor inferior olivary neurons have distinct electrophysiological phenotypes Francisco J. Urbano, John I. Simpson, and Rodolfo R. Llinás Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16550–16555. Published online 2006 October 18. doi: 10.1073/pnas.0607888103.PMCID: PMC1616941 Acid-sensing ion channel 1a is a postsynaptic proton receptor that affects the density of dendritic spines Xiang-ming Zha, John A. Wemmie, Steven H. Green, and Michael J. Welsh Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16556–16561. Published online 2006 October 23. doi: 10.1073/pnas.0608018103.PMCID: PMC1621052 Loss of AP-3 function affects spontaneous and evoked release at hippocampal mossy fiber synapses Anita Scheuber, Rachel Rudge, Lydia Danglot, Graca Raposo, Thomas Binz, Jean-Christophe Poncer, and Thierry Galli Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16562–16567. Published online 2006 October 20. doi: 10.1073/pnas.0603511103.PMCID: PMC1637621 Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory Pamela Maher, Tatsuhiro Akaishi, and Kazuho Abe Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16568–16573. Published online 2006 October 18. doi: 10.1073/pnas.0607822103.PMCID: PMC1637622 Physiology Phosphorylation of serine 1928 in the distal C-terminal domain of cardiac CaV1.2 channels during β1-adrenergic regulation Joanne T. Hulme, Ruth E. Westenbroek, Todd Scheuer, and William A. Catterall Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16574–16579. Published online 2006 October 19. doi: 10.1073/pnas.0607294103.PMCID: PMC1637623 Urocortin 2 modulates glucose utilization and insulin sensitivity in skeletal muscle Alon Chen, Bhawanjit Brar, Cheol Soo Choi, David Rousso, Joan Vaughan, Yael Kuperman, Shee Ne Kim, Cindy Donaldson, Sean M. Smith, Pauline Jamieson, Chien Li, Tim R. Nagy, Gerald I. Shulman, Kuo-Fen Lee, and Wylie Vale Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16580–16585. Published online 2006 October 18. doi: 10.1073/pnas.0607337103.PMCID: PMC1637624 A common mechanism underlies stretch activation and receptor activation of TRPC6 channels Maria A. Spassova, Thamara Hewavitharana, Wen Xu, Jonathan Soboloff, and Donald L. Gill Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16586–16591. Published online 2006 October 20. doi: 10.1073/pnas.0606894103.PMCID: PMC1637625 Plant Biology The gene responsible for borate cross-linking of pectin Rhamnogalacturonan-II is required for plant reproductive tissue development and fertilization Hiroaki Iwai, Akiko Hokura, Masahiro Oishi, Hiroshi Chida, Tadashi Ishii, Shingo Sakai, and Shinobu Satoh Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16592–16597. Published online 2006 October 19. doi: 10.1073/pnas.0605141103.PMCID: PMC1637626 Roles of Arabidopsis ATP/ADP isopentenyltransferases and tRNA isopentenyltransferases in cytokinin biosynthesis Kaori Miyawaki, Petr Tarkowski, Miho Matsumoto-Kitano, Tomohiko Kato, Shusei Sato, Danuse Tarkowska, Satoshi Tabata, Göran Sandberg, and Tatsuo Kakimoto Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16598–16603. Published online 2006 October 24. doi: 10.1073/pnas.0603522103.PMCID: PMC1637627 Population Biology INAUGURAL ARTICLE by a Recently Elected Academy Member: Genomic dissection of behavioral maturation in the honey bee Charles W. Whitfield, Yehuda Ben-Shahar, Charles Brillet, Isabelle Leoncini, Didier Crauser, Yves LeConte, Sandra Rodriguez-Zas, and Gene E. Robinson Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16068–16075. Published online 2006 October 25. doi: 10.1073/pnas.0606909103.PMCID: PMC1622924 Evaluation of mortality trajectories in evolutionary biodemography Stephan B. Munch and Marc Mangel Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16604–16607. Published online 2006 October 23. doi: 10.1073/pnas.0601735103.PMCID: PMC1637628 Social Sciences Environmental Sciences Evaluation of mortality trajectories in evolutionary biodemography Stephan B. Munch and Marc Mangel Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16604–16607. Published online 2006 October 23. doi: 10.1073/pnas.0601735103.PMCID: PMC1637628 Psychology Universality of color names Delwin T. Lindsey and Angela M. Brown Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16608–16613. Published online 2006 October 17. doi: 10.1073/pnas.0607708103.PMCID: PMC1614705 Corrections Correction for Head-Gordon et al., Tetrahedral structure or chains for liquid water Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16614–16615. Published online 2006 October 18. doi: 10.1073/pnas.0608020103.PMCID: PMC1637630 Corrects: Teresa Head-Gordon, et al. Tetrahedral structure or chains for liquid water. Proc Natl Acad Sci U S A. 2006 May 23; 103(21): 7973–7977. Correction for Limberis et al., Adeno-associated virus serotype 9 vectors transduce murine alveolar and nasal epithelia and can be readministered Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16614–16615. Published online 2006 October 18. doi: 10.1073/pnas.0608505103.PMCID: PMC1637631 Corrects: Maria P. Limberis, et al. Adeno-associated virus serotype 9 vectors transduce murine alveolar and nasal epithelia and can be readministered. Proc Natl Acad Sci U S A. 2006 August 29; 103(35): 12993–12998. Correction for Colot et al., A high-throughput gene knockout procedure for Neurospora reveals functions for multiple transcription factors Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16614–16615. Published online 2006 October 18. doi: 10.1073/pnas.0608497103.PMCID: PMC1637632 Corrects: Hildur V. Colot, et al. A high-throughput gene knockout procedure for Neurospora reveals functions for multiple transcription factors. Proc Natl Acad Sci U S A. 2006 July 5; 103(27): 10352–10357. Correction for Kuroda et al., Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16614–16615. Published online 2006 October 18. doi: 10.1073/pnas.0608594103.PMCID: PMC1637633 Corrects: Junya Kuroda, et al. Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic. Proc Natl Acad Sci U S A. 2006 October 3; 103(40): 14907–14912. Correction for Zandbergen et al., Leishmania disease development depends on the presence of apoptotic promastigotes in the virulent inoculum Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16615. Published online 2006 October 20. doi: 10.1073/pnas.0607935103.PMCID: PMC1637634 Corrects: Ger van Zandbergen, et al. Leishmania disease development depends on the presence of apoptotic promastigotes in the virulent inoculum. Proc Natl Acad Sci U S A. 2006 September 12; 103(37): 13837–13842. |