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Job's like syndrome in HIV-1 infection.

Raiteri R, Pippione M, Picciotto L, Martinetto P, Sinicco A; International Conference on AIDS.

Int Conf AIDS. 1992 Jul 19-24; 8: 125 (abstract no. PuB 7460).

Inst. of Infect. Diseases, University of Turin, Italy.

OBJECTIVE: To report 9 cases of unusual skin lesions in HIV-1 patients (HIV+) with hyperimmunoglobulinemia E (HIE) and recurrent skin lesions by Staphylococcus aureus. METHODS: From Jun 1990 to Feb 1992, 9 HIV+ with HIE and recurrent staphylococcal lesions of the skin were periodically examined. Total serum IgE (IgE), antistaphylococcal IgE (AIgE), IgE binding factors (IgE-Bf), chemotactic responses of PMN cells both in vivo and in vitro (PMN-CH), phagocytic activity (PHA), CD4+, CD8+, gamma-INF and IL-4 were monitored. Skin biopsy was taken when patient's permission was given. RESULTS: Skin lesions occurred preferentially within the great folds and macroscopically deal in some way with atopic dermatitis and herpes simplex lesions. However, clinical follow-up, cultural tests (S. aureus was always cultured from the lesions) and biopsy specimens focused the peculiar character of the lesions. Increased titres of IgE and AIgE were observed and they dramatically decreased when patients were treated with antistaphylococcal drugs. A negative correlation between AIgE and the number of recidives was seen (r = -0.834; P = 0.015). IgE-BF was increased, but there was no correlation with IgE or AIgE. PMN-CH was depressed, PHA was lower compared to HIV+ without skin lesions (P = 0.03). IL-4 was often higher than control values, gamma-IFN increased. CONCLUSIONS: We propose that those cases in which there are skin lesions by Staphylococcus aureus with HIE in HIV+ are described as an acquired Job's like syndrome.

Publication Types:
  • Meeting Abstracts
  • Acquired Immunodeficiency Syndrome
  • Dermatitis, Atopic
  • HIV Seropositivity
  • HIV-1
  • Humans
  • In Vitro
  • Interleukin-4
  • Job's Syndrome
  • Skin
  • Staphylococcal Skin Infections
  • Staphylococcus
  • Staphylococcus aureus
  • Syndrome
Other ID:
  • 92403516
UI: 102201230

From Meeting Abstracts

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