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JCV virological and immunological parameters associated to Progressive Multifocal Leukoencephalopathy (PML) progression in AIDS patients.

Taoufik Y, Sala M, Kahraman M, Vartanian JP, Kousignian P, De Goer MG, Wain-Hobson S, Delfraissy JP, Gasnault J; International Conference on AIDS.

Int Conf AIDS. 2000 Jul 9-14; 13: abstract no. MoPeB2294.

Y. Taoufik, Laboratoire CR Inserm, Universite Paris-Sud, 63, rue Gabriel Peri, 94276 Le Kremlin Bicetre Cedex, France, Tel.: +33 1 49 59 67 54, Fax: +33 1 49 59 67 53, E-mail:

Background: Despite the use of combination antiretroviral therapy (CART) following PML diagnosis, the survival remains poor in about 50% of patients with AIDS-associated PML. Objective: To examine virological and immunological mechanisms underlying survival heterogeneity in AIDS-associated PML patients on CART. Methods: JC virus (JCV) load in CSF was determined by using a quantitative PCR assay (37 patients). Sequencing of the region of VP1 and the transcription control region (TCR) was performed (10 patients). In parallel, proliferation of PBMC to purified JCV was examined (10 patients). Results: We found a significant correlation between JCV load in CSF and survival (r = -0.55, p > 0.0001). All the JCV TCR sequences in CSF were rearranged. In this series of patients, no particular TCR rearrangement patterns or VP1 genotypes were associated with poor outcome. A trend to negative correlation was found between CD4 T cell proliferation to JCV and JCV load in CSF. Conclusions: High JCV load in CSF and weak anti-JCV CD4 T cell response are related to a poor outcome in AIDS-associated PML.

Publication Types:
  • Meeting Abstracts
  • Acquired Immunodeficiency Syndrome
  • Base Sequence
  • CD4-Positive T-Lymphocytes
  • Disease Progression
  • Genotype
  • Humans
  • JC Virus
  • Leukoencephalopathy, Progressive Multifocal
  • Polymerase Chain Reaction
  • Transcription, Genetic
  • genetics
  • immunology
  • virology
Other ID:
  • GWAIDS0000403
UI: 102237894

From Meeting Abstracts

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